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Protein

Transmembrane protein 9

Gene

TMEM9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in intracellular transport.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000116857-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 9
Alternative name(s):
Dermal papilla-derived protein 4
Gene namesi
Name:TMEM9
Synonyms:DERP41 Publication, TMEM9A
ORF Names:HSPC186, PSEC0012, UNQ631/PRO1248
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:18823. TMEM9.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 89ExtracellularSequence analysisAdd BLAST69
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Topological domaini111 – 183CytoplasmicSequence analysisAdd BLAST73

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • late endosome Source: UniProtKB
  • late endosome membrane Source: UniProtKB-SubCell
  • lysosomal membrane Source: UniProtKB-SubCell
  • lysosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi252839.
OpenTargetsiENSG00000116857.
PharmGKBiPA38696.

Polymorphism and mutation databases

DMDMi20532090.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000003437421 – 183Transmembrane protein 9Add BLAST163

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi21N-linked (GlcNAc...)Sequence analysis1
Glycosylationi38N-linked (GlcNAc...)Sequence analysis1
Glycosylationi47N-linked (GlcNAc...)Sequence analysis1
Modified residuei137PhosphoserineCombined sources1
Modified residuei144PhosphoserineCombined sources1

Post-translational modificationi

N-glycosylated.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9P0T7.
MaxQBiQ9P0T7.
PaxDbiQ9P0T7.
PeptideAtlasiQ9P0T7.
PRIDEiQ9P0T7.

PTM databases

iPTMnetiQ9P0T7.
PhosphoSitePlusiQ9P0T7.

Expressioni

Tissue specificityi

Highly expressed in adrenal gland, thyroid gland, testis, ovary and prostate. Moderate expression in trachea, spinal cord, stomach, colon, small intestine and spleen. Low expression in bone marrow, lymph node, thymus and peripheral blood lymphocytes. Expression was detected in hematopoietic cell lines including those of myeloid, erythroid, B- and T-cell origin.1 Publication

Gene expression databases

BgeeiENSG00000116857.
CleanExiHS_TMEM9.
ExpressionAtlasiQ9P0T7. baseline and differential.
GenevisibleiQ9P0T7. HS.

Organism-specific databases

HPAiHPA035616.

Interactioni

Subunit structurei

Dimer.Curated

Protein-protein interaction databases

BioGridi128927. 13 interactors.
IntActiQ9P0T7. 5 interactors.
MINTiMINT-4721075.
STRINGi9606.ENSP00000356298.

Structurei

3D structure databases

ProteinModelPortaliQ9P0T7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM9 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4007. Eukaryota.
ENOG4111KV2. LUCA.
GeneTreeiENSGT00390000000819.
HOVERGENiHBG050972.
InParanoidiQ9P0T7.
PhylomeDBiQ9P0T7.
TreeFamiTF315146.

Family and domain databases

InterProiIPR008853. TMEM9.
[Graphical view]
PANTHERiPTHR13064. PTHR13064. 1 hit.
PfamiPF05434. Tmemb_9. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9P0T7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLSLVAVV GCLLVPPAEA NKSSEDIRCK CICPPYRNIS GHIYNQNVSQ
60 70 80 90 100
KDCNCLHVVE PMPVPGHDVE AYCLLCECRY EERSTTTIKV IIVIYLSVVG
110 120 130 140 150
ALLLYMAFLM LVDPLIRKPD AYTEQLHNEE ENEDARSMAA AAASLGGPRA
160 170 180
NTVLERVEGA QQRWKLQVQE QRKTVFDRHK MLS
Length:183
Mass (Da):20,574
Last modified:October 1, 2000 - v1
Checksum:i6BC020EC9FE7F70E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22K → KVRE in BAB70820 (PubMed:14702039).Curated1
Sequence conflicti53C → CCS in CAB66535 (PubMed:11230166).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY138587 mRNA. Translation: AAN15925.1.
AB013909 mRNA. Translation: BAB87799.1.
AF151020 mRNA. Translation: AAF36106.1.
AL136600 mRNA. Translation: CAB66535.1.
AY359012 mRNA. Translation: AAQ89371.1.
AK054883 mRNA. Translation: BAB70820.1.
AK075335 mRNA. Translation: BAC11554.1.
AL139159 Genomic DNA. Translation: CAI23212.1.
CH471067 Genomic DNA. Translation: EAW91338.1.
BC001106 mRNA. Translation: AAH01106.1.
CCDSiCCDS1408.1.
RefSeqiNP_001275493.1. NM_001288564.1.
NP_001275494.1. NM_001288565.1.
NP_001275495.1. NM_001288566.1.
NP_001275496.1. NM_001288567.1.
NP_001275497.1. NM_001288568.1.
NP_001275498.1. NM_001288569.1.
NP_001275499.1. NM_001288570.1.
NP_001275500.1. NM_001288571.1.
NP_057540.1. NM_016456.4.
XP_011507687.1. XM_011509385.1.
XP_011507688.1. XM_011509386.2.
XP_011507689.1. XM_011509387.2.
UniGeneiHs.181444.

Genome annotation databases

EnsembliENST00000367330; ENSP00000356299; ENSG00000116857.
ENST00000367333; ENSP00000356302; ENSG00000116857.
ENST00000367334; ENSP00000356303; ENSG00000116857.
ENST00000485839; ENSP00000476893; ENSG00000116857.
GeneIDi252839.
KEGGihsa:252839.
UCSCiuc001gvx.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY138587 mRNA. Translation: AAN15925.1.
AB013909 mRNA. Translation: BAB87799.1.
AF151020 mRNA. Translation: AAF36106.1.
AL136600 mRNA. Translation: CAB66535.1.
AY359012 mRNA. Translation: AAQ89371.1.
AK054883 mRNA. Translation: BAB70820.1.
AK075335 mRNA. Translation: BAC11554.1.
AL139159 Genomic DNA. Translation: CAI23212.1.
CH471067 Genomic DNA. Translation: EAW91338.1.
BC001106 mRNA. Translation: AAH01106.1.
CCDSiCCDS1408.1.
RefSeqiNP_001275493.1. NM_001288564.1.
NP_001275494.1. NM_001288565.1.
NP_001275495.1. NM_001288566.1.
NP_001275496.1. NM_001288567.1.
NP_001275497.1. NM_001288568.1.
NP_001275498.1. NM_001288569.1.
NP_001275499.1. NM_001288570.1.
NP_001275500.1. NM_001288571.1.
NP_057540.1. NM_016456.4.
XP_011507687.1. XM_011509385.1.
XP_011507688.1. XM_011509386.2.
XP_011507689.1. XM_011509387.2.
UniGeneiHs.181444.

3D structure databases

ProteinModelPortaliQ9P0T7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128927. 13 interactors.
IntActiQ9P0T7. 5 interactors.
MINTiMINT-4721075.
STRINGi9606.ENSP00000356298.

PTM databases

iPTMnetiQ9P0T7.
PhosphoSitePlusiQ9P0T7.

Polymorphism and mutation databases

DMDMi20532090.

Proteomic databases

EPDiQ9P0T7.
MaxQBiQ9P0T7.
PaxDbiQ9P0T7.
PeptideAtlasiQ9P0T7.
PRIDEiQ9P0T7.

Protocols and materials databases

DNASUi252839.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367330; ENSP00000356299; ENSG00000116857.
ENST00000367333; ENSP00000356302; ENSG00000116857.
ENST00000367334; ENSP00000356303; ENSG00000116857.
ENST00000485839; ENSP00000476893; ENSG00000116857.
GeneIDi252839.
KEGGihsa:252839.
UCSCiuc001gvx.5. human.

Organism-specific databases

CTDi252839.
DisGeNETi252839.
GeneCardsiTMEM9.
HGNCiHGNC:18823. TMEM9.
HPAiHPA035616.
MIMi616877. gene.
neXtProtiNX_Q9P0T7.
OpenTargetsiENSG00000116857.
PharmGKBiPA38696.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4007. Eukaryota.
ENOG4111KV2. LUCA.
GeneTreeiENSGT00390000000819.
HOVERGENiHBG050972.
InParanoidiQ9P0T7.
PhylomeDBiQ9P0T7.
TreeFamiTF315146.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000116857-MONOMER.

Miscellaneous databases

ChiTaRSiTMEM9. human.
GeneWikiiTMEM9.
GenomeRNAii252839.
PROiQ9P0T7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000116857.
CleanExiHS_TMEM9.
ExpressionAtlasiQ9P0T7. baseline and differential.
GenevisibleiQ9P0T7. HS.

Family and domain databases

InterProiIPR008853. TMEM9.
[Graphical view]
PANTHERiPTHR13064. PTHR13064. 1 hit.
PfamiPF05434. Tmemb_9. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTMEM9_HUMAN
AccessioniPrimary (citable) accession number: Q9P0T7
Secondary accession number(s): B1ALM6, Q96NQ9, Q9BQF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.