Q9P0X4 (CAC1I_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Voltage-dependent T-type calcium channel subunit alpha-1I

Alternative name(s):
Voltage-gated calcium channel subunit alpha Cav3.3
Short name=Ca(v)3.3

Gene names

Name:	CACNA1I
Synonyms:	KIAA1120

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2223 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Isoform alpha-1I gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Gates in voltage ranges similar to, but higher than alpha 1G or alpha 1H By similarity.
Subunit structure	Interacts with CATSPER1 and CATSPER2, leading to suppress T-type calcium channel activity. Ref.6
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Brain specific.
Domain	Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.
Post-translational modification	In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II By similarity.
Sequence similarities	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1I subfamily. [View classification]

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Transmembrane Transmembrane helix
Ligand	Calcium
Molecular function	Calcium channel Ion channel Voltage-gated channel
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axon guidance Traceable author statement. Source: Reactome signal transduction Traceable author statement Ref.1. Source: ProtInc
Cellular_component	voltage-gated calcium channel complex Non-traceable author statement. Source: UniProtKB
Molecular_function	low voltage-gated calcium channel activity Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CATSPER1	Q8NEC5	5	EBI-1220829,EBI-744545
CATSPER2	Q96P56	3	EBI-1220829,EBI-2215024

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9P0X4-1)

Also known as: Delta36b;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9P0X4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     2010-2223: ATGSDTSLDA...PGDAASKRKR → VPTPPRP

Isoform 3 (identifier: Q9P0X4-3)

Also known as: Alpha1I-a;

The sequence of this isoform differs from the canonical sequence as follows:
     488-523: HGKTKGQGDEGRHLGSRHCQTLHGPASPGNDHSGRE → Q
     2010-2223: ATGSDTSLDA...PGDAASKRKR → VPTPPRP

Isoform 4 (identifier: Q9P0X4-4)

The sequence of this isoform differs from the canonical sequence as follows:
     488-523: HGKTKGQGDEGRHLGSRHCQTLHGPASPGNDHSGRE → Q

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2223	2223	Voltage-dependent T-type calcium channel subunit alpha-1I		PRO_0000053957
Regions
	Topological domain	1 – 78	78	Cytoplasmic Potential
	Transmembrane	79 – 99	21	Helical; Name=S1 of repeat I; Potential
	Topological domain	100 – 120	21	Extracellular Potential
	Transmembrane	121 – 141	21	Helical; Name=S2 of repeat I; Potential
	Topological domain	142 – 148	7	Cytoplasmic Potential
	Transmembrane	149 – 168	20	Helical; Name=S3 of repeat I; Potential
	Topological domain	169 – 173	5	Extracellular Potential
	Transmembrane	174 – 191	18	Helical; Name=S4 of repeat I; Potential
	Topological domain	192 – 211	20	Cytoplasmic Potential
	Transmembrane	212 – 232	21	Helical; Name=S5 of repeat I; Potential
	Topological domain	233 – 377	145	Extracellular Potential
	Transmembrane	378 – 398	21	Helical; Name=S6 of repeat I; Potential
	Topological domain	399 – 640	242	Cytoplasmic Potential
	Transmembrane	641 – 661	21	Helical; Name=S1 of repeat II; Potential
	Topological domain	662 – 676	15	Extracellular Potential
	Transmembrane	677 – 697	21	Helical; Name=S2 of repeat II; Potential
	Topological domain	698 – 702	5	Cytoplasmic Potential
	Transmembrane	703 – 721	19	Helical; Name=S3 of repeat II; Potential
	Topological domain	722 – 729	8	Extracellular Potential
	Transmembrane	730 – 753	24	Helical; Name=S4 of repeat II; Potential
	Topological domain	754 – 764	11	Cytoplasmic Potential
	Transmembrane	765 – 785	21	Helical; Name=S5 of repeat II; Potential
	Topological domain	786 – 841	56	Extracellular Potential
	Transmembrane	842 – 862	21	Helical; Name=S6 of repeat II; Potential
	Topological domain	863 – 1166	304	Cytoplasmic Potential
	Transmembrane	1167 – 1187	21	Helical; Name=S1 of repeat III; Potential
	Topological domain	1188 – 1209	22	Extracellular Potential
	Transmembrane	1210 – 1230	21	Helical; Name=S2 of repeat III; Potential
	Topological domain	1231 – 1244	14	Cytoplasmic Potential
	Transmembrane	1245 – 1265	21	Helical; Name=S3 of repeat III; Potential
	Topological domain	1266 – 1272	7	Extracellular Potential
	Transmembrane	1273 – 1294	22	Helical; Name=S4 of repeat III; Potential
	Topological domain	1295 – 1304	10	Cytoplasmic Potential
	Transmembrane	1305 – 1325	21	Helical; Name=S5 of repeat III; Potential
	Topological domain	1326 – 1410	85	Extracellular Potential
	Transmembrane	1411 – 1431	21	Helical; Name=S6 of repeat III; Potential
	Topological domain	1432 – 1485	54	Cytoplasmic Potential
	Transmembrane	1486 – 1506	21	Helical; Name=S1 of repeat IV; Potential
	Topological domain	1507 – 1522	16	Extracellular Potential
	Transmembrane	1523 – 1543	21	Helical; Name=S2 of repeat IV; Potential
	Topological domain	1544 – 1556	13	Cytoplasmic Potential
	Transmembrane	1557 – 1577	21	Helical; Name=S3 of repeat IV; Potential
	Topological domain	1578 – 1583	6	Extracellular Potential
	Transmembrane	1584 – 1607	24	Helical; Name=S4 of repeat IV; Potential
	Topological domain	1608 – 1621	14	Cytoplasmic Potential
	Transmembrane	1622 – 1642	21	Helical; Name=S5 of repeat IV; Potential
	Topological domain	1643 – 1709	67	Extracellular Potential
	Transmembrane	1710 – 1730	21	Helical; Name=S6 of repeat IV; Potential
	Topological domain	1731 – 2223	493	Cytoplasmic Potential
	Repeat	66 – 401	336	I
	Repeat	626 – 865	240	II
	Repeat	1157 – 1434	278	III
	Repeat	1472 – 1733	262	IV
	Compositional bias	608 – 613	6	Poly-Glu
	Compositional bias	1775 – 1783	9	Poly-Gly
	Compositional bias	2110 – 2120	11	Poly-Gly
	Compositional bias	2138 – 2145	8	Poly-Pro
Sites
	Site	357	1	Calcium ion selectivity and permeability By similarity
	Site	821	1	Calcium ion selectivity and permeability By similarity
	Site	1380	1	Calcium ion selectivity and permeability By similarity
	Site	1678	1	Calcium ion selectivity and permeability By similarity
Amino acid modifications
	Glycosylation	173	1	N-linked (GlcNAc...) Potential
	Glycosylation	244	1	N-linked (GlcNAc...) Potential
	Glycosylation	311	1	N-linked (GlcNAc...) Potential
	Glycosylation	1342	1	N-linked (GlcNAc...) Potential
	Glycosylation	1345	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	488 – 523	36	HGKTK…HSGRE → Q in isoform 3 and isoform 4.		VSP_000950
	Alternative sequence	2010 – 2223	214	ATGSD…SKRKR → VPTPPRP in isoform 2 and isoform 3.		VSP_000951
	Natural variant	1040	1	I → V. Ref.3 Corresponds to variant rs136853 [ dbSNP | Ensembl ].		VAR_013883
	Natural variant	1513	1	T → M. Corresponds to variant rs8141262 [ dbSNP | Ensembl ].		VAR_048745
	Natural variant	1782	1	G → A. Corresponds to variant rs2294369 [ dbSNP | Ensembl ].		VAR_013884
	Natural variant	1782	1	G → R. Corresponds to variant rs2294369 [ dbSNP | Ensembl ].		VAR_020050

