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Q9P0X4 (CAC1I_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Voltage-dependent T-type calcium channel subunit alpha-1I
Alternative name(s):
Voltage-gated calcium channel subunit alpha Cav3.3
Short name=Ca(v)3.3
Gene names
Name:CACNA1I
Synonyms:KIAA1120
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length2223 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Isoform alpha-1Igives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Gates in voltage ranges similar to, but higher than alpha 1G or alpha 1H By similarity.

Subunit structure

Interacts with CATSPER1 and CATSPER2, leading to suppress T-type calcium channel activity. Ref.6

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Brain specific.

Domain

Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.

Post-translational modification

In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II By similarity.

Sequence similarities

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1I subfamily. [View classification]

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CATSPER1Q8NEC55EBI-1220829,EBI-744545
CATSPER2Q96P563EBI-1220829,EBI-2215024

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9P0X4-1)

Also known as: Delta36b;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9P0X4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     2010-2223: ATGSDTSLDA...PGDAASKRKR → VPTPPRP
Isoform 3 (identifier: Q9P0X4-3)

Also known as: Alpha1I-a;

The sequence of this isoform differs from the canonical sequence as follows:
     488-523: HGKTKGQGDEGRHLGSRHCQTLHGPASPGNDHSGRE → Q
     2010-2223: ATGSDTSLDA...PGDAASKRKR → VPTPPRP
Isoform 4 (identifier: Q9P0X4-4)

The sequence of this isoform differs from the canonical sequence as follows:
     488-523: HGKTKGQGDEGRHLGSRHCQTLHGPASPGNDHSGRE → Q

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 22232223Voltage-dependent T-type calcium channel subunit alpha-1I
PRO_0000053957

Regions

Topological domain1 – 7878Cytoplasmic Potential
Transmembrane79 – 9921Helical; Name=S1 of repeat I; Potential
Topological domain100 – 12021Extracellular Potential
Transmembrane121 – 14121Helical; Name=S2 of repeat I; Potential
Topological domain142 – 1487Cytoplasmic Potential
Transmembrane149 – 16820Helical; Name=S3 of repeat I; Potential
Topological domain169 – 1735Extracellular Potential
Transmembrane174 – 19118Helical; Name=S4 of repeat I; Potential
Topological domain192 – 21120Cytoplasmic Potential
Transmembrane212 – 23221Helical; Name=S5 of repeat I; Potential
Topological domain233 – 377145Extracellular Potential
Transmembrane378 – 39821Helical; Name=S6 of repeat I; Potential
Topological domain399 – 640242Cytoplasmic Potential
Transmembrane641 – 66121Helical; Name=S1 of repeat II; Potential
Topological domain662 – 67615Extracellular Potential
Transmembrane677 – 69721Helical; Name=S2 of repeat II; Potential
Topological domain698 – 7025Cytoplasmic Potential
Transmembrane703 – 72119Helical; Name=S3 of repeat II; Potential
Topological domain722 – 7298Extracellular Potential
Transmembrane730 – 75324Helical; Name=S4 of repeat II; Potential
Topological domain754 – 76411Cytoplasmic Potential
Transmembrane765 – 78521Helical; Name=S5 of repeat II; Potential
Topological domain786 – 84156Extracellular Potential
Transmembrane842 – 86221Helical; Name=S6 of repeat II; Potential
Topological domain863 – 1166304Cytoplasmic Potential
Transmembrane1167 – 118721Helical; Name=S1 of repeat III; Potential
Topological domain1188 – 120922Extracellular Potential
Transmembrane1210 – 123021Helical; Name=S2 of repeat III; Potential
Topological domain1231 – 124414Cytoplasmic Potential
Transmembrane1245 – 126521Helical; Name=S3 of repeat III; Potential
Topological domain1266 – 12727Extracellular Potential
Transmembrane1273 – 129422Helical; Name=S4 of repeat III; Potential
Topological domain1295 – 130410Cytoplasmic Potential
Transmembrane1305 – 132521Helical; Name=S5 of repeat III; Potential
Topological domain1326 – 141085Extracellular Potential
Transmembrane1411 – 143121Helical; Name=S6 of repeat III; Potential
Topological domain1432 – 148554Cytoplasmic Potential
Transmembrane1486 – 150621Helical; Name=S1 of repeat IV; Potential
Topological domain1507 – 152216Extracellular Potential
Transmembrane1523 – 154321Helical; Name=S2 of repeat IV; Potential
Topological domain1544 – 155613Cytoplasmic Potential
Transmembrane1557 – 157721Helical; Name=S3 of repeat IV; Potential
Topological domain1578 – 15836Extracellular Potential
Transmembrane1584 – 160724Helical; Name=S4 of repeat IV; Potential
Topological domain1608 – 162114Cytoplasmic Potential
Transmembrane1622 – 164221Helical; Name=S5 of repeat IV; Potential
Topological domain1643 – 170967Extracellular Potential
Transmembrane1710 – 173021Helical; Name=S6 of repeat IV; Potential
Topological domain1731 – 2223493Cytoplasmic Potential
Repeat66 – 401336I
Repeat626 – 865240II
Repeat1157 – 1434278III
Repeat1472 – 1733262IV
Compositional bias608 – 6136Poly-Glu
Compositional bias1775 – 17839Poly-Gly
Compositional bias2110 – 212011Poly-Gly
Compositional bias2138 – 21458Poly-Pro

