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Protein

Interferon kappa

Gene

IFNK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon-stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin.2 Publications

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • type I interferon receptor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processAntiviral defense

Enzyme and pathway databases

SignaLinkiQ9P0W0

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon kappa
Short name:
IFN-kappa
Gene namesi
Name:IFNK
ORF Names:UNQ6124/PRO20084
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000147896.3
HGNCiHGNC:21714 IFNK
MIMi615326 gene
neXtProtiNX_Q9P0W0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi56832
OpenTargetsiENSG00000147896
PharmGKBiPA134970126

Polymorphism and mutation databases

BioMutaiIFNK
DMDMi317373367

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 271 PublicationAdd BLAST27
ChainiPRO_000001641028 – 207Interferon kappaAdd BLAST180

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 128By similarity
Disulfide bondi59 ↔ 181By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9P0W0
PeptideAtlasiQ9P0W0
PRIDEiQ9P0W0
ProteomicsDBi83609

Expressioni

Tissue specificityi

Expressed in keratinocytes, monocytes and in resting dendritic cells.2 Publications

Inductioni

By viral infection, upon exposure to double-stranded RNA, or upon treatment with either interferon-gamma or interferon-beta.1 Publication

Gene expression databases

BgeeiENSG00000147896
CleanExiHS_IFNK
GenevisibleiQ9P0W0 HS

Interactioni

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • type I interferon receptor binding Source: UniProtKB

Protein-protein interaction databases

STRINGi9606.ENSP00000276943

Structurei

3D structure databases

ProteinModelPortaliQ9P0W0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili118 – 148Sequence analysisAdd BLAST31

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiENOG410J1FR Eukaryota
ENOG41114KE LUCA
GeneTreeiENSGT00760000119150
HOGENOMiHOG000230501
HOVERGENiHBG052086
InParanoidiQ9P0W0
KOiK05441
OMAiRVTWQNL
OrthoDBiEOG091G0R88
PhylomeDBiQ9P0W0
TreeFamiTF336177

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000471 Interferon_alpha/beta/delta
PANTHERiPTHR11691 PTHR11691, 1 hit
PfamiView protein in Pfam
PF00143 Interferon, 1 hit
PRINTSiPR00266 INTERFERONAB
SMARTiView protein in SMART
SM00076 IFabd, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00252 INTERFERON_A_B_D, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9P0W0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTKPDMIQK CLWLEILMGI FIAGTLSLDC NLLNVHLRRV TWQNLRHLSS
60 70 80 90 100
MSNSFPVECL RENIAFELPQ EFLQYTQPMK RDIKKAFYEM SLQAFNIFSQ
110 120 130 140 150
HTFKYWKERH LKQIQIGLDQ QAEYLNQCLE EDKNENEDMK EMKENEMKPS
160 170 180 190 200
EARVPQLSSL ELRRYFHRID NFLKEKKYSD CAWEIVRVEI RRCLYYFYKF

TALFRRK
Length:207
Mass (Da):25,218
Last modified:January 11, 2011 - v2
Checksum:i49CF4CB5785F0E21
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03271097I → N. Corresponds to variant dbSNP:rs34933275Ensembl.1
Natural variantiVAR_021303133K → E3 PublicationsCorresponds to variant dbSNP:rs700785Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF146759 mRNA Translation: AAF67468.1
AF315688 mRNA Translation: AAK01623.1
AF384048 Genomic DNA Translation: AAK63835.1
AY358855 mRNA Translation: AAQ89214.1
AL451123 Genomic DNA No translation available.
CCDSiCCDS6521.1
RefSeqiNP_064509.2, NM_020124.2
UniGeneiHs.591083

Genome annotation databases

EnsembliENST00000276943; ENSP00000276943; ENSG00000147896
GeneIDi56832
KEGGihsa:56832
UCSCiuc003zqp.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIFNK_HUMAN
AccessioniPrimary (citable) accession number: Q9P0W0
Secondary accession number(s): Q5T166
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: January 11, 2011
Last modified: June 20, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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