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Protein

Schwannomin-interacting protein 1

Gene

SCHIP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000151967-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Schwannomin-interacting protein 1
Short name:
SCHIP-1
Gene namesi
Name:SCHIP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:15678. SCHIP1.

Subcellular locationi

  • Cytoplasm 1 Publication

  • Note: Partially colocalizes with NF2 beneath the cytoplasmic membrane.

GO - Cellular componenti

  • cytoplasm Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi29970.
OpenTargetsiENSG00000151967.
ENSG00000283154.
ENSG00000283245.
PharmGKBiPA34997.

Polymorphism and mutation databases

BioMutaiSCHIP1.
DMDMi74719771.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002889271 – 487Schwannomin-interacting protein 1Add BLAST487

Proteomic databases

MaxQBiQ9P0W5.
PaxDbiQ9P0W5.
PeptideAtlasiQ9P0W5.
PRIDEiQ9P0W5.

PTM databases

iPTMnetiQ9P0W5.
PhosphoSitePlusiQ9P0W5.

Expressioni

Tissue specificityi

Isoform 5 and isoform 6 are highly expressed in the brain. Both isoforms derive from naturally occurring readthrough transcripts which produce IQCJ-SCHIP1 fusion proteins.1 Publication

Gene expression databases

BgeeiENSG00000151967.
CleanExiHS_SCHIP1.
ExpressionAtlasiQ9P0W5. baseline and differential.
GenevisibleiQ9P0W5. HS.

Organism-specific databases

HPAiHPA003243.
HPA003445.

Interactioni

Subunit structurei

Isoform 5 interacts (via C-terminal IQ motif) with calmodulin in the absence of Ca2+ (By similarity). Isoform 5 interacts (via C-terminus) with ANK3 (via N-terminal ANK repeats); this interaction is required for the localization at axon initial segments (AISs) and nodes of Ranvier (NRs) (By similarity). Self-associates through its coiled coil domain. Interacts with NF2 isoform 4, but not NF2 isoform 1. Interacts with NF2 variant PHE-119 DEL.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-1397509,EBI-1397509
PSMD4P550362EBI-1397509,EBI-359318
SCOCQ9UIL14EBI-1397509,EBI-2686537
ZC3H13Q5T2002EBI-1397509,EBI-2679720

Protein-protein interaction databases

BioGridi119003. 8 interactors.
IntActiQ9P0W5. 48 interactors.
STRINGi9606.ENSP00000420182.

Structurei

3D structure databases

ProteinModelPortaliQ9P0W5.
SMRiQ9P0W5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili424 – 458Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi32 – 67Ser-richAdd BLAST36
Compositional biasi99 – 106Poly-Glu8
Compositional biasi132 – 136Poly-Gly5

Sequence similaritiesi

Belongs to the SCHIP1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4847. Eukaryota.
ENOG4111HYM. LUCA.
GeneTreeiENSGT00390000011127.
HOVERGENiHBG054427.
InParanoidiQ9P0W5.
OMAiPRRAIQK.
PhylomeDBiQ9P0W5.
TreeFamiTF323326.

Family and domain databases

InterProiIPR015649. SCHIP_1.
[Graphical view]
PANTHERiPTHR13103. PTHR13103. 1 hit.
PfamiPF10148. SCHIP-1. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P0W5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERSGQRVTT WDCDQGKHSD SDYREDGMDL GSDAGSSSSS SRASSQSNST
60 70 80 90 100
KVTPCSECKS SSSPGGSLDL VSALEDYEEP FPVYQKKVID EWAPEEDGEE
110 120 130 140 150
EEEEDERDQR GYRDDRSPAR EPGDVSARTR SGGGGGRSAT TAMPPPVPNG
160 170 180 190 200
NLHQHDPQDL RHNGNVVVAG RPSCSRGPRR AIQKPQPAGG RRSGRGPAAG
210 220 230 240 250
GLCLQPPDGG TCVPEEPPVP PMDWEALEKH LAGLQFREQE VRNQGQARTN
260 270 280 290 300
STSAQKNERE SIRQKLALGS FFDDGPGIYT SCSKSGKPSL SSRLQSGMNL
310 320 330 340 350
QICFVNDSGS DKDSDADDSK TETSLDTPLS PMSKQSSSYS DRDTTEEESE
360 370 380 390 400
SLDDMDFLTR QKKLQAEAKM ALAMAKPMAK MQVEVEKQNR KKSPVADLLP
410 420 430 440 450
HMPHISECLM KRSLKPTDLR DMTIGQLQVI VNDLHSQIES LNEELVQLLL
460 470 480
IRDELHTEQD AMLVDIEDLT RHAESQQKHM AEKMPAK
Length:487
Mass (Da):53,480
Last modified:October 1, 2000 - v1
Checksum:i86F86EDD64A475BF
GO
Isoform 2 (identifier: Q9P0W5-2) [UniParc]FASTAAdd to basket
Also known as: SCHIP-1-D241/253

The sequence of this isoform differs from the canonical sequence as follows:
     241-253: Missing.

