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Protein

Zinc finger protein 581

Gene

ZNF581

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri87 – 10923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri115 – 13723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri145 – 16723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri173 – 19624C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 581
Gene namesi
Name:ZNF581
ORF Names:HSPC189
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:25017. ZNF581.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134899657.

Polymorphism and mutation databases

BioMutaiZNF581.
DMDMi55976774.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 197197Zinc finger protein 581PRO_0000047673Add
BLAST

Proteomic databases

EPDiQ9P0T4.
MaxQBiQ9P0T4.
PaxDbiQ9P0T4.
PeptideAtlasiQ9P0T4.
PRIDEiQ9P0T4.

PTM databases

iPTMnetiQ9P0T4.

Expressioni

Gene expression databases

BgeeiQ9P0T4.
CleanExiHS_ZNF581.
ExpressionAtlasiQ9P0T4. baseline and differential.
GenevisibleiQ9P0T4. HS.

Organism-specific databases

HPAiHPA059657.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BANPQ8N9N53EBI-745520,EBI-744695
CALCOCO2Q131373EBI-745520,EBI-739580
CCDC136Q96JN2-23EBI-745520,EBI-10171416
CCNDBP1O952733EBI-745520,EBI-748961
DOCK8Q8NF50-23EBI-745520,EBI-10174653
FSD2A1L4K13EBI-745520,EBI-5661036
GOLGA2Q083793EBI-745520,EBI-618309
GOPCQ9HD263EBI-745520,EBI-349832
HMBOX1Q6NT763EBI-745520,EBI-2549423
IKZF1Q134223EBI-745520,EBI-745305
KRT40Q6A1623EBI-745520,EBI-10171697
KRTAP10-7P604093EBI-745520,EBI-10172290
KRTAP10-9P604113EBI-745520,EBI-10172052
KRTAP4-12Q9BQ664EBI-745520,EBI-739863
KRTAP4-2Q9BYR53EBI-745520,EBI-10172511
KRTAP5-9P263713EBI-745520,EBI-3958099
LNX1Q8TBB13EBI-745520,EBI-739832
LZTS2Q9BRK44EBI-745520,EBI-741037
MDFIQ997504EBI-745520,EBI-724076
MTUS2Q5JR593EBI-745520,EBI-742948
NOTCH2NLQ7Z3S93EBI-745520,EBI-945833
PDE4DIPQ5VU433EBI-745520,EBI-1105124
PNMA1Q8ND903EBI-745520,EBI-302345
RBPMSQ930624EBI-745520,EBI-740322
SDCBP2Q9H1903EBI-745520,EBI-742426
SOX5P357113EBI-745520,EBI-3505701
SPERTQ8NA613EBI-745520,EBI-741724
TMCC2Q7Z6C63EBI-745520,EBI-10177480
TRAF1Q130773EBI-745520,EBI-359224
TRAF4Q9BUZ43EBI-745520,EBI-3650647
TRIM23P364064EBI-745520,EBI-740098
TRIM27P143733EBI-745520,EBI-719493

Protein-protein interaction databases

BioGridi119601. 47 interactions.
IntActiQ9P0T4. 38 interactions.
MINTiMINT-1443145.
STRINGi9606.ENSP00000270451.

