Q9P0Z9 (SOX_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peroxisomal sarcosine oxidase
Short name=PSO
EC=1.5.3.1
EC=1.5.3.7

Alternative name(s):
L-pipecolate oxidase
L-pipecolic acid oxidase

Gene names

Name:	PIPOX
Synonyms:	LPIPOX, PSO

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	390 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Metabolizes sarcosine, L-pipecolic acid and L-proline.
Catalytic activity	Sarcosine + H2O + O2 = glycine + formaldehyde + H2O2. L-pipecolate + O2 = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2.
Cofactor	Binds 1 FAD per subunit.
Subunit structure	Monomer By similarity.
Subcellular location	Peroxisome.
Sequence similarities	Belongs to the MSOX/MTOX family.

Ontologies

Keywords
Cellular component	Peroxisome
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	tetrahydrofolate metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	peroxisome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	L-pipecolate oxidase activity Inferred from electronic annotation. Source: EC sarcosine oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 390	390	Peroxisomal sarcosine oxidase		PRO_0000213773
Regions
	Nucleotide binding	9 – 39	31	FAD Potential
	Motif	388 – 390	3	Microbody targeting signal Potential
Amino acid modifications
	Modified residue	319	1	S-8alpha-FAD cysteine By similarity
Experimental info
	Sequence conflict	376 – 390	15	PFRIS…GKAHL → AFSNQPFPKPGQSPPLTSGQ KPPFCAQEPVSQMEKMSQMK GVSLRYHPFLLPRLNPP Ref.3
	Sequence conflict	386	1	G → A in AAF37331. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9P0Z9 [UniParc]. Last modified October 11, 2004. Version 2. Checksum: 581ADDA6F5D19C0F	FASTA	390	44,066
	10 20 30 40 50 60 MAAQKDLWDA IVIGAGIQGC FTAYHLAKHR KRILLLEQFF LPHSRGSSHG QSRIIRKAYL 70 80 90 100 110 120 EDFYTRMMHE CYQIWAQLEH EAGTQLHRQT GLLLLGMKEN QELKTIQANL SRQRVEHQCL 130 140 150 160 170 180 SSEELKQRFP NIRLPRGEVG LLDNSGGVIY AYKALRALQD AIRQLGGIVR DGEKVVEINP 190 200 210 220 230 240 GLLVTVKTTS RSYQAKSLVI TAGPWTNQLL RPLGIEMPLQ TLRINVCYWR EMVPGSYGVS 250 260 270 280 290 300 QAFPCFLWLG LCPHHIYGLP TGEYPGLMKV SYHHGNHADP EERDCPTART DIGDVQILSS 310 320 330 340 350 360 FVRDHLPDLK PEPAVIESCM YTNTPDEQFI LDRHPKYDNI VIGAGFSGHG FKLAPVVGKI 370 380 390 LYELSMKLTP SYDLAPFRIS RFPSLGKAHL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and expression of human L-pipecolate oxidase." Ijlst L., de Kromme I., Oostheim W., Wanders R.J.A. Biochem. Biophys. Res. Commun. 270:1101-1105(2000) [PubMed: 10772957] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"L-pipecolic acid oxidase, a human enzyme essential for the degradation of L-pipecolic acid, is most similar to the monomeric sarcosine oxidases." Dodt G., Kim D.G., Reimann S.A., Reuber B.E., McCabe K., Gould S.J., Mihalik S.J. Biochem. J. 345:487-494(2000) [PubMed: 10642506] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L. Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed: 10931946] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Adrenal gland.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Muscle.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF134593 mRNA. Translation: AAF37331.1. AF136970 mRNA. Translation: AAG49431.1. AK027498 mRNA. Translation: BAG51332.1. CH471159 Genomic DNA. Translation: EAW51169.1. BC008960 mRNA. Translation: AAH08960.1.
IPI	IPI00554660.
PIR	JC7256.
RefSeq	NP_057602.2. NM_016518.2.
UniGene	Hs.462585.
3D structure databases
ProteinModelPortal	Q9P0Z9.
SMR	Q9P0Z9. Positions 6-384.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9P0Z9. 1 interaction.
STRING	Q9P0Z9.
Polymorphism databases
DMDM	54042061.
Proteomic databases
PRIDE	Q9P0Z9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000323372; ENSP00000317721; ENSG00000179761.
GeneID	51268.
KEGG	hsa:51268.
UCSC	uc002hdr.1. human.
Organism-specific databases
CTD	51268.
GeneCards	GC17P027369.
H-InvDB	HIX0019115.
HGNC	HGNC:17804. PIPOX.
HPA	HPA015567.
neXtProt	NX_Q9P0Z9.
PharmGKB	PA33332.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00390000011000.
HOGENOM	HBG589227.
HOVERGEN	HBG023161.
InParanoid	Q9P0Z9.
OMA	KTPSFDL.
OrthoDB	EOG4GQQ50.
PhylomeDB	Q9P0Z9.
Gene expression databases
ArrayExpress	Q9P0Z9.
Bgee	Q9P0Z9.
CleanEx	HS_PIPOX.
Genevestigator	Q9P0Z9.
GermOnline	ENSG00000179761. Homo sapiens.
Family and domain databases
InterPro	IPR006076. FAD-dep_OxRdtase. IPR006281. SoxA_mon. [Graphical view]
KO	K00306.
Pfam	PF01266. DAO. 1 hit. [Graphical view]
TIGRFAMs	TIGR01377. SoxA_mon. 1 hit.
ProtoNet	Search...
Other
DrugBank	DB00145. Glycine.
NextBio	54463.

Entry information

Entry name

SOX_HUMAN

Accession

Primary (citable) accession number: Q9P0Z9
Secondary accession number(s): B3KNH0, Q96H28, Q9C070

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 89 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.