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Delta36b) [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 3CAE4D1C4289D08B	FASTA	2,223	245,103
	10 20 30 40 50 60 MAESASPPSS SAAAPAAEPG VTTEQPGPRS PPSSPPGLEE PLDGADPHVP HPDLAPIAFF 70 80 90 100 110 120 CLRQTTSPRN WCIKMVCNPW FECVSMLVIL LNCVTLGMYQ PCDDMDCLSD RCKILQVFDD 130 140 150 160 170 180 FIFIFFAMEM VLKMVALGIF GKKCYLGDTW NRLDFFIVMA GMVEYSLDLQ NINLSAIRTV 190 200 210 220 230 240 RVLRPLKAIN RVPSMRILVN LLLDTLPMLG NVLLLCFFVF FIFGIIGVQL WAGLLRNRCF 250 260 270 280 290 300 LEENFTIQGD VALPPYYQPE EDDEMPFICS LSGDNGIMGC HEIPPLKEQG RECCLSKDDV 310 320 330 340 350 360 YDFGAGRQDL NASGLCVNWN RYYNVCRTGS ANPHKGAINF DNIGYAWIVI FQVITLEGWV 370 380 390 400 410 420 EIMYYVMDAH SFYNFIYFIL LIIVGSFFMI NLCLVVIATQ FSETKQREHR LMLEQRQRYL 430 440 450 460 470 480 SSSTVASYAE PGDCYEEIFQ YVCHILRKAK RRALGLYQAL QSRRQALGPE APAPAKPGPH 490 500 510 520 530 540 AKEPRHYHGK TKGQGDEGRH LGSRHCQTLH GPASPGNDHS GRELCPQHSP LDATPHTLVQ 550 560 570 580 590 600 PIPATLASDP ASCPCCQHED GRRPSGLGST DSGQEGSGSG SSAGGEDEAD GDGARSSEDG 610 620 630 640 650 660 ASSELGKEEE EEEQADGAVW LCGDVWRETR AKLRGIVDSK YFNRGIMMAI LVNTVSMGIE 670 680 690 700 710 720 HHEQPEELTN ILEICNVVFT SMFALEMILK LAAFGLFDYL RNPYNIFDSI IVIISIWEIV 730 740 750 760 770 780 GQADGGLSVL RTFRLLRVLK LVRFMPALRR QLVVLMKTMD NVATFCMLLM LFIFIFSILG 790 800 810 820 830 840 MHIFGCKFSL RTDTGDTVPD RKNFDSLLWA IVTVFQILTQ EDWNVVLYNG MASTSPWASL 850 860 870 880 890 900 YFVALMTFGN YVLFNLLVAI LVEGFQAEGD ANRSYSDEDQ SSSNIEEFDK LQEGLDSSGD 910 920 930 940 950 960 PKLCPIPMTP NGHLDPSLPL GGHLGPAGAA GPAPRLSLQP DPMLVALGSR KSSVMSLGRM 970 980 990 1000 1010 1020 SYDQRSLSSS RSSYYGPWGR SAAWASRRSS WNSLKHKPPS AEHESLLSAE RGGGARVCEV 1030 1040 1050 1060 1070 1080 AADEGPPRAA PLHTPHAHHI HHGPHLAHRH RHHRRTLSLD NRDSVDLAEL VPAVGAHPRA 1090 1100 1110 1120 1130 1140 AWRAAGPAPG HEDCNGRMPS IAKDVFTKMG DRGDRGEDEE EIDYTLCFRV RKMIDVYKPD 1150 1160 1170 1180 1190 1200 WCEVREDWSV YLFSPENRFR VLCQTIIAHK LFDYVVLAFI FLNCITIALE RPQIEAGSTE 1210 1220 1230 1240 1250 1260 RIFLTVSNYI FTAIFVGEMT LKVVSLGLYF GEQAYLRSSW NVLDGFLVFV SIIDIVVSLA 1270 1280 1290 1300 1310 1320 SAGGAKILGV LRVLRLLRTL RPLRVISRAP GLKLVVETLI SSLKPIGNIV LICCAFFIIF 1330 1340 1350 1360 1370 1380 GILGVQLFKG KFYHCLGVDT RNITNRSDCM AANYRWVHHK YNFDNLGQAL MSLFVLASKD 1390 1400 1410 1420 1430 1440 GWVNIMYNGL DAVAVDQQPV TNHNPWMLLY FISFLLIVSF FVLNMFVGVV VENFHKCRQH 1450 1460 1470 1480 1490 1500 QEAEEARRRE EKRLRRLEKK RRKAQRLPYY ATYCHTRLLI HSMCTSHYLD IFITFIICLN 1510 1520 1530 1540 1550 1560 VVTMSLEHYN QPTSLETALK YCNYMFTTVF VLEAVLKLVA FGLRRFFKDR WNQLDLAIVL 1570 1580 1590 1600 1610 1620 LSVMGITLEE IEINAALPIN PTIIRIMRVL RIARVLKLLK MATGMRALLD TVVQALPQVG 1630 1640 1650 1660 1670 1680 NLGLLFMLLF FIYAALGVEL FGKLVCNDEN PCEGMSRHAT FENFGMAFLT LFQVSTGDNW 1690 1700 1710 1720 1730 1740 NGIMKDTLRD CTHDERSCLS SLQFVSPLYF VSFVLTAQFV LINVVVAVLM KHLDDSNKEA 1750 1760 1770 1780 1790 1800 QEDAEMDAEL ELEMAHGLGP GPRLPTGSPG APGRGPGGAG GGGDTEGGLC RRCYSPAQEN 1810 1820 1830 1840 1850 1860 LWLDSVSLII