Sites

Site3571Calcium ion selectivity and permeability By similarity
Site8211Calcium ion selectivity and permeability By similarity
Site13801Calcium ion selectivity and permeability By similarity
Site16781Calcium ion selectivity and permeability By similarity

Amino acid modifications

Glycosylation1731N-linked (GlcNAc...) Potential
Glycosylation2441N-linked (GlcNAc...) Potential
Glycosylation3111N-linked (GlcNAc...) Potential
Glycosylation13421N-linked (GlcNAc...) Potential
Glycosylation13451N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence488 – 52336HGKTK…HSGRE → Q in isoform 3 and isoform 4.
VSP_000950
Alternative sequence2010 – 2223214ATGSD…SKRKR → VPTPPRP in isoform 2 and isoform 3.
VSP_000951
Natural variant10401I → V. Ref.3
Corresponds to variant rs136853 [ dbSNP | Ensembl ].
VAR_013883
Natural variant15131T → M.
Corresponds to variant rs8141262 [ dbSNP | Ensembl ].
VAR_048745
Natural variant17821G → A.
Corresponds to variant rs2294369 [ dbSNP | Ensembl ].
VAR_013884
Natural variant17821G → R.
Corresponds to variant rs2294369 [ dbSNP | Ensembl ].
VAR_020050

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Delta36b) [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 3CAE4D1C4289D08B

FASTA2,223245,103
        10         20         30         40         50         60 
MAESASPPSS SAAAPAAEPG VTTEQPGPRS PPSSPPGLEE PLDGADPHVP HPDLAPIAFF 

        70         80         90        100        110        120 
CLRQTTSPRN WCIKMVCNPW FECVSMLVIL LNCVTLGMYQ PCDDMDCLSD RCKILQVFDD 

       130        140        150        160        170        180 
FIFIFFAMEM VLKMVALGIF GKKCYLGDTW NRLDFFIVMA GMVEYSLDLQ NINLSAIRTV 

       190        200        210        220        230        240 
RVLRPLKAIN RVPSMRILVN LLLDTLPMLG NVLLLCFFVF FIFGIIGVQL WAGLLRNRCF 

       250        260        270        280        290        300 
LEENFTIQGD VALPPYYQPE EDDEMPFICS LSGDNGIMGC HEIPPLKEQG RECCLSKDDV 

       310        320        330        340        350        360 
YDFGAGRQDL NASGLCVNWN RYYNVCRTGS ANPHKGAINF DNIGYAWIVI FQVITLEGWV 

       370        380        390        400        410        420 
EIMYYVMDAH SFYNFIYFIL LIIVGSFFMI NLCLVVIATQ FSETKQREHR LMLEQRQRYL 

