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Protein

Zinc finger protein 581

Gene

ZNF581

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri87 – 109C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri115 – 137C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri145 – 167C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri173 – 196C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 581
Gene namesi
Name:ZNF581
ORF Names:HSPC189
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:25017. ZNF581.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171425.
PharmGKBiPA134899657.

Polymorphism and mutation databases

BioMutaiZNF581.
DMDMi55976774.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476731 – 197Zinc finger protein 581Add BLAST197

Proteomic databases

EPDiQ9P0T4.
MaxQBiQ9P0T4.
PaxDbiQ9P0T4.
PeptideAtlasiQ9P0T4.
PRIDEiQ9P0T4.

PTM databases

iPTMnetiQ9P0T4.
PhosphoSitePlusiQ9P0T4.

Expressioni

Gene expression databases

BgeeiENSG00000171425.
CleanExiHS_ZNF581.
ExpressionAtlasiQ9P0T4. baseline and differential.
GenevisibleiQ9P0T4. HS.

Organism-specific databases

HPAiHPA059657.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi119601. 47 interactors.
IntActiQ9P0T4. 61 interactors.
MINTiMINT-1443145.
STRINGi9606.ENSP00000270451.

Structurei

3D structure databases

ProteinModelPortaliQ9P0T4.
SMRiQ9P0T4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri87 – 109C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri115 – 137C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri145 – 167C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri173 – 196C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129799.
HOGENOMiHOG000059663.
HOVERGENiHBG079385.
InParanoidiQ9P0T4.
OMAiAQKKCYS.
OrthoDBiEOG093705I2.
PhylomeDBiQ9P0T4.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiView protein in InterPro
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
PfamiView protein in Pfam
PF00096. zf-C2H2. 1 hit.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 4 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.

Sequencei

Sequence statusi: Complete.

Q9P0T4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVLPSPCPQ PLAFSSVETM EGPPRRTCRS PEPGPSSSIG SPQASSPPRP
60 70 80 90 100
NHYLLIDTQG VPYTVLVDEE SQREPGASGA PGQKKCYSCP VCSRVFEYMS
110 120 130 140 150
YLQRHSITHS EVKPFECDIC GKAFKRASHL ARHHSIHLAG GGRPHGCPLC
160 170 180 190
PRRFRDAGEL AQHSRVHSGE RPFQCPHCPR RFMEQNTLQK HTRWKHP
Length:197
Mass (Da):22,010
Last modified:October 1, 2000 - v1
Checksum:iB62F1FAFD4829EE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151023 mRNA. Translation: AAF36109.2.
AK315603 mRNA. Translation: BAG37973.1.
CH471135 Genomic DNA. Translation: EAW72400.1.
BC010097 mRNA. Translation: AAH10097.1.
BC001219 mRNA. Translation: AAH01219.1.
BC071620 mRNA. Translation: AAH71620.1.
BC071845 mRNA. Translation: AAH71845.1.
CCDSiCCDS12932.1.
RefSeqiNP_057619.1. NM_016535.3.
XP_006723303.1. XM_006723240.3.
XP_016882356.1. XM_017026867.1.
UniGeneiHs.20768.

Genome annotation databases

EnsembliENST00000270451; ENSP00000270451; ENSG00000171425.
ENST00000587252; ENSP00000466047; ENSG00000171425.
ENST00000588537; ENSP00000466564; ENSG00000171425.
GeneIDi51545.
KEGGihsa:51545.
UCSCiuc002qln.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151023 mRNA. Translation: AAF36109.2.
AK315603 mRNA. Translation: BAG37973.1.
CH471135 Genomic DNA. Translation: EAW72400.1.
BC010097 mRNA. Translation: AAH10097.1.
BC001219 mRNA. Translation: AAH01219.1.
BC071620 mRNA. Translation: AAH71620.1.
BC071845 mRNA. Translation: AAH71845.1.
CCDSiCCDS12932.1.
RefSeqiNP_057619.1. NM_016535.3.
XP_006723303.1. XM_006723240.3.
XP_016882356.1. XM_017026867.1.
UniGeneiHs.20768.

3D structure databases

ProteinModelPortaliQ9P0T4.
SMRiQ9P0T4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119601. 47 interactors.
IntActiQ9P0T4. 61 interactors.
MINTiMINT-1443145.
STRINGi9606.ENSP00000270451.

PTM databases

iPTMnetiQ9P0T4.
PhosphoSitePlusiQ9P0T4.

Polymorphism and mutation databases

BioMutaiZNF581.
DMDMi55976774.

Proteomic databases

EPDiQ9P0T4.
MaxQBiQ9P0T4.
PaxDbiQ9P0T4.
PeptideAtlasiQ9P0T4.
PRIDEiQ9P0T4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000270451; ENSP00000270451; ENSG00000171425.
ENST00000587252; ENSP00000466047; ENSG00000171425.
ENST00000588537; ENSP00000466564; ENSG00000171425.
GeneIDi51545.
KEGGihsa:51545.
UCSCiuc002qln.4. human.

Organism-specific databases

CTDi51545.
GeneCardsiZNF581.
HGNCiHGNC:25017. ZNF581.
HPAiHPA059657.
neXtProtiNX_Q9P0T4.
OpenTargetsiENSG00000171425.
PharmGKBiPA134899657.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129799.
HOGENOMiHOG000059663.
HOVERGENiHBG079385.
InParanoidiQ9P0T4.
OMAiAQKKCYS.
OrthoDBiEOG093705I2.
PhylomeDBiQ9P0T4.

Miscellaneous databases

GenomeRNAii51545.
PROiQ9P0T4.

Gene expression databases

BgeeiENSG00000171425.
CleanExiHS_ZNF581.
ExpressionAtlasiQ9P0T4. baseline and differential.
GenevisibleiQ9P0T4. HS.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiView protein in InterPro
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
PfamiView protein in Pfam
PF00096. zf-C2H2. 1 hit.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 4 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiZN581_HUMAN
AccessioniPrimary (citable) accession number: Q9P0T4
Secondary accession number(s): B2RDM6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: October 1, 2000
Last modified: February 15, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.