Show »
Length:474
Mass (Da):52,079
Checksum:i5C4EF8E1867A78F9
GO
Isoform 3 (identifier: Q9P0W5-3) [UniParc]FASTAAdd to basket
Also known as: SCHIP-1-D22/253

The sequence of this isoform differs from the canonical sequence as follows:
     22-253: Missing.

Show »
Length:255
Mass (Da):28,691
Checksum:i2FCF0C1AE277E4BE
GO
Isoform 4 (identifier: Q9P0W5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-243: Missing.
     244-253: QGQARTNSTS → MVHQDNCSYQ

Show »
Length:244
Mass (Da):27,492
Checksum:iC4576A71F9F216B6
GO
Isoform 5 (identifier: Q9P0W5-5) [UniParc]FASTAAdd to basket
Also known as: IQCJ-SCHIP1 variant 1

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MERSGQRVTTWDCDQGKHSDS → MRLEELKRLQ...MNTFSDSSTP

Note: Based on a naturally occurring readthrough transcript which produces an IQCJ-SCHIP1 fusion protein.
Show »
Length:563
Mass (Da):62,248
Checksum:i54C0F2D21E4B2739
GO
Isoform 6 (identifier: Q9P0W5-6) [UniParc]FASTAAdd to basket
Also known as: IQCJ-SCHIP1 variant 2

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MERSGQRVTTWDCDQGKHSDS → MRLEELKRLQ...MNTFSDSSTP

Note: Based on a naturally occurring readthrough transcript which produces an IQCJ-SCHIP1 fusion protein.
Show »
Length:536
Mass (Da):59,129
Checksum:i6FB3CEF2E518FD02
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti154Q → R in ABA42889 (PubMed:17045569).Curated1
Sequence conflicti154Q → R in ABA42890 (PubMed:17045569).Curated1
Sequence conflicti178Missing in AAH36535 (PubMed:15489334).Curated1
Sequence conflicti460D → A in ABA42889 (PubMed:17045569).Curated1
Sequence conflicti460D → A in ABA42890 (PubMed:17045569).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051332101E → K.Corresponds to variant rs3732851dbSNPEnsembl.1
Natural variantiVAR_032534481A → V.1 PublicationCorresponds to variant rs17850021dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0258271 – 243Missing in isoform 4. 2 PublicationsAdd BLAST243
Alternative sequenceiVSP_0305981 – 21MERSG…KHSDS → MRLEELKRLQNPLEQVNDGK YSFENHQLAMDAENNIEKYP LNLQPLESKVKIIQRAWREY LQRQEPLGKRSPSPPSVSSE KLSSSVSMNTFSDSSTP in isoform 5. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_0305991 – 21MERSG…KHSDS → MRLEELKRLQNPLEQVNDGK YSFENIQRAWREYLQRQEPL GKRSPSPPSVSSEKLSSSVS MNTFSDSSTP in isoform 6. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_02582822 – 253Missing in isoform 3. 1 PublicationAdd BLAST232
Alternative sequenceiVSP_025829241 – 253Missing in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_025830244 – 253QGQARTNSTS → MVHQDNCSYQ in isoform 4. 2 Publications10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF145713 mRNA. Translation: AAF34241.1.
AF145714 mRNA. Translation: AAF34242.1.
AF145715 mRNA. Translation: AAF34243.1.
DQ157847 mRNA. Translation: ABA42889.1.
DQ157848 mRNA. Translation: ABA42890.1.
AK091871 mRNA. Translation: BAG52432.1.
CH471052 Genomic DNA. Translation: EAW78662.1.
BC005947 mRNA. Translation: AAH05947.1.
BC036535 mRNA. Translation: AAH36535.1.
AF070614 mRNA. Translation: AAC25386.1.
CCDSiCCDS3186.1. [Q9P0W5-1]
CCDS56292.1. [Q9P0W5-2]
CCDS56293.1. [Q9P0W5-3]
CCDS56294.1. [Q9P0W5-4]
RefSeqiNP_001184036.1. NM_001197107.1. [Q9P0W5-2]
NP_001184037.1. NM_001197108.1. [Q9P0W5-3]
NP_001184038.1. NM_001197109.1. [Q9P0W5-4]
NP_001184043.1. NM_001197114.1. [Q9P0W5-6]
NP_055390.1. NM_014575.3. [Q9P0W5-1]
UniGeneiHs.134665.

