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Q9P0U1 (TOM7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitochondrial import receptor subunit TOM7 homolog
Alternative name(s):
Translocase of outer membrane 7 kDa subunit homolog
Gene names
Name:TOMM7
Synonyms:TOM7, TOMM07
ORF Names:AD-014
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length55 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for assembly and stability of the TOM complex. Ref.5

Subunit structure

Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Ref.4 Ref.5

Subcellular location

Mitochondrion outer membrane; Single-pass membrane protein Ref.4.

Sequence similarities

Belongs to the Tom7 family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

TOMM22Q9NS692EBI-1180558,EBI-1047508

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 5555Mitochondrial import receptor subunit TOM7 homolog
PRO_0000046759

Regions

Topological domain1 – 2020Cytoplasmic Ref.4
Transmembrane21 – 3616Helical; Potential
Topological domain37 – 5519Mitochondrial intermembrane Ref.4

Experimental info

Sequence conflict451P → S in CAB38060. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9P0U1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 720E850940262ED1

FASTA556,248
        10         20         30         40         50 
MVKLSKEAKQ RLQQLFKGSQ FAIRWGFIPL VIYLGFKRGA DPGMPEPTVL SLLWG 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of the human novel gene encoding 6.2 kDa protein highly expressed upon ultraviolet irradiation in DNA-PK-deleted human glioma M059J cells."
Lee J.-S.
DNA Seq. 10:195-198(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain tumor.
[2]"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning."
Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. expand/collapse author list , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L.
Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Adrenal gland.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
[4]"Insertion and assembly of human tom7 into the preprotein translocase complex of the outer mitochondrial membrane."
Johnston A.J., Hoogenraad J., Dougan D.A., Truscott K.N., Yano M., Mori M., Hoogenraad N.J., Ryan M.T.
J. Biol. Chem. 277:42197-42204(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, IDENTIFICATION IN THE TOM COMPLEX WITH TOMM20; TOMM22 AND TOMM40, TOPOLOGY.
[5]"Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane."
Kato H., Mihara K.
Biochem. Biophys. Res. Commun. 369:958-963(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, IDENTIFICATION IN THE TOM COMPLEX.
[6]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ011007 mRNA. Translation: CAB38060.1.
AF150733 mRNA. Translation: AAF67473.1.
BC001732 mRNA. Translation: AAH01732.1.
RefSeqNP_061932.1. NM_019059.3.
UniGeneHs.112318.

3D structure databases

ProteinModelPortalQ9P0U1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120030. 19 interactions.
IntActQ9P0U1. 2 interactions.
STRING9606.ENSP00000351214.

PTM databases

PhosphoSiteQ9P0U1.

Polymorphism databases

DMDM12643829.

Proteomic databases

PaxDbQ9P0U1.
PeptideAtlasQ9P0U1.
PRIDEQ9P0U1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000358435; ENSP00000351214; ENSG00000196683.
GeneID54543.
KEGGhsa:54543.
UCSCuc003svk.4. human.

Organism-specific databases

CTD54543.
GeneCardsGC07M022818.
HGNCHGNC:21648. TOMM7.
MIM607980. gene.
neXtProtNX_Q9P0U1.
PharmGKBPA134864325.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG117169.
HOVERGENHBG065915.
KOK17771.
OrthoDBEOG7CCBV6.
PhylomeDBQ9P0U1.
TreeFamTF106199.

Enzyme and pathway databases

ReactomeREACT_17015. Metabolism of proteins.

Gene expression databases

ArrayExpressQ9P0U1.
BgeeQ9P0U1.
CleanExHS_TOMM7.
GenevestigatorQ9P0U1.

Family and domain databases

InterProIPR012621. Tom7.
[Graphical view]
PfamPF08038. Tom7. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTOMM7. human.
GenomeRNAi54543.
NextBio56991.
PROQ9P0U1.
SOURCESearch...

Entry information

Entry nameTOM7_HUMAN
AccessionPrimary (citable) accession number: Q9P0U1
Secondary accession number(s): O95939
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM