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Protein

Voltage-dependent T-type calcium channel subunit alpha-1I

Gene

CACNA1I

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Gates in voltage ranges similar to, but higher than alpha 1G or alpha 1H (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei357Calcium ion selectivity and permeabilityBy similarity1
Sitei821Calcium ion selectivity and permeabilityBy similarity1
Sitei1380Calcium ion selectivity and permeabilityBy similarity1
Sitei1678Calcium ion selectivity and permeabilityBy similarity1

GO - Molecular functioni

  • low voltage-gated calcium channel activity Source: InterPro
  • voltage-gated calcium channel activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100346-MONOMER.
ReactomeiR-HSA-419037. NCAM1 interactions.

Protein family/group databases

TCDBi1.A.1.11.7. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent T-type calcium channel subunit alpha-1I
Alternative name(s):
Voltage-gated calcium channel subunit alpha Cav3.3
Short name:
Ca(v)3.3
Gene namesi
Name:CACNA1I
Synonyms:KIAA1120
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:1396. CACNA1I.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 78CytoplasmicSequence analysisAdd BLAST78
Transmembranei79 – 99Helical; Name=S1 of repeat ISequence analysisAdd BLAST21
Topological domaini100 – 120ExtracellularSequence analysisAdd BLAST21
Transmembranei121 – 141Helical; Name=S2 of repeat ISequence analysisAdd BLAST21
Topological domaini142 – 148CytoplasmicSequence analysis7
Transmembranei149 – 168Helical; Name=S3 of repeat ISequence analysisAdd BLAST20
Topological domaini169 – 173ExtracellularSequence analysis5
Transmembranei174 – 191Helical; Name=S4 of repeat ISequence analysisAdd BLAST18
Topological domaini192 – 211CytoplasmicSequence analysisAdd BLAST20
Transmembranei212 – 232Helical; Name=S5 of repeat ISequence analysisAdd BLAST21
Topological domaini233 – 377ExtracellularSequence analysisAdd BLAST145
Transmembranei378 – 398Helical; Name=S6 of repeat ISequence analysisAdd BLAST21
Topological domaini399 – 640CytoplasmicSequence analysisAdd BLAST242
Transmembranei641 – 661Helical; Name=S1 of repeat IISequence analysisAdd BLAST21
Topological domaini662 – 676ExtracellularSequence analysisAdd BLAST15
Transmembranei677 – 697Helical; Name=S2 of repeat IISequence analysisAdd BLAST21
Topological domaini698 – 702CytoplasmicSequence analysis5
Transmembranei703 – 721Helical; Name=S3 of repeat IISequence analysisAdd BLAST19
Topological domaini722 – 729ExtracellularSequence analysis8
Transmembranei730 – 753Helical; Name=S4 of repeat IISequence analysisAdd BLAST24
Topological domaini754 – 764CytoplasmicSequence analysisAdd BLAST11
Transmembranei765 – 785Helical; Name=S5 of repeat IISequence analysisAdd BLAST21
Topological domaini786 – 841ExtracellularSequence analysisAdd BLAST56
Transmembranei842 – 862Helical; Name=S6 of repeat IISequence analysisAdd BLAST21
Topological domaini863 – 1166CytoplasmicSequence analysisAdd BLAST304
Transmembranei1167 – 1187Helical; Name=S1 of repeat IIISequence analysisAdd BLAST21
Topological domaini1188 – 1209ExtracellularSequence analysisAdd BLAST22
Transmembranei1210 – 1230Helical; Name=S2 of repeat IIISequence analysisAdd BLAST21
Topological domaini1231 – 1244CytoplasmicSequence analysisAdd BLAST14
Transmembranei1245 – 1265Helical; Name=S3 of repeat IIISequence analysisAdd BLAST21
Topological domaini1266 – 1272ExtracellularSequence analysis7
Transmembranei1273 – 1294Helical; Name=S4 of repeat IIISequence analysisAdd BLAST22
Topological domaini1295 – 1304CytoplasmicSequence analysis10
Transmembranei1305 – 1325Helical; Name=S5 of repeat IIISequence analysisAdd BLAST21
Topological domaini1326 – 1410ExtracellularSequence analysisAdd BLAST85
Transmembranei1411 – 1431Helical; Name=S6 of repeat IIISequence analysisAdd BLAST21
Topological domaini1432 – 1485CytoplasmicSequence analysisAdd BLAST54
Transmembranei1486 – 1506Helical; Name=S1 of repeat IVSequence analysisAdd BLAST21
Topological domaini1507 – 1522ExtracellularSequence analysisAdd BLAST16
Transmembranei1523 – 1543Helical; Name=S2 of repeat IVSequence analysisAdd BLAST21
Topological domaini1544 – 1556CytoplasmicSequence analysisAdd BLAST13
Transmembranei1557 – 1577Helical; Name=S3 of repeat IVSequence analysisAdd BLAST21
Topological domaini1578 – 1583ExtracellularSequence analysis6
Transmembranei1584 – 1607Helical; Name=S4 of repeat IVSequence analysisAdd BLAST24
Topological domaini1608 – 1621CytoplasmicSequence analysisAdd BLAST14
Transmembranei1622 – 1642Helical; Name=S5 of repeat IVSequence analysisAdd BLAST21
Topological domaini1643 – 1709ExtracellularSequence analysisAdd BLAST67
Transmembranei1710 – 1730Helical; Name=S6 of repeat IVSequence analysisAdd BLAST21
Topological domaini1731 – 2223CytoplasmicSequence analysisAdd BLAST493

