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Protein

Mitochondrial import receptor subunit TOM7 homolog

Gene

TOMM7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for assembly and stability of the TOM complex. Positive regulator of PARK2 translocation to damaged mitochondria. Acts probably by stabilizing PINK1 on the outer membrane of depolarized mitochondria.2 Publications

GO - Molecular functioni

  • protein transmembrane transporter activity Source: BHF-UCL

GO - Biological processi

  • macroautophagy Source: Reactome
  • mitophagy in response to mitochondrial depolarization Source: ParkinsonsUK-UCL
  • positive regulation of protein targeting to mitochondrion Source: ParkinsonsUK-UCL
  • protein import into mitochondrial matrix Source: GO_Central
  • protein import into mitochondrial outer membrane Source: GO_Central
  • protein targeting to mitochondrion Source: BHF-UCL
  • regulation of protein stability Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciZFISH:G66-32949-MONOMER.
ReactomeiR-HSA-1268020. Mitochondrial protein import.
R-HSA-5205685. Pink/Parkin Mediated Mitophagy.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM7 homolog
Alternative name(s):
Translocase of outer membrane 7 kDa subunit homolog
Gene namesi
Name:TOMM7
Synonyms:TOM7, TOMM07
ORF Names:AD-014
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:21648. TOMM7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20Cytoplasmic1 PublicationAdd BLAST20
Transmembranei21 – 36HelicalSequence analysisAdd BLAST16
Topological domaini37 – 55Mitochondrial intermembrane1 PublicationAdd BLAST19

GO - Cellular componenti

  • integral component of mitochondrial outer membrane Source: GO_Central
  • mitochondrial outer membrane Source: Reactome
  • mitochondrial outer membrane translocase complex Source: BHF-UCL
  • mitochondrion Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi54543.
OpenTargetsiENSG00000196683.
PharmGKBiPA134864325.

Polymorphism and mutation databases

DMDMi12643829.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000467591 – 55Mitochondrial import receptor subunit TOM7 homologAdd BLAST55

Proteomic databases

EPDiQ9P0U1.
MaxQBiQ9P0U1.
PaxDbiQ9P0U1.
PeptideAtlasiQ9P0U1.
PRIDEiQ9P0U1.
TopDownProteomicsiQ9P0U1.

PTM databases

iPTMnetiQ9P0U1.
PhosphoSitePlusiQ9P0U1.

Expressioni

Gene expression databases

BgeeiENSG00000196683.
CleanExiHS_TOMM7.
ExpressionAtlasiQ9P0U1. baseline and differential.
GenevisibleiQ9P0U1. HS.

Interactioni

Subunit structurei

Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TOMM22Q9NS692EBI-1180558,EBI-1047508

Protein-protein interaction databases

BioGridi120030. 18 interactors.
IntActiQ9P0U1. 2 interactors.
STRINGi9606.ENSP00000351214.

Structurei

3D structure databases

ProteinModelPortaliQ9P0U1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Tom7 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4449. Eukaryota.
ENOG41123F4. LUCA.
GeneTreeiENSGT00390000014833.
HOVERGENiHBG065915.
InParanoidiQ9P0U1.
KOiK17771.
PhylomeDBiQ9P0U1.
TreeFamiTF106199.

Family and domain databases

InterProiIPR012621. Tom7.
[Graphical view]
PfamiPF08038. Tom7. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P0U1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKLSKEAKQ RLQQLFKGSQ FAIRWGFIPL VIYLGFKRGA DPGMPEPTVL

SLLWG
Length:55
Mass (Da):6,248
Last modified:October 1, 2000 - v1
Checksum:i720E850940262ED1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti45P → S in CAB38060 (PubMed:10647823).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011007 mRNA. Translation: CAB38060.1.
AF150733 mRNA. Translation: AAF67473.1.
BC001732 mRNA. Translation: AAH01732.1.
CCDSiCCDS5376.1.
RefSeqiNP_061932.1. NM_019059.3.
UniGeneiHs.112318.

Genome annotation databases

EnsembliENST00000358435; ENSP00000351214; ENSG00000196683.
GeneIDi54543.
KEGGihsa:54543.
UCSCiuc003svk.6. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011007 mRNA. Translation: CAB38060.1.
AF150733 mRNA. Translation: AAF67473.1.
BC001732 mRNA. Translation: AAH01732.1.
CCDSiCCDS5376.1.
RefSeqiNP_061932.1. NM_019059.3.
UniGeneiHs.112318.

3D structure databases

ProteinModelPortaliQ9P0U1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120030. 18 interactors.
IntActiQ9P0U1. 2 interactors.
STRINGi9606.ENSP00000351214.

PTM databases

iPTMnetiQ9P0U1.
PhosphoSitePlusiQ9P0U1.

Polymorphism and mutation databases

DMDMi12643829.

Proteomic databases

EPDiQ9P0U1.
MaxQBiQ9P0U1.
PaxDbiQ9P0U1.
PeptideAtlasiQ9P0U1.
PRIDEiQ9P0U1.
TopDownProteomicsiQ9P0U1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358435; ENSP00000351214; ENSG00000196683.
GeneIDi54543.
KEGGihsa:54543.
UCSCiuc003svk.6. human.

Organism-specific databases

CTDi54543.
DisGeNETi54543.
GeneCardsiTOMM7.
HGNCiHGNC:21648. TOMM7.
MIMi607980. gene.
neXtProtiNX_Q9P0U1.
OpenTargetsiENSG00000196683.
PharmGKBiPA134864325.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4449. Eukaryota.
ENOG41123F4. LUCA.
GeneTreeiENSGT00390000014833.
HOVERGENiHBG065915.
InParanoidiQ9P0U1.
KOiK17771.
PhylomeDBiQ9P0U1.
TreeFamiTF106199.

Enzyme and pathway databases

BioCyciZFISH:G66-32949-MONOMER.
ReactomeiR-HSA-1268020. Mitochondrial protein import.
R-HSA-5205685. Pink/Parkin Mediated Mitophagy.

Miscellaneous databases

ChiTaRSiTOMM7. human.
GenomeRNAii54543.
PROiQ9P0U1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196683.
CleanExiHS_TOMM7.
ExpressionAtlasiQ9P0U1. baseline and differential.
GenevisibleiQ9P0U1. HS.

Family and domain databases

InterProiIPR012621. Tom7.
[Graphical view]
PfamiPF08038. Tom7. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTOM7_HUMAN
AccessioniPrimary (citable) accession number: Q9P0U1
Secondary accession number(s): O95939
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.