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Protein

Interferon kappa

Gene

IFNK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon-stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin.2 Publications

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • type I interferon receptor binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense

Enzyme and pathway databases

SignaLinkiQ9P0W0.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon kappa
Short name:
IFN-kappa
Gene namesi
Name:IFNK
ORF Names:UNQ6124/PRO20084
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:21714. IFNK.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB
  • extracellular space Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134970126.

Polymorphism and mutation databases

BioMutaiIFNK.
DMDMi317373367.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 27271 PublicationAdd
BLAST
Chaini28 – 207180Interferon kappaPRO_0000016410Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 128By similarity
Disulfide bondi59 ↔ 181By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ9P0W0.

Expressioni

Tissue specificityi

Expressed in keratinocytes, monocytes and in resting dendritic cells.2 Publications

Inductioni

By viral infection, upon exposure to double-stranded RNA, or upon treatment with either interferon-gamma or interferon-beta.1 Publication

Gene expression databases

BgeeiQ9P0W0.
CleanExiHS_IFNK.
GenevestigatoriQ9P0W0.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000276943.

Structurei

3D structure databases

ProteinModelPortaliQ9P0W0.
SMRiQ9P0W0. Positions 30-205.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili118 – 14831Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiNOG43286.
GeneTreeiENSGT00760000119150.
HOGENOMiHOG000230501.
HOVERGENiHBG052086.
InParanoidiQ9P0W0.
KOiK05441.
OMAiRVTWQNL.
OrthoDBiEOG7BS4BW.
PhylomeDBiQ9P0W0.
TreeFamiTF336177.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9P0W0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTKPDMIQK CLWLEILMGI FIAGTLSLDC NLLNVHLRRV TWQNLRHLSS
60 70 80 90 100
MSNSFPVECL RENIAFELPQ EFLQYTQPMK RDIKKAFYEM SLQAFNIFSQ
110 120 130 140 150
HTFKYWKERH LKQIQIGLDQ QAEYLNQCLE EDKNENEDMK EMKENEMKPS
160 170 180 190 200
EARVPQLSSL ELRRYFHRID NFLKEKKYSD CAWEIVRVEI RRCLYYFYKF

TALFRRK
Length:207
Mass (Da):25,218
Last modified:January 11, 2011 - v2
Checksum:i49CF4CB5785F0E21
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti97 – 971I → N.
Corresponds to variant rs34933275 [ dbSNP | Ensembl ].
VAR_032710
Natural varianti133 – 1331K → E.3 Publications
Corresponds to variant rs700785 [ dbSNP | Ensembl ].
VAR_021303

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF146759 mRNA. Translation: AAF67468.1.
AF315688 mRNA. Translation: AAK01623.1.
AF384048 Genomic DNA. Translation: AAK63835.1.
AY358855 mRNA. Translation: AAQ89214.1.
AL451123 Genomic DNA. Translation: CAI13042.1.
CCDSiCCDS6521.1.
RefSeqiNP_064509.2. NM_020124.2.
UniGeneiHs.591083.

Genome annotation databases

EnsembliENST00000276943; ENSP00000276943; ENSG00000147896.
GeneIDi56832.
KEGGihsa:56832.
UCSCiuc003zqp.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF146759 mRNA. Translation: AAF67468.1.
AF315688 mRNA. Translation: AAK01623.1.
AF384048 Genomic DNA. Translation: AAK63835.1.
AY358855 mRNA. Translation: AAQ89214.1.
AL451123 Genomic DNA. Translation: CAI13042.1.
CCDSiCCDS6521.1.
RefSeqiNP_064509.2. NM_020124.2.
UniGeneiHs.591083.

3D structure databases

ProteinModelPortaliQ9P0W0.
SMRiQ9P0W0. Positions 30-205.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000276943.

Polymorphism and mutation databases

BioMutaiIFNK.
DMDMi317373367.

Proteomic databases

PRIDEiQ9P0W0.

Protocols and materials databases

DNASUi56832.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276943; ENSP00000276943; ENSG00000147896.
GeneIDi56832.
KEGGihsa:56832.
UCSCiuc003zqp.3. human.

Organism-specific databases

CTDi56832.
GeneCardsiGC09P027514.
H-InvDBHIX0034769.
HGNCiHGNC:21714. IFNK.
MIMi615326. gene.
neXtProtiNX_Q9P0W0.
PharmGKBiPA134970126.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG43286.
GeneTreeiENSGT00760000119150.
HOGENOMiHOG000230501.
HOVERGENiHBG052086.
InParanoidiQ9P0W0.
KOiK05441.
OMAiRVTWQNL.
OrthoDBiEOG7BS4BW.
PhylomeDBiQ9P0W0.
TreeFamiTF336177.

Enzyme and pathway databases

SignaLinkiQ9P0W0.

Miscellaneous databases

GeneWikiiIFNK.
GenomeRNAii56832.
NextBioi62232.
PROiQ9P0W0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9P0W0.
CleanExiHS_IFNK.
GenevestigatoriQ9P0W0.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Novel human interferon."
    Cao X., Zhang W.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-133.
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, INDUCTION, TISSUE SPECIFICITY, VARIANT GLU-133.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-133.
  4. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 28-42.
  6. "Regulatory effect of IFN-kappa, a novel type I IFN, on cytokine production by cells of the innate immune system."
    Nardelli B., Zaritskaya L., Semenuk M., Cho Y.H., LaFleur D.W., Shah D., Ullrich S., Girolomoni G., Albanesi C., Moore P.A.
    J. Immunol. 169:4822-4830(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiIFNK_HUMAN
AccessioniPrimary (citable) accession number: Q9P0W0
Secondary accession number(s): Q5T166
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: January 11, 2011
Last modified: April 29, 2015
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.