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Q9P0V8

- SLAF8_HUMAN

UniProt

Q9P0V8 - SLAF8_HUMAN

Protein

SLAM family member 8

Gene

SLAMF8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    May play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor.1 Publication

    GO - Molecular functioni

    1. receptor activity Source: InterPro

    GO - Biological processi

    1. cellular response to drug Source: Ensembl
    2. defense response to bacterium Source: Ensembl
    3. phagosome acidification Source: Ensembl
    4. regulation of kinase activity Source: Ensembl
    5. regulation of NAD(P)H oxidase activity Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SLAM family member 8
    Alternative name(s):
    B-lymphocyte activator macrophage expressed
    BCM-like membrane protein
    CD_antigen: CD353
    Gene namesi
    Name:SLAMF8
    Synonyms:BLAME
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:21391. SLAMF8.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134983606.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 22221 PublicationAdd
    BLAST
    Chaini23 – 285263SLAM family member 8PRO_0000014965Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi85 – 851N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi152 ↔ 201PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9P0V8.
    PRIDEiQ9P0V8.

    Expressioni

    Tissue specificityi

    Expressed in lymph node, spleen, thymus and bone marrow.1 Publication

    Gene expression databases

    BgeeiQ9P0V8.
    CleanExiHS_SLAMF8.
    GenevestigatoriQ9P0V8.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000289707.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9P0V8.
    SMRiQ9P0V8. Positions 26-212.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 233211ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini255 – 28531CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei234 – 25421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini128 – 21588Ig-like C2-typeAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46451.
    HOGENOMiHOG000133036.
    HOVERGENiHBG083118.
    InParanoidiQ9P0V8.
    KOiK16853.
    OMAiAQPPKTC.
    OrthoDBiEOG7CCBRS.
    PhylomeDBiQ9P0V8.
    TreeFamiTF334964.

    Family and domain databases

    InterProiIPR007110. Ig-like_dom.
    IPR015631. SLAM_fam_rcpts.
    [Graphical view]
    PANTHERiPTHR12080. PTHR12080. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9P0V8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVMRPLWSLL LWEALLPITV TGAQVLSKVG GSVLLVAARP PGFQVREAIW    50
    RSLWPSEELL ATFFRGSLET LYHSRFLGRA QLHSNLSLEL GPLESGDSGN 100
    FSVLMVDTRG QPWTQTLQLK VYDAVPRPVV QVFIAVERDA QPSKTCQVFL 150
    SCWAPNISEI TYSWRRETTM DFGMEPHSLF TDGQVLSISL GPGDRDVAYS 200
    CIVSNPVSWD LATVTPWDSC HHEAAPGKAS YKDVLLVVVP VSLLLMLVTL 250
    FSAWHWCPCS GKKKKDVHAD RVGPETENPL VQDLP 285
    Length:285
    Mass (Da):31,670
    Last modified:October 1, 2000 - v1
    Checksum:i1BA63F4F90739AB2
    GO
    Isoform 2 (identifier: Q9P0V8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         14-122: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:176
    Mass (Da):19,707
    Checksum:iA96ABE0AFAEDC4F9
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti5 – 51P → T.
    Corresponds to variant rs2494514 [ dbSNP | Ensembl ].
    VAR_049940
    Natural varianti99 – 991G → S.1 Publication
    Corresponds to variant rs34687326 [ dbSNP | Ensembl ].
    VAR_049941
    Natural varianti129 – 1291V → M.
    Corresponds to variant rs3795331 [ dbSNP | Ensembl ].
    VAR_049942

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei14 – 122109Missing in isoform 2. CuratedVSP_013896Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF146761 mRNA. Translation: AAF67470.1.
    AK074669 mRNA. Translation: BAC11123.1.
    AL590560 Genomic DNA. Translation: CAH71103.1.
    AL590560 Genomic DNA. Translation: CAH71104.1.
    BC109194 mRNA. Translation: AAI09195.1.
    CCDSiCCDS1188.1. [Q9P0V8-1]
    RefSeqiNP_064510.1. NM_020125.2. [Q9P0V8-1]
    UniGeneiHs.438683.

    Genome annotation databases

    EnsembliENST00000289707; ENSP00000289707; ENSG00000158714. [Q9P0V8-1]
    ENST00000368104; ENSP00000357084; ENSG00000158714. [Q9P0V8-2]
    GeneIDi56833.
    KEGGihsa:56833.
    UCSCiuc001fue.4. human. [Q9P0V8-1]

    Polymorphism databases

    DMDMi67461583.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF146761 mRNA. Translation: AAF67470.1 .
    AK074669 mRNA. Translation: BAC11123.1 .
    AL590560 Genomic DNA. Translation: CAH71103.1 .
    AL590560 Genomic DNA. Translation: CAH71104.1 .
    BC109194 mRNA. Translation: AAI09195.1 .
    CCDSi CCDS1188.1. [Q9P0V8-1 ]
    RefSeqi NP_064510.1. NM_020125.2. [Q9P0V8-1 ]
    UniGenei Hs.438683.

    3D structure databases

    ProteinModelPortali Q9P0V8.
    SMRi Q9P0V8. Positions 26-212.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000289707.

    Polymorphism databases

    DMDMi 67461583.

    Proteomic databases

    PaxDbi Q9P0V8.
    PRIDEi Q9P0V8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000289707 ; ENSP00000289707 ; ENSG00000158714 . [Q9P0V8-1 ]
    ENST00000368104 ; ENSP00000357084 ; ENSG00000158714 . [Q9P0V8-2 ]
    GeneIDi 56833.
    KEGGi hsa:56833.
    UCSCi uc001fue.4. human. [Q9P0V8-1 ]

    Organism-specific databases

    CTDi 56833.
    GeneCardsi GC01P159796.
    HGNCi HGNC:21391. SLAMF8.
    MIMi 606620. gene.
    neXtProti NX_Q9P0V8.
    PharmGKBi PA134983606.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46451.
    HOGENOMi HOG000133036.
    HOVERGENi HBG083118.
    InParanoidi Q9P0V8.
    KOi K16853.
    OMAi AQPPKTC.
    OrthoDBi EOG7CCBRS.
    PhylomeDBi Q9P0V8.
    TreeFami TF334964.

    Miscellaneous databases

    GeneWikii SLAMF8.
    GenomeRNAii 56833.
    NextBioi 62236.
    PROi Q9P0V8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9P0V8.
    CleanExi HS_SLAMF8.
    Genevestigatori Q9P0V8.

    Family and domain databases

    InterProi IPR007110. Ig-like_dom.
    IPR015631. SLAM_fam_rcpts.
    [Graphical view ]
    PANTHERi PTHR12080. PTHR12080. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, VARIANT SER-99.
      Tissue: Lymphocyte.
    2. "Novel human cell membrane protein."
      Zhang W., Wan T., Cao X.
      Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Mammary gland.
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 23-37.

    Entry informationi

    Entry nameiSLAF8_HUMAN
    AccessioniPrimary (citable) accession number: Q9P0V8
    Secondary accession number(s): Q32MC6, Q5VU15
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3