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Protein

Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

Gene

PPP4R1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein uncertaini

Functioni

May be a regulatory subunit of serine/threonine-protein phosphatase 4.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like
Gene namesi
Name:PPP4R1L
Synonyms:C20orf192
ORF Names:PRO1085
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:15755. PPP4R1L.

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi374095492.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 415415Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-likePRO_0000071530Add
BLAST

Proteomic databases

PaxDbiQ9P1A2.
PRIDEiQ9P1A2.

PTM databases

iPTMnetiQ9P1A2.

Expressioni

Gene expression databases

BgeeiQ9P1A2.

Organism-specific databases

HPAiHPA054865.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000335579.

Structurei

3D structure databases

ProteinModelPortaliQ9P1A2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati86 – 12439HEAT 1Add
BLAST
Repeati163 – 20240HEAT 2Add
BLAST
Repeati203 – 24139HEAT 3Add
BLAST
Repeati242 – 28039HEAT 4Add
BLAST

Sequence similaritiesi

Contains 4 HEAT repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0211. Eukaryota.
ENOG410XQVI. LUCA.
HOGENOMiHOG000070067.
HOVERGENiHBG074930.
InParanoidiQ9P1A2.
PhylomeDBiQ9P1A2.
TreeFamiTF105560.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR021133. HEAT_type_2.
IPR031088. PPP4R1L.
[Graphical view]
PANTHERiPTHR10648:SF7. PTHR10648:SF7. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50077. HEAT_REPEAT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P1A2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEIPLYFVD LQDDLDDYGF EDYGTDCDNM RVTAFLDIPG QDNLPPLTRL
60 70 80 90 100
EKYAFSENTF NRQIIARGLL DIFRDFGNNE EDFLTVMEIV VRLSEDAEPT
110 120 130 140 150
VRTELMEQIP PIAIFLQENR SNFPVVLSEY LIPIVVRYLT DPNNQIICKM
160 170 180 190 200
ASMLSKSTVE RLLLPRFCEL CGDRKLFQVR KVCAANFGDI CHAVGQEATE
210 220 230 240 250
KFLIPKFFEL CSDAVWGMRK ACAECFTAVS HSSSPGVRRT QLFPLFIRLV
260 270 280 290 300
SDPCRWVHQA AFQSLGPFTS TFANPSRAGL YLREDGALSI WPLTQDLDSG
310 320 330 340 350
FASGSPAPSS GGNTSPASLT RSAKPVRSEP ELPVEGTSAK TSDCPHSSSS
360 370 380 390 400
SDGPAESPVE SCVSAGAEWT RVSPETSACS KLSDMNDLPI SSYPGSDSWA
410
CPGNTEDVFS HFLYW
Length:415
Mass (Da):45,908
Last modified:January 25, 2012 - v3
Checksum:iF6E0FD9FDC1A2CFA
GO
Isoform 2 (identifier: Q9P1A2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-144: Missing.

Note: No experimental confirmation available.
Show »
Length:272
Mass (Da):29,353
Checksum:i8836F544AD3F7E74
GO

Sequence cautioni

The sequence AAF69597.1 differs from that shown.Wrong choice of frame.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei2 – 144143Missing in isoform 2. 1 PublicationVSP_056120Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057583 mRNA. Translation: BAB71529.1.
AK299330 mRNA. Translation: BAG61336.1.
AL035455 Genomic DNA. No translation available.
AL354776 Genomic DNA. No translation available.
AL354834 Genomic DNA. No translation available.
AF119843 mRNA. Translation: AAF69597.1. Sequence problems.
UniGeneiHs.473179.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057583 mRNA. Translation: BAB71529.1.
AK299330 mRNA. Translation: BAG61336.1.
AL035455 Genomic DNA. No translation available.
AL354776 Genomic DNA. No translation available.
AL354834 Genomic DNA. No translation available.
AF119843 mRNA. Translation: AAF69597.1. Sequence problems.
UniGeneiHs.473179.

3D structure databases

ProteinModelPortaliQ9P1A2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000335579.

PTM databases

iPTMnetiQ9P1A2.

Polymorphism and mutation databases

DMDMi374095492.

Proteomic databases

PaxDbiQ9P1A2.
PRIDEiQ9P1A2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiPPP4R1L.
HGNCiHGNC:15755. PPP4R1L.
HPAiHPA054865.
neXtProtiNX_Q9P1A2.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0211. Eukaryota.
ENOG410XQVI. LUCA.
HOGENOMiHOG000070067.
HOVERGENiHBG074930.
InParanoidiQ9P1A2.
PhylomeDBiQ9P1A2.
TreeFamiTF105560.

Miscellaneous databases

ChiTaRSiPPP4R1L. human.
PROiQ9P1A2.

Gene expression databases

BgeeiQ9P1A2.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR021133. HEAT_type_2.
IPR031088. PPP4R1L.
[Graphical view]
PANTHERiPTHR10648:SF7. PTHR10648:SF7. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50077. HEAT_REPEAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Thymus.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Functional prediction of the coding sequences of 79 new genes deduced by analysis of cDNA clones from human fetal liver."
    Zhang C., Yu Y., Zhang S., Wei H., Zhang Y., Zhou G., Bi J., Liu M., He F.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 325-415 (ISOFORM 1).
    Tissue: Fetal liver.

Entry informationi

Entry nameiPP4RL_HUMAN
AccessioniPrimary (citable) accession number: Q9P1A2
Secondary accession number(s): B4DRM4
, Q96LY6, Q9BZ17, Q9BZ18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: January 25, 2012
Last modified: March 16, 2016
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.