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Q9P0X4

- CAC1I_HUMAN

UniProt

Q9P0X4 - CAC1I_HUMAN

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Protein

Voltage-dependent T-type calcium channel subunit alpha-1I

Gene
CACNA1I, KIAA1120
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Isoform alpha-1I gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Gates in voltage ranges similar to, but higher than alpha 1G or alpha 1H By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei357 – 3571Calcium ion selectivity and permeability By similarity
Sitei821 – 8211Calcium ion selectivity and permeability By similarity
Sitei1380 – 13801Calcium ion selectivity and permeability By similarity
Sitei1678 – 16781Calcium ion selectivity and permeability By similarity

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. voltage-gated calcium channel activity Source: RefGenome

GO - Biological processi

  1. axon guidance Source: Reactome
  2. calcium ion import Source: RefGenome
  3. membrane depolarization during action potential Source: RefGenome
  4. neuronal action potential Source: Ensembl
  5. signal transduction Source: ProtInc
  6. sleep Source: Ensembl
  7. transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_18312. NCAM1 interactions.

Protein family/group databases

TCDBi1.A.1.11.7. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent T-type calcium channel subunit alpha-1I
Alternative name(s):
Voltage-gated calcium channel subunit alpha Cav3.3
Short name:
Ca(v)3.3
Gene namesi
Name:CACNA1I
Synonyms:KIAA1120
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:1396. CACNA1I.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7878Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei79 – 9921Helical; Name=S1 of repeat I; Reviewed predictionAdd
BLAST
Topological domaini100 – 12021Extracellular Reviewed predictionAdd
BLAST
Transmembranei121 – 14121Helical; Name=S2 of repeat I; Reviewed predictionAdd
BLAST
Topological domaini142 – 1487Cytoplasmic Reviewed prediction
Transmembranei149 – 16820Helical; Name=S3 of repeat I; Reviewed predictionAdd
BLAST
Topological domaini169 – 1735Extracellular Reviewed prediction
Transmembranei174 – 19118Helical; Name=S4 of repeat I; Reviewed predictionAdd
BLAST
Topological domaini192 – 21120Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei212 – 23221Helical; Name=S5 of repeat I; Reviewed predictionAdd
BLAST
Topological domaini233 – 377145Extracellular Reviewed predictionAdd
BLAST
Transmembranei378 – 39821Helical; Name=S6 of repeat I; Reviewed predictionAdd
BLAST
Topological domaini399 – 640242Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei641 – 66121Helical; Name=S1 of repeat II; Reviewed predictionAdd
BLAST
Topological domaini662 – 67615Extracellular Reviewed predictionAdd
BLAST
Transmembranei677 – 69721Helical; Name=S2 of repeat II; Reviewed predictionAdd
BLAST
Topological domaini698 – 7025Cytoplasmic Reviewed prediction
Transmembranei703 – 72119Helical; Name=S3 of repeat II; Reviewed predictionAdd
BLAST
Topological domaini722 – 7298Extracellular Reviewed prediction
Transmembranei730 – 75324Helical; Name=S4 of repeat II; Reviewed predictionAdd
BLAST
Topological domaini754 – 76411Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei765 – 78521Helical; Name=S5 of repeat II; Reviewed predictionAdd
BLAST
Topological domaini786 – 84156Extracellular Reviewed predictionAdd
BLAST
Transmembranei842 – 86221Helical; Name=S6 of repeat II; Reviewed predictionAdd
BLAST
Topological domaini863 – 1166304Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei1167 – 118721Helical; Name=S1 of repeat III; Reviewed predictionAdd
BLAST
Topological domaini1188 – 120922Extracellular Reviewed predictionAdd
BLAST
Transmembranei1210 – 123021Helical; Name=S2 of repeat III; Reviewed predictionAdd
BLAST
Topological domaini1231 – 124414Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei1245 – 126521Helical; Name=S3 of repeat III; Reviewed predictionAdd
BLAST
Topological domaini1266 – 12727Extracellular Reviewed prediction
Transmembranei1273 – 129422Helical; Name=S4 of repeat III; Reviewed predictionAdd
BLAST
Topological domaini1295 – 130410Cytoplasmic Reviewed prediction
Transmembranei1305 – 132521Helical; Name=S5 of repeat III; Reviewed predictionAdd
BLAST
Topological domaini1326 – 141085Extracellular Reviewed predictionAdd
BLAST
Transmembranei1411 – 143121Helical; Name=S6 of repeat III; Reviewed predictionAdd
BLAST
Topological domaini1432 – 148554Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei1486 – 150621Helical; Name=S1 of repeat IV; Reviewed predictionAdd
BLAST
Topological domaini1507 – 152216Extracellular Reviewed predictionAdd
BLAST
Transmembranei1523 – 154321Helical; Name=S2 of repeat IV; Reviewed predictionAdd
BLAST
Topological domaini1544 – 155613Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei1557 – 157721Helical; Name=S3 of repeat IV; Reviewed predictionAdd
BLAST
Topological domaini1578 – 15836Extracellular Reviewed prediction
Transmembranei1584 – 160724Helical; Name=S4 of repeat IV; Reviewed predictionAdd
BLAST
Topological domaini1608 – 162114Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei1622 – 164221Helical; Name=S5 of repeat IV; Reviewed predictionAdd
BLAST
Topological domaini1643 – 170967Extracellular Reviewed predictionAdd
BLAST
Transmembranei1710 – 173021Helical; Name=S6 of repeat IV; Reviewed predictionAdd
BLAST
Topological domaini1731 – 2223493Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. plasma membrane Source: RefGenome
  2. voltage-gated calcium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26011.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 22232223Voltage-dependent T-type calcium channel subunit alpha-1IPRO_0000053957Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi173 – 1731N-linked (GlcNAc...) Reviewed prediction
Glycosylationi244 – 2441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi311 – 3111N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1342 – 13421N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1345 – 13451N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II By similarity.