Structurei

3D structure databases

ProteinModelPortaliQ9P0T4.
SMRiQ9P0T4. Positions 76-193.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri87 – 10923C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri115 – 13723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri145 – 16723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri173 – 19624C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129893.
HOGENOMiHOG000059663.
HOVERGENiHBG079385.
InParanoidiQ9P0T4.
OMAiAQKKCYS.
OrthoDBiEOG74XS7Q.
PhylomeDBiQ9P0T4.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P0T4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVLPSPCPQ PLAFSSVETM EGPPRRTCRS PEPGPSSSIG SPQASSPPRP
60 70 80 90 100
NHYLLIDTQG VPYTVLVDEE SQREPGASGA PGQKKCYSCP VCSRVFEYMS
110 120 130 140 150
YLQRHSITHS EVKPFECDIC GKAFKRASHL ARHHSIHLAG GGRPHGCPLC
160 170 180 190
PRRFRDAGEL AQHSRVHSGE RPFQCPHCPR RFMEQNTLQK HTRWKHP
Length:197
Mass (Da):22,010
Last modified:October 1, 2000 - v1
Checksum:iB62F1FAFD4829EE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151023 mRNA. Translation: AAF36109.2.
AK315603 mRNA. Translation: BAG37973.1.
CH471135 Genomic DNA. Translation: EAW72400.1.
BC010097 mRNA. Translation: AAH10097.1.
BC001219 mRNA. Translation: AAH01219.1.
BC071620 mRNA. Translation: AAH71620.1.
BC071845 mRNA. Translation: AAH71845.1.
CCDSiCCDS12932.1.
RefSeqiNP_057619.1. NM_016535.3.
XP_006723303.1. XM_006723240.2.
UniGeneiHs.20768.

Genome annotation databases

EnsembliENST00000270451; ENSP00000270451; ENSG00000171425.
ENST00000587252; ENSP00000466047; ENSG00000171425.
ENST00000588537; ENSP00000466564; ENSG00000171425.
GeneIDi51545.
KEGGihsa:51545.
UCSCiuc002qln.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151023 mRNA. Translation: AAF36109.2.
AK315603 mRNA. Translation: BAG37973.1.
CH471135 Genomic DNA. Translation: EAW72400.1.
BC010097 mRNA. Translation: AAH10097.1.
BC001219 mRNA. Translation: AAH01219.1.
BC071620 mRNA. Translation: AAH71620.1.
BC071845 mRNA. Translation: AAH71845.1.
CCDSiCCDS12932.1.
RefSeqiNP_057619.1. NM_016535.3.
XP_006723303.1. XM_006723240.2.
UniGeneiHs.20768.

3D structure databases

ProteinModelPortaliQ9P0T4.
SMRiQ9P0T4. Positions 76-193.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119601. 47 interactions.
IntActiQ9P0T4. 38 interactions.
MINTiMINT-1443145.
STRINGi9606.ENSP00000270451.

PTM databases

iPTMnetiQ9P0T4.

Polymorphism and mutation databases

BioMutaiZNF581.
DMDMi55976774.

Proteomic databases

EPDiQ9P0T4.
MaxQBiQ9P0T4.
PaxDbiQ9P0T4.
PeptideAtlasiQ9P0T4.
PRIDEiQ9P0T4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000270451; ENSP00000270451; ENSG00000171425.
ENST00000587252; ENSP00000466047; ENSG00000171425.
ENST00000588537; ENSP00000466564; ENSG00000171425.
GeneIDi51545.
KEGGihsa:51545.
UCSCiuc002qln.4. human.

Organism-specific databases

CTDi51545.
GeneCardsiZNF581.
HGNCiHGNC:25017. ZNF581.
HPAiHPA059657.
neXtProtiNX_Q9P0T4.
PharmGKBiPA134899657.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129893.
HOGENOMiHOG000059663.
HOVERGENiHBG079385.
InParanoidiQ9P0T4.
OMAiAQKKCYS.
OrthoDBiEOG74XS7Q.
PhylomeDBiQ9P0T4.

Miscellaneous databases

GenomeRNAii51545.
PROiQ9P0T4.

Gene expression databases

BgeeiQ9P0T4.
CleanExiHS_ZNF581.
ExpressionAtlasiQ9P0T4. baseline and differential.
GenevisibleiQ9P0T4. HS.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Umbilical cord blood.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skeletal muscle.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: B-cell, Kidney, Muscle and Placenta.

Entry informationi

Entry nameiZN581_HUMAN
AccessioniPrimary (citable) accession number: Q9P0T4
Secondary accession number(s): B2RDM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: October 1, 2000
Last modified: July 6, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.