Reviewed, UniProtKB/Swiss-Prot Q9P0Z9 (SOX_HUMAN)

Names and origin

Protein names

Recommended name:
    Peroxisomal sarcosine oxidase
      Short name=PSO
    EC=1.5.3.1
    EC=1.5.3.7
Alternative name(s):
    L-pipecolate oxidase
    L-pipecolic acid oxidase

Gene names

Name:	PIPOX
Synonyms:	LPIPOX, PSO

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	390 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Metabolizes sarcosine, L-pipecolic acid and L-proline.
Catalytic activity	Sarcosine + H2O + O2 = glycine + formaldehyde + H2O2. L-pipecolate + O2 = 2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2.
Cofactor	Binds 1 FAD per subunit.
Subunit structure	Monomer By similarity.
Subcellular location	Peroxisome.
Sequence similarities	Belongs to the MSOX/MTOX family.

Ontologies

Keywords
Cellular component	Peroxisome
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tetrahydrofolate metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	peroxisome Ref.2 Traceable author statement. Source: ProtInc
Molecular function	L-pipecolate oxidase activity Inferred from electronic annotation. Source: EC sarcosine oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 390	390	Peroxisomal sarcosine oxidase		PRO_0000213773
Regions
	Nucleotide binding	9 – 39	31	FAD Potential
	Motif	388 – 390	3	Microbody targeting signal Potential
Amino acid modifications
	Modified residue	319	1	S-8alpha-FAD cysteine By similarity
Experimental info
	Sequence conflict	376 – 390	15	PFRIS…GKAHL → AFSNQPFPKPGQSPPLTSGQ KPPFCAQEPVSQMEKMSQMK GVSLRYHPFLLPRLNPP Ref.3
	Sequence conflict	386	1	G → A in AAF37331. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9P0Z9-1 [UniParc]. Last modified October 11, 2004. Version 2. Checksum: 581ADDA6F5D19C0F	FASTA	390	44,066
	10 20 30 40 50 60 MAAQKDLWDA IVIGAGIQGC FTAYHLAKHR KRILLLEQFF LPHSRGSSHG QSRIIRKAYL 70 80 90 100 110 120 EDFYTRMMHE CYQIWAQLEH EAGTQLHRQT GLLLLGMKEN QELKTIQANL SRQRVEHQCL 130 140 150 160 170 180 SSEELKQRFP NIRLPRGEVG LLDNSGGVIY AYKALRALQD AIRQLGGIVR DGEKVVEINP 190 200 210 220 230 240 GLLVTVKTTS RSYQAKSLVI TAGPWTNQLL RPLGIEMPLQ TLRINVCYWR EMVPGSYGVS 250 260 270 280 290 300 QAFPCFLWLG LCPHHIYGLP TGEYPGLMKV SYHHGNHADP EERDCPTART DIGDVQILSS 310 320 330 340 350 360 FVRDHLPDLK PEPAVIESCM YTNTPDEQFI LDRHPKYDNI VIGAGFSGHG FKLAPVVGKI 370 380 390 LYELSMKLTP SYDLAPFRIS RFPSLGKAHL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and expression of human L-pipecolate oxidase." Ijlst L., de Kromme I., Oostheim W., Wanders R.J.A. Biochem. Biophys. Res. Commun. 270:1101-1105(2000) [PubMed: 10772957] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"L-pipecolic acid oxidase, a human enzyme essential for the degradation of L-pipecolic acid, is most similar to the monomeric sarcosine oxidases." Dodt G., Kim D.G., Reimann S.A., Reuber B.E., McCabe K., Gould S.J., Mihalik S.J. Biochem. J. 345:487-494(2000) [PubMed: 10642506] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L. Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed: 10931946] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Adrenal gland.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Muscle.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF134593 mRNA. Translation: AAF37331.1. AF136970 mRNA. Translation: AAG49431.1. BC008960 mRNA. Translation: AAH08960.1.
IPI	IPI00554660.
PIR	JC7256.
RefSeq	NP_057602.2.
UniGene	Hs.462585
3D structure databases
HSSP	HSSP built from PDB template 1EL5 based on UniProtKB P40859.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9P0Z9. 1 interaction.
Proteomic databases
PRIDE	Q9P0Z9.
Genome annotation databases
Ensembl	ENSG00000179761. Homo sapiens. [Contig view]
GeneID	51268.
KEGG	hsa:51268.
Organism-specific databases
GeneCards	GC17P024394.
H-InvDB	HIX0019115.
HGNC	HGNC:17804. PIPOX.
HPA	HPA015567.
PharmGKB	PA33332.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9P0Z9.
HOVERGEN	Q9P0Z9.
OMA	Q9P0Z9. KTPSFDL.
Enzyme and pathway databases
BRENDA	1.5.3.1. 247. 1.5.3.7. 247.
Gene expression databases
ArrayExpress	Q9P0Z9.
Bgee	Q9P0Z9.
CleanEx	HS_PIPOX.
GermOnline	ENSG00000179761. Homo sapiens.
Family and domain databases
InterPro	IPR006076. FAD-dep_OxRdtase. IPR006281. SoxA_mon. [Graphical view]
Pfam	PF01266. DAO. 1 hit. [Graphical view]
TIGRFAMs	TIGR01377. soxA_mon. 1 hit.
ProtoNet	Search...
Other Resources
DrugBank	DB00145. Glycine.
NextBio	54463.

Entry information

Entry name

SOX_HUMAN

Accession

Primary (citable) accession number: Q9P0Z9
Secondary accession number(s): Q96H28, Q9C070

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	October 11, 2004
Last modified:	June 16, 2009
This is version 66 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)