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9P0X4.
PRIDEiQ9P0X4.

PTM databases

PhosphoSiteiQ9P0X4.

Expressioni

Tissue specificityi

Brain specific.

Gene expression databases

ArrayExpressiQ9P0X4.
BgeeiQ9P0X4.
GenevestigatoriQ9P0X4.

Interactioni

Subunit structurei

Interacts with CATSPER1 and CATSPER2, leading to suppress T-type calcium channel activity.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CATSPER1Q8NEC55EBI-1220829,EBI-744545
CATSPER2Q96P563EBI-1220829,EBI-2215024

Protein-protein interaction databases

BioGridi114425. 1 interaction.
IntActiQ9P0X4. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9P0X4.
SMRiQ9P0X4. Positions 75-232, 642-866, 1172-1446, 1493-1745.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati66 – 401336IAdd
BLAST
Repeati626 – 865240IIAdd
BLAST
Repeati1157 – 1434278IIIAdd
BLAST
Repeati1472 – 1733262IVAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi608 – 6136Poly-Glu
Compositional biasi1775 – 17839Poly-Gly
Compositional biasi2110 – 212011Poly-GlyAdd
BLAST
Compositional biasi2138 – 21458Poly-Pro

Domaini

Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
HOVERGENiHBG050764.
KOiK04856.
OrthoDBiEOG7MKW55.
PhylomeDBiQ9P0X4.
TreeFamiTF313555.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR005445. VDCC_T_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PfamiPF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01629. TVDCCALPHA1.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9P0X4-1) [UniParc]FASTAAdd to Basket

