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Q9P0W0 (IFNK_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interferon kappa

Short name=IFN-kappa
Gene names
Name:IFNK
ORF Names:UNQ6124/PRO20084
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length207 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon-stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin. Ref.2 Ref.6

Subcellular location

Secreted.

Tissue specificity

Expressed in keratinocytes, monocytes and in resting dendritic cells. Ref.2 Ref.6

Induction

By viral infection, upon exposure to double-stranded RNA, or upon treatment with either interferon-gamma or interferon-beta. Ref.2

Sequence similarities

Belongs to the alpha/beta interferon family.

Ontologies

Keywords
   Biological processAntiviral defense
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainCoiled coil
Signal
   Molecular functionCytokine
   PTMDisulfide bond
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processB cell differentiation

Inferred from Biological aspect of Ancestor. Source: RefGenome

B cell proliferation

Inferred from Biological aspect of Ancestor. Source: RefGenome

T cell activation involved in immune response

Inferred from Biological aspect of Ancestor. Source: RefGenome

adaptive immune response

Inferred from Biological aspect of Ancestor. Source: RefGenome

cytokine-mediated signaling pathway

Inferred from direct assay Ref.2. Source: UniProtKB

defense response to virus

Inferred from electronic annotation. Source: UniProtKB-KW

humoral immune response

Inferred from Biological aspect of Ancestor. Source: RefGenome

innate immune response

Inferred from Biological aspect of Ancestor. Source: RefGenome

natural killer cell activation

Non-traceable author statement Ref.2. Source: UniProtKB

natural killer cell activation involved in immune response

Inferred from Biological aspect of Ancestor. Source: RefGenome

negative regulation of cell proliferation

Non-traceable author statement Ref.2. Source: UniProtKB

positive regulation of innate immune response

Traceable author statement Ref.2. Source: UniProtKB

positive regulation of peptidyl-serine phosphorylation of STAT protein

Inferred from Biological aspect of Ancestor. Source: RefGenome

regulation of MHC class I biosynthetic process

Inferred from Biological aspect of Ancestor. Source: RefGenome

regulation of transcription, DNA-templated

Inferred from direct assay Ref.2. Source: UniProtKB

response to exogenous dsRNA

Inferred from Biological aspect of Ancestor. Source: RefGenome

response to virus

Inferred from expression pattern Ref.2. Source: UniProtKB

   Cellular_componentextracellular region

Inferred by curator Ref.2. Source: UniProtKB

extracellular space

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functioncytokine activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

type I interferon receptor binding

Inferred from direct assay Ref.2. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Ref.5
Chain28 – 207180Interferon kappa
PRO_0000016410

Regions

Coiled coil118 – 14831 Potential

Amino acid modifications

Disulfide bond30 ↔ 128 By similarity
Disulfide bond59 ↔ 181 By similarity

Natural variations

Natural variant971I → N.
Corresponds to variant rs34933275 [ dbSNP | Ensembl ].
VAR_032710
Natural variant1331K → E. Ref.1 Ref.2 Ref.3
Corresponds to variant rs700785 [ dbSNP | Ensembl ].
VAR_021303

Sequences

Sequence LengthMass (Da)Tools
Q9P0W0 [UniParc].

Last modified January 11, 2011. Version 2.
Checksum: 49CF4CB5785F0E21

FASTA20725,218
        10         20         30         40         50         60 
MSTKPDMIQK CLWLEILMGI FIAGTLSLDC NLLNVHLRRV TWQNLRHLSS MSNSFPVECL 

        70         80         90        100        110        120 
RENIAFELPQ EFLQYTQPMK RDIKKAFYEM SLQAFNIFSQ HTFKYWKERH LKQIQIGLDQ 

       130        140        150        160        170        180 
QAEYLNQCLE EDKNENEDMK EMKENEMKPS EARVPQLSSL ELRRYFHRID NFLKEKKYSD 

       190        200 
CAWEIVRVEI RRCLYYFYKF TALFRRK 

« Hide

References

« Hide 'large scale' references
[1]"Novel human interferon."
Cao X., Zhang W.
Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-133.
[2]"Interferon-kappa, a novel type I interferon expressed in human keratinocytes."
LaFleur D.W., Nardelli B., Tsareva T., Mather D., Feng P., Semenuk M., Taylor K., Buergin M., Chinchilla D., Roshke V., Chen G., Ruben S.M., Pitha P.M., Coleman T.A., Moore P.A.
J. Biol. Chem. 276:39765-39771(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, INDUCTION, TISSUE SPECIFICITY, VARIANT GLU-133.
[3]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-133.
[4]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 28-42.
[6]"Regulatory effect of IFN-kappa, a novel type I IFN, on cytokine production by cells of the innate immune system."
Nardelli B., Zaritskaya L., Semenuk M., Cho Y.H., LaFleur D.W., Shah D., Ullrich S., Girolomoni G., Albanesi C., Moore P.A.
J. Immunol. 169:4822-4830(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF146759 mRNA. Translation: AAF67468.1.
AF315688 mRNA. Translation: AAK01623.1.
AF384048 Genomic DNA. Translation: AAK63835.1.
AY358855 mRNA. Translation: AAQ89214.1.
AL451123 Genomic DNA. Translation: CAI13042.1.
RefSeqNP_064509.2. NM_020124.2.
UniGeneHs.591083.

3D structure databases

ProteinModelPortalQ9P0W0.
SMRQ9P0W0. Positions 28-206.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000276943.

Polymorphism databases

DMDM317373367.

Proteomic databases

PRIDEQ9P0W0.

Protocols and materials databases

DNASU56832.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000276943; ENSP00000276943; ENSG00000147896.
GeneID56832.
KEGGhsa:56832.
UCSCuc003zqp.3. human.

Organism-specific databases

CTD56832.
GeneCardsGC09P027514.
H-InvDBHIX0034769.
HGNCHGNC:21714. IFNK.
MIM615326. gene.
neXtProtNX_Q9P0W0.
PharmGKBPA134970126.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG43286.
HOGENOMHOG000230501.
HOVERGENHBG052086.
InParanoidQ9P0W0.
KOK05441.
OMARVTWQNL.
OrthoDBEOG7BS4BW.
PhylomeDBQ9P0W0.
TreeFamTF336177.

Enzyme and pathway databases

SignaLinkQ9P0W0.

Gene expression databases

BgeeQ9P0W0.
CleanExHS_IFNK.
GenevestigatorQ9P0W0.

Family and domain databases

Gene3D1.20.1250.10. 1 hit.
InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERPTHR11691. PTHR11691. 1 hit.
PfamPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSPR00266. INTERFERONAB.
SMARTSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMSSF47266. SSF47266. 1 hit.
PROSITEPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiIFNK.
GenomeRNAi56832.
NextBio62232.
PROQ9P0W0.
SOURCESearch...

Entry information

Entry nameIFNK_HUMAN
AccessionPrimary (citable) accession number: Q9P0W0
Secondary accession number(s): Q5T166
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: January 11, 2011
Last modified: April 16, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM