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Q9P0X4

- CAC1I_HUMAN

UniProt

Q9P0X4 - CAC1I_HUMAN

Protein

Voltage-dependent T-type calcium channel subunit alpha-1I

Gene

CACNA1I

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Isoform alpha-1I gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Gates in voltage ranges similar to, but higher than alpha 1G or alpha 1H By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei357 – 3571Calcium ion selectivity and permeabilityBy similarity
    Sitei821 – 8211Calcium ion selectivity and permeabilityBy similarity
    Sitei1380 – 13801Calcium ion selectivity and permeabilityBy similarity
    Sitei1678 – 16781Calcium ion selectivity and permeabilityBy similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. voltage-gated calcium channel activity Source: RefGenome

    GO - Biological processi

    1. axon guidance Source: Reactome
    2. calcium ion import Source: RefGenome
    3. membrane depolarization during action potential Source: RefGenome
    4. neuronal action potential Source: Ensembl
    5. signal transduction Source: ProtInc
    6. sleep Source: Ensembl
    7. transport Source: ProtInc

    Keywords - Molecular functioni

    Calcium channel, Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium

    Enzyme and pathway databases

    ReactomeiREACT_18312. NCAM1 interactions.

    Protein family/group databases

    TCDBi1.A.1.11.7. the voltage-gated ion channel (vic) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Voltage-dependent T-type calcium channel subunit alpha-1I
    Alternative name(s):
    Voltage-gated calcium channel subunit alpha Cav3.3
    Short name:
    Ca(v)3.3
    Gene namesi
    Name:CACNA1I
    Synonyms:KIAA1120
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:1396. CACNA1I.

    Subcellular locationi

    GO - Cellular componenti

    1. plasma membrane Source: RefGenome
    2. voltage-gated calcium channel complex Source: InterPro

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26011.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 22232223Voltage-dependent T-type calcium channel subunit alpha-1IPRO_0000053957Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi244 – 2441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi311 – 3111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1342 – 13421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1345 – 13451N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II.By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9P0X4.
    PRIDEiQ9P0X4.

    PTM databases

    PhosphoSiteiQ9P0X4.

    Expressioni

    Tissue specificityi

    Brain specific.

    Gene expression databases

    ArrayExpressiQ9P0X4.
    BgeeiQ9P0X4.
    GenevestigatoriQ9P0X4.

    Interactioni

    Subunit structurei

    Interacts with CATSPER1 and CATSPER2, leading to suppress T-type calcium channel activity.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CATSPER1Q8NEC55EBI-1220829,EBI-744545
    CATSPER2Q96P563EBI-1220829,EBI-2215024

    Protein-protein interaction databases

    BioGridi114425. 1 interaction.
    IntActiQ9P0X4. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9P0X4.
    SMRiQ9P0X4. Positions 75-232, 642-866, 1172-1446, 1493-1745.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7878CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini100 – 12021ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini142 – 1487CytoplasmicSequence Analysis
    Topological domaini169 – 1735ExtracellularSequence Analysis
    Topological domaini192 – 21120CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini233 – 377145ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini399 – 640242CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini662 – 67615ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini698 – 7025CytoplasmicSequence Analysis
    Topological domaini722 – 7298ExtracellularSequence Analysis
    Topological domaini754 – 76411CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini786 – 84156ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini863 – 1166304CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1188 – 120922ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1231 – 124414CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1266 – 12727ExtracellularSequence Analysis
    Topological domaini1295 – 130410CytoplasmicSequence Analysis
    Topological domaini1326 – 141085ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1432 – 148554CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1507 – 152216ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1544 – 155613CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1578 – 15836ExtracellularSequence Analysis
    Topological domaini1608 – 162114CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1643 – 170967ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1731 – 2223493CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei79 – 9921Helical; Name=S1 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei121 – 14121Helical; Name=S2 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei149 – 16820Helical; Name=S3 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei174 – 19118Helical; Name=S4 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei212 – 23221Helical; Name=S5 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei378 – 39821Helical; Name=S6 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei641 – 66121Helical; Name=S1 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei677 – 69721Helical; Name=S2 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei703 – 72119Helical; Name=S3 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei730 – 75324Helical; Name=S4 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei765 – 78521Helical; Name=S5 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei842 – 86221Helical; Name=S6 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei1167 – 118721Helical; Name=S1 of repeat IIISequence AnalysisAdd
    BLAST
    Transmembranei1210 – 123021Helical; Name=S2 of repeat IIISequence AnalysisAdd
    BLAST
    Transmembranei1245 – 126521Helical; Name=S3 of repeat IIISequence AnalysisAdd
    BLAST
    Transmembranei1273 – 129422Helical; Name=S4 of repeat IIISequence AnalysisAdd
    BLAST
    Transmembranei1305 – 132521Helical; Name=S5 of repeat IIISequence AnalysisAdd
    BLAST
    Transmembranei1411 – 143121Helical; Name=S6 of repeat IIISequence AnalysisAdd
    BLAST
    Transmembranei1486 – 150621Helical; Name=S1 of repeat IVSequence AnalysisAdd
    BLAST
    Transmembranei1523 – 154321Helical; Name=S2 of repeat IVSequence AnalysisAdd
    BLAST
    Transmembranei1557 – 157721Helical; Name=S3 of repeat IVSequence AnalysisAdd
    BLAST
    Transmembranei1584 – 160724Helical; Name=S4 of repeat IVSequence AnalysisAdd
    BLAST
    Transmembranei1622 – 164221Helical; Name=S5 of repeat IVSequence AnalysisAdd
    BLAST
    Transmembranei1710 – 173021Helical; Name=S6 of repeat IVSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati66 – 401336IAdd
    BLAST
    Repeati626 – 865240IIAdd
    BLAST
    Repeati1157 – 1434278IIIAdd
    BLAST
    Repeati1472 – 1733262IVAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi608 – 6136Poly-Glu
    Compositional biasi1775 – 17839Poly-Gly
    Compositional biasi2110 – 212011Poly-GlyAdd
    BLAST
    Compositional biasi2138 – 21458Poly-Pro

    Domaini

    Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.

    Sequence similaritiesi

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1226.
    HOVERGENiHBG050764.
    KOiK04856.
    OrthoDBiEOG7MKW55.
    PhylomeDBiQ9P0X4.
    TreeFamiTF313555.

    Family and domain databases

    Gene3Di1.20.120.350. 4 hits.
    InterProiIPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR005445. VDCC_T_a1su.
    IPR002077. VDCCAlpha1.
    [Graphical view]
    PfamiPF00520. Ion_trans. 4 hits.
    [Graphical view]
    PRINTSiPR00167. CACHANNEL.
    PR01629. TVDCCALPHA1.

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9P0X4-1) [UniParc]FASTAAdd to Basket

