Reviewed, UniProtKB/Swiss-Prot Q9P0W0 (IFNK_HUMAN)

Names and origin

Protein names

Recommended name:
    Interferon kappa
      Short name=IFN-kappa

Gene names

Name:	IFNK
ORF Names:	UNQ6124/PRO20084

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	207 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon-stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin. Ref.2 Ref.6
Subcellular location	Secreted.
Tissue specificity	Expressed in keratinocytes, monocytes and in resting dendritic cells. Ref.2 Ref.6
Induction	By viral infection, upon exposure to double-stranded RNA, or upon treatment with either interferon-gamma or interferon-beta. Ref.2
Sequence similarities	Belongs to the alpha/beta interferon family.

Ontologies

Keywords
Biological process	Antiviral defense
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Coiled coil Signal
Molecular function	Cytokine
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	cytokine-mediated signaling pathway Ref.2 Inferred from direct assay. Source: UniProtKB defense response Inferred from electronic annotation. Source: InterPro natural killer cell activation Ref.2 Non-traceable author statement. Source: UniProtKB negative regulation of cell proliferation Ref.2 Non-traceable author statement. Source: UniProtKB positive regulation of innate immune response Ref.2 Traceable author statement. Source: UniProtKB regulation of transcription Ref.2 Inferred from direct assay. Source: UniProtKB response to virus Ref.2 Inferred from expression pattern. Source: UniProtKB
Cellular component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	cytokine activity Inferred from electronic annotation. Source: UniProtKB-KW interferon-alpha/beta receptor binding Ref.2 Inferred from direct assay. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 27	27	Ref.5
	Chain	28 – 207	180	Interferon kappa		PRO_0000016410
Regions
	Coiled coil	118 – 148	31	Potential
Amino acid modifications
	Disulfide bond	30 ↔ 128		By similarity
	Disulfide bond	59 ↔ 181		By similarity
Natural variations
	Natural variant	97	1	I → N: dbSNP rs34933275.		VAR_032710
	Natural variant	133	1	E → K: dbSNP rs700785. Ref.4		VAR_021303

Sequences

	Sequence		Length	Mass (Da)
	Q9P0W0-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 49CF410ECE52B597	FASTA	207	25,219
	10 20 30 40 50 60 MSTKPDMIQK CLWLEILMGI FIAGTLSLDC NLLNVHLRRV TWQNLRHLSS MSNSFPVECL 70 80 90 100 110 120 RENIAFELPQ EFLQYTQPMK RDIKKAFYEM SLQAFNIFSQ HTFKYWKERH LKQIQIGLDQ 130 140 150 160 170 180 QAEYLNQCLE EDENENEDMK EMKENEMKPS EARVPQLSSL ELRRYFHRID NFLKEKKYSD 190 200 CAWEIVRVEI RRCLYYFYKF TALFRRK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Novel human interferon." Cao X., Zhang W. Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Interferon-kappa, a novel type I interferon expressed in human keratinocytes." LaFleur D.W., Nardelli B., Tsareva T., Mather D., Feng P., Semenuk M., Taylor K., Buergin M., Chinchilla D., Roshke V., Chen G., Ruben S.M., Pitha P.M., Coleman T.A., Moore P.A. J. Biol. Chem. 276:39765-39771(2001) [PubMed: 11514542] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, INDUCTION, TISSUE SPECIFICITY.
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LYS-133.
[5]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 28-42.
[6]	"Regulatory effect of IFN-kappa, a novel type I IFN, on cytokine production by cells of the innate immune system." Nardelli B., Zaritskaya L., Semenuk M., Cho Y.H., LaFleur D.W., Shah D., Ullrich S., Girolomoni G., Albanesi C., Moore P.A. J. Immunol. 169:4822-4830(2002) [PubMed: 12391192] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF146759 mRNA. Translation: AAF67468.1. AF315688 mRNA. Translation: AAK01623.1. AF384048 Genomic DNA. Translation: AAK63835.1. AY358855 mRNA. Translation: AAQ89214.1. AL451123 Genomic DNA. Translation: CAI13042.1.
IPI	IPI00015079.
RefSeq	NP_064509.2.
UniGene	Hs.591083
3D structure databases
HSSP	HSSP built from PDB template 1B5L based on UniProtKB P56828.
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000147896. Homo sapiens. [Contig view]
GeneID	56832.
KEGG	hsa:56832.
Organism-specific databases
GeneCards	GC09P027514.
H-InvDB	HIX0034769.
HGNC	HGNC:21714. IFNK.
PharmGKB	PA134970126.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9P0W0.
HOVERGEN	Q9P0W0.
Gene expression databases
ArrayExpress	Q9P0W0.
Bgee	Q9P0W0.
CleanEx	HS_IFNK.
GermOnline	ENSG00000147896. Homo sapiens.
Family and domain databases
InterPro	IPR012351. 4_helix_cytokine_core. IPR000471. IInterferon_alpha/beta/delta. [Graphical view]
Gene3D	G3DSA:1.20.1250.10. 4_helix_cytokine_core. 1 hit.
PANTHER	PTHR11691. Interferon_abd. 1 hit.
Pfam	PF00143. Interferon. 1 hit. [Graphical view]
PRINTS	PR00266. INTERFERONAB.
ProDom	PD000550. Interferon_abd. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00076. IFabd. 1 hit. [Graphical view]
PROSITE	PS00252. INTERFERON_A_B_D. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	62232.

Entry information

Entry name

IFNK_HUMAN

Accession

Primary (citable) accession number: Q9P0W0
Secondary accession number(s): Q5T166

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2005
Last sequence update:	October 1, 2000
Last modified:	June 16, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)