Q9P0V9 (SEP10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Septin-10

Gene names

Name:

SEPT10

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	454 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Filament-forming cytoskeletal GTPase. May play a role in cytokinesis Potential.
Subunit structure	Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation By similarity.
Subcellular location	Cytoplasm. Cytoplasm › cytoskeleton By similarity. Note: Using a GFP-fusion protein, detected in the nucleus (Ref.1). Ref.1
Tissue specificity	Widely expressed. Abundantly expressed in heart and kidney, placenta, skeletal muscles, liver and lung, as well as various tumor cell lines. Ref.1 Ref.6
Sequence similarities	Belongs to the septin family.
Sequence caution	The sequence AAF67469.1 differs from that shown. Reason: Frameshift at position 444. Isoform 2: The sequence AAH50345.2 differs from that shown. Reason: Frameshift at position 503.

Ontologies

Keywords
Biological process	Cell cycle Cell division
Cellular component	Cytoplasm Cytoskeleton
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	GTP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	septin complex Inferred from electronic annotation. Source: InterPro
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9P0V9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9P0V9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     450-454: NSNFL → KEPGCRFELLCIDVRACETNGGRKDAEKAPIFCKTEVPEHRRSSSQANFIKKKN

Isoform 3 (identifier: Q9P0V9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     11-33: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 454	454	Septin-10		PRO_0000173538
Regions
	Nucleotide binding	73 – 80	8	GTP By similarity
	Nucleotide binding	209 – 217	9	GTP By similarity
Sites
	Binding site	128	1	GTP; via amide nitrogen By similarity
	Binding site	263	1	GTP; via amide nitrogen and carbonyl oxygen By similarity
	Binding site	278	1	GTP By similarity
Natural variations
	Alternative sequence	11 – 33	23	Missing in isoform 3.		VSP_041479
	Alternative sequence	450 – 454	5	NSNFL → KEPGCRFELLCIDVRACETN GGRKDAEKAPIFCKTEVPEH RRSSSQANFIKKKN in isoform 2.		VSP_014091
	Natural variant	189	1	L → P. Corresponds to variant rs3829701 [ dbSNP | Ensembl ].		VAR_051936