KDSLEGELTI IDNLSGSIFH HYSSPAGCKK CHHDKQEVQL AETEAFSLNS 1870 1880 1890 1900 1910 1920 DRSSSILLGD DLSLEDPTAC PPGRKDSKGE LDPPEPMRVG DLGECFFPLS STAVSPDPEN 1930 1940 1950 1960 1970 1980 FLCEMEEIPF NPVRSWLKHD SSQAPPSPFS PDASSPLLPM PAEFFHPAVS ASQKGPEKGT 1990 2000 2010 2020 2030 2040 GTGTLPKIAL QGSWASLRSP RVNCTLLRQA TGSDTSLDAS PSSSAGSLQT TLEDSLTLSD 2050 2060 2070 2080 2090 2100 SPRRALGPPA PAPGPRAGLS PAARRRLSLR GRGLFSLRGL RAHQRSHSSG GSTSPGCTHH 2110 2120 2130 2140 2150 2160 DSMDPSDEEG RGGAGGGGAG SEHSETLSSL SLTSLFCPPP PPPAPGLTPA RKFSSTSSLA 2170 2180 2190 2200 2210 2220 APGRPHAAAL AHGLARSPSW AADRSKDPPG RAPLPMGLGP LAPPPQPLPG ELEPGDAASK RKR
	Isoform 2 [UniParc]. Checksum: 7721511BDA564B80	FASTA	2,016	224,404
	10 20 30 40 50 60 MAESASPPSS SAAAPAAEPG VTTEQPGPRS PPSSPPGLEE PLDGADPHVP HPDLAPIAFF 70 80 90 100 110 120 CLRQTTSPRN WCIKMVCNPW FECVSMLVIL LNCVTLGMYQ PCDDMDCLSD RCKILQVFDD 130 140 150 160 170 180 FIFIFFAMEM VLKMVALGIF GKKCYLGDTW NRLDFFIVMA GMVEYSLDLQ NINLSAIRTV 190 200 210 220 230 240 RVLRPLKAIN RVPSMRILVN LLLDTLPMLG NVLLLCFFVF FIFGIIGVQL WAGLLRNRCF 250 260 270 280 290 300 LEENFTIQGD VALPPYYQPE EDDEMPFICS LSGDNGIMGC HEIPPLKEQG RECCLSKDDV 310 320 330 340 350 360 YDFGAGRQDL NASGLCVNWN RYYNVCRTGS ANPHKGAINF DNIGYAWIVI FQVITLEGWV 370 380 390 400 410 420 EIMYYVMDAH SFYNFIYFIL LIIVGSFFMI NLCLVVIATQ FSETKQREHR LMLEQRQRYL 430 440 450 460 470 480 SSSTVASYAE PGDCYEEIFQ YVCHILRKAK RRALGLYQAL QSRRQALGPE APAPAKPGPH 490 500 510 520 530 540 AKEPRHYHGK TKGQGDEGRH LGSRHCQTLH GPASPGNDHS GRELCPQHSP LDATPHTLVQ 550 560 570 580 590 600 PIPATLASDP ASCPCCQHED GRRPSGLGST DSGQEGSGSG SSAGGEDEAD GDGARSSEDG 610 620 630 640 650 660 ASSELGKEEE EEEQADGAVW LCGDVWRETR AKLRGIVDSK YFNRGIMMAI LVNTVSMGIE 670 680 690 700 710 720 HHEQPEELTN ILEICNVVFT SMFALEMILK LAAFGLFDYL RNPYNIFDSI IVIISIWEIV 730 740 750 760 770 780 GQADGGLSVL RTFRLLRVLK LVRFMPALRR QLVVLMKTMD NVATFCMLLM LFIFIFSILG 790 800 810 820 830 840 MHIFGCKFSL RTDTGDTVPD RKNFDSLLWA IVTVFQILTQ EDWNVVLYNG MASTSPWASL 850 860 870 880 890 900 YFVALMTFGN YVLFNLLVAI LVEGFQAEGD ANRSYSDEDQ SSSNIEEFDK LQEGLDSSGD 910 920 930 940 950 960 PKLCPIPMTP NGHLDPSLPL GGHLGPAGAA GPAPRLSLQP DPMLVALGSR KSSVMSLGRM 970 980 990 1000 1010 1020 SYDQRSLSSS RSSYYGPWGR SAAWASRRSS WNSLKHKPPS AEHESLLSAE RGGGARVCEV 1030 1040 1050 1060 1070 1080 AADEGPPRAA PLHTPHAHHI HHGPHLAHRH RHHRRTLSLD NRDSVDLAEL VPAVGAHPRA 1090 1100 1110 1120 1130 1140 AWRAAGPAPG HEDCNGRMPS IAKDVFTKMG DRGDRGEDEE EIDYTLCFRV RKMIDVYKPD 1150 1160 1170 1180 1190 1200 WCEVREDWSV YLFSPENRFR VLCQTIIAHK LFDYVVLAFI FLNCITIALE RPQIEAGSTE 1210 1220 1230 1240 1250 1260 RIFLTVSNYI FTAIFVGEMT LKVVSLGLYF GEQAYLRSSW NVLDGFLVFV SIIDIVVSLA 1270 1280 1290 1300 1310 1320 SAGGAKILGV LRVLRLLRTL RPLRVISRAP GLKLVVETLI SSLKPIGNIV LICCAFFIIF 1330 1340 1350 1360 1370 1380 GILGVQLFKG KFYHCLGVDT RNITNRSDCM AANYRWVHHK YNFDNLGQAL MSLFVLASKD 1390 1400 1410 1420 1430 1440 GWVNIMYNGL DAVAVDQQPV TNHNPWMLLY FISFLLIVSF FVLNMFVGVV VENFHKCRQH 1450 1460 1470 1480 1490 1500 QEAEEARRRE EKRLRRLEKK RRKAQRLPYY ATYCHTRLLI