Also known as: Delta36b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAESASPPSS SAAAPAAEPG VTTEQPGPRS PPSSPPGLEE PLDGADPHVP     50
HPDLAPIAFF CLRQTTSPRN WCIKMVCNPW FECVSMLVIL LNCVTLGMYQ 100
PCDDMDCLSD RCKILQVFDD FIFIFFAMEM VLKMVALGIF GKKCYLGDTW 150
NRLDFFIVMA GMVEYSLDLQ NINLSAIRTV RVLRPLKAIN RVPSMRILVN 200
LLLDTLPMLG NVLLLCFFVF FIFGIIGVQL WAGLLRNRCF LEENFTIQGD 250
VALPPYYQPE EDDEMPFICS LSGDNGIMGC HEIPPLKEQG RECCLSKDDV 300
YDFGAGRQDL NASGLCVNWN RYYNVCRTGS ANPHKGAINF DNIGYAWIVI 350
FQVITLEGWV EIMYYVMDAH SFYNFIYFIL LIIVGSFFMI NLCLVVIATQ 400
FSETKQREHR LMLEQRQRYL SSSTVASYAE PGDCYEEIFQ YVCHILRKAK 450
RRALGLYQAL QSRRQALGPE APAPAKPGPH AKEPRHYHGK TKGQGDEGRH 500
LGSRHCQTLH GPASPGNDHS GRELCPQHSP LDATPHTLVQ PIPATLASDP 550
ASCPCCQHED GRRPSGLGST DSGQEGSGSG SSAGGEDEAD GDGARSSEDG 600
ASSELGKEEE EEEQADGAVW LCGDVWRETR AKLRGIVDSK YFNRGIMMAI 650
LVNTVSMGIE HHEQPEELTN ILEICNVVFT SMFALEMILK LAAFGLFDYL 700
RNPYNIFDSI IVIISIWEIV GQADGGLSVL RTFRLLRVLK LVRFMPALRR 750
QLVVLMKTMD NVATFCMLLM LFIFIFSILG MHIFGCKFSL RTDTGDTVPD 800
RKNFDSLLWA IVTVFQILTQ EDWNVVLYNG MASTSPWASL YFVALMTFGN 850
YVLFNLLVAI LVEGFQAEGD ANRSYSDEDQ SSSNIEEFDK LQEGLDSSGD 900
PKLCPIPMTP NGHLDPSLPL GGHLGPAGAA GPAPRLSLQP DPMLVALGSR 950
KSSVMSLGRM SYDQRSLSSS RSSYYGPWGR SAAWASRRSS WNSLKHKPPS 1000
AEHESLLSAE RGGGARVCEV AADEGPPRAA PLHTPHAHHI HHGPHLAHRH 1050
RHHRRTLSLD NRDSVDLAEL VPAVGAHPRA AWRAAGPAPG HEDCNGRMPS 1100
IAKDVFTKMG DRGDRGEDEE EIDYTLCFRV RKMIDVYKPD WCEVREDWSV 1150
YLFSPENRFR VLCQTIIAHK LFDYVVLAFI FLNCITIALE RPQIEAGSTE 1200
RIFLTVSNYI FTAIFVGEMT LKVVSLGLYF GEQAYLRSSW NVLDGFLVFV 1250
SIIDIVVSLA SAGGAKILGV LRVLRLLRTL RPLRVISRAP GLKLVVETLI 1300
SSLKPIGNIV LICCAFFIIF GILGVQLFKG KFYHCLGVDT RNITNRSDCM 1350
AANYRWVHHK YNFDNLGQAL MSLFVLASKD GWVNIMYNGL DAVAVDQQPV 1400
TNHNPWMLLY FISFLLIVSF FVLNMFVGVV VENFHKCRQH QEAEEARRRE 1450
EKRLRRLEKK RRKAQRLPYY ATYCHTRLLI HSMCTSHYLD IFITFIICLN 1500
VVTMSLEHYN QPTSLETALK YCNYMFTTVF VLEAVLKLVA FGLRRFFKDR 1550
WNQLDLAIVL LSVMGITLEE IEINAALPIN PTIIRIMRVL RIARVLKLLK 1600
MATGMRALLD TVVQALPQVG NLGLLFMLLF FIYAALGVEL FGKLVCNDEN 1650
PCEGMSRHAT FENFGMAFLT LFQVSTGDNW NGIMKDTLRD CTHDERSCLS 1700
SLQFVSPLYF VSFVLTAQFV LINVVVAVLM KHLDDSNKEA QEDAEMDAEL 1750
ELEMAHGLGP GPRLPTGSPG APGRGPGGAG GGGDTEGGLC RRCYSPAQEN 1800
LWLDSVSLII KDSLEGELTI IDNLSGSIFH HYSSPAGCKK CHHDKQEVQL 1850
AETEAFSLNS DRSSSILLGD DLSLEDPTAC PPGRKDSKGE LDPPEPMRVG 1900
DLGECFFPLS STAVSPDPEN FLCEMEEIPF NPVRSWLKHD SSQAPPSPFS 1950
PDASSPLLPM PAEFFHPAVS ASQKGPEKGT GTGTLPKIAL QGSWASLRSP 2000
RVNCTLLRQA TGSDTSLDAS PSSSAGSLQT TLEDSLTLSD SPRRALGPPA 2050
PAPGPRAGLS PAARRRLSLR GRGLFSLRGL RAHQRSHSSG GSTSPGCTHH 2100
DSMDPSDEEG RGGAGGGGAG SEHSETLSSL SLTSLFCPPP PPPAPGLTPA 2150
RKFSSTSSLA APGRPHAAAL AHGLARSPSW AADRSKDPPG RAPLPMGLGP 2200
LAPPPQPLPG ELEPGDAASK RKR 2223
Length:2,223
Mass (Da):245,103
Last modified:October 1, 2000 - v1
Checksum:i3CAE4D1C4289D08B
GO
Isoform 2 (identifier: Q9P0X4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2010-2223: ATGSDTSLDA...PGDAASKRKR → VPTPPRP