       430        440        450        460        470        480 
SSSTVASYAE PGDCYEEIFQ YVCHILRKAK RRALGLYQAL QSRRQALGPE APAPAKPGPH 

       490        500        510        520        530        540 
AKEPRHYHGK TKGQGDEGRH LGSRHCQTLH GPASPGNDHS GRELCPQHSP LDATPHTLVQ 

       550        560        570        580        590        600 
PIPATLASDP ASCPCCQHED GRRPSGLGST DSGQEGSGSG SSAGGEDEAD GDGARSSEDG 

       610        620        630        640        650        660 
ASSELGKEEE EEEQADGAVW LCGDVWRETR AKLRGIVDSK YFNRGIMMAI LVNTVSMGIE 

       670        680        690        700        710        720 
HHEQPEELTN ILEICNVVFT SMFALEMILK LAAFGLFDYL RNPYNIFDSI IVIISIWEIV 

       730        740        750        760        770        780 
GQADGGLSVL RTFRLLRVLK LVRFMPALRR QLVVLMKTMD NVATFCMLLM LFIFIFSILG 

       790        800        810        820        830        840 
MHIFGCKFSL RTDTGDTVPD RKNFDSLLWA IVTVFQILTQ EDWNVVLYNG MASTSPWASL 

       850        860        870        880        890        900 
YFVALMTFGN YVLFNLLVAI LVEGFQAEGD ANRSYSDEDQ SSSNIEEFDK LQEGLDSSGD 

       910        920        930        940        950        960 
PKLCPIPMTP NGHLDPSLPL GGHLGPAGAA GPAPRLSLQP DPMLVALGSR KSSVMSLGRM 

       970        980        990       1000       1010       1020 
SYDQRSLSSS RSSYYGPWGR SAAWASRRSS WNSLKHKPPS AEHESLLSAE RGGGARVCEV 

      1030       1040       1050       1060       1070       1080 
AADEGPPRAA PLHTPHAHHI HHGPHLAHRH RHHRRTLSLD NRDSVDLAEL VPAVGAHPRA 

      1090       1100       1110       1120       1130       1140 
AWRAAGPAPG HEDCNGRMPS IAKDVFTKMG DRGDRGEDEE EIDYTLCFRV RKMIDVYKPD 

      1150       1160       1170       1180       1190       1200 
WCEVREDWSV YLFSPENRFR VLCQTIIAHK LFDYVVLAFI FLNCITIALE RPQIEAGSTE 

      1210       1220       1230       1240       1250       1260 
RIFLTVSNYI FTAIFVGEMT LKVVSLGLYF GEQAYLRSSW NVLDGFLVFV SIIDIVVSLA 

      1270       1280       1290       1300       1310       1320 
SAGGAKILGV LRVLRLLRTL RPLRVISRAP GLKLVVETLI SSLKPIGNIV LICCAFFIIF 

      1330       1340       1350       1360       1370       1380 
GILGVQLFKG KFYHCLGVDT RNITNRSDCM AANYRWVHHK YNFDNLGQAL MSLFVLASKD 

      1390       1400       1410       1420       1430       1440 
GWVNIMYNGL DAVAVDQQPV TNHNPWMLLY FISFLLIVSF FVLNMFVGVV VENFHKCRQH 

      1450       1460       1470       1480       1490       1500 
QEAEEARRRE EKRLRRLEKK RRKAQRLPYY ATYCHTRLLI HSMCTSHYLD IFITFIICLN 

      1510       1520       1530       1540       1550       1560 
VVTMSLEHYN QPTSLETALK YCNYMFTTVF VLEAVLKLVA FGLRRFFKDR WNQLDLAIVL 

      1570       1580       1590       1600       1610       1620 
LSVMGITLEE IEINAALPIN PTIIRIMRVL RIARVLKLLK MATGMRALLD TVVQALPQVG 

      1630       1640       1650       1660       1670       1680 
NLGLLFMLLF FIYAALGVEL FGKLVCNDEN PCEGMSRHAT FENFGMAFLT LFQVSTGDNW 

      1690       1700       1710       1720       1730       1740 
NGIMKDTLRD CTHDERSCLS SLQFVSPLYF VSFVLTAQFV LINVVVAVLM KHLDDSNKEA 

      1750       1760       1770       1780       1790       1800 
QEDAEMDAEL ELEMAHGLGP GPRLPTGSPG APGRGPGGAG GGGDTEGGLC RRCYSPAQEN 

      1810       1820       1830       1840       1850       1860 
LWLDSVSLII KDSLEGELTI IDNLSGSIFH HYSSPAGCKK CHHDKQEVQL AETEAFSLNS 

      1870       1880       1890       1900       1910       1920 
DRSSSILLGD DLSLEDPTAC PPGRKDSKGE LDPPEPMRVG DLGECFFPLS STAVSPDPEN 

      1930       1940       1950       1960       1970       1980 
FLCEMEEIPF NPVRSWLKHD SSQAPPSPFS PDASSPLLPM PAEFFHPAVS ASQKGPEKGT 

      1990       2000       2010       2020       2030       2040 
GTGTLPKIAL QGSWASLRSP RVNCTLLRQA TGSDTSLDAS PSSSAGSLQT TLEDSLTLSD 

      2050       2060       2070       2080       2090       2100 
SPRRALGPPA PAPGPRAGLS PAARRRLSLR GRGLFSLRGL RAHQRSHSSG GSTSPGCTHH 

      2110       2120       2130       2140       2150       2160 
DSMDPSDEEG RGGAGGGGAG SEHSETLSSL SLTSLFCPPP PPPAPGLTPA RKFSSTSSLA 

      2170       2180       2190       2200       2210       2220 
APGRPHAAAL AHGLARSPSW AADRSKDPPG RAPLPMGLGP LAPPPQPLPG ELEPGDAASK 


RKR 

« Hide

Isoform 2 [UniParc].

Checksum: 7721511BDA564B80
Show »

FASTA2,016224,404
Isoform 3 (Alpha1I-a) [UniParc].

Checksum: 3AF7A61ECEBC7AEC
Show »

FASTA1,981220,748
Isoform 4 [UniParc].

Checksum: 87E508C40BBEFEAB
Show »

FASTA2,188241,448

References

« Hide 'large scale' references
[1]"Structure and alternative splicing of the gene encoding alpha1I, a human brain T calcium channel alpha1 subunit."
Mittman S., Guo J., Emerick M.C., Agnew W.S.
Neurosci. Lett. 269:121-124(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
Tissue: Brain.
[2]"Specific properties of T-type calcium channels generated by the human alpha1I subunit."
Monteil A., Chemin J., Leuranguer V., Altier C., Mennessier G., Bourinet E., Lory P., Nargeot J.
J. Biol. Chem. 275:16530-16535(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
Tissue: Brain.
[3]"Cloning and expression of the human T-type channel Ca(v)3.3: insights into prepulse facilitation."
Gomora J.C., Murbartian J., Arias J.M., Lee J.-H., Perez-Reyes E.
Biophys. J. 83:229-241(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), VARIANT VAL-1040.
Tissue: Brain.
[4]"The DNA sequence of human chromosome 22."
Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. expand/collapse author list , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1200-2223 (ISOFORM 1).
Tissue: Brain.
[6]"Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity."
Zhang D., Chen J., Saraf A., Cassar S., Han P., Rogers J.C., Brioni J.D., Sullivan J.P., Gopalakrishnan M.
J. Biol. Chem. 281:22332-22341(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CATSPER1 AND CATSPER2.
[7]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF129133 mRNA. Translation: AAD45251.1.
AF142567 mRNA. Translation: AAF25722.1.
AF211189 mRNA. Translation: AAF44626.1.
AF393329 mRNA. Translation: AAM67414.1.
AL008716, AL022312, AL022319 Genomic DNA. Translation: CAI17903.1.
AL022312, AL008716, AL022319 Genomic DNA. Translation: CAI19180.1.
AL022319, AL022312, AL008716 Genomic DNA. Translation: CAI19662.1.
AL022312, AL008716, AL022319 Genomic DNA. Translation: CAQ08289.1.
AL022312, AL008716, AL022319 Genomic DNA. Translation: CAQ08290.1.
AL022312, AL008716, AL022319 Genomic DNA. Translation: CAQ08291.1.
AL008716, AL022312, AL022319 Genomic DNA. Translation: CAQ09516.1.
AL008716, AL022312, AL022319 Genomic DNA. Translation: CAQ09517.1.
AL008716, AL022312, AL022319 Genomic DNA. Translation: CAQ09518.1.
AL022319, AL008716, AL022312 Genomic DNA. Translation: CAQ09681.1.
AL022319, AL008716, AL022312 Genomic DNA. Translation: CAQ09682.1.
AL022319, AL008716, AL022312 Genomic DNA. Translation: CAQ09683.1.
AB032946 mRNA. Translation: BAA86434.1.
RefSeqNP_001003406.1. NM_001003406.1.
NP_066919.2. NM_021096.3.
UniGeneHs.125116.