HSMCTSHYLD IFITFIICLN 1510 1520 1530 1540 1550 1560 VVTMSLEHYN QPTSLETALK YCNYMFTTVF VLEAVLKLVA FGLRRFFKDR WNQLDLAIVL 1570 1580 1590 1600 1610 1620 LSVMGITLEE IEINAALPIN PTIIRIMRVL RIARVLKLLK MATGMRALLD TVVQALPQVG 1630 1640 1650 1660 1670 1680 NLGLLFMLLF FIYAALGVEL FGKLVCNDEN PCEGMSRHAT FENFGMAFLT LFQVSTGDNW 1690 1700 1710 1720 1730 1740 NGIMKDTLRD CTHDERSCLS SLQFVSPLYF VSFVLTAQFV LINVVVAVLM KHLDDSNKEA 1750 1760 1770 1780 1790 1800 QEDAEMDAEL ELEMAHGLGP GPRLPTGSPG APGRGPGGAG GGGDTEGGLC RRCYSPAQEN 1810 1820 1830 1840 1850 1860 LWLDSVSLII KDSLEGELTI IDNLSGSIFH HYSSPAGCKK CHHDKQEVQL AETEAFSLNS 1870 1880 1890 1900 1910 1920 DRSSSILLGD DLSLEDPTAC PPGRKDSKGE LDPPEPMRVG DLGECFFPLS STAVSPDPEN 1930 1940 1950 1960 1970 1980 FLCEMEEIPF NPVRSWLKHD SSQAPPSPFS PDASSPLLPM PAEFFHPAVS ASQKGPEKGT 1990 2000 2010 GTGTLPKIAL QGSWASLRSP RVNCTLLRQV PTPPRP
	Isoform 3 (Alpha1I-a) [UniParc]. Checksum: 3AF7A61ECEBC7AEC	FASTA	1,981	220,748
	10 20 30 40 50 60 MAESASPPSS SAAAPAAEPG VTTEQPGPRS PPSSPPGLEE PLDGADPHVP HPDLAPIAFF 70 80 90 100 110 120 CLRQTTSPRN WCIKMVCNPW FECVSMLVIL LNCVTLGMYQ PCDDMDCLSD RCKILQVFDD 130 140 150 160 170 180 FIFIFFAMEM VLKMVALGIF GKKCYLGDTW NRLDFFIVMA GMVEYSLDLQ NINLSAIRTV 190 200 210 220 230 240 RVLRPLKAIN RVPSMRILVN LLLDTLPMLG NVLLLCFFVF FIFGIIGVQL WAGLLRNRCF 250 260 270 280 290 300 LEENFTIQGD VALPPYYQPE EDDEMPFICS LSGDNGIMGC HEIPPLKEQG RECCLSKDDV 310 320 330 340 350 360 YDFGAGRQDL NASGLCVNWN RYYNVCRTGS ANPHKGAINF DNIGYAWIVI FQVITLEGWV 370 380 390 400 410 420 EIMYYVMDAH SFYNFIYFIL LIIVGSFFMI NLCLVVIATQ FSETKQREHR LMLEQRQRYL 430 440 450 460 470 480 SSSTVASYAE PGDCYEEIFQ YVCHILRKAK RRALGLYQAL QSRRQALGPE APAPAKPGPH 490 500 510 520 530 540 AKEPRHYQLC PQHSPLDATP HTLVQPIPAT LASDPASCPC CQHEDGRRPS GLGSTDSGQE 550 560 570 580 590 600 GSGSGSSAGG EDEADGDGAR SSEDGASSEL GKEEEEEEQA DGAVWLCGDV WRETRAKLRG 610 620 630 640 650 660 IVDSKYFNRG IMMAILVNTV SMGIEHHEQP EELTNILEIC NVVFTSMFAL EMILKLAAFG 670 680 690 700 710 720 LFDYLRNPYN IFDSIIVIIS IWEIVGQADG GLSVLRTFRL LRVLKLVRFM PALRRQLVVL 730 740 750 760 770 780 MKTMDNVATF CMLLMLFIFI FSILGMHIFG CKFSLRTDTG DTVPDRKNFD SLLWAIVTVF 790 800 810 820 830 840 QILTQEDWNV VLYNGMASTS PWASLYFVAL MTFGNYVLFN LLVAILVEGF QAEGDANRSY 850 860 870 880 890 900 SDEDQSSSNI EEFDKLQEGL DSSGDPKLCP IPMTPNGHLD PSLPLGGHLG PAGAAGPAPR 910 920 930 940 950 960 LSLQPDPMLV ALGSRKSSVM SLGRMSYDQR SLSSSRSSYY GPWGRSAAWA SRRSSWNSLK 970 980 990 1000 1010 1020 HKPPSAEHES LLSAERGGGA RVCEVAADEG PPRAAPLHTP HAHHIHHGPH LAHRHRHHRR 1030 1040 1050 1060 1070 1080 TLSLDNRDSV DLAELVPAVG AHPRAAWRAA GPAPGHEDCN GRMPSIAKDV FTKMGDRGDR 1090 1100 1110 1120 1130 1140 GEDEEEIDYT LCFRVRKMID VYKPDWCEVR EDWSVYLFSP ENRFRVLCQT IIAHKLFDYV 1150 1160 1170 1180 1190 1200 VLAFIFLNCI TIALERPQIE AGSTERIFLT VSNYIFTAIF VGEMTLKVVS LGLYFGEQAY 1210 1220 1230 1240 1250 1260 LRSSWNVLDG FLVFVSIIDI VVSLASAGGA KILGVLRVLR LLRTLRPLRV ISRAPGLKLV 1270 1280 1290 1300 1310 1320 VETLISSLKP IGNIVLICCA FFIIFGILGV QLFKGKFYHC LGVDTRNITN RSDCMAANYR 1330 1340 1350 1360 1370 1380 WVHHKYNFDN