Q9P0U1 (TOM7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mitochondrial import receptor subunit TOM7 homolog

Alternative name(s):
Translocase of outer membrane 7 kDa subunit homolog

Gene names

Name:	TOMM7
Synonyms:	TOM7, TOMM07
ORF Names:	AD-014

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	55 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for assembly and stability of the TOM complex. Ref.5
Subunit structure	Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Ref.4 Ref.5
Subcellular location	Mitochondrion outer membrane; Single-pass membrane protein Ref.4.
Sequence similarities	Belongs to the Tom7 family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Membrane Mitochondrion Mitochondrion outer membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular protein metabolic process Traceable author statement. Source: Reactome protein import into mitochondrial matrix Inferred from electronic annotation. Source: InterPro protein targeting to mitochondrion Traceable author statement PubMed 15644312. Source: BHF-UCL
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial outer membrane translocase complex Inferred from direct assay Ref.4. Source: BHF-UCL
Molecular_function	protein transmembrane transporter activity Traceable author statement PubMed 15644312. Source: BHF-UCL
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
TOMM22	Q9NS69	2	EBI-1180558,EBI-1047508

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 55	55	Mitochondrial import receptor subunit TOM7 homolog		PRO_0000046759
Regions
	Topological domain	1 – 20	20	Cytoplasmic Ref.4
	Transmembrane	21 – 36	16	Helical; Potential
	Topological domain	37 – 55	19	Mitochondrial intermembrane Ref.4
Experimental info
	Sequence conflict	45	1	P → S in CAB38060. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9P0U1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 720E850940262ED1	FASTA	55	6,248
	10 20 30 40 50 MVKLSKEAKQ RLQQLFKGSQ FAIRWGFIPL VIYLGFKRGA DPGMPEPTVL SLLWG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of the human novel gene encoding 6.2 kDa protein highly expressed upon ultraviolet irradiation in DNA-PK-deleted human glioma M059J cells." Lee J.-S. DNA Seq. 10:195-198(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain tumor.
[2]	"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L. Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Adrenal gland.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
[4]	"Insertion and assembly of human tom7 into the preprotein translocase complex of the outer mitochondrial membrane." Johnston A.J., Hoogenraad J., Dougan D.A., Truscott K.N., Yano M., Mori M., Hoogenraad N.J., Ryan M.T. J. Biol. Chem. 277:42197-42204(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, IDENTIFICATION IN THE TOM COMPLEX WITH TOMM20; TOMM22 AND TOMM40, TOPOLOGY.
[5]	"Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane." Kato H., Mihara K. Biochem. Biophys. Res. Commun. 369:958-963(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, IDENTIFICATION IN TOM COMPLEX.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ011007 mRNA. Translation: CAB38060.1. AF150733 mRNA. Translation: AAF67473.1. BC001732 mRNA. Translation: AAH01732.1.
IPI	IPI00000980.
RefSeq	NP_061932.1. NM_019059.3.
UniGene	Hs.112318.
3D structure databases
ProteinModelPortal	Q9P0U1.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9P0U1. 2 interactions.
STRING	9606.ENSP00000351214.
PTM databases
PhosphoSite	Q9P0U1.
Polymorphism databases
DMDM	12643829.
Proteomic databases
PaxDb	Q9P0U1.
PeptideAtlas	Q9P0U1.
PRIDE	Q9P0U1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000358435; ENSP00000351214; ENSG00000196683.
GeneID	54543.
KEGG	hsa:54543.
UCSC	uc003svk.3. human.
Organism-specific databases
CTD	54543.
GeneCards	GC07M022818.
HGNC	HGNC:21648. TOMM7.
MIM	607980. gene.
neXtProt	NX_Q9P0U1.
PharmGKB	PA134864325.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG117169.
HOVERGEN	HBG065915.
OrthoDB	EOG48SGVT.
PhylomeDB	Q9P0U1.
Enzyme and pathway databases
Reactome	REACT_17015. Metabolism of proteins.
Gene expression databases
ArrayExpress	Q9P0U1.
Bgee	Q9P0U1.
CleanEx	HS_TOMM7.
Genevestigator	Q9P0U1.
GermOnline	ENSG00000196683. Homo sapiens.
Family and domain databases
InterPro	IPR012621. Tom7. [Graphical view]
Pfam	PF08038. Tom7. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TOMM7. human.
GenomeRNAi	54543.
NextBio	56991.
SOURCE	Search...

Entry information

Entry name

TOM7_HUMAN

Accession

Primary (citable) accession number: Q9P0U1
Secondary accession number(s): O95939

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.