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Q9P0W0

- IFNK_HUMAN

UniProt

Q9P0W0 - IFNK_HUMAN

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Protein

Interferon kappa

Gene
IFNK, UNQ6124/PRO20084
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon-stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin.2 Publications

GO - Molecular functioni

  1. cytokine activity Source: RefGenome
  2. type I interferon receptor binding Source: UniProtKB

GO - Biological processi

  1. adaptive immune response Source: RefGenome
  2. B cell differentiation Source: RefGenome
  3. B cell proliferation Source: RefGenome
  4. cytokine-mediated signaling pathway Source: UniProtKB
  5. defense response to virus Source: UniProtKB-KW
  6. humoral immune response Source: RefGenome
  7. innate immune response Source: RefGenome
  8. natural killer cell activation Source: UniProtKB
  9. natural killer cell activation involved in immune response Source: RefGenome
  10. negative regulation of cell proliferation Source: UniProtKB
  11. positive regulation of innate immune response Source: UniProtKB
  12. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: RefGenome
  13. regulation of MHC class I biosynthetic process Source: RefGenome
  14. regulation of transcription, DNA-templated Source: UniProtKB
  15. response to exogenous dsRNA Source: RefGenome
  16. response to virus Source: UniProtKB
  17. T cell activation involved in immune response Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense

Enzyme and pathway databases

SignaLinkiQ9P0W0.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon kappa
Short name:
IFN-kappa
Gene namesi
Name:IFNK
ORF Names:UNQ6124/PRO20084
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:21714. IFNK.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
  2. extracellular space Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134970126.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 27271 PublicationAdd
BLAST
Chaini28 – 207180Interferon kappaPRO_0000016410Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 128 By similarity
Disulfide bondi59 ↔ 181 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ9P0W0.

Expressioni

Tissue specificityi

Expressed in keratinocytes, monocytes and in resting dendritic cells.2 Publications

Inductioni

By viral infection, upon exposure to double-stranded RNA, or upon treatment with either interferon-gamma or interferon-beta.1 Publication

Gene expression databases

BgeeiQ9P0W0.
CleanExiHS_IFNK.
GenevestigatoriQ9P0W0.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000276943.

Structurei

3D structure databases

ProteinModelPortaliQ9P0W0.
SMRiQ9P0W0. Positions 30-205.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili118 – 14831 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiNOG43286.
HOGENOMiHOG000230501.
HOVERGENiHBG052086.
InParanoidiQ9P0W0.
KOiK05441.
OMAiRVTWQNL.
OrthoDBiEOG7BS4BW.
PhylomeDBiQ9P0W0.
TreeFamiTF336177.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9P0W0-1 [UniParc]FASTAAdd to Basket

« Hide

MSTKPDMIQK CLWLEILMGI FIAGTLSLDC NLLNVHLRRV TWQNLRHLSS    50
MSNSFPVECL RENIAFELPQ EFLQYTQPMK RDIKKAFYEM SLQAFNIFSQ 100
HTFKYWKERH LKQIQIGLDQ QAEYLNQCLE EDKNENEDMK EMKENEMKPS 150
EARVPQLSSL ELRRYFHRID NFLKEKKYSD CAWEIVRVEI RRCLYYFYKF 200
TALFRRK 207
Length:207
Mass (Da):25,218
Last modified:January 11, 2011 - v2
Checksum:i49CF4CB5785F0E21
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti97 – 971I → N.
Corresponds to variant rs34933275 [ dbSNP | Ensembl ].
VAR_032710
Natural varianti133 – 1331K → E.3 Publications
Corresponds to variant rs700785 [ dbSNP | Ensembl ].
VAR_021303

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF146759 mRNA. Translation: AAF67468.1.
AF315688 mRNA. Translation: AAK01623.1.
AF384048 Genomic DNA. Translation: AAK63835.1.
AY358855 mRNA. Translation: AAQ89214.1.
AL451123 Genomic DNA. Translation: CAI13042.1.
CCDSiCCDS6521.1.
RefSeqiNP_064509.2. NM_020124.2.
UniGeneiHs.591083.

Genome annotation databases

EnsembliENST00000276943; ENSP00000276943; ENSG00000147896.
GeneIDi56832.
KEGGihsa:56832.
UCSCiuc003zqp.3. human.

Polymorphism databases

DMDMi317373367.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF146759 mRNA. Translation: AAF67468.1 .
AF315688 mRNA. Translation: AAK01623.1 .
AF384048 Genomic DNA. Translation: AAK63835.1 .
AY358855 mRNA. Translation: AAQ89214.1 .
AL451123 Genomic DNA. Translation: CAI13042.1 .
CCDSi CCDS6521.1.
RefSeqi NP_064509.2. NM_020124.2.
UniGenei Hs.591083.

3D structure databases

ProteinModelPortali Q9P0W0.
SMRi Q9P0W0. Positions 30-205.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000276943.

Polymorphism databases

DMDMi 317373367.

Proteomic databases

PRIDEi Q9P0W0.

Protocols and materials databases

DNASUi 56832.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000276943 ; ENSP00000276943 ; ENSG00000147896 .
GeneIDi 56832.
KEGGi hsa:56832.
UCSCi uc003zqp.3. human.

Organism-specific databases

CTDi 56832.
GeneCardsi GC09P027514.
H-InvDB HIX0034769.
HGNCi HGNC:21714. IFNK.
MIMi 615326. gene.
neXtProti NX_Q9P0W0.
PharmGKBi PA134970126.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG43286.
HOGENOMi HOG000230501.
HOVERGENi HBG052086.
InParanoidi Q9P0W0.
KOi K05441.
OMAi RVTWQNL.
OrthoDBi EOG7BS4BW.
PhylomeDBi Q9P0W0.
TreeFami TF336177.

Enzyme and pathway databases

SignaLinki Q9P0W0.

Miscellaneous databases

GeneWikii IFNK.
GenomeRNAii 56832.
NextBioi 62232.
PROi Q9P0W0.
SOURCEi Search...

Gene expression databases

Bgeei Q9P0W0.
CleanExi HS_IFNK.
Genevestigatori Q9P0W0.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view ]
PANTHERi PTHR11691. PTHR11691. 1 hit.
Pfami PF00143. Interferon. 1 hit.
[Graphical view ]
PRINTSi PR00266. INTERFERONAB.
SMARTi SM00076. IFabd. 1 hit.
[Graphical view ]
SUPFAMi SSF47266. SSF47266. 1 hit.
PROSITEi PS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Novel human interferon."
    Cao X., Zhang W.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-133.
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, INDUCTION, TISSUE SPECIFICITY, VARIANT GLU-133.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLU-133.
  4. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 28-42.
  6. "Regulatory effect of IFN-kappa, a novel type I IFN, on cytokine production by cells of the innate immune system."
    Nardelli B., Zaritskaya L., Semenuk M., Cho Y.H., LaFleur D.W., Shah D., Ullrich S., Girolomoni G., Albanesi C., Moore P.A.
    J. Immunol. 169:4822-4830(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiIFNK_HUMAN
AccessioniPrimary (citable) accession number: Q9P0W0
Secondary accession number(s): Q5T166
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: January 11, 2011
Last modified: July 9, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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