Show »
Length:2,016
Mass (Da):224,404
Checksum:i7721511BDA564B80
GO
Isoform 3 (identifier: Q9P0X4-3) [UniParc]FASTAAdd to Basket

Also known as: Alpha1I-a

The sequence of this isoform differs from the canonical sequence as follows:
     488-523: HGKTKGQGDEGRHLGSRHCQTLHGPASPGNDHSGRE → Q
     2010-2223: ATGSDTSLDA...PGDAASKRKR → VPTPPRP

Show »
Length:1,981
Mass (Da):220,748
Checksum:i3AF7A61ECEBC7AEC
GO
Isoform 4 (identifier: Q9P0X4-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     488-523: HGKTKGQGDEGRHLGSRHCQTLHGPASPGNDHSGRE → Q

Show »
Length:2,188
Mass (Da):241,448
Checksum:i87E508C40BBEFEAB
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1040 – 10401I → V.1 Publication
Corresponds to variant rs136853 [ dbSNP | Ensembl ].
VAR_013883
Natural varianti1513 – 15131T → M.
Corresponds to variant rs8141262 [ dbSNP | Ensembl ].
VAR_048745
Natural varianti1782 – 17821G → A.
Corresponds to variant rs2294369 [ dbSNP | Ensembl ].
VAR_013884
Natural varianti1782 – 17821G → R.
Corresponds to variant rs2294369 [ dbSNP | Ensembl ].
VAR_020050