LGQALMSLFV LASKDGWVNI MYNGLDAVAV DQQPVTNHNP WMLLYFISFL 1390 1400 1410 1420 1430 1440 LIVSFFVLNM FVGVVVENFH KCRQHQEAEE ARRREEKRLR RLEKKRRKAQ RLPYYATYCH 1450 1460 1470 1480 1490 1500 TRLLIHSMCT SHYLDIFITF IICLNVVTMS LEHYNQPTSL ETALKYCNYM FTTVFVLEAV 1510 1520 1530 1540 1550 1560 LKLVAFGLRR FFKDRWNQLD LAIVLLSVMG ITLEEIEINA ALPINPTIIR IMRVLRIARV 1570 1580 1590 1600 1610 1620 LKLLKMATGM RALLDTVVQA LPQVGNLGLL FMLLFFIYAA LGVELFGKLV CNDENPCEGM 1630 1640 1650 1660 1670 1680 SRHATFENFG MAFLTLFQVS TGDNWNGIMK DTLRDCTHDE RSCLSSLQFV SPLYFVSFVL 1690 1700 1710 1720 1730 1740 TAQFVLINVV VAVLMKHLDD SNKEAQEDAE MDAELELEMA HGLGPGPRLP TGSPGAPGRG 1750 1760 1770 1780 1790 1800 PGGAGGGGDT EGGLCRRCYS PAQENLWLDS VSLIIKDSLE GELTIIDNLS GSIFHHYSSP 1810 1820 1830 1840 1850 1860 AGCKKCHHDK QEVQLAETEA FSLNSDRSSS ILLGDDLSLE DPTACPPGRK DSKGELDPPE 1870 1880 1890 1900 1910 1920 PMRVGDLGEC FFPLSSTAVS PDPENFLCEM EEIPFNPVRS WLKHDSSQAP PSPFSPDASS 1930 1940 1950 1960 1970 1980 PLLPMPAEFF HPAVSASQKG PEKGTGTGTL PKIALQGSWA SLRSPRVNCT LLRQVPTPPR P
	Isoform 4 [UniParc]. Checksum: 87E508C40BBEFEAB	FASTA	2,188	241,448
	10 20 30 40 50 60 MAESASPPSS SAAAPAAEPG VTTEQPGPRS PPSSPPGLEE PLDGADPHVP HPDLAPIAFF 70 80 90 100 110 120 CLRQTTSPRN WCIKMVCNPW FECVSMLVIL LNCVTLGMYQ PCDDMDCLSD RCKILQVFDD 130 140 150 160 170 180 FIFIFFAMEM VLKMVALGIF GKKCYLGDTW NRLDFFIVMA GMVEYSLDLQ NINLSAIRTV 190 200 210 220 230 240 RVLRPLKAIN RVPSMRILVN LLLDTLPMLG NVLLLCFFVF FIFGIIGVQL WAGLLRNRCF 250 260 270 280 290 300 LEENFTIQGD VALPPYYQPE EDDEMPFICS LSGDNGIMGC HEIPPLKEQG RECCLSKDDV 310 320 330 340 350 360 YDFGAGRQDL NASGLCVNWN RYYNVCRTGS ANPHKGAINF DNIGYAWIVI FQVITLEGWV 370 380 390 400 410 420 EIMYYVMDAH SFYNFIYFIL LIIVGSFFMI NLCLVVIATQ FSETKQREHR LMLEQRQRYL 430 440 450 460 470 480 SSSTVASYAE PGDCYEEIFQ YVCHILRKAK RRALGLYQAL QSRRQALGPE APAPAKPGPH 490 500 510 520 530 540 AKEPRHYQLC PQHSPLDATP HTLVQPIPAT LASDPASCPC CQHEDGRRPS GLGSTDSGQE 550 560 570 580 590 600 GSGSGSSAGG EDEADGDGAR SSEDGASSEL GKEEEEEEQA DGAVWLCGDV WRETRAKLRG 610 620 630 640 650 660 IVDSKYFNRG IMMAILVNTV SMGIEHHEQP EELTNILEIC NVVFTSMFAL EMILKLAAFG 670 680 690 700 710 720 LFDYLRNPYN IFDSIIVIIS IWEIVGQADG GLSVLRTFRL LRVLKLVRFM PALRRQLVVL 730 740 750 760 770 780 MKTMDNVATF CMLLMLFIFI FSILGMHIFG CKFSLRTDTG DTVPDRKNFD SLLWAIVTVF 790 800 810 820 830 840 QILTQEDWNV VLYNGMASTS PWASLYFVAL MTFGNYVLFN LLVAILVEGF QAEGDANRSY 850 860 870 880 890 900 SDEDQSSSNI EEFDKLQEGL DSSGDPKLCP IPMTPNGHLD PSLPLGGHLG PAGAAGPAPR 910 920 930 940 950 960 LSLQPDPMLV ALGSRKSSVM SLGRMSYDQR SLSSSRSSYY GPWGRSAAWA SRRSSWNSLK 970 980 990 1000 1010 1020 HKPPSAEHES LLSAERGGGA RVCEVAADEG PPRAAPLHTP HAHHIHHGPH LAHRHRHHRR 1030 1040 1050 1060 1070 1080 TLSLDNRDSV DLAELVPAVG AHPRAAWRAA GPAPGHEDCN GRMPSIAKDV FTKMGDRGDR 1090 1100 1110 1120 1130 1140 GEDEEEIDYT LCFRVRKMID VYKPDWCEVR EDWSVYLFSP ENRFRVLCQT IIAHKLFDYV 1150 1160 1170 1180 1190 1200 VLAFIFLNCI TIALERPQIE AGSTERIFLT VSNYIFTAIF VGEMTLKVVS LGLYFGEQAY 1210 1220 1230 1240 1250 1260 LRSSWNVLDG FLVFVSIIDI VVSLASAGGA KILGVLRVLR