    Also known as: Delta36b

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAESASPPSS SAAAPAAEPG VTTEQPGPRS PPSSPPGLEE PLDGADPHVP     50
    HPDLAPIAFF CLRQTTSPRN WCIKMVCNPW FECVSMLVIL LNCVTLGMYQ 100
    PCDDMDCLSD RCKILQVFDD FIFIFFAMEM VLKMVALGIF GKKCYLGDTW 150
    NRLDFFIVMA GMVEYSLDLQ NINLSAIRTV RVLRPLKAIN RVPSMRILVN 200
    LLLDTLPMLG NVLLLCFFVF FIFGIIGVQL WAGLLRNRCF LEENFTIQGD 250
    VALPPYYQPE EDDEMPFICS LSGDNGIMGC HEIPPLKEQG RECCLSKDDV 300
    YDFGAGRQDL NASGLCVNWN RYYNVCRTGS ANPHKGAINF DNIGYAWIVI 350
    FQVITLEGWV EIMYYVMDAH SFYNFIYFIL LIIVGSFFMI NLCLVVIATQ 400
    FSETKQREHR LMLEQRQRYL SSSTVASYAE PGDCYEEIFQ YVCHILRKAK 450
    RRALGLYQAL QSRRQALGPE APAPAKPGPH AKEPRHYHGK TKGQGDEGRH 500
    LGSRHCQTLH GPASPGNDHS GRELCPQHSP LDATPHTLVQ PIPATLASDP 550
    ASCPCCQHED GRRPSGLGST DSGQEGSGSG SSAGGEDEAD GDGARSSEDG 600
    ASSELGKEEE EEEQADGAVW LCGDVWRETR AKLRGIVDSK YFNRGIMMAI 650
    LVNTVSMGIE HHEQPEELTN ILEICNVVFT SMFALEMILK LAAFGLFDYL 700
    RNPYNIFDSI IVIISIWEIV GQADGGLSVL RTFRLLRVLK LVRFMPALRR 750
    QLVVLMKTMD NVATFCMLLM LFIFIFSILG MHIFGCKFSL RTDTGDTVPD 800
    RKNFDSLLWA IVTVFQILTQ EDWNVVLYNG MASTSPWASL YFVALMTFGN 850
    YVLFNLLVAI LVEGFQAEGD ANRSYSDEDQ SSSNIEEFDK LQEGLDSSGD 900
    PKLCPIPMTP NGHLDPSLPL GGHLGPAGAA GPAPRLSLQP DPMLVALGSR 950
    KSSVMSLGRM SYDQRSLSSS RSSYYGPWGR SAAWASRRSS WNSLKHKPPS 1000
    AEHESLLSAE RGGGARVCEV AADEGPPRAA PLHTPHAHHI HHGPHLAHRH 1050
    RHHRRTLSLD NRDSVDLAEL VPAVGAHPRA AWRAAGPAPG HEDCNGRMPS 1100
    IAKDVFTKMG DRGDRGEDEE EIDYTLCFRV RKMIDVYKPD WCEVREDWSV 1150
    YLFSPENRFR VLCQTIIAHK LFDYVVLAFI FLNCITIALE RPQIEAGSTE 1200
    RIFLTVSNYI FTAIFVGEMT LKVVSLGLYF GEQAYLRSSW NVLDGFLVFV 1250
    SIIDIVVSLA SAGGAKILGV LRVLRLLRTL RPLRVISRAP GLKLVVETLI 1300
    SSLKPIGNIV LICCAFFIIF GILGVQLFKG KFYHCLGVDT RNITNRSDCM 1350
    AANYRWVHHK YNFDNLGQAL MSLFVLASKD GWVNIMYNGL DAVAVDQQPV 1400
    TNHNPWMLLY FISFLLIVSF FVLNMFVGVV VENFHKCRQH QEAEEARRRE 1450
    EKRLRRLEKK RRKAQRLPYY ATYCHTRLLI HSMCTSHYLD IFITFIICLN 1500
    VVTMSLEHYN QPTSLETALK YCNYMFTTVF VLEAVLKLVA FGLRRFFKDR 1550
    WNQLDLAIVL LSVMGITLEE IEINAALPIN PTIIRIMRVL RIARVLKLLK 1600
    MATGMRALLD TVVQALPQVG NLGLLFMLLF FIYAALGVEL FGKLVCNDEN 1650
    PCEGMSRHAT FENFGMAFLT LFQVSTGDNW NGIMKDTLRD CTHDERSCLS 1700
    SLQFVSPLYF VSFVLTAQFV LINVVVAVLM KHLDDSNKEA QEDAEMDAEL 1750
    ELEMAHGLGP GPRLPTGSPG APGRGPGGAG GGGDTEGGLC RRCYSPAQEN 1800
    LWLDSVSLII KDSLEGELTI IDNLSGSIFH HYSSPAGCKK CHHDKQEVQL 1850
    AETEAFSLNS DRSSSILLGD DLSLEDPTAC PPGRKDSKGE LDPPEPMRVG 1900
    DLGECFFPLS STAVSPDPEN FLCEMEEIPF NPVRSWLKHD SSQAPPSPFS 1950
    PDASSPLLPM PAEFFHPAVS ASQKGPEKGT GTGTLPKIAL QGSWASLRSP 2000
    RVNCTLLRQA TGSDTSLDAS PSSSAGSLQT TLEDSLTLSD SPRRALGPPA 2050
    PAPGPRAGLS PAARRRLSLR GRGLFSLRGL RAHQRSHSSG GSTSPGCTHH 2100
    DSMDPSDEEG RGGAGGGGAG SEHSETLSSL SLTSLFCPPP PPPAPGLTPA 2150
    RKFSSTSSLA APGRPHAAAL AHGLARSPSW AADRSKDPPG RAPLPMGLGP 2200
    LAPPPQPLPG ELEPGDAASK RKR 2223
    Length:2,223
    Mass (Da):245,103
    Last modified:October 1, 2000 - v1
    Checksum:i3CAE4D1C4289D08B
    GO
    Isoform 2 (identifier: Q9P0X4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         2010-2223: ATGSDTSLDA...PGDAASKRKR → VPTPPRP

    Show »
    Length:2,016
    Mass (Da):224,404
    Checksum:i7721511BDA564B80
    GO
    Isoform 3 (identifier: Q9P0X4-3) [UniParc]FASTAAdd to Basket

    Also known as: Alpha1I-a

    The sequence of this isoform differs from the canonical sequence as follows:
         488-523: HGKTKGQGDEGRHLGSRHCQTLHGPASPGNDHSGRE → Q
         2010-2223: ATGSDTSLDA...PGDAASKRKR → VPTPPRP

    Show »
    Length:1,981
    Mass (Da):220,748
    Checksum:i3AF7A61ECEBC7AEC
    GO
    Isoform 4 (identifier: Q9P0X4-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         488-523: HGKTKGQGDEGRHLGSRHCQTLHGPASPGNDHSGRE → Q

    Show »
    Length:2,188
    Mass (Da):241,448
    Checksum:i87E508C40BBEFEAB
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti1040 – 10401I → V.1 Publication
    Corresponds to variant rs136853 [ dbSNP | Ensembl ].
    VAR_013883
    Natural varianti1513 – 15131T → M.
    Corresponds to variant rs8141262 [ dbSNP | Ensembl ].
    VAR_048745
    Natural varianti1782 – 17821G → A.
    Corresponds to variant rs2294369 [ dbSNP | Ensembl ].
    VAR_013884
    Natural varianti1782 – 17821G → R.
    Corresponds to variant rs2294369 [ dbSNP | Ensembl ].
    VAR_020050

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei488 – 52336HGKTK…HSGRE → Q in isoform 3 and isoform 4. 2 PublicationsVSP_000950Add
    BLAST
    Alternative sequencei2010 – 2223214ATGSD…SKRKR → VPTPPRP in isoform 2 and isoform 3. 2 PublicationsVSP_000951Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF129133 mRNA. Translation: AAD45251.1.
    AF142567 mRNA. Translation: AAF25722.1.
    AF211189 mRNA. Translation: AAF44626.1.
    AF393329 mRNA. Translation: AAM67414.1.
    AL008716, AL022312, AL022319 Genomic DNA. Translation: CAI17903.1.
    AL022312, AL008716, AL022319 Genomic DNA. Translation: CAI19180.1.
    AL022319, AL022312, AL008716 Genomic DNA. Translation: CAI19662.1.
    AL022312, AL008716, AL022319 Genomic DNA. Translation: CAQ08289.1.
    AL022312, AL008716, AL022319 Genomic DNA. Translation: CAQ08290.1.
    AL022312, AL008716, AL022319 Genomic DNA. Translation: CAQ08291.1.
    AL008716, AL022312, AL022319 Genomic DNA. Translation: CAQ09516.1.
    AL008716, AL022312, AL022319 Genomic DNA. Translation: CAQ09517.1.
    AL008716, AL022312, AL022319 Genomic DNA. Translation: CAQ09518.1.
    AL022319, AL008716, AL022312 Genomic DNA. Translation: CAQ09681.1.
    AL022319, AL008716, AL022312 Genomic DNA. Translation: CAQ09682.1.
    AL022319, AL008716, AL022312 Genomic DNA. Translation: CAQ09683.1.
    AB032946 mRNA. Translation: BAA86434.1.
    CCDSiCCDS46710.1. [Q9P0X4-1]
    CCDS46711.1. [Q9P0X4-4]
    RefSeqiNP_001003406.1. NM_001003406.1. [Q9P0X4-4]
    NP_066919.2. NM_021096.3. [Q9P0X4-1]
    UniGeneiHs.125116.

