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Q9P104

- DOK5_HUMAN

UniProt

Q9P104 - DOK5_HUMAN

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Protein

Docking protein 5

Gene

DOK5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.

GO - Molecular functioni

  1. receptor signaling protein activity Source: Ensembl

GO - Biological processi

  1. MAPK cascade Source: Ensembl
  2. nervous system development Source: Ensembl
  3. transmembrane receptor protein tyrosine kinase signaling pathway Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ9P104.

Names & Taxonomyi

Protein namesi
Recommended name:
Docking protein 5
Alternative name(s):
Downstream of tyrosine kinase 5
Insulin receptor substrate 6
Short name:
IRS-6
Short name:
IRS6
Gene namesi
Name:DOK5
Synonyms:C20orf180
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:16173. DOK5.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25724.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306Docking protein 5PRO_0000187277Add
BLAST

Post-translational modificationi

Phosphorylated on tyrosine residues in response to insulin, IGF1 and GDNF.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9P104.
PRIDEiQ9P104.

PTM databases

PhosphoSiteiQ9P104.

Expressioni

Tissue specificityi

Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T-lymphocytes.2 Publications

Gene expression databases

BgeeiQ9P104.
CleanExiHS_DOK5.
GenevestigatoriQ9P104.

Interactioni

Subunit structurei

Interacts with phosphorylated RET. In contrast to other DOK proteins, it does not interact with RASGAP (By similarity).By similarity

Protein-protein interaction databases

BioGridi120926. 4 interactions.
IntActiQ9P104. 4 interactions.
MINTiMINT-1435904.
STRINGi9606.ENSP00000262593.

Structurei

Secondary structure

1
306
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi137 – 1437Combined sources
Beta strandi153 – 1597Combined sources
Beta strandi161 – 17111Combined sources
Beta strandi174 – 1807Combined sources
Helixi181 – 1833Combined sources
Beta strandi184 – 1896Combined sources
Beta strandi191 – 1988Combined sources
Beta strandi200 – 2045Combined sources
Beta strandi206 – 2127Combined sources
Helixi216 – 22914Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1J0WX-ray2.50A/B133-232[»]
ProteinModelPortaliQ9P104.
SMRiQ9P104. Positions 133-232.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9P104.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 112105PHAdd
BLAST
Domaini132 – 237106IRS-type PTBPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi263 – 27311DKFBH motifAdd
BLAST

Domaini

PTB domain mediates receptor interaction.By similarity

Sequence similaritiesi

Belongs to the DOK family. Type B subfamily.Curated
Contains 1 IRS-type PTB domain.PROSITE-ProRule annotation
Contains 1 PH domain.Curated

Phylogenomic databases

eggNOGiNOG256436.
GeneTreeiENSGT00730000110348.
HOVERGENiHBG002356.
InParanoidiQ9P104.
OMAiHAVGIYF.
OrthoDBiEOG7GTT3W.
PhylomeDBiQ9P104.
TreeFamiTF324994.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR002404. Insln_rcpt_S1.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view]
PfamiPF02174. IRS. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00310. PTBI. 1 hit.
[Graphical view]
PROSITEiPS51064. IRS_PTB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9P104-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASNFNDIVK QGYVRIRSRR LGIYQRCWLV FKKASSKGPK RLEKFSDERA
60 70 80 90 100
AYFRCYHKVT ELNNVKNVAR LPKSTKKHAI GIYFNDDTSK TFACESDLEA
110 120 130 140 150
DEWCKVLQME CVGTRINDIS LGEPDLLATG VEREQSERFN VYLMPSPNLD
160 170 180 190 200
VHGECALQIT YEYICLWDVQ NPRVKLISWP LSALRRYGRD TTWFTFEAGR
210 220 230 240 250
MCETGEGLFI FQTRDGEAIY QKVHSAALAI AEQHERLLQS VKNSMLQMKM
260 270 280 290 300
SERAASLSTM VPLPRSAYWQ HITRQHSTGQ LYRLQDVSSP LKLHRTETFP

AYRSEH
Length:306
Mass (Da):35,464
Last modified:December 6, 2002 - v2
Checksum:i2F259529E8B068DB
GO
Isoform 2 (identifier: Q9P104-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: Missing.

Note: No experimental confirmation available.

Show »
Length:198
Mass (Da):22,824
Checksum:i291F9F2A419FE062
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti225 – 23410SAALAIAEQH → LLQMKMSERA in AAF66443. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 108108Missing in isoform 2. 1 PublicationVSP_003854Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132732 mRNA. Translation: AAF66443.1.
AF466368 mRNA. Translation: AAL74194.1.
AL118501, AL162292 Genomic DNA. Translation: CAI19415.1.
AL118501 Genomic DNA. Translation: CAI19416.1.
AL162292, AL118501 Genomic DNA. Translation: CAI16465.1.
BC008992 mRNA. Translation: AAH08992.1.
AL050069 mRNA. Translation: CAB43255.3.
CCDSiCCDS13446.1. [Q9P104-1]
CCDS13447.1. [Q9P104-2]
PIRiT08731.
RefSeqiNP_060901.2. NM_018431.4. [Q9P104-1]
NP_808874.1. NM_177959.2. [Q9P104-2]
UniGeneiHs.473133.
Hs.656582.

Genome annotation databases

EnsembliENST00000262593; ENSP00000262593; ENSG00000101134. [Q9P104-1]
ENST00000395939; ENSP00000379270; ENSG00000101134. [Q9P104-2]
GeneIDi55816.
KEGGihsa:55816.
UCSCiuc002xwy.3. human. [Q9P104-1]

Polymorphism databases

DMDMi26393190.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132732 mRNA. Translation: AAF66443.1 .
AF466368 mRNA. Translation: AAL74194.1 .
AL118501 , AL162292 Genomic DNA. Translation: CAI19415.1 .
AL118501 Genomic DNA. Translation: CAI19416.1 .
AL162292 , AL118501 Genomic DNA. Translation: CAI16465.1 .
BC008992 mRNA. Translation: AAH08992.1 .
AL050069 mRNA. Translation: CAB43255.3 .
CCDSi CCDS13446.1. [Q9P104-1 ]
CCDS13447.1. [Q9P104-2 ]
PIRi T08731.
RefSeqi NP_060901.2. NM_018431.4. [Q9P104-1 ]
NP_808874.1. NM_177959.2. [Q9P104-2 ]
UniGenei Hs.473133.
Hs.656582.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1J0W X-ray 2.50 A/B 133-232 [» ]
ProteinModelPortali Q9P104.
SMRi Q9P104. Positions 133-232.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120926. 4 interactions.
IntActi Q9P104. 4 interactions.
MINTi MINT-1435904.
STRINGi 9606.ENSP00000262593.

PTM databases

PhosphoSitei Q9P104.

Polymorphism databases

DMDMi 26393190.

Proteomic databases

PaxDbi Q9P104.
PRIDEi Q9P104.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000262593 ; ENSP00000262593 ; ENSG00000101134 . [Q9P104-1 ]
ENST00000395939 ; ENSP00000379270 ; ENSG00000101134 . [Q9P104-2 ]
GeneIDi 55816.
KEGGi hsa:55816.
UCSCi uc002xwy.3. human. [Q9P104-1 ]

Organism-specific databases

CTDi 55816.
GeneCardsi GC20P053092.
HGNCi HGNC:16173. DOK5.
MIMi 608334. gene.
neXtProti NX_Q9P104.
PharmGKBi PA25724.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG256436.
GeneTreei ENSGT00730000110348.
HOVERGENi HBG002356.
InParanoidi Q9P104.
OMAi HAVGIYF.
OrthoDBi EOG7GTT3W.
PhylomeDBi Q9P104.
TreeFami TF324994.

Enzyme and pathway databases

SignaLinki Q9P104.

Miscellaneous databases

EvolutionaryTracei Q9P104.
GeneWikii DOK5.
GenomeRNAii 55816.
NextBioi 60998.
PROi Q9P104.
SOURCEi Search...

Gene expression databases

Bgeei Q9P104.
CleanExi HS_DOK5.
Genevestigatori Q9P104.

Family and domain databases

Gene3Di 2.30.29.30. 2 hits.
InterProi IPR002404. Insln_rcpt_S1.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view ]
Pfami PF02174. IRS. 1 hit.
[Graphical view ]
SMARTi SM00233. PH. 1 hit.
SM00310. PTBI. 1 hit.
[Graphical view ]
PROSITEi PS51064. IRS_PTB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Luo W.Q., Chen J.H., Huang X.W., Zhou Y., Zhou H.J., Hu S.N., Yuan J.G.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "DOK4 and DOK5: new Dok-related genes expressed in human T cells."
    Favre C., Gerard A., Clauzier E., Pontarotti P., Olive D., Nunes J.A.
    Genes Immun. 4:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  3. "Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5."
    Cai D., Dhe-Paganon S., Melendez P.A., Lee J., Shoelson S.E.
    J. Biol. Chem. 278:25323-25330(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, PHOSPHORYLATION AT TYROSINE RESIDUES.
    Tissue: Skeletal muscle.
  4. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 42-306 (ISOFORM 1).
    Tissue: Kidney.
  7. "Expression, crystallization and preliminary X-ray studies of the recombinant PTB domain of human dok-5 protein."
    Shi N., Zhou W., Tang K., Gao Y., Jin J., Gao F., Peng X., Bartlam M., Qiang B., Yuan J., Rao Z.
    Acta Crystallogr. D 58:2170-2172(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: CRYSTALLIZATION.

Entry informationi

Entry nameiDOK5_HUMAN
AccessioniPrimary (citable) accession number: Q9P104
Secondary accession number(s): Q5T7Y0
, Q5TE53, Q8TEW7, Q96H13, Q9BZ24, Q9NQF4, Q9Y411
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: December 6, 2002
Last modified: October 29, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3