LLRTLRPLRV ISRAPGLKLV 1270 1280 1290 1300 1310 1320 VETLISSLKP IGNIVLICCA FFIIFGILGV QLFKGKFYHC LGVDTRNITN RSDCMAANYR 1330 1340 1350 1360 1370 1380 WVHHKYNFDN LGQALMSLFV LASKDGWVNI MYNGLDAVAV DQQPVTNHNP WMLLYFISFL 1390 1400 1410 1420 1430 1440 LIVSFFVLNM FVGVVVENFH KCRQHQEAEE ARRREEKRLR RLEKKRRKAQ RLPYYATYCH 1450 1460 1470 1480 1490 1500 TRLLIHSMCT SHYLDIFITF IICLNVVTMS LEHYNQPTSL ETALKYCNYM FTTVFVLEAV 1510 1520 1530 1540 1550 1560 LKLVAFGLRR FFKDRWNQLD LAIVLLSVMG ITLEEIEINA ALPINPTIIR IMRVLRIARV 1570 1580 1590 1600 1610 1620 LKLLKMATGM RALLDTVVQA LPQVGNLGLL FMLLFFIYAA LGVELFGKLV CNDENPCEGM 1630 1640 1650 1660 1670 1680 SRHATFENFG MAFLTLFQVS TGDNWNGIMK DTLRDCTHDE RSCLSSLQFV SPLYFVSFVL 1690 1700 1710 1720 1730 1740 TAQFVLINVV VAVLMKHLDD SNKEAQEDAE MDAELELEMA HGLGPGPRLP TGSPGAPGRG 1750 1760 1770 1780 1790 1800 PGGAGGGGDT EGGLCRRCYS PAQENLWLDS VSLIIKDSLE GELTIIDNLS GSIFHHYSSP 1810 1820 1830 1840 1850 1860 AGCKKCHHDK QEVQLAETEA FSLNSDRSSS ILLGDDLSLE DPTACPPGRK DSKGELDPPE 1870 1880 1890 1900 1910 1920 PMRVGDLGEC FFPLSSTAVS PDPENFLCEM EEIPFNPVRS WLKHDSSQAP PSPFSPDASS 1930 1940 1950 1960 1970 1980 PLLPMPAEFF HPAVSASQKG PEKGTGTGTL PKIALQGSWA SLRSPRVNCT LLRQATGSDT 1990 2000 2010 2020 2030 2040 SLDASPSSSA GSLQTTLEDS LTLSDSPRRA LGPPAPAPGP RAGLSPAARR RLSLRGRGLF 2050 2060 2070 2080 2090 2100 SLRGLRAHQR SHSSGGSTSP GCTHHDSMDP SDEEGRGGAG GGGAGSEHSE TLSSLSLTSL 2110 2120 2130 2140 2150 2160 FCPPPPPPAP GLTPARKFSS TSSLAAPGRP HAAALAHGLA RSPSWAADRS KDPPGRAPLP 2170 2180 MGLGPLAPPP QPLPGELEPG DAASKRKR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure and alternative splicing of the gene encoding alpha1I, a human brain T calcium channel alpha1 subunit." Mittman S., Guo J., Emerick M.C., Agnew W.S. Neurosci. Lett. 269:121-124(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). Tissue: Brain.
[2]	"Specific properties of T-type calcium channels generated by the human alpha1I subunit." Monteil A., Chemin J., Leuranguer V., Altier C., Mennessier G., Bourinet E., Lory P., Nargeot J. J. Biol. Chem. 275:16530-16535(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3). Tissue: Brain.
[3]	"Cloning and expression of the human T-type channel Ca(v)3.3: insights into prepulse facilitation." Gomora J.C., Murbartian J., Arias J.M., Lee J.-H., Perez-Reyes E. Biophys. J. 83:229-241(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), VARIANT VAL-1040. Tissue: Brain.
[4]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain." Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O. DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1200-2223 (ISOFORM 1). Tissue: Brain.
[6]	"Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity." Zhang D., Chen J., Saraf A., Cassar S., Han P., Rogers J.C., Brioni J.D., Sullivan J.P., Gopalakrishnan M. J. Biol. Chem. 281:22332-22341(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CATSPER1 AND CATSPER2.