    Genome annotation databases

    EnsembliENST00000401624; ENSP00000383887; ENSG00000100346. [Q9P0X4-2]
    ENST00000402142; ENSP00000385019; ENSG00000100346. [Q9P0X4-1]
    ENST00000404898; ENSP00000384093; ENSG00000100346. [Q9P0X4-4]
    ENST00000407673; ENSP00000385680; ENSG00000100346. [Q9P0X4-3]
    GeneIDi8911.
    KEGGihsa:8911.
    UCSCiuc003ayc.3. human. [Q9P0X4-1]
    uc003ayd.3. human. [Q9P0X4-4]
    uc003aye.3. human. [Q9P0X4-2]
    uc003ayf.3. human. [Q9P0X4-3]

    Polymorphism databases

    DMDMi23396521.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF129133 mRNA. Translation: AAD45251.1 .
    AF142567 mRNA. Translation: AAF25722.1 .
    AF211189 mRNA. Translation: AAF44626.1 .
    AF393329 mRNA. Translation: AAM67414.1 .
    AL008716 , AL022312 , AL022319 Genomic DNA. Translation: CAI17903.1 .
    AL022312 , AL008716 , AL022319 Genomic DNA. Translation: CAI19180.1 .
    AL022319 , AL022312 , AL008716 Genomic DNA. Translation: CAI19662.1 .
    AL022312 , AL008716 , AL022319 Genomic DNA. Translation: CAQ08289.1 .
    AL022312 , AL008716 , AL022319 Genomic DNA. Translation: CAQ08290.1 .
    AL022312 , AL008716 , AL022319 Genomic DNA. Translation: CAQ08291.1 .
    AL008716 , AL022312 , AL022319 Genomic DNA. Translation: CAQ09516.1 .
    AL008716 , AL022312 , AL022319 Genomic DNA. Translation: CAQ09517.1 .
    AL008716 , AL022312 , AL022319 Genomic DNA. Translation: CAQ09518.1 .
    AL022319 , AL008716 , AL022312 Genomic DNA. Translation: CAQ09681.1 .
    AL022319 , AL008716 , AL022312 Genomic DNA. Translation: CAQ09682.1 .
    AL022319 , AL008716 , AL022312 Genomic DNA. Translation: CAQ09683.1 .
    AB032946 mRNA. Translation: BAA86434.1 .
    CCDSi CCDS46710.1. [Q9P0X4-1 ]
    CCDS46711.1. [Q9P0X4-4 ]
    RefSeqi NP_001003406.1. NM_001003406.1. [Q9P0X4-4 ]
    NP_066919.2. NM_021096.3. [Q9P0X4-1 ]
    UniGenei Hs.125116.

    3D structure databases

    ProteinModelPortali Q9P0X4.
    SMRi Q9P0X4. Positions 75-232, 642-866, 1172-1446, 1493-1745.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114425. 1 interaction.
    IntActi Q9P0X4. 3 interactions.

    Chemistry

    BindingDBi Q9P0X4.
    ChEMBLi CHEMBL5558.
    DrugBanki DB04841. Flunarizine.
    DB00617. Paramethadione.
    DB00661. Verapamil.
    GuidetoPHARMACOLOGYi 537.

    Protein family/group databases

    TCDBi 1.A.1.11.7. the voltage-gated ion channel (vic) superfamily.

