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Protein

Zinc finger protein 581

Gene

ZNF581

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri87 – 109C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri115 – 137C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri145 – 167C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri173 – 196C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 581
Gene namesi
Name:ZNF581
ORF Names:HSPC189
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000171425.9
HGNCiHGNC:25017 ZNF581
neXtProtiNX_Q9P0T4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171425
PharmGKBiPA134899657

Polymorphism and mutation databases

BioMutaiZNF581
DMDMi55976774

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476731 – 197Zinc finger protein 581Add BLAST197

Proteomic databases

EPDiQ9P0T4
MaxQBiQ9P0T4
PaxDbiQ9P0T4
PeptideAtlasiQ9P0T4
PRIDEiQ9P0T4

PTM databases

iPTMnetiQ9P0T4
PhosphoSitePlusiQ9P0T4

Expressioni

Gene expression databases

BgeeiENSG00000171425
CleanExiHS_ZNF581
ExpressionAtlasiQ9P0T4 baseline and differential
GenevisibleiQ9P0T4 HS

Organism-specific databases

HPAiHPA059657

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi119601, 48 interactors
IntActiQ9P0T4, 86 interactors
MINTiQ9P0T4
STRINGi9606.ENSP00000270451

Structurei

3D structure databases

ProteinModelPortaliQ9P0T4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri87 – 109C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri115 – 137C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri145 – 167C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri173 – 196C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00900000141050
HOGENOMiHOG000059663
HOVERGENiHBG079385
InParanoidiQ9P0T4
OMAiSAQKKCY
OrthoDBiEOG091G0KD9
PhylomeDBiQ9P0T4

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequencei

Sequence statusi: Complete.

Q9P0T4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVLPSPCPQ PLAFSSVETM EGPPRRTCRS PEPGPSSSIG SPQASSPPRP
60 70 80 90 100
NHYLLIDTQG VPYTVLVDEE SQREPGASGA PGQKKCYSCP VCSRVFEYMS
110 120 130 140 150
YLQRHSITHS EVKPFECDIC GKAFKRASHL ARHHSIHLAG GGRPHGCPLC
160 170 180 190
PRRFRDAGEL AQHSRVHSGE RPFQCPHCPR RFMEQNTLQK HTRWKHP
Length:197
Mass (Da):22,010
Last modified:October 1, 2000 - v1
Checksum:iB62F1FAFD4829EE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151023 mRNA Translation: AAF36109.2
AK315603 mRNA Translation: BAG37973.1
CH471135 Genomic DNA Translation: EAW72400.1
BC010097 mRNA Translation: AAH10097.1
BC001219 mRNA Translation: AAH01219.1
BC071620 mRNA Translation: AAH71620.1
BC071845 mRNA Translation: AAH71845.1
CCDSiCCDS12932.1
RefSeqiNP_057619.1, NM_016535.3
XP_006723303.1, XM_006723240.3
XP_016882356.1, XM_017026867.1
UniGeneiHs.20768

Genome annotation databases

EnsembliENST00000270451; ENSP00000270451; ENSG00000171425
ENST00000587252; ENSP00000466047; ENSG00000171425
ENST00000588537; ENSP00000466564; ENSG00000171425
GeneIDi51545
KEGGihsa:51545
UCSCiuc002qln.4 human

Similar proteinsi

Entry informationi

Entry nameiZN581_HUMAN
AccessioniPrimary (citable) accession number: Q9P0T4
Secondary accession number(s): B2RDM6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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