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Q9P0W0

- IFNK_HUMAN

UniProt

Q9P0W0 - IFNK_HUMAN

Protein

Interferon kappa

Gene

IFNK

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 2 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon-stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin.2 Publications

    GO - Molecular functioni

    1. cytokine activity Source: RefGenome
    2. type I interferon receptor binding Source: UniProtKB

    GO - Biological processi

    1. adaptive immune response Source: RefGenome
    2. B cell differentiation Source: RefGenome
    3. B cell proliferation Source: RefGenome
    4. cytokine-mediated signaling pathway Source: UniProtKB
    5. defense response to virus Source: UniProtKB-KW
    6. humoral immune response Source: RefGenome
    7. innate immune response Source: RefGenome
    8. natural killer cell activation Source: UniProtKB
    9. natural killer cell activation involved in immune response Source: RefGenome
    10. negative regulation of cell proliferation Source: UniProtKB
    11. positive regulation of innate immune response Source: UniProtKB
    12. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: RefGenome
    13. regulation of MHC class I biosynthetic process Source: RefGenome
    14. regulation of transcription, DNA-templated Source: UniProtKB
    15. response to exogenous dsRNA Source: RefGenome
    16. response to virus Source: UniProtKB
    17. T cell activation involved in immune response Source: RefGenome

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Antiviral defense

    Enzyme and pathway databases

    SignaLinkiQ9P0W0.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interferon kappa
    Short name:
    IFN-kappa
    Gene namesi
    Name:IFNK
    ORF Names:UNQ6124/PRO20084
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:21714. IFNK.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB
    2. extracellular space Source: RefGenome

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134970126.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 27271 PublicationAdd
    BLAST
    Chaini28 – 207180Interferon kappaPRO_0000016410Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi30 ↔ 128By similarity
    Disulfide bondi59 ↔ 181By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ9P0W0.

    Expressioni

    Tissue specificityi

    Expressed in keratinocytes, monocytes and in resting dendritic cells.2 Publications

    Inductioni

    By viral infection, upon exposure to double-stranded RNA, or upon treatment with either interferon-gamma or interferon-beta.1 Publication

    Gene expression databases

    BgeeiQ9P0W0.
    CleanExiHS_IFNK.
    GenevestigatoriQ9P0W0.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000276943.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9P0W0.
    SMRiQ9P0W0. Positions 30-205.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili118 – 14831Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the alpha/beta interferon family.Curated

    Keywords - Domaini

    Coiled coil, Signal

    Phylogenomic databases

    eggNOGiNOG43286.
    HOGENOMiHOG000230501.
    HOVERGENiHBG052086.
    InParanoidiQ9P0W0.
    KOiK05441.
    OMAiRVTWQNL.
    OrthoDBiEOG7BS4BW.
    PhylomeDBiQ9P0W0.
    TreeFamiTF336177.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000471. Interferon_alpha/beta/delta.
    [Graphical view]
    PANTHERiPTHR11691. PTHR11691. 1 hit.
    PfamiPF00143. Interferon. 1 hit.
    [Graphical view]
    PRINTSiPR00266. INTERFERONAB.
    SMARTiSM00076. IFabd. 1 hit.
    [Graphical view]
    SUPFAMiSSF47266. SSF47266. 1 hit.
    PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9P0W0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTKPDMIQK CLWLEILMGI FIAGTLSLDC NLLNVHLRRV TWQNLRHLSS    50
    MSNSFPVECL RENIAFELPQ EFLQYTQPMK RDIKKAFYEM SLQAFNIFSQ 100
    HTFKYWKERH LKQIQIGLDQ QAEYLNQCLE EDKNENEDMK EMKENEMKPS 150
    EARVPQLSSL ELRRYFHRID NFLKEKKYSD CAWEIVRVEI RRCLYYFYKF 200
    TALFRRK 207
    Length:207
    Mass (Da):25,218
    Last modified:January 11, 2011 - v2
    Checksum:i49CF4CB5785F0E21
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti97 – 971I → N.
    Corresponds to variant rs34933275 [ dbSNP | Ensembl ].
    VAR_032710
    Natural varianti133 – 1331K → E.3 Publications
    Corresponds to variant rs700785 [ dbSNP | Ensembl ].
    VAR_021303

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF146759 mRNA. Translation: AAF67468.1.
    AF315688 mRNA. Translation: AAK01623.1.
    AF384048 Genomic DNA. Translation: AAK63835.1.
    AY358855 mRNA. Translation: AAQ89214.1.
    AL451123 Genomic DNA. Translation: CAI13042.1.
    CCDSiCCDS6521.1.
    RefSeqiNP_064509.2. NM_020124.2.
    UniGeneiHs.591083.

    Genome annotation databases

    EnsembliENST00000276943; ENSP00000276943; ENSG00000147896.
    GeneIDi56832.
    KEGGihsa:56832.
    UCSCiuc003zqp.3. human.

    Polymorphism databases

    DMDMi317373367.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF146759 mRNA. Translation: AAF67468.1 .
    AF315688 mRNA. Translation: AAK01623.1 .
    AF384048 Genomic DNA. Translation: AAK63835.1 .
    AY358855 mRNA. Translation: AAQ89214.1 .
    AL451123 Genomic DNA. Translation: CAI13042.1 .
    CCDSi CCDS6521.1.
    RefSeqi NP_064509.2. NM_020124.2.
    UniGenei Hs.591083.

    3D structure databases

    ProteinModelPortali Q9P0W0.
    SMRi Q9P0W0. Positions 30-205.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000276943.

    Polymorphism databases

    DMDMi 317373367.

    Proteomic databases

    PRIDEi Q9P0W0.

    Protocols and materials databases

    DNASUi 56832.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000276943 ; ENSP00000276943 ; ENSG00000147896 .
    GeneIDi 56832.
    KEGGi hsa:56832.
    UCSCi uc003zqp.3. human.

    Organism-specific databases

    CTDi 56832.
    GeneCardsi GC09P027514.
    H-InvDB HIX0034769.
    HGNCi HGNC:21714. IFNK.
    MIMi 615326. gene.
    neXtProti NX_Q9P0W0.
    PharmGKBi PA134970126.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG43286.
    HOGENOMi HOG000230501.
    HOVERGENi HBG052086.
    InParanoidi Q9P0W0.
    KOi K05441.
    OMAi RVTWQNL.
    OrthoDBi EOG7BS4BW.
    PhylomeDBi Q9P0W0.
    TreeFami TF336177.

    Enzyme and pathway databases

    SignaLinki Q9P0W0.

    Miscellaneous databases

    GeneWikii IFNK.
    GenomeRNAii 56832.
    NextBioi 62232.
    PROi Q9P0W0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9P0W0.
    CleanExi HS_IFNK.
    Genevestigatori Q9P0W0.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000471. Interferon_alpha/beta/delta.
    [Graphical view ]
    PANTHERi PTHR11691. PTHR11691. 1 hit.
    Pfami PF00143. Interferon. 1 hit.
    [Graphical view ]
    PRINTSi PR00266. INTERFERONAB.
    SMARTi SM00076. IFabd. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    PROSITEi PS00252. INTERFERON_A_B_D. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Novel human interferon."
      Cao X., Zhang W.
      Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-133.
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, INDUCTION, TISSUE SPECIFICITY, VARIANT GLU-133.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-133.
    4. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 28-42.
    6. "Regulatory effect of IFN-kappa, a novel type I IFN, on cytokine production by cells of the innate immune system."
      Nardelli B., Zaritskaya L., Semenuk M., Cho Y.H., LaFleur D.W., Shah D., Ullrich S., Girolomoni G., Albanesi C., Moore P.A.
      J. Immunol. 169:4822-4830(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiIFNK_HUMAN
    AccessioniPrimary (citable) accession number: Q9P0W0
    Secondary accession number(s): Q5T166
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 101 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3