[7]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF129133 mRNA. Translation: AAD45251.1. AF142567 mRNA. Translation: AAF25722.1. AF211189 mRNA. Translation: AAF44626.1. AF393329 mRNA. Translation: AAM67414.1. AL008716, AL022312, AL022319 Genomic DNA. Translation: CAI17903.1. AL022312, AL008716, AL022319 Genomic DNA. Translation: CAI19180.1. AL022319, AL022312, AL008716 Genomic DNA. Translation: CAI19662.1. AL022312, AL008716, AL022319 Genomic DNA. Translation: CAQ08289.1. AL022312, AL008716, AL022319 Genomic DNA. Translation: CAQ08290.1. AL022312, AL008716, AL022319 Genomic DNA. Translation: CAQ08291.1. AL008716, AL022312, AL022319 Genomic DNA. Translation: CAQ09516.1. AL008716, AL022312, AL022319 Genomic DNA. Translation: CAQ09517.1. AL008716, AL022312, AL022319 Genomic DNA. Translation: CAQ09518.1. AL022319, AL008716, AL022312 Genomic DNA. Translation: CAQ09681.1. AL022319, AL008716, AL022312 Genomic DNA. Translation: CAQ09682.1. AL022319, AL008716, AL022312 Genomic DNA. Translation: CAQ09683.1. AB032946 mRNA. Translation: BAA86434.1.
IPI	IPI00152899. IPI00217484. IPI00412316. IPI00938135.
RefSeq	NP_001003406.1. NM_001003406.1. NP_066919.2. NM_021096.3.
UniGene	Hs.125116.
3D structure databases
ProteinModelPortal	Q9P0X4.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9P0X4. 3 interactions.
Protein family/group databases
TCDB	1.A.1.11.7. voltage-gated ion channel (VIC) superfamily.
PTM databases
PhosphoSite	Q9P0X4.
Polymorphism databases
DMDM	23396521.
Proteomic databases
PaxDb	Q9P0X4.
PRIDE	Q9P0X4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000401624; ENSP00000383887; ENSG00000100346. ENST00000402142; ENSP00000385019; ENSG00000100346. ENST00000404898; ENSP00000384093; ENSG00000100346. ENST00000407673; ENSP00000385680; ENSG00000100346.
GeneID	8911.
KEGG	hsa:8911.
UCSC	uc003ayc.3. human. uc003ayd.3. human. uc003aye.3. human. uc003ayf.3. human.
Organism-specific databases
CTD	8911.
GeneCards	GC22P039966.
HGNC	HGNC:1396. CACNA1I.
MIM	608230. gene.
neXtProt	NX_Q9P0X4.
PharmGKB	PA26011.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1226.
HOVERGEN	HBG050764.
KO	K04856.
OrthoDB	EOG4F4S97.
Enzyme and pathway databases
Reactome	REACT_111045. Developmental Biology.
Gene expression databases
ArrayExpress	Q9P0X4.
Bgee	Q9P0X4.
Genevestigator	Q9P0X4.
Family and domain databases
InterPro	IPR005821. Ion_trans_dom. IPR005445. VDCC_T_a1su. IPR002077. VDCCAlpha1. [Graphical view]
Pfam	PF00520. Ion_trans. 4 hits. [Graphical view]
PRINTS	PR00167. CACHANNEL. PR01629. TVDCCALPHA1.
ProtoNet	Search...
Other
BindingDB	Q9P0X4.
ChEMBL	CHEMBL5558.
ChiTaRS	CACNA1I. human.
DrugBank	DB04841. Flunarizine. DB00617. Paramethadione. DB00661. Verapamil.
GenomeRNAi	8911.
NextBio	33488.
SOURCE	Search...

Entry information

Entry name

CAC1I_HUMAN

Accession

Primary (citable) accession number: Q9P0X4
Secondary accession number(s): B0QY12 , B0QY13, B0QY14, O95504, Q5JZ88, Q7Z6S9, Q8NFX6, Q9NZC8, Q9UH15, Q9UH30, Q9ULU9, Q9UNE6

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 104 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.