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Protein

SLAM family member 8

Gene

SLAMF8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor.1 Publication

Enzyme and pathway databases

BioCyciZFISH:ENSG00000158714-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
SLAM family member 8
Alternative name(s):
B-lymphocyte activator macrophage expressed
BCM-like membrane protein
CD_antigen: CD353
Gene namesi
Name:SLAMF8
Synonyms:BLAME
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:21391. SLAMF8.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 233ExtracellularSequence analysisAdd BLAST211
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Topological domaini255 – 285CytoplasmicSequence analysisAdd BLAST31

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi56833.
OpenTargetsiENSG00000158714.
PharmGKBiPA134983606.

Polymorphism and mutation databases

BioMutaiSLAMF8.
DMDMi67461583.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
ChainiPRO_000001496523 – 285SLAM family member 8Add BLAST263

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi85N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi152 ↔ 201PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9P0V8.
PeptideAtlasiQ9P0V8.
PRIDEiQ9P0V8.

Expressioni

Tissue specificityi

Expressed in lymph node, spleen, thymus and bone marrow.1 Publication

Gene expression databases

BgeeiENSG00000158714.
CleanExiHS_SLAMF8.
GenevisibleiQ9P0V8. HS.

Interactioni

Protein-protein interaction databases

BioGridi121206. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ9P0V8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini128 – 215Ig-like C2-typeAdd BLAST88

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVMT. Eukaryota.
ENOG410Y74Q. LUCA.
GeneTreeiENSGT00510000048737.
HOGENOMiHOG000133036.
HOVERGENiHBG083118.
InParanoidiQ9P0V8.
KOiK16853.
OMAiNFSVLMV.
OrthoDBiEOG091G0GFI.
PhylomeDBiQ9P0V8.
TreeFamiTF334964.

Family and domain databases

InterProiIPR007110. Ig-like_dom.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P0V8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVMRPLWSLL LWEALLPITV TGAQVLSKVG GSVLLVAARP PGFQVREAIW
60 70 80 90 100
RSLWPSEELL ATFFRGSLET LYHSRFLGRA QLHSNLSLEL GPLESGDSGN
110 120 130 140 150
FSVLMVDTRG QPWTQTLQLK VYDAVPRPVV QVFIAVERDA QPSKTCQVFL
160 170 180 190 200
SCWAPNISEI TYSWRRETTM DFGMEPHSLF TDGQVLSISL GPGDRDVAYS
210 220 230 240 250
CIVSNPVSWD LATVTPWDSC HHEAAPGKAS YKDVLLVVVP VSLLLMLVTL
260 270 280
FSAWHWCPCS GKKKKDVHAD RVGPETENPL VQDLP
Length:285
Mass (Da):31,670
Last modified:October 1, 2000 - v1
Checksum:i1BA63F4F90739AB2
GO
Isoform 2 (identifier: Q9P0V8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     14-122: Missing.

Note: No experimental confirmation available.
Show »
Length:176
Mass (Da):19,707
Checksum:iA96ABE0AFAEDC4F9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0499405P → T.Corresponds to variant rs2494514dbSNPEnsembl.1
Natural variantiVAR_04994199G → S.1 PublicationCorresponds to variant rs34687326dbSNPEnsembl.1
Natural variantiVAR_049942129V → M.Corresponds to variant rs3795331dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01389614 – 122Missing in isoform 2. CuratedAdd BLAST109

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF146761 mRNA. Translation: AAF67470.1.
AK074669 mRNA. Translation: BAC11123.1.
AL590560 Genomic DNA. Translation: CAH71103.1.
AL590560 Genomic DNA. Translation: CAH71104.1.
BC109194 mRNA. Translation: AAI09195.1.
CCDSiCCDS1188.1. [Q9P0V8-1]
CCDS81387.1. [Q9P0V8-2]
RefSeqiNP_001317670.1. NM_001330741.1.
NP_064510.1. NM_020125.2. [Q9P0V8-1]
UniGeneiHs.438683.

Genome annotation databases

EnsembliENST00000289707; ENSP00000289707; ENSG00000158714. [Q9P0V8-1]
ENST00000368104; ENSP00000357084; ENSG00000158714. [Q9P0V8-2]
GeneIDi56833.
KEGGihsa:56833.
UCSCiuc001fue.5. human. [Q9P0V8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF146761 mRNA. Translation: AAF67470.1.
AK074669 mRNA. Translation: BAC11123.1.
AL590560 Genomic DNA. Translation: CAH71103.1.
AL590560 Genomic DNA. Translation: CAH71104.1.
BC109194 mRNA. Translation: AAI09195.1.
CCDSiCCDS1188.1. [Q9P0V8-1]
CCDS81387.1. [Q9P0V8-2]
RefSeqiNP_001317670.1. NM_001330741.1.
NP_064510.1. NM_020125.2. [Q9P0V8-1]
UniGeneiHs.438683.

3D structure databases

ProteinModelPortaliQ9P0V8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121206. 1 interactor.

Polymorphism and mutation databases

BioMutaiSLAMF8.
DMDMi67461583.

Proteomic databases

PaxDbiQ9P0V8.
PeptideAtlasiQ9P0V8.
PRIDEiQ9P0V8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000289707; ENSP00000289707; ENSG00000158714. [Q9P0V8-1]
ENST00000368104; ENSP00000357084; ENSG00000158714. [Q9P0V8-2]
GeneIDi56833.
KEGGihsa:56833.
UCSCiuc001fue.5. human. [Q9P0V8-1]

Organism-specific databases

CTDi56833.
DisGeNETi56833.
GeneCardsiSLAMF8.
HGNCiHGNC:21391. SLAMF8.
MIMi606620. gene.
neXtProtiNX_Q9P0V8.
OpenTargetsiENSG00000158714.
PharmGKBiPA134983606.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVMT. Eukaryota.
ENOG410Y74Q. LUCA.
GeneTreeiENSGT00510000048737.
HOGENOMiHOG000133036.
HOVERGENiHBG083118.
InParanoidiQ9P0V8.
KOiK16853.
OMAiNFSVLMV.
OrthoDBiEOG091G0GFI.
PhylomeDBiQ9P0V8.
TreeFamiTF334964.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000158714-MONOMER.

Miscellaneous databases

GeneWikiiSLAMF8.
GenomeRNAii56833.
PROiQ9P0V8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158714.
CleanExiHS_SLAMF8.
GenevisibleiQ9P0V8. HS.

Family and domain databases

InterProiIPR007110. Ig-like_dom.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSLAF8_HUMAN
AccessioniPrimary (citable) accession number: Q9P0V8
Secondary accession number(s): Q32MC6, Q5VU15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.