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 23, 2007. Version 2. Checksum: 95C8F7FAA266BC10	FASTA	454	52,593
	10 20 30 40 50 60 MASSEVARHL LFQSHMATKT TCMSSQGSDD EQIKRENIRS LTMSGHVGFE SLPDQLVNRS 70 80 90 100 110 120 IQQGFCFNIL CVGETGIGKS TLIDTLFNTN FEDYESSHFC PNVKLKAQTY ELQESNVQLK 130 140 150 160 170 180 LTIVNTVGFG DQINKEESYQ PIVDYIDAQF EAYLQEELKI KRSLFTYHDS RIHVCLYFIS 190 200 210 220 230 240 PTGHSLKTLD LLTMKNLDSK VNIIPVIAKA DTVSKTELQK FKIKLMSELV SNGVQIYQFP 250 260 270 280 290 300 TDDDTIAKVN AAMNGQLPFA VVGSMDEVKV GNKMVKARQY PWGVVQVENE NHCDFVKLRE 310 320 330 340 350 360 MLICTNMEDL REQTHTRHYE LYRRCKLEEM GFTDVGPENK PVSVQETYEA KRHEFHGERQ 370 380 390 400 410 420 RKEEEMKQMF VQRVKEKEAI LKEAERELQA KFEHLKRLHQ EERMKLEEKR RLLEEEIIAF 430 440 450 SKKKATSEIF HSQSFLATGS NLRKDKDRKN SNFL
	Isoform 2 [UniParc]. Checksum: 4313FEB8875291E9	FASTA	503	58,136
	10 20 30 40 50 60 MASSEVARHL LFQSHMATKT TCMSSQGSDD EQIKRENIRS LTMSGHVGFE SLPDQLVNRS 70 80 90 100 110 120 IQQGFCFNIL CVGETGIGKS TLIDTLFNTN FEDYESSHFC PNVKLKAQTY ELQESNVQLK 130 140 150 160 170 180 LTIVNTVGFG DQINKEESYQ PIVDYIDAQF EAYLQEELKI KRSLFTYHDS RIHVCLYFIS 190 200 210 220 230 240 PTGHSLKTLD LLTMKNLDSK VNIIPVIAKA DTVSKTELQK FKIKLMSELV SNGVQIYQFP 250 260 270 280 290 300 TDDDTIAKVN AAMNGQLPFA VVGSMDEVKV GNKMVKARQY PWGVVQVENE NHCDFVKLRE 310 320 330 340 350 360 MLICTNMEDL REQTHTRHYE LYRRCKLEEM GFTDVGPENK PVSVQETYEA KRHEFHGERQ 370 380 390 400 410 420 RKEEEMKQMF VQRVKEKEAI LKEAERELQA KFEHLKRLHQ EERMKLEEKR RLLEEEIIAF 430 440 450 460 470 480 SKKKATSEIF HSQSFLATGS NLRKDKDRKK EPGCRFELLC IDVRACETNG GRKDAEKAPI 490 500 FCKTEVPEHR RSSSQANFIK KKN
	Isoform 3 [UniParc]. Checksum: CF6F70189AA897DA	FASTA	431	50,065
	10 20 30 40 50 60 MASSEVARHL KRENIRSLTM SGHVGFESLP DQLVNRSIQQ GFCFNILCVG ETGIGKSTLI 70 80 90 100 110 120 DTLFNTNFED YESSHFCPNV KLKAQTYELQ ESNVQLKLTI VNTVGFGDQI NKEESYQPIV 130 140 150 160 170 180 DYIDAQFEAY LQEELKIKRS LFTYHDSRIH VCLYFISPTG HSLKTLDLLT MKNLDSKVNI 190 200 210 220 230 240 IPVIAKADTV SKTELQKFKI KLMSELVSNG VQIYQFPTDD DTIAKVNAAM NGQLPFAVVG 250 260 270 280 290 300 SMDEVKVGNK MVKARQYPWG VVQVENENHC DFVKLREMLI CTNMEDLREQ THTRHYELYR 310 320 330 340 350 360 RCKLEEMGFT DVGPENKPVS VQETYEAKRH EFHGERQRKE EEMKQMFVQR VKEKEAILKE 370 380 390 400 410 420 AERELQAKFE HLKRLHQEER MKLEEKRRLL EEEIIAFSKK KATSEIFHSQ SFLATGSNLR 430 KDKDRKNSNF L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and functional characterization of human septin 10, a novel member of septin family cloned from dendritic cells." Sui L., Zhang W., Liu Q., Chen T., Li N., Wan T., Yu M., Cao X. Biochem. Biophys. Res. Commun. 304:393-398(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), GTPASE ACTIVITY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Dendritic cell.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
[3]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Testis and Uterus.
[6]	"Expression profiling the human septin gene family." Hall P.A., Jung K., Hillan K.J., Russell S.E.H. J. Pathol. 206:269-278(2005) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF146760 mRNA. Translation: AAF67469.1. Frameshift. AK092033 mRNA. Translation: BAG52471.1. AK021681 mRNA. Translation: BAB13873.1. AC140485 Genomic DNA. Translation: AAY24142.1. CH471182 Genomic DNA. Translation: EAW53864.1. BC020502 mRNA. Translation: AAH20502.1. BC050345 mRNA. Translation: AAH50345.2. Frameshift.
IPI	IPI00374970. IPI00872036. IPI00873459.
RefSeq	NP_653311.1. NM_144710.3. NP_848699.1. NM_178584.2.
UniGene	Hs.469615.
3D structure databases
ProteinModelPortal	Q9P0V9.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9P0V9. 2 interactions.
MINT	MINT-6945309.
STRING	9606.ENSP00000380824.
PTM databases
PhosphoSite	Q9P0V9.
Polymorphism databases
DMDM	160400057.
Proteomic databases
PaxDb	Q9P0V9.
PRIDE	Q9P0V9.
Protocols and materials databases
DNASU	151011.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000397712; ENSP00000380824; ENSG00000186522. ENST00000397714; ENSP00000380826; ENSG00000186522.
GeneID	151011.
KEGG	hsa:151011.
UCSC	uc002tew.3. human. uc002tex.3. human.
Organism-specific databases
CTD	151011.
GeneCards	GC02M110300.
H-InvDB	HIX0018271.
HGNC	HGNC:14349. SEPT10.
HPA	HPA056304.
MIM	611737. gene.
neXtProt	NX_Q9P0V9.
PharmGKB	PA134918683.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5019.
HOGENOM	HOG000233586.
HOVERGEN	HBG065093.
Gene expression databases
ArrayExpress	Q9P0V9.
Bgee	Q9P0V9.
CleanEx	HS_SEPT10.
Genevestigator	Q9P0V9.
GermOnline	ENSG00000186522. Homo sapiens.
Family and domain databases
InterPro	IPR000038. Cell_div_GTP-bd. IPR016491. Septin. [Graphical view]
PANTHER	PTHR18884. PTHR18884. 1 hit.
Pfam	PF00735. Septin. 1 hit. [Graphical view]
PIRSF	PIRSF006698. Septin. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	151011.
NextBio	86574.
SOURCE	Search...

Entry information

Entry name

SEP10_HUMAN

Accession

Primary (citable) accession number: Q9P0V9
Secondary accession number(s): B3KRQ9, Q86VP5, Q9HAH6

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 21, 2005
Last sequence update:	October 23, 2007
Last modified:	May 1, 2013
This is version 88 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.