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000100346.
PharmGKBiPA26011.

Chemistry databases

ChEMBLiCHEMBL5558.
DrugBankiDB00568. Cinnarizine.
DB04841. Flunarizine.
DB00617. Paramethadione.
DB00421. Spironolactone.
DB00661. Verapamil.
DB00909. Zonisamide.
GuidetoPHARMACOLOGYi537.

Polymorphism and mutation databases

BioMutaiCACNA1I.
DMDMi23396521.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000539571 – 2223Voltage-dependent T-type calcium channel subunit alpha-1IAdd BLAST2223

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi173N-linked (GlcNAc...)Sequence analysis1
Glycosylationi244N-linked (GlcNAc...)Sequence analysis1
Glycosylationi311N-linked (GlcNAc...)Sequence analysis1
Modified residuei1058PhosphoserineBy similarity1
Glycosylationi1342N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1345N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9P0X4.
PaxDbiQ9P0X4.
PeptideAtlasiQ9P0X4.
PRIDEiQ9P0X4.

PTM databases

iPTMnetiQ9P0X4.
PhosphoSitePlusiQ9P0X4.

Expressioni

Tissue specificityi

Brain specific.

Gene expression databases

BgeeiENSG00000100346.
GenevisibleiQ9P0X4. HS.

Interactioni

Subunit structurei

Interacts with CATSPER1 and CATSPER2, leading to suppress T-type calcium channel activity.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CATSPER1Q8NEC55EBI-1220829,EBI-744545
CATSPER2Q96P563EBI-1220829,EBI-2215024

Protein-protein interaction databases

BioGridi114425. 1 interactor.
IntActiQ9P0X4. 3 interactors.
STRINGi9606.ENSP00000385019.

Chemistry databases

BindingDBiQ9P0X4.

Structurei

3D structure databases

ProteinModelPortaliQ9P0X4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati66 – 401IAdd BLAST336
Repeati626 – 865IIAdd BLAST240
Repeati1157 – 1434IIIAdd BLAST278
Repeati1472 – 1733IVAdd BLAST262

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi608 – 613Poly-Glu6
Compositional biasi1775 – 1783Poly-Gly9
Compositional biasi2110 – 2120Poly-GlyAdd BLAST11
Compositional biasi2138 – 2145Poly-Pro8

Domaini

Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2302. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00830000128242.
HOVERGENiHBG050764.
InParanoidiQ9P0X4.
KOiK04856.
OMAiKMPNIAK.
OrthoDBiEOG091G02L1.
PhylomeDBiQ9P0X4.
TreeFamiTF313555.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR030162. CACNA1I.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR005445. VDCC_T_a1.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF209. PTHR10037:SF209. 3 hits.
PfamiPF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01629. TVDCCALPHA1.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P0X4-1) [UniParc]FASTAAdd to basket
Also known as: Delta36b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAESASPPSS SAAAPAAEPG VTTEQPGPRS PPSSPPGLEE PLDGADPHVP
60 70 80 90 100
HPDLAPIAFF CLRQTTSPRN WCIKMVCNPW FECVSMLVIL LNCVTLGMYQ
110 120 130 140 150
PCDDMDCLSD RCKILQVFDD FIFIFFAMEM VLKMVALGIF GKKCYLGDTW
160 170 180 190 200
NRLDFFIVMA GMVEYSLDLQ NINLSAIRTV RVLRPLKAIN RVPSMRILVN
210 220 230 240 250
LLLDTLPMLG NVLLLCFFVF FIFGIIGVQL WAGLLRNRCF LEENFTIQGD
260 270 280 290 300
VALPPYYQPE EDDEMPFICS LSGDNGIMGC HEIPPLKEQG RECCLSKDDV
310 320 330 340 350
YDFGAGRQDL NASGLCVNWN RYYNVCRTGS ANPHKGAINF DNIGYAWIVI
360 370 380 390 400
FQVITLEGWV EIMYYVMDAH SFYNFIYFIL LIIVGSFFMI NLCLVVIATQ
410 420 430 440 450
FSETKQREHR LMLEQRQRYL SSSTVASYAE PGDCYEEIFQ YVCHILRKAK
460 470 480 490 500
RRALGLYQAL QSRRQALGPE APAPAKPGPH AKEPRHYHGK TKGQGDEGRH
510 520 530 540 550
LGSRHCQTLH GPASPGNDHS GRELCPQHSP LDATPHTLVQ PIPATLASDP
560 570 580 590 600
ASCPCCQHED GRRPSGLGST DSGQEGSGSG SSAGGEDEAD GDGARSSEDG
610 620 630 640 650
ASSELGKEEE EEEQADGAVW LCGDVWRETR AKLRGIVDSK YFNRGIMMAI
660 670 680 690 700
LVNTVSMGIE HHEQPEELTN ILEICNVVFT SMFALEMILK LAAFGLFDYL
710 720 730 740 750
RNPYNIFDSI IVIISIWEIV GQADGGLSVL RTFRLLRVLK LVRFMPALRR
760 770 780 790 800
QLVVLMKTMD NVATFCMLLM LFIFIFSILG MHIFGCKFSL RTDTGDTVPD
810 820 830 840 850
RKNFDSLLWA IVTVFQILTQ EDWNVVLYNG MASTSPWASL YFVALMTFGN
860 870 880 890 900
YVLFNLLVAI LVEGFQAEGD ANRSYSDEDQ SSSNIEEFDK LQEGLDSSGD
910 920 930 940 950
PKLCPIPMTP NGHLDPSLPL GGHLGPAGAA GPAPRLSLQP DPMLVALGSR
960 970 980 990 1000
KSSVMSLGRM SYDQRSLSSS RSSYYGPWGR SAAWASRRSS WNSLKHKPPS
1010 1020 1030 1040 1050
AEHESLLSAE RGGGARVCEV AADEGPPRAA PLHTPHAHHI HHGPHLAHRH
1060 1070 1080 1090 1100
RHHRRTLSLD NRDSVDLAEL VPAVGAHPRA AWRAAGPAPG HEDCNGRMPS
1110 1120 1130 1140 1150
IAKDVFTKMG DRGDRGEDEE EIDYTLCFRV RKMIDVYKPD WCEVREDWSV
1160 1170 1180 1190 1200
YLFSPENRFR VLCQTIIAHK LFDYVVLAFI FLNCITIALE RPQIEAGSTE
1210 1220 1230 1240 1250
RIFLTVSNYI FTAIFVGEMT LKVVSLGLYF GEQAYLRSSW NVLDGFLVFV
1260 1270 1280 1290 1300
SIIDIVVSLA SAGGAKILGV LRVLRLLRTL RPLRVISRAP GLKLVVETLI
1310 1320 1330 1340 1350
SSLKPIGNIV LICCAFFIIF GILGVQLFKG KFYHCLGVDT RNITNRSDCM
1360 1370 1380 1390 1400
AANYRWVHHK YNFDNLGQAL MSLFVLASKD GWVNIMYNGL DAVAVDQQPV
1410 1420 1430 1440 1450
TNHNPWMLLY FISFLLIVSF FVLNMFVGVV VENFHKCRQH QEAEEARRRE
1460 1470 1480 1490 1500
EKRLRRLEKK RRKAQRLPYY ATYCHTRLLI HSMCTSHYLD IFITFIICLN
1510 1520 1530 1540 1550
VVTMSLEHYN QPTSLETALK YCNYMFTTVF VLEAVLKLVA FGLRRFFKDR
1560 1570 1580 1590 1600
WNQLDLAIVL LSVMGITLEE IEINAALPIN PTIIRIMRVL RIARVLKLLK
1610 1620 1630 1640 1650
MATGMRALLD TVVQALPQVG NLGLLFMLLF FIYAALGVEL FGKLVCNDEN
1660 1670 1680 1690 1700
PCEGMSRHAT FENFGMAFLT LFQVSTGDNW NGIMKDTLRD CTHDERSCLS
1710 1720 1730 1740 1750
SLQFVSPLYF VSFVLTAQFV LINVVVAVLM KHLDDSNKEA QEDAEMDAEL
1760 1770 1780 1790 1800
ELEMAHGLGP GPRLPTGSPG APGRGPGGAG GGGDTEGGLC RRCYSPAQEN
1810 1820 1830 1840 1850
LWLDSVSLII KDSLEGELTI IDNLSGSIFH HYSSPAGCKK CHHDKQEVQL
1860 1870 1880 1890 1900
AETEAFSLNS DRSSSILLGD DLSLEDPTAC PPGRKDSKGE LDPPEPMRVG
1910 1920 1930 1940 1950
DLGECFFPLS STAVSPDPEN FLCEMEEIPF NPVRSWLKHD SSQAPPSPFS
1960 1970 1980 1990 2000
PDASSPLLPM PAEFFHPAVS ASQKGPEKGT GTGTLPKIAL QGSWASLRSP
2010 2020 2030 2040 2050
RVNCTLLRQA TGSDTSLDAS PSSSAGSLQT TLEDSLTLSD SPRRALGPPA
2060 2070 2080 2090 2100
PAPGPRAGLS PAARRRLSLR GRGLFSLRGL RAHQRSHSSG GSTSPGCTHH
2110 2120 2130 2140 2150
DSMDPSDEEG RGGAGGGGAG SEHSETLSSL SLTSLFCPPP PPPAPGLTPA
2160 2170 2180 2190 2200
RKFSSTSSLA APGRPHAAAL AHGLARSPSW AADRSKDPPG RAPLPMGLGP
2210 2220
LAPPPQPLPG ELEPGDAASK RKR
Length:2,223
Mass (Da):245,103
Last modified:October 1, 2000 - v1
Checksum:i3CAE4D1C4289D08B
GO
Isoform 2 (identifier: Q9P0X4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2010-2223: ATGSDTSLDA...PGDAASKRKR → VPTPPRP

Show »
Length:2,016
Mass (Da):224,404
Checksum:i7721511BDA564B80
GO
Isoform 3 (identifier: Q9P0X4-3) [UniParc]FASTAAdd to basket
Also known as: Alpha1I-a

The sequence of this isoform differs from the canonical sequence as follows:
     488-523: HGKTKGQGDEGRHLGSRHCQTLHGPASPGNDHSGRE → Q
     2010-2223: ATGSDTSLDA...PGDAASKRKR → VPTPPRP

Show »
Length:1,981
Mass (Da):220,748
Checksum:i3AF7A61ECEBC7AEC
GO
Isoform 4 (identifier: Q9P0X4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     488-523: HGKTKGQGDEGRHLGSRHCQTLHGPASPGNDHSGRE → Q

Show »
Length:2,188
Mass (Da):241,448
Checksum:i87E508C40BBEFEAB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0138831040I → V.1 PublicationCorresponds to variant rs136853dbSNPEnsembl.1
Natural variantiVAR_0487451513T → M.Corresponds to variant rs8141262dbSNPEnsembl.1
Natural variantiVAR_0138841782G → A.Corresponds to variant rs2294369dbSNPEnsembl.1
Natural variantiVAR_0200501782G → R.Corresponds to variant rs2294369dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000950488 – 523HGKTK…HSGRE → Q in isoform 3 and isoform 4. 2 PublicationsAdd BLAST36
Alternative sequenceiVSP_0009512010 – 2223ATGSD…SKRKR → VPTPPRP in isoform 2 and isoform 3. 2 PublicationsAdd BLAST214

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF129133 mRNA. Translation: AAD45251.1.
AF142567 mRNA. Translation: AAF25722.1.
AF211189 mRNA. Translation: AAF44626.1.
AF393329 mRNA. Translation: AAM67414.1.
AL008716, AL022312, AL022319 Genomic DNA. Translation: CAI17903.1.
AL022312, AL008716, AL022319 Genomic DNA. Translation: CAI19180.1.
AL022319, AL022312, AL008716 Genomic DNA. Translation: CAI19662.1.
AL022312, AL008716, AL022319 Genomic DNA. Translation: CAQ08289.1.
AL022312, AL008716, AL022319 Genomic DNA. Translation: CAQ08290.1.
AL022312, AL008716, AL022319 Genomic DNA. Translation: CAQ08291.1.
AL008716, AL022312, AL022319 Genomic DNA. Translation: CAQ09516.1.
AL008716, AL022312, AL022319 Genomic DNA. Translation: CAQ09517.1.
AL008716, AL022312, AL022319 Genomic DNA. Translation: CAQ09518.1.
AL022319, AL008716, AL022312 Genomic DNA. Translation: CAQ09681.1.
AL022319, AL008716, AL022312 Genomic DNA. Translation: CAQ09682.1.
AL022319, AL008716, AL022312 Genomic DNA. Translation: CAQ09683.1.
AB032946 mRNA. Translation: BAA86434.1.
CCDSiCCDS46710.1. [Q9P0X4-1]
CCDS46711.1. [Q9P0X4-4]
RefSeqiNP_001003406.1. NM_001003406.1. [Q9P0X4-4]
NP_066919.2. NM_021096.3. [Q9P0X4-1]
UniGeneiHs.125116.

Genome annotation databases

EnsembliENST00000401624; ENSP00000383887; ENSG00000100346. [Q9P0X4-2]
ENST00000402142; ENSP00000385019; ENSG00000100346. [Q9P0X4-1]
ENST00000404898; ENSP00000384093; ENSG00000100346. [Q9P0X4-4]
ENST00000407673; ENSP00000385680; ENSG00000100346. [Q9P0X4-3]
GeneIDi8911.
KEGGihsa:8911.
UCSCiuc003ayc.5. human. [Q9P0X4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF129133 mRNA. Translation: AAD45251.1.
AF142567 mRNA. Translation: AAF25722.1.
AF211189 mRNA. Translation: AAF44626.1.
AF393329 mRNA. Translation: AAM67414.1.
AL008716, AL022312, AL022319 Genomic DNA. Translation: CAI17903.1.
AL022312, AL008716, AL022319 Genomic DNA. Translation: CAI19180.1.
AL022319, AL022312, AL008716 Genomic DNA. Translation: CAI19662.1.
AL022312, AL008716, AL022319 Genomic DNA. Translation: CAQ08289.1.
AL022312, AL008716, AL022319 Genomic DNA. Translation: CAQ08290.1.
AL022312, AL008716, AL022319 Genomic DNA. Translation: CAQ08291.1.
AL008716, AL022312, AL022319 Genomic DNA. Translation: CAQ09516.1.
AL008716, AL022312, AL022319 Genomic DNA. Translation: CAQ09517.1.
AL008716, AL022312, AL022319 Genomic DNA. Translation: CAQ09518.1.
AL022319, AL008716, AL022312 Genomic DNA. Translation: CAQ09681.1.
AL022319, AL008716, AL022312 Genomic DNA. Translation: CAQ09682.1.
AL022319, AL008716, AL022312 Genomic DNA. Translation: CAQ09683.1.
AB032946 mRNA. Translation: BAA86434.1.
CCDSiCCDS46710.1. [Q9P0X4-1]
CCDS46711.1. [Q9P0X4-4]
RefSeqiNP_001003406.1. NM_001003406.1. [Q9P0X4-4]
NP_066919.2. NM_021096.3. [Q9P0X4-1]
UniGeneiHs.125116.

3D structure databases

ProteinModelPortaliQ9P0X4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114425. 1 interactor.
IntActiQ9P0X4. 3 interactors.
STRINGi9606.ENSP00000385019.

Chemistry databases

BindingDBiQ9P0X4.
ChEMBLiCHEMBL5558.
DrugBankiDB00568. Cinnarizine.
DB04841. Flunarizine.
DB00617. Paramethadione.
DB00421. Spironolactone.
DB00661. Verapamil.
DB00909. Zonisamide.
GuidetoPHARMACOLOGYi537.

Protein family/group databases

TCDBi1.A.1.11.7. the voltage-gated ion channel (vic) superfamily.

PTM databases

iPTMnetiQ9P0X4.
PhosphoSitePlusiQ9P0X4.

Polymorphism and mutation databases

BioMutaiCACNA1I.
DMDMi23396521.

Proteomic databases

EPDiQ9P0X4.
PaxDbiQ9P0X4.
PeptideAtlasiQ9P0X4.
PRIDEiQ9P0X4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000401624; ENSP00000383887; ENSG00000100346. [Q9P0X4-2]
ENST00000402142; ENSP00000385019; ENSG00000100346. [Q9P0X4-1]
ENST00000404898; ENSP00000384093; ENSG00000100346. [Q9P0X4-4]
ENST00000407673; ENSP00000385680; ENSG00000100346. [Q9P0X4-3]
GeneIDi8911.
KEGGihsa:8911.
UCSCiuc003ayc.5. human. [Q9P0X4-1]

Organism-specific databases

CTDi8911.
GeneCardsiCACNA1I.
HGNCiHGNC:1396. CACNA1I.
MIMi608230. gene.
neXtProtiNX_Q9P0X4.
OpenTargetsiENSG00000100346.
PharmGKBiPA26011.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2302. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00830000128242.
HOVERGENiHBG050764.
InParanoidiQ9P0X4.
KOiK04856.
OMAiKMPNIAK.
OrthoDBiEOG091G02L1.
PhylomeDBiQ9P0X4.
TreeFamiTF313555.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100346-MONOMER.
ReactomeiR-HSA-419037. NCAM1 interactions.

Miscellaneous databases

ChiTaRSiCACNA1I. human.
GeneWikiiCACNA1I.
GenomeRNAii8911.
PROiQ9P0X4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100346.
GenevisibleiQ9P0X4. HS.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR030162. CACNA1I.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR005445. VDCC_T_a1.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF209. PTHR10037:SF209. 3 hits.
PfamiPF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01629. TVDCCALPHA1.
ProtoNetiSearch...

Entry informationi

Entry nameiCAC1I_HUMAN
AccessioniPrimary (citable) accession number: Q9P0X4
Secondary accession number(s): B0QY12
, B0QY13, B0QY14, O95504, Q5JZ88, Q7Z6S9, Q8NFX6, Q9NZC8, Q9UH15, Q9UH30, Q9ULU9, Q9UNE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.