    PTM databases

    PhosphoSitei Q9P0X4.

    Polymorphism databases

    DMDMi 23396521.

    Proteomic databases

    PaxDbi Q9P0X4.
    PRIDEi Q9P0X4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000401624 ; ENSP00000383887 ; ENSG00000100346 . [Q9P0X4-2 ]
    ENST00000402142 ; ENSP00000385019 ; ENSG00000100346 . [Q9P0X4-1 ]
    ENST00000404898 ; ENSP00000384093 ; ENSG00000100346 . [Q9P0X4-4 ]
    ENST00000407673 ; ENSP00000385680 ; ENSG00000100346 . [Q9P0X4-3 ]
    GeneIDi 8911.
    KEGGi hsa:8911.
    UCSCi uc003ayc.3. human. [Q9P0X4-1 ]
    uc003ayd.3. human. [Q9P0X4-4 ]
    uc003aye.3. human. [Q9P0X4-2 ]
    uc003ayf.3. human. [Q9P0X4-3 ]

    Organism-specific databases

    CTDi 8911.
    GeneCardsi GC22P039966.
    HGNCi HGNC:1396. CACNA1I.
    MIMi 608230. gene.
    neXtProti NX_Q9P0X4.
    PharmGKBi PA26011.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1226.
    HOVERGENi HBG050764.
    KOi K04856.
    OrthoDBi EOG7MKW55.
    PhylomeDBi Q9P0X4.
    TreeFami TF313555.

    Enzyme and pathway databases

    Reactomei REACT_18312. NCAM1 interactions.

    Miscellaneous databases

    ChiTaRSi CACNA1I. human.
    GeneWikii CACNA1I.
    GenomeRNAii 8911.
    NextBioi 33488.
    PROi Q9P0X4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9P0X4.
    Bgeei Q9P0X4.
    Genevestigatori Q9P0X4.

    Family and domain databases

    Gene3Di 1.20.120.350. 4 hits.
    InterProi IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR005445. VDCC_T_a1su.
    IPR002077. VDCCAlpha1.
    [Graphical view ]
    Pfami PF00520. Ion_trans. 4 hits.
    [Graphical view ]
    PRINTSi PR00167. CACHANNEL.
    PR01629. TVDCCALPHA1.
    ProtoNeti Search...

    Publicationsi

    1. "Structure and alternative splicing of the gene encoding alpha1I, a human brain T calcium channel alpha1 subunit."
      Mittman S., Guo J., Emerick M.C., Agnew W.S.
      Neurosci. Lett. 269:121-124(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain.
    2. "Specific properties of T-type calcium channels generated by the human alpha1I subunit."
      Monteil A., Chemin J., Leuranguer V., Altier C., Mennessier G., Bourinet E., Lory P., Nargeot J.
      J. Biol. Chem. 275:16530-16535(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
      Tissue: Brain.
    3. "Cloning and expression of the human T-type channel Ca(v)3.3: insights into prepulse facilitation."
      Gomora J.C., Murbartian J., Arias J.M., Lee J.-H., Perez-Reyes E.
      Biophys. J. 83:229-241(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), VARIANT VAL-1040.
      Tissue: Brain.
    4. "The DNA sequence of human chromosome 22."
      Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
      , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
      Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
      Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
      DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1200-2223 (ISOFORM 1).
      Tissue: Brain.
    6. "Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity."
      Zhang D., Chen J., Saraf A., Cassar S., Han P., Rogers J.C., Brioni J.D., Sullivan J.P., Gopalakrishnan M.
      J. Biol. Chem. 281:22332-22341(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CATSPER1 AND CATSPER2.
    7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.

    Entry informationi

    Entry nameiCAC1I_HUMAN
    AccessioniPrimary (citable) accession number: Q9P0X4
    Secondary accession number(s): B0QY12
    , B0QY13, B0QY14, O95504, Q5JZ88, Q7Z6S9, Q8NFX6, Q9NZC8, Q9UH15, Q9UH30, Q9ULU9, Q9UNE6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3