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Q9P0U1

- TOM7_HUMAN

UniProt

Q9P0U1 - TOM7_HUMAN

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Protein

Mitochondrial import receptor subunit TOM7 homolog

Gene

TOMM7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Required for assembly and stability of the TOM complex. Positive regulator of PARK2 translocation to damaged mitochondria. Acts probably by stabilizing PINK1 on the outer membrane of depolarized mitochondria.2 Publications

GO - Molecular functioni

  1. protein transmembrane transporter activity Source: BHF-UCL

GO - Biological processi

  1. cellular protein metabolic process Source: Reactome
  2. protein import into mitochondrial matrix Source: InterPro
  3. protein targeting to mitochondrion Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiREACT_118595. Mitochondrial protein import.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM7 homolog
Alternative name(s):
Translocase of outer membrane 7 kDa subunit homolog
Gene namesi
Name:TOMM7
Synonyms:TOM7, TOMM07
ORF Names:AD-014
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:21648. TOMM7.

Subcellular locationi

Mitochondrion outer membrane 1 Publication; Single-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020Cytoplasmic1 PublicationAdd
BLAST
Transmembranei21 – 3616HelicalSequence AnalysisAdd
BLAST
Topological domaini37 – 5519Mitochondrial intermembrane1 PublicationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial outer membrane translocase complex Source: BHF-UCL
  3. mitochondrion Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134864325.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5555Mitochondrial import receptor subunit TOM7 homologPRO_0000046759Add
BLAST

Proteomic databases

MaxQBiQ9P0U1.
PaxDbiQ9P0U1.
PeptideAtlasiQ9P0U1.
PRIDEiQ9P0U1.

PTM databases

PhosphoSiteiQ9P0U1.

Expressioni

Gene expression databases

BgeeiQ9P0U1.
CleanExiHS_TOMM7.
ExpressionAtlasiQ9P0U1. baseline and differential.
GenevestigatoriQ9P0U1.

Interactioni

Subunit structurei

Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TOMM22Q9NS692EBI-1180558,EBI-1047508

Protein-protein interaction databases

BioGridi120030. 19 interactions.
IntActiQ9P0U1. 2 interactions.
STRINGi9606.ENSP00000351214.

Structurei

3D structure databases

ProteinModelPortaliQ9P0U1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Tom7 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG117169.
GeneTreeiENSGT00390000014833.
HOVERGENiHBG065915.
InParanoidiQ9P0U1.
KOiK17771.
OrthoDBiEOG7CCBV6.
PhylomeDBiQ9P0U1.
TreeFamiTF106199.

Family and domain databases

InterProiIPR012621. Tom7.
[Graphical view]
PfamiPF08038. Tom7. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P0U1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVKLSKEAKQ RLQQLFKGSQ FAIRWGFIPL VIYLGFKRGA DPGMPEPTVL

SLLWG
Length:55
Mass (Da):6,248
Last modified:October 1, 2000 - v1
Checksum:i720E850940262ED1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti45 – 451P → S in CAB38060. (PubMed:10647823)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011007 mRNA. Translation: CAB38060.1.
AF150733 mRNA. Translation: AAF67473.1.
BC001732 mRNA. Translation: AAH01732.1.
CCDSiCCDS5376.1.
RefSeqiNP_061932.1. NM_019059.3.
UniGeneiHs.112318.

Genome annotation databases

EnsembliENST00000358435; ENSP00000351214; ENSG00000196683.
GeneIDi54543.
KEGGihsa:54543.
UCSCiuc003svk.4. human.

Polymorphism databases

DMDMi12643829.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011007 mRNA. Translation: CAB38060.1 .
AF150733 mRNA. Translation: AAF67473.1 .
BC001732 mRNA. Translation: AAH01732.1 .
CCDSi CCDS5376.1.
RefSeqi NP_061932.1. NM_019059.3.
UniGenei Hs.112318.

3D structure databases

ProteinModelPortali Q9P0U1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120030. 19 interactions.
IntActi Q9P0U1. 2 interactions.
STRINGi 9606.ENSP00000351214.

PTM databases

PhosphoSitei Q9P0U1.

Polymorphism databases

DMDMi 12643829.

Proteomic databases

MaxQBi Q9P0U1.
PaxDbi Q9P0U1.
PeptideAtlasi Q9P0U1.
PRIDEi Q9P0U1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000358435 ; ENSP00000351214 ; ENSG00000196683 .
GeneIDi 54543.
KEGGi hsa:54543.
UCSCi uc003svk.4. human.

Organism-specific databases

CTDi 54543.
GeneCardsi GC07M022853.
HGNCi HGNC:21648. TOMM7.
MIMi 607980. gene.
neXtProti NX_Q9P0U1.
PharmGKBi PA134864325.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG117169.
GeneTreei ENSGT00390000014833.
HOVERGENi HBG065915.
InParanoidi Q9P0U1.
KOi K17771.
OrthoDBi EOG7CCBV6.
PhylomeDBi Q9P0U1.
TreeFami TF106199.

Enzyme and pathway databases

Reactomei REACT_118595. Mitochondrial protein import.

Miscellaneous databases

ChiTaRSi TOMM7. human.
GenomeRNAii 54543.
NextBioi 56991.
PROi Q9P0U1.
SOURCEi Search...

Gene expression databases

Bgeei Q9P0U1.
CleanExi HS_TOMM7.
ExpressionAtlasi Q9P0U1. baseline and differential.
Genevestigatori Q9P0U1.

Family and domain databases

InterProi IPR012621. Tom7.
[Graphical view ]
Pfami PF08038. Tom7. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of the human novel gene encoding 6.2 kDa protein highly expressed upon ultraviolet irradiation in DNA-PK-deleted human glioma M059J cells."
    Lee J.-S.
    DNA Seq. 10:195-198(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain tumor.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Adrenal gland.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  4. "Insertion and assembly of human tom7 into the preprotein translocase complex of the outer mitochondrial membrane."
    Johnston A.J., Hoogenraad J., Dougan D.A., Truscott K.N., Yano M., Mori M., Hoogenraad N.J., Ryan M.T.
    J. Biol. Chem. 277:42197-42204(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, IDENTIFICATION IN THE TOM COMPLEX WITH TOMM20; TOMM22 AND TOMM40, TOPOLOGY.
  5. "Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane."
    Kato H., Mihara K.
    Biochem. Biophys. Res. Commun. 369:958-963(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE TOM COMPLEX.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy."
    Hasson S.A., Kane L.A., Yamano K., Huang C.H., Sliter D.A., Buehler E., Wang C., Heman-Ackah S.M., Hessa T., Guha R., Martin S.E., Youle R.J.
    Nature 504:291-295(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiTOM7_HUMAN
AccessioniPrimary (citable) accession number: Q9P0U1
Secondary accession number(s): O95939
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3