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Protein

Transmembrane protein 14C

Gene

TMEM14C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for normal heme biosynthesis.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Heme biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 14C
Gene namesi
Name:TMEM14C
Synonyms:C6orf53
ORF Names:HSPC194
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:20952. TMEM14C.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721HelicalSequence analysisAdd
BLAST
Transmembranei32 – 5221HelicalSequence analysisAdd
BLAST
Transmembranei62 – 8221HelicalSequence analysisAdd
BLAST
Transmembranei88 – 10821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134874746.

Polymorphism and mutation databases

BioMutaiTMEM14C.
DMDMi27734405.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 112112Transmembrane protein 14CPRO_0000221173Add
BLAST

Proteomic databases

EPDiQ9P0S9.
MaxQBiQ9P0S9.
PaxDbiQ9P0S9.
PRIDEiQ9P0S9.
TopDownProteomicsiQ9P0S9.

PTM databases

PhosphoSiteiQ9P0S9.
SwissPalmiQ9P0S9.

Expressioni

Gene expression databases

BgeeiQ9P0S9.
CleanExiHS_TMEM14C.
ExpressionAtlasiQ9P0S9. baseline and differential.
GenevisibleiQ9P0S9. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC155Q8N6L03EBI-2339195,EBI-749265

Protein-protein interaction databases

BioGridi119585. 8 interactions.
IntActiQ9P0S9. 5 interactions.
STRINGi9606.ENSP00000229563.

Structurei

Secondary structure

1
112
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi10 – 2920Combined sources
Helixi35 – 5218Combined sources
Beta strandi54 – 574Combined sources
Helixi59 – 7416Combined sources
Beta strandi76 – 783Combined sources
Beta strandi87 – 893Combined sources
Helixi91 – 10414Combined sources
Beta strandi105 – 1073Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LOSNMR-A1-112[»]
ProteinModelPortaliQ9P0S9.
SMRiQ9P0S9. Positions 1-112.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM14 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4267. Eukaryota.
ENOG4112205. LUCA.
GeneTreeiENSGT00390000013475.
HOGENOMiHOG000211932.
HOVERGENiHBG054211.
InParanoidiQ9P0S9.
OMAiRILCRAF.
OrthoDBiEOG7NKKP0.
PhylomeDBiQ9P0S9.
TreeFamiTF323345.

Family and domain databases

InterProiIPR005349. TMEM14.
[Graphical view]
PANTHERiPTHR12668. PTHR12668. 1 hit.
PfamiPF03647. Tmemb_14. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P0S9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQDTGSVVPL HWFGFGYAAL VASGGIIGYV KAGSVPSLAA GLLFGSLAGL
60 70 80 90 100
GAYQLSQDPR NVWVFLATSG TLAGIMGMRF YHSGKFMPAG LIAGASLLMV
110
AKVGVSMFNR PH
Length:112
Mass (Da):11,565
Last modified:October 1, 2000 - v1
Checksum:i0C54AD12A50A96E0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti106 – 1061S → R.
Corresponds to variant rs1045961 [ dbSNP | Ensembl ].
VAR_046947
Natural varianti108 – 1081F → L.
Corresponds to variant rs1045964 [ dbSNP | Ensembl ].
VAR_046948
Natural varianti109 – 1091N → I.
Corresponds to variant rs1045967 [ dbSNP | Ensembl ].
VAR_046949
Natural varianti112 – 1121H → D.
Corresponds to variant rs1045986 [ dbSNP | Ensembl ].
VAR_046950

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151028 mRNA. Translation: AAF36114.1.
AL358777 Genomic DNA. Translation: CAI14003.1.
CH471087 Genomic DNA. Translation: EAW55271.1.
BC002496 mRNA. Translation: AAH02496.1.
BC010086 mRNA. Translation: AAH10086.1.
CCDSiCCDS4514.1.
RefSeqiNP_001158730.1. NM_001165258.1.
NP_057546.1. