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Protein

Transmembrane protein 9

Gene

TMEM9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in intracellular transport.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 9
Alternative name(s):
Dermal papilla-derived protein 4
Gene namesi
Name:TMEM9
Synonyms:DERP4
ORF Names:HSPC186, PSEC0012, UNQ631/PRO1248
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:18823. TMEM9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 8969ExtracellularSequence analysisAdd
BLAST
Transmembranei90 – 11021HelicalSequence analysisAdd
BLAST
Topological domaini111 – 18373CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • late endosome Source: UniProtKB
  • late endosome membrane Source: UniProtKB-SubCell
  • lysosomal membrane Source: UniProtKB-SubCell
  • lysosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38696.

Polymorphism and mutation databases

DMDMi20532090.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 183163Transmembrane protein 9PRO_0000034374Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi21 – 211N-linked (GlcNAc...)Sequence analysis
Glycosylationi38 – 381N-linked (GlcNAc...)Sequence analysis
Glycosylationi47 – 471N-linked (GlcNAc...)Sequence analysis
Modified residuei137 – 1371PhosphoserineCombined sources

Post-translational modificationi

N-glycosylated.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9P0T7.
MaxQBiQ9P0T7.
PaxDbiQ9P0T7.
PRIDEiQ9P0T7.

PTM databases

iPTMnetiQ9P0T7.
PhosphoSiteiQ9P0T7.

Expressioni

Tissue specificityi

Highly expressed in adrenal gland, thyroid gland, testis, ovary and prostate. Moderate expression in trachea, spinal cord, stomach, colon, small intestine and spleen. Low expression in bone marrow, lymph node, thymus and peripheral blood lymphocytes. Expression was detected in hematopoietic cell lines including those of myeloid, erythroid, B- and T-cell origin.1 Publication

Gene expression databases

BgeeiQ9P0T7.
CleanExiHS_TMEM9.
ExpressionAtlasiQ9P0T7. baseline and differential.
GenevisibleiQ9P0T7. HS.

Organism-specific databases

HPAiHPA035616.

Interactioni

Subunit structurei

Dimer.Curated

Protein-protein interaction databases

BioGridi128927. 13 interactions.
IntActiQ9P0T7. 5 interactions.
MINTiMINT-4721075.
STRINGi9606.ENSP00000356298.

Structurei

3D structure databases

ProteinModelPortaliQ9P0T7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM9 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4007. Eukaryota.
ENOG4111KV2. LUCA.
GeneTreeiENSGT00390000000819.
HOVERGENiHBG050972.
InParanoidiQ9P0T7.
OrthoDBiEOG70GMH0.
PhylomeDBiQ9P0T7.
TreeFamiTF315146.

Family and domain databases

InterProiIPR008853. TMEM9.
[Graphical view]
PANTHERiPTHR13064. PTHR13064. 1 hit.
PfamiPF05434. Tmemb_9. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9P0T7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLSLVAVV GCLLVPPAEA NKSSEDIRCK CICPPYRNIS GHIYNQNVSQ
60 70 80 90 100
KDCNCLHVVE PMPVPGHDVE AYCLLCECRY EERSTTTIKV IIVIYLSVVG
110 120 130 140 150
ALLLYMAFLM LVDPLIRKPD AYTEQLHNEE ENEDARSMAA AAASLGGPRA
160 170 180
NTVLERVEGA QQRWKLQVQE QRKTVFDRHK MLS
Length:183
Mass (Da):20,574
Last modified:October 1, 2000 - v1
Checksum:i6BC020EC9FE7F70E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti22 – 221K → KVRE in BAB70820 (PubMed:14702039).Curated
Sequence conflicti53 – 531C → CCS in CAB66535 (PubMed:11230166).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY138587 mRNA. Translation: AAN15925.1.
AB013909 mRNA. Translation: BAB87799.1.
AF151020 mRNA. Translation: AAF36106.1.
AL136600 mRNA. Translation: CAB66535.1.
AY359012 mRNA. Translation: AAQ89371.1.
AK054883 mRNA. Translation: BAB70820.1.
AK075335 mRNA. Translation: BAC11554.1.
AL139159 Genomic DNA. Translation: CAI23212.1.
CH471067 Genomic DNA. Translation: EAW91338.1.
BC001106 mRNA. Translation: AAH01106.1.
CCDSiCCDS1408.1.
RefSeqiNP_001275493.1. NM_001288564.1.
NP_001275494.1. NM_001288565.1.
NP_001275495.1. NM_001288566.1.
NP_001275496.1. NM_001288567.1.
NP_001275497.1. NM_001288568.1.
NP_001275498.1. NM_001288569.1.
NP_001275499.1. NM_001288570.1.
NP_001275500.1. NM_001288571.1.
NP_057540.1. NM_016456.4.
XP_011507687.1. XM_011509385.1.
XP_011507688.1. XM_011509386.1.
XP_011507689.1. XM_011509387.1.
UniGeneiHs.181444.

Genome annotation databases

EnsembliENST00000367330; ENSP00000356299; ENSG00000116857.
ENST00000367333; ENSP00000356302; ENSG00000116857.
ENST00000367334; ENSP00000356303; ENSG00000116857.
ENST00000485839; ENSP00000476893; ENSG00000116857.
GeneIDi252839.
KEGGihsa:252839.
UCSCiuc001gvx.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY138587 mRNA. Translation: AAN15925.1.
AB013909 mRNA. Translation: BAB87799.1.
AF151020 mRNA. Translation: AAF36106.1.
AL136600 mRNA. Translation: CAB66535.1.
AY359012 mRNA. Translation: AAQ89371.1.
AK054883 mRNA. Translation: BAB70820.1.
AK075335 mRNA. Translation: BAC11554.1.
AL139159 Genomic DNA. Translation: CAI23212.1.
CH471067 Genomic DNA. Translation: EAW91338.1.
BC001106 mRNA. Translation: AAH01106.1.
CCDSiCCDS1408.1.
RefSeqiNP_001275493.1. NM_001288564.1.
NP_001275494.1. NM_001288565.1.
NP_001275495.1. NM_001288566.1.
NP_001275496.1. NM_001288567.1.
NP_001275497.1. NM_001288568.1.
NP_001275498.1. NM_001288569.1.
NP_001275499.1. NM_001288570.1.
NP_001275500.1. NM_001288571.1.
NP_057540.1. NM_016456.4.
XP_011507687.1. XM_011509385.1.
XP_011507688.1. XM_011509386.1.
XP_011507689.1. XM_011509387.1.
UniGeneiHs.181444.

3D structure databases

ProteinModelPortaliQ9P0T7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128927. 13 interactions.
IntActiQ9P0T7. 5 interactions.
MINTiMINT-4721075.
STRINGi9606.ENSP00000356298.

PTM databases

iPTMnetiQ9P0T7.
PhosphoSiteiQ9P0T7.

Polymorphism and mutation databases

DMDMi20532090.

Proteomic databases

EPDiQ9P0T7.
MaxQBiQ9P0T7.
PaxDbiQ9P0T7.
PRIDEiQ9P0T7.

Protocols and materials databases

DNASUi252839.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367330; ENSP00000356299; ENSG00000116857.
ENST00000367333; ENSP00000356302; ENSG00000116857.
ENST00000367334; ENSP00000356303; ENSG00000116857.
ENST00000485839; ENSP00000476893; ENSG00000116857.
GeneIDi252839.
KEGGihsa:252839.
UCSCiuc001gvx.5. human.

Organism-specific databases

CTDi252839.
GeneCardsiTMEM9.
HGNCiHGNC:18823. TMEM9.
HPAiHPA035616.
neXtProtiNX_Q9P0T7.
PharmGKBiPA38696.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4007. Eukaryota.
ENOG4111KV2. LUCA.
GeneTreeiENSGT00390000000819.
HOVERGENiHBG050972.
InParanoidiQ9P0T7.
OrthoDBiEOG70GMH0.
PhylomeDBiQ9P0T7.
TreeFamiTF315146.

Miscellaneous databases

ChiTaRSiTMEM9. human.
GeneWikiiTMEM9.
GenomeRNAii252839.
NextBioi91986.
PROiQ9P0T7.

Gene expression databases

BgeeiQ9P0T7.
CleanExiHS_TMEM9.
ExpressionAtlasiQ9P0T7. baseline and differential.
GenevisibleiQ9P0T7. HS.

Family and domain databases

InterProiIPR008853. TMEM9.
[Graphical view]
PANTHERiPTHR13064. PTHR13064. 1 hit.
PfamiPF05434. Tmemb_9. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the novel human transmembrane protein 9 (TMEM9) that localizes to lysosomes and late endosomes."
    Kveine M., Tenstad E., Dosen G., Funderud S., Rian E.
    Biochem. Biophys. Res. Commun. 297:912-917(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "Molecular cloning of a dermal papilla derived gene."
    Ikeda A., Yoshimoto M.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hair follicle dermal papilla.
  3. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Umbilical cord blood.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.
  7. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Teratocarcinoma.
  8. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-137, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-137, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-137, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-137, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTMEM9_HUMAN
AccessioniPrimary (citable) accession number: Q9P0T7
Secondary accession number(s): B1ALM6, Q96NQ9, Q9BQF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: October 1, 2000
Last modified: April 13, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.