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Protein

Peroxisomal sarcosine oxidase

Gene

PIPOX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Metabolizes sarcosine, L-pipecolic acid and L-proline.

Catalytic activityi

Sarcosine + H2O + O2 = glycine + formaldehyde + H2O2.
L-pipecolate + O2 = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2.

Cofactori

FADNote: Binds 1 FAD per subunit.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 39FADSequence analysisAdd BLAST31

GO - Molecular functioni

  • L-pipecolate oxidase activity Source: UniProtKB
  • sarcosine oxidase activity Source: UniProtKB
  • signaling receptor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-HSA-71064 Lysine catabolism
R-HSA-9033241 Peroxisomal protein import

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal sarcosine oxidase (EC:1.5.3.1, EC:1.5.3.7)
Short name:
PSO
Alternative name(s):
L-pipecolate oxidase
L-pipecolic acid oxidase
Gene namesi
Name:PIPOX
Synonyms:LPIPOX, PSO
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000179761.11
HGNCiHGNC:17804 PIPOX
MIMi616713 gene
neXtProtiNX_Q9P0Z9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

Pathology & Biotechi

Organism-specific databases

DisGeNETi51268
OpenTargetsiENSG00000179761
PharmGKBiPA33332

Chemistry databases

ChEMBLiCHEMBL2254
DrugBankiDB00145 Glycine

Polymorphism and mutation databases

BioMutaiPIPOX
DMDMi54042061

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002137731 – 390Peroxisomal sarcosine oxidaseAdd BLAST390

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei126N6-acetyllysineBy similarity1
Modified residuei319S-8alpha-FAD cysteineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9P0Z9
MaxQBiQ9P0Z9
PaxDbiQ9P0Z9
PeptideAtlasiQ9P0Z9
PRIDEiQ9P0Z9

PTM databases

iPTMnetiQ9P0Z9
PhosphoSitePlusiQ9P0Z9

Expressioni

Gene expression databases

BgeeiENSG00000179761
CleanExiHS_PIPOX
ExpressionAtlasiQ9P0Z9 baseline and differential
GenevisibleiQ9P0Z9 HS

Interactioni

Subunit structurei

Monomer.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
POT1Q9NUX52EBI-725582,EBI-752420

GO - Molecular functioni

  • signaling receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi119422, 8 interactors
IntActiQ9P0Z9, 2 interactors
STRINGi9606.ENSP00000317721

Chemistry databases

BindingDBiQ9P0Z9

Structurei

3D structure databases

ProteinModelPortaliQ9P0Z9
SMRiQ9P0Z9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi388 – 390Microbody targeting signalSequence analysis3

Sequence similaritiesi

Belongs to the MSOX/MTOX family.Curated

Phylogenomic databases

eggNOGiKOG2820 Eukaryota
COG0665 LUCA
GeneTreeiENSGT00390000011000
HOGENOMiHOG000236097
HOVERGENiHBG023161
InParanoidiQ9P0Z9
KOiK00306
OMAiRIIRHAY
OrthoDBiEOG091G0DNX
PhylomeDBiQ9P0Z9
TreeFamiTF313837

Family and domain databases

Gene3Di3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR006076 FAD-dep_OxRdtase
IPR036188 FAD/NAD-bd_sf
IPR006281 SoxA_mon
PfamiView protein in Pfam
PF01266 DAO, 1 hit
SUPFAMiSSF51905 SSF51905, 2 hits
TIGRFAMsiTIGR01377 soxA_mon, 1 hit

Sequencei

Sequence statusi: Complete.

Q9P0Z9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAQKDLWDA IVIGAGIQGC FTAYHLAKHR KRILLLEQFF LPHSRGSSHG
60 70 80 90 100
QSRIIRKAYL EDFYTRMMHE CYQIWAQLEH EAGTQLHRQT GLLLLGMKEN
110 120 130 140 150
QELKTIQANL SRQRVEHQCL SSEELKQRFP NIRLPRGEVG LLDNSGGVIY
160 170 180 190 200
AYKALRALQD AIRQLGGIVR DGEKVVEINP GLLVTVKTTS RSYQAKSLVI
210 220 230 240 250
TAGPWTNQLL RPLGIEMPLQ TLRINVCYWR EMVPGSYGVS QAFPCFLWLG
260 270 280 290 300
LCPHHIYGLP TGEYPGLMKV SYHHGNHADP EERDCPTART DIGDVQILSS
310 320 330 340 350
FVRDHLPDLK PEPAVIESCM YTNTPDEQFI LDRHPKYDNI VIGAGFSGHG
360 370 380 390
FKLAPVVGKI LYELSMKLTP SYDLAPFRIS RFPSLGKAHL
Length:390
Mass (Da):44,066
Last modified:October 11, 2004 - v2
Checksum:i581ADDA6F5D19C0F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti376 – 390PFRIS…GKAHL → AFSNQPFPKPGQSPPLTSGQ KPPFCAQEPVSQMEKMSQMK GVSLRYHPFLLPRLNPP (PubMed:10931946).CuratedAdd BLAST15
Sequence conflicti386G → A in AAF37331 (PubMed:10642506).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134593 mRNA Translation: AAF37331.1
AF136970 mRNA Translation: AAG49431.1
AK027498 mRNA Translation: BAG51332.1
CH471159 Genomic DNA Translation: EAW51169.1
BC008960 mRNA Translation: AAH08960.1
CCDSiCCDS11248.1
PIRiJC7256
RefSeqiNP_057602.2, NM_016518.2
UniGeneiHs.462585

Genome annotation databases

EnsembliENST00000323372; ENSP00000317721; ENSG00000179761
GeneIDi51268
KEGGihsa:51268
UCSCiuc002hdr.2 human

Similar proteinsi

Entry informationi

Entry nameiSOX_HUMAN
AccessioniPrimary (citable) accession number: Q9P0Z9
Secondary accession number(s): B3KNH0, Q96H28, Q9C070
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: October 11, 2004
Last modified: May 23, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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