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Q9P0U1

- TOM7_HUMAN

UniProt

Q9P0U1 - TOM7_HUMAN

Protein

Mitochondrial import receptor subunit TOM7 homolog

Gene

TOMM7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Required for assembly and stability of the TOM complex. Positive regulator of PARK2 translocation to damaged mitochondria. Acts probably by stabilizing PINK1 on the outer membrane of depolarized mitochondria.2 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. protein transmembrane transporter activity Source: BHF-UCL

    GO - Biological processi

    1. cellular protein metabolic process Source: Reactome
    2. protein import into mitochondrial matrix Source: InterPro
    3. protein targeting to mitochondrion Source: BHF-UCL

    Keywords - Biological processi

    Protein transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_118595. Mitochondrial protein import.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial import receptor subunit TOM7 homolog
    Alternative name(s):
    Translocase of outer membrane 7 kDa subunit homolog
    Gene namesi
    Name:TOMM7
    Synonyms:TOM7, TOMM07
    ORF Names:AD-014
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:21648. TOMM7.

    Subcellular locationi

    Mitochondrion outer membrane 1 Publication; Single-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial outer membrane translocase complex Source: BHF-UCL
    3. mitochondrion Source: BHF-UCL

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion outer membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134864325.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 5555Mitochondrial import receptor subunit TOM7 homologPRO_0000046759Add
    BLAST

    Proteomic databases

    MaxQBiQ9P0U1.
    PaxDbiQ9P0U1.
    PeptideAtlasiQ9P0U1.
    PRIDEiQ9P0U1.

    PTM databases

    PhosphoSiteiQ9P0U1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9P0U1.
    BgeeiQ9P0U1.
    CleanExiHS_TOMM7.
    GenevestigatoriQ9P0U1.

    Interactioni

    Subunit structurei

    Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70).2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TOMM22Q9NS692EBI-1180558,EBI-1047508

    Protein-protein interaction databases

    BioGridi120030. 19 interactions.
    IntActiQ9P0U1. 2 interactions.
    STRINGi9606.ENSP00000351214.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9P0U1.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2020Cytoplasmic1 PublicationAdd
    BLAST
    Topological domaini37 – 5519Mitochondrial intermembrane1 PublicationAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei21 – 3616HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Tom7 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG117169.
    HOVERGENiHBG065915.
    KOiK17771.
    OrthoDBiEOG7CCBV6.
    PhylomeDBiQ9P0U1.
    TreeFamiTF106199.

    Family and domain databases

    InterProiIPR012621. Tom7.
    [Graphical view]
    PfamiPF08038. Tom7. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9P0U1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVKLSKEAKQ RLQQLFKGSQ FAIRWGFIPL VIYLGFKRGA DPGMPEPTVL   50
    SLLWG 55
    Length:55
    Mass (Da):6,248
    Last modified:October 1, 2000 - v1
    Checksum:i720E850940262ED1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti45 – 451P → S in CAB38060. (PubMed:10647823)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ011007 mRNA. Translation: CAB38060.1.
    AF150733 mRNA. Translation: AAF67473.1.
    BC001732 mRNA. Translation: AAH01732.1.
    CCDSiCCDS5376.1.
    RefSeqiNP_061932.1. NM_019059.3.
    UniGeneiHs.112318.

    Genome annotation databases

    EnsembliENST00000358435; ENSP00000351214; ENSG00000196683.
    GeneIDi54543.
    KEGGihsa:54543.
    UCSCiuc003svk.4. human.

    Polymorphism databases

    DMDMi12643829.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ011007 mRNA. Translation: CAB38060.1 .
    AF150733 mRNA. Translation: AAF67473.1 .
    BC001732 mRNA. Translation: AAH01732.1 .
    CCDSi CCDS5376.1.
    RefSeqi NP_061932.1. NM_019059.3.
    UniGenei Hs.112318.

    3D structure databases

    ProteinModelPortali Q9P0U1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120030. 19 interactions.
    IntActi Q9P0U1. 2 interactions.
    STRINGi 9606.ENSP00000351214.

    PTM databases

    PhosphoSitei Q9P0U1.

    Polymorphism databases

    DMDMi 12643829.

    Proteomic databases

    MaxQBi Q9P0U1.
    PaxDbi Q9P0U1.
    PeptideAtlasi Q9P0U1.
    PRIDEi Q9P0U1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000358435 ; ENSP00000351214 ; ENSG00000196683 .
    GeneIDi 54543.
    KEGGi hsa:54543.
    UCSCi uc003svk.4. human.

    Organism-specific databases

    CTDi 54543.
    GeneCardsi GC07M022818.
    HGNCi HGNC:21648. TOMM7.
    MIMi 607980. gene.
    neXtProti NX_Q9P0U1.
    PharmGKBi PA134864325.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG117169.
    HOVERGENi HBG065915.
    KOi K17771.
    OrthoDBi EOG7CCBV6.
    PhylomeDBi Q9P0U1.
    TreeFami TF106199.

    Enzyme and pathway databases

    Reactomei REACT_118595. Mitochondrial protein import.

    Miscellaneous databases

    ChiTaRSi TOMM7. human.
    GenomeRNAii 54543.
    NextBioi 56991.
    PROi Q9P0U1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9P0U1.
    Bgeei Q9P0U1.
    CleanExi HS_TOMM7.
    Genevestigatori Q9P0U1.

    Family and domain databases

    InterProi IPR012621. Tom7.
    [Graphical view ]
    Pfami PF08038. Tom7. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of the human novel gene encoding 6.2 kDa protein highly expressed upon ultraviolet irradiation in DNA-PK-deleted human glioma M059J cells."
      Lee J.-S.
      DNA Seq. 10:195-198(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain tumor.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Adrenal gland.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.
    4. "Insertion and assembly of human tom7 into the preprotein translocase complex of the outer mitochondrial membrane."
      Johnston A.J., Hoogenraad J., Dougan D.A., Truscott K.N., Yano M., Mori M., Hoogenraad N.J., Ryan M.T.
      J. Biol. Chem. 277:42197-42204(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, IDENTIFICATION IN THE TOM COMPLEX WITH TOMM20; TOMM22 AND TOMM40, TOPOLOGY.
    5. "Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane."
      Kato H., Mihara K.
      Biochem. Biophys. Res. Commun. 369:958-963(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION IN THE TOM COMPLEX.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy."
      Hasson S.A., Kane L.A., Yamano K., Huang C.H., Sliter D.A., Buehler E., Wang C., Heman-Ackah S.M., Hessa T., Guha R., Martin S.E., Youle R.J.
      Nature 504:291-295(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiTOM7_HUMAN
    AccessioniPrimary (citable) accession number: Q9P0U1
    Secondary accession number(s): O95939
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3