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Protein

Neurotrimin

Gene

NTM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Neural cell adhesion molecule.

GO - Biological processi

  • cell adhesion Source: ProtInc
  • neuron recognition Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

BioCyciZFISH:G66-33229-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotrimin
Short name:
hNT
Alternative name(s):
IgLON family member 2
Gene namesi
Name:NTM
Synonyms:IGLON2, NT
ORF Names:UNQ297/PRO337
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:17941. NTM.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi50863.
OpenTargetsiENSG00000182667.
PharmGKBiPA164724212.

Polymorphism and mutation databases

BioMutaiNTM.
DMDMi27151645.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 331 PublicationAdd BLAST33
ChainiPRO_000001511034 – 321NeurotriminAdd BLAST288
PropeptideiPRO_0000015111322 – 344Removed in mature formSequence analysisAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi44N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi57 ↔ 115PROSITE-ProRule annotation
Glycosylationi70N-linked (GlcNAc...)Sequence analysis1
Glycosylationi152N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi157 ↔ 201PROSITE-ProRule annotation
Disulfide bondi243 ↔ 295PROSITE-ProRule annotation
Glycosylationi284N-linked (GlcNAc...)Sequence analysis1
Glycosylationi292N-linked (GlcNAc...)Sequence analysis1
Glycosylationi305N-linked (GlcNAc...)Sequence analysis1
Lipidationi321GPI-anchor amidated asparagineSequence analysis1
Glycosylationi321N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDiQ9P121.
MaxQBiQ9P121.
PaxDbiQ9P121.
PeptideAtlasiQ9P121.
PRIDEiQ9P121.

PTM databases

iPTMnetiQ9P121.
PhosphoSitePlusiQ9P121.

Expressioni

Gene expression databases

BgeeiENSG00000182667.
ExpressionAtlasiQ9P121. baseline and differential.
GenevisibleiQ9P121. HS.

Organism-specific databases

HPAiCAB024875.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
C19orf47Q8N9M13EBI-4315078,EBI-2835503
CCKBRP322393EBI-4315078,EBI-1753137
KRTAP3-2Q9BYR73EBI-4315078,EBI-751260
KRTAP5-9P263713EBI-4315078,EBI-3958099
LSAMPQ134492EBI-4315078,EBI-4314821
NEGR1Q7Z3B12EBI-4315078,EBI-4314838

Protein-protein interaction databases

BioGridi119163. 16 interactors.
IntActiQ9P121. 12 interactors.
STRINGi9606.ENSP00000396722.

Structurei

3D structure databases

ProteinModelPortaliQ9P121.
SMRiQ9P121.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 126Ig-like C2-type 1Add BLAST88
Domaini136 – 218Ig-like C2-type 2Add BLAST83
Domaini222 – 309Ig-like C2-type 3Add BLAST88

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IQJF. Eukaryota.
ENOG4111SM8. LUCA.
GeneTreeiENSGT00860000133697.
HOGENOMiHOG000019085.
HOVERGENiHBG017341.
InParanoidiQ9P121.
KOiK06774.
OMAiASMILYE.
OrthoDBiEOG091G0B5D.
PhylomeDBiQ9P121.
TreeFamiTF325565.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
PF00047. ig. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P121-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGVCGYLFLP WKCLVVVSLR LLFLVPTGVP VRSGDATFPK AMDNVTVRQG
60 70 80 90 100
ESATLRCTID NRVTRVAWLN RSTILYAGND KWCLDPRVVL LSNTQTQYSI
110 120 130 140 150
EIQNVDVYDE GPYTCSVQTD NHPKTSRVHL IVQVSPKIVE ISSDISINEG
160 170 180 190 200
NNISLTCIAT GRPEPTVTWR HISPKAVGFV SEDEYLEIQG ITREQSGDYE
210 220 230 240 250
CSASNDVAAP VVRRVKVTVN YPPYISEAKG TGVPVGQKGT LQCEASAVPS
260 270 280 290 300
AEFQWYKDDK RLIEGKKGVK VENRPFLSKL IFFNVSEHDY GNYTCVASNK
310 320 330 340
LGHTNASIML FGPGAVSEVS NGTSRRAGCV WLLPLLVLHL LLKF
Length:344
Mass (Da):37,971
Last modified:October 1, 2000 - v1
Checksum:iDA4D12C295ABBE3A
GO
Isoform 2 (identifier: Q9P121-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: MGVCGYLFLPWKCLVVVSLRLLFLVPT → MKTIQPKMHNSISWAIFTGLAALCLFQ

Note: No experimental confirmation available.
Show »
Length:344
Mass (Da):37,954
Checksum:i9423373042A196CD
GO
Isoform 3 (identifier: Q9P121-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     313-316: PGAV → ETVL
     317-344: Missing.

Note: No experimental confirmation available.
Show »
Length:316
Mass (Da):34,985
Checksum:i4AA281427476437F
GO
Isoform 4 (identifier: Q9P121-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     311-311: F → FEVKTTALTPWK

Show »
Length:355
Mass (Da):39,227
Checksum:iBF3350144F424D27
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0109391 – 27MGVCG…FLVPT → MKTIQPKMHNSISWAIFTGL AALCLFQ in isoform 2. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_041165311F → FEVKTTALTPWK in isoform 4. Curated1
Alternative sequenceiVSP_010940313 – 316PGAV → ETVL in isoform 3. 2 Publications4
Alternative sequenceiVSP_010941317 – 344Missing in isoform 3. 2 PublicationsAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126426 mRNA. Translation: AAF37591.1.
EF043567 mRNA. Translation: ABK34282.1.
AY358331 mRNA. Translation: AAQ88697.1.
BC050716 mRNA. Translation: AAH50716.1.
CCDSiCCDS41733.1. [Q9P121-2]
CCDS44777.1. [Q9P121-4]
CCDS44778.1. [Q9P121-3]
CCDS8491.1. [Q9P121-1]
RefSeqiNP_001041674.1. NM_001048209.1. [Q9P121-2]
NP_001137530.1. NM_001144058.1. [Q9P121-4]
NP_001137531.1. NM_001144059.1. [Q9P121-3]
NP_057606.1. NM_016522.2. [Q9P121-1]
UniGeneiHs.504352.

Genome annotation databases

EnsembliENST00000374784; ENSP00000363916; ENSG00000182667. [Q9P121-3]
ENST00000374786; ENSP00000363918; ENSG00000182667. [Q9P121-1]
ENST00000374791; ENSP00000363923; ENSG00000182667. [Q9P121-2]
ENST00000425719; ENSP00000396722; ENSG00000182667. [Q9P121-4]
GeneIDi50863.
KEGGihsa:50863.
UCSCiuc001qgm.4. human. [Q9P121-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126426 mRNA. Translation: AAF37591.1.
EF043567 mRNA. Translation: ABK34282.1.
AY358331 mRNA. Translation: AAQ88697.1.
BC050716 mRNA. Translation: AAH50716.1.
CCDSiCCDS41733.1. [Q9P121-2]
CCDS44777.1. [Q9P121-4]
CCDS44778.1. [Q9P121-3]
CCDS8491.1. [Q9P121-1]
RefSeqiNP_001041674.1. NM_001048209.1. [Q9P121-2]
NP_001137530.1. NM_001144058.1. [Q9P121-4]
NP_001137531.1. NM_001144059.1. [Q9P121-3]
NP_057606.1. NM_016522.2. [Q9P121-1]
UniGeneiHs.504352.

3D structure databases

ProteinModelPortaliQ9P121.
SMRiQ9P121.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119163. 16 interactors.
IntActiQ9P121. 12 interactors.
STRINGi9606.ENSP00000396722.

PTM databases

iPTMnetiQ9P121.
PhosphoSitePlusiQ9P121.

Polymorphism and mutation databases

BioMutaiNTM.
DMDMi27151645.

Proteomic databases

EPDiQ9P121.
MaxQBiQ9P121.
PaxDbiQ9P121.
PeptideAtlasiQ9P121.
PRIDEiQ9P121.

Protocols and materials databases

DNASUi50863.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374784; ENSP00000363916; ENSG00000182667. [Q9P121-3]
ENST00000374786; ENSP00000363918; ENSG00000182667. [Q9P121-1]
ENST00000374791; ENSP00000363923; ENSG00000182667. [Q9P121-2]
ENST00000425719; ENSP00000396722; ENSG00000182667. [Q9P121-4]
GeneIDi50863.
KEGGihsa:50863.
UCSCiuc001qgm.4. human. [Q9P121-1]

Organism-specific databases

CTDi50863.
DisGeNETi50863.
GeneCardsiNTM.
HGNCiHGNC:17941. NTM.
HPAiCAB024875.
MIMi607938. gene.
neXtProtiNX_Q9P121.
OpenTargetsiENSG00000182667.
PharmGKBiPA164724212.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQJF. Eukaryota.
ENOG4111SM8. LUCA.
GeneTreeiENSGT00860000133697.
HOGENOMiHOG000019085.
HOVERGENiHBG017341.
InParanoidiQ9P121.
KOiK06774.
OMAiASMILYE.
OrthoDBiEOG091G0B5D.
PhylomeDBiQ9P121.
TreeFamiTF325565.

Enzyme and pathway databases

BioCyciZFISH:G66-33229-MONOMER.

Miscellaneous databases

ChiTaRSiNTM. human.
GeneWikiiHNT.
GenomeRNAii50863.
PROiQ9P121.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000182667.
ExpressionAtlasiQ9P121. baseline and differential.
GenevisibleiQ9P121. HS.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
PF00047. ig. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNTRI_HUMAN
AccessioniPrimary (citable) accession number: Q9P121
Secondary accession number(s): A0MTT2, Q6UXJ3, Q86VJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 13, 2002
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.