3D structure databases

ProteinModelPortalQ9P0X4.
SMRQ9P0X4. Positions 75-408, 642-892, 1172-1446, 1493-1745.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114425. 1 interaction.
IntActQ9P0X4. 3 interactions.

Chemistry

BindingDBQ9P0X4.
ChEMBLCHEMBL5558.
DrugBankDB04841. Flunarizine.
DB00617. Paramethadione.
DB00661. Verapamil.
GuidetoPHARMACOLOGY537.

Protein family/group databases

TCDB1.A.1.11.7. the voltage-gated ion channel (vic) superfamily.

PTM databases

PhosphoSiteQ9P0X4.

Polymorphism databases

DMDM23396521.

Proteomic databases

PaxDbQ9P0X4.
PRIDEQ9P0X4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000401624; ENSP00000383887; ENSG00000100346. [Q9P0X4-2]
ENST00000402142; ENSP00000385019; ENSG00000100346. [Q9P0X4-1]
ENST00000404898; ENSP00000384093; ENSG00000100346. [Q9P0X4-4]
ENST00000407673; ENSP00000385680; ENSG00000100346. [Q9P0X4-3]
GeneID8911.
KEGGhsa:8911.
UCSCuc003ayc.3. human. [Q9P0X4-1]
uc003ayd.3. human. [Q9P0X4-4]
uc003aye.3. human. [Q9P0X4-2]
uc003ayf.3. human. [Q9P0X4-3]

Organism-specific databases

CTD8911.
GeneCardsGC22P039966.
HGNCHGNC:1396. CACNA1I.
MIM608230. gene.
neXtProtNX_Q9P0X4.
PharmGKBPA26011.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1226.
HOVERGENHBG050764.
KOK04856.
OrthoDBEOG7MKW55.
PhylomeDBQ9P0X4.
TreeFamTF313555.

Enzyme and pathway databases

ReactomeREACT_111045. Developmental Biology.

Gene expression databases

ArrayExpressQ9P0X4.
BgeeQ9P0X4.
GenevestigatorQ9P0X4.

Family and domain databases

Gene3D1.20.120.350. 4 hits.
InterProIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR005445. VDCC_T_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PfamPF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSPR00167. CACHANNEL.
PR01629. TVDCCALPHA1.
ProtoNetSearch...

Other

ChiTaRSCACNA1I. human.
GeneWikiCACNA1I.
GenomeRNAi8911.
NextBio33488.
PROQ9P0X4.
SOURCESearch...

Entry information

Entry nameCAC1I_HUMAN
AccessionPrimary (citable) accession number: Q9P0X4
Secondary accession number(s): B0QY12 expand/collapse secondary AC list , B0QY13, B0QY14, O95504, Q5JZ88, Q7Z6S9, Q8NFX6, Q9NZC8, Q9UH15, Q9UH30, Q9ULU9, Q9UNE6
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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SIMILARITY comments

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