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei488 – 52336HGKTK…HSGRE → Q in isoform 3 and isoform 4. VSP_000950Add
BLAST
Alternative sequencei2010 – 2223214ATGSD…SKRKR → VPTPPRP in isoform 2 and isoform 3. VSP_000951Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF129133 mRNA. Translation: AAD45251.1.
AF142567 mRNA. Translation: AAF25722.1.
AF211189 mRNA. Translation: AAF44626.1.
AF393329 mRNA. Translation: AAM67414.1.
AL008716, AL022312, AL022319 Genomic DNA. Translation: CAI17903.1.
AL022312, AL008716, AL022319 Genomic DNA. Translation: CAI19180.1.
AL022319, AL022312, AL008716 Genomic DNA. Translation: CAI19662.1.
AL022312, AL008716, AL022319 Genomic DNA. Translation: CAQ08289.1.
AL022312, AL008716, AL022319 Genomic DNA. Translation: CAQ08290.1.
AL022312, AL008716, AL022319 Genomic DNA. Translation: CAQ08291.1.
AL008716, AL022312, AL022319 Genomic DNA. Translation: CAQ09516.1.
AL008716, AL022312, AL022319 Genomic DNA. Translation: CAQ09517.1.
AL008716, AL022312, AL022319 Genomic DNA. Translation: CAQ09518.1.
AL022319, AL008716, AL022312 Genomic DNA. Translation: CAQ09681.1.
AL022319, AL008716, AL022312 Genomic DNA. Translation: CAQ09682.1.
AL022319, AL008716, AL022312 Genomic DNA. Translation: CAQ09683.1.
AB032946 mRNA. Translation: BAA86434.1.
CCDSiCCDS46710.1. [Q9P0X4-1]
CCDS46711.1. [Q9P0X4-4]
RefSeqiNP_001003406.1. NM_001003406.1. [Q9P0X4-4]
NP_066919.2. NM_021096.3. [Q9P0X4-1]
UniGeneiHs.125116.

Genome annotation databases

EnsembliENST00000401624; ENSP00000383887; ENSG00000100346. [Q9P0X4-2]
ENST00000402142; ENSP00000385019; ENSG00000100346. [Q9P0X4-1]
ENST00000404898; ENSP00000384093; ENSG00000100346. [Q9P0X4-4]
ENST00000407673; ENSP00000385680; ENSG00000100346. [Q9P0X4-3]
GeneIDi8911.
KEGGihsa:8911.
UCSCiuc003ayc.3. human. [Q9P0X4-1]
uc003ayd.3. human. [Q9P0X4-4]
uc003aye.3. human. [Q9P0X4-2]
uc003ayf.3. human. [Q9P0X4-3]

Polymorphism databases

DMDMi23396521.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF129133 mRNA. Translation: AAD45251.1 .
AF142567 mRNA. Translation: AAF25722.1 .
AF211189 mRNA. Translation: AAF44626.1 .
AF393329 mRNA. Translation: AAM67414.1 .
AL008716 , AL022312 , AL022319 Genomic DNA. Translation: CAI17903.1 .
AL022312 , AL008716 , AL022319 Genomic DNA. Translation: CAI19180.1 .
AL022319 , AL022312 , AL008716 Genomic DNA. Translation: CAI19662.1 .
AL022312 , AL008716 , AL022319 Genomic DNA. Translation: CAQ08289.1 .
AL022312 , AL008716 , AL022319 Genomic DNA. Translation: CAQ08290.1 .
AL022312 , AL008716 , AL022319 Genomic DNA. Translation: CAQ08291.1 .
AL008716 , AL022312 , AL022319 Genomic DNA. Translation: CAQ09516.1 .
AL008716 , AL022312 , AL022319 Genomic DNA. Translation: CAQ09517.1 .
AL008716 , AL022312 , AL022319 Genomic DNA. Translation: CAQ09518.1 .
AL022319 , AL008716 , AL022312 Genomic DNA. Translation: CAQ09681.1 .
AL022319 , AL008716 , AL022312 Genomic DNA. Translation: CAQ09682.1 .
AL022319 , AL008716 , AL022312 Genomic DNA. Translation: CAQ09683.1 .
AB032946 mRNA. Translation: BAA86434.1 .
CCDSi CCDS46710.1. [Q9P0X4-1 ]
CCDS46711.1. [Q9P0X4-4 ]
RefSeqi NP_001003406.1. NM_001003406.1. [Q9P0X4-4 ]
NP_066919.2. NM_021096.3. [Q9P0X4-1 ]
UniGenei Hs.125116.

3D structure databases

ProteinModelPortali Q9P0X4.
SMRi Q9P0X4. Positions 75-232, 642-866, 1172-1446, 1493-1745.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114425. 1 interaction.
IntActi Q9P0X4. 3 interactions.

Chemistry

BindingDBi Q9P0X4.
ChEMBLi CHEMBL5558.
DrugBanki DB04841. Flunarizine.
DB00617. Paramethadione.
DB00661. Verapamil.
GuidetoPHARMACOLOGYi 537.

Protein family/group databases

TCDBi 1.A.1.11.7. the voltage-gated ion channel (vic) superfamily.

PTM databases

PhosphoSitei Q9P0X4.

Polymorphism databases

DMDMi 23396521.

Proteomic databases

PaxDbi Q9P0X4.
PRIDEi Q9P0X4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000401624 ; ENSP00000383887 ; ENSG00000100346 . [Q9P0X4-2 ]
ENST00000402142 ; ENSP00000385019 ; ENSG00000100346 . [Q9P0X4-1 ]
ENST00000404898 ; ENSP00000384093 ; ENSG00000100346 . [Q9P0X4-4 ]
ENST00000407673 ; ENSP00000385680 ; ENSG00000100346 . [Q9P0X4-3 ]
GeneIDi 8911.
KEGGi hsa:8911.
UCSCi uc003ayc.3. human. [Q9P0X4-1 ]
uc003ayd.3. human. [Q9P0X4-4 ]
uc003aye.3. human. [Q9P0X4-2 ]
uc003ayf.3. human. [Q9P0X4-3 ]

Organism-specific databases

CTDi 8911.
GeneCardsi GC22P039966.
HGNCi HGNC:1396. CACNA1I.
MIMi 608230. gene.
neXtProti NX_Q9P0X4.
PharmGKBi PA26011.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1226.
HOVERGENi HBG050764.
KOi K04856.
OrthoDBi EOG7MKW55.
PhylomeDBi Q9P0X4.
TreeFami TF313555.

Enzyme and pathway databases

Reactomei REACT_18312. NCAM1 interactions.

Miscellaneous databases

ChiTaRSi CACNA1I. human.
GeneWikii CACNA1I.
GenomeRNAii 8911.
NextBioi 33488.
PROi Q9P0X4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9P0X4.
Bgeei Q9P0X4.
Genevestigatori Q9P0X4.

Family and domain databases

Gene3Di 1.20.120.350. 4 hits.
InterProi IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR005445. VDCC_T_a1su.
IPR002077. VDCCAlpha1.
[Graphical view ]
Pfami PF00520. Ion_trans. 4 hits.
[Graphical view ]
PRINTSi PR00167. CACHANNEL.
PR01629. TVDCCALPHA1.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and alternative splicing of the gene encoding alpha1I, a human brain T calcium channel alpha1 subunit."
    Mittman S., Guo J., Emerick M.C., Agnew W.S.
    Neurosci. Lett. 269:121-124(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  2. "Specific properties of T-type calcium channels generated by the human alpha1I subunit."
    Monteil A., Chemin J., Leuranguer V., Altier C., Mennessier G., Bourinet E., Lory P., Nargeot J.
    J. Biol. Chem. 275:16530-16535(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    Tissue: Brain.
  3. "Cloning and expression of the human T-type channel Ca(v)3.3: insights into prepulse facilitation."
    Gomora J.C., Murbartian J., Arias J.M., Lee J.-H., Perez-Reyes E.
    Biophys. J. 83:229-241(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), VARIANT VAL-1040.
    Tissue: Brain.
  4. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
    Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
    DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1200-2223 (ISOFORM 1).
    Tissue: Brain.
  6. "Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity."
    Zhang D., Chen J., Saraf A., Cassar S., Han P., Rogers J.C., Brioni J.D., Sullivan J.P., Gopalakrishnan M.
    J. Biol. Chem. 281:22332-22341(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CATSPER1 AND CATSPER2.
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiCAC1I_HUMAN
AccessioniPrimary (citable) accession number: Q9P0X4
Secondary accession number(s): B0QY12
, B0QY13, B0QY14, O95504, Q5JZ88, Q7Z6S9, Q8NFX6, Q9NZC8, Q9UH15, Q9UH30, Q9ULU9, Q9UNE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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