Genome annotation databases

EnsembliENST00000412423; ENSP00000400942; ENSG00000283245. [Q9P0W5-2]
ENST00000445224; ENSP00000404860; ENSG00000151967. [Q9P0W5-4]
ENST00000460298; ENSP00000417305; ENSG00000283245. [Q9P0W5-1]
ENST00000527095; ENSP00000436076; ENSG00000283245. [Q9P0W5-3]
GeneIDi100505385.
29970.
KEGGihsa:100505385.
hsa:29970.
UCSCiuc003fcs.3. human. [Q9P0W5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF145713 mRNA. Translation: AAF34241.1.
AF145714 mRNA. Translation: AAF34242.1.
AF145715 mRNA. Translation: AAF34243.1.
DQ157847 mRNA. Translation: ABA42889.1.
DQ157848 mRNA. Translation: ABA42890.1.
AK091871 mRNA. Translation: BAG52432.1.
CH471052 Genomic DNA. Translation: EAW78662.1.
BC005947 mRNA. Translation: AAH05947.1.
BC036535 mRNA. Translation: AAH36535.1.
AF070614 mRNA. Translation: AAC25386.1.
CCDSiCCDS3186.1. [Q9P0W5-1]
CCDS56292.1. [Q9P0W5-2]
CCDS56293.1. [Q9P0W5-3]
CCDS56294.1. [Q9P0W5-4]
RefSeqiNP_001184036.1. NM_001197107.1. [Q9P0W5-2]
NP_001184037.1. NM_001197108.1. [Q9P0W5-3]
NP_001184038.1. NM_001197109.1. [Q9P0W5-4]
NP_001184043.1. NM_001197114.1. [Q9P0W5-6]
NP_055390.1. NM_014575.3. [Q9P0W5-1]
UniGeneiHs.134665.

3D structure databases

ProteinModelPortaliQ9P0W5.
SMRiQ9P0W5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119003. 8 interactors.
IntActiQ9P0W5. 48 interactors.
STRINGi9606.ENSP00000420182.

PTM databases

iPTMnetiQ9P0W5.
PhosphoSitePlusiQ9P0W5.

Polymorphism and mutation databases

BioMutaiSCHIP1.
DMDMi74719771.

Proteomic databases

MaxQBiQ9P0W5.
PaxDbiQ9P0W5.
PeptideAtlasiQ9P0W5.
PRIDEiQ9P0W5.

Protocols and materials databases

DNASUi29970.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000412423; ENSP00000400942; ENSG00000283245. [Q9P0W5-2]
ENST00000445224; ENSP00000404860; ENSG00000151967. [Q9P0W5-4]
ENST00000460298; ENSP00000417305; ENSG00000283245. [Q9P0W5-1]
ENST00000527095; ENSP00000436076; ENSG00000283245. [Q9P0W5-3]
GeneIDi100505385.
29970.
KEGGihsa:100505385.
hsa:29970.
UCSCiuc003fcs.3. human. [Q9P0W5-1]

Organism-specific databases

CTDi100505385.
29970.
DisGeNETi29970.
GeneCardsiSCHIP1.
HGNCiHGNC:15678. SCHIP1.
HPAiHPA003243.
HPA003445.
neXtProtiNX_Q9P0W5.
OpenTargetsiENSG00000151967.
ENSG00000283154.
ENSG00000283245.
PharmGKBiPA34997.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4847. Eukaryota.
ENOG4111HYM. LUCA.
GeneTreeiENSGT00390000011127.
HOVERGENiHBG054427.
InParanoidiQ9P0W5.
OMAiPRRAIQK.
PhylomeDBiQ9P0W5.
TreeFamiTF323326.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000151967-MONOMER.

Miscellaneous databases

PROiQ9P0W5.

Gene expression databases

BgeeiENSG00000151967.
CleanExiHS_SCHIP1.
ExpressionAtlasiQ9P0W5. baseline and differential.
GenevisibleiQ9P0W5. HS.

Family and domain databases

InterProiIPR015649. SCHIP_1.
[Graphical view]
PANTHERiPTHR13103. PTHR13103. 1 hit.
PfamiPF10148. SCHIP-1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCHI1_HUMAN
AccessioniPrimary (citable) accession number: Q9P0W5
Secondary accession number(s): B3KRM0
, O75543, Q00P30, Q00P31, Q7Z3Y3, Q8IY83, Q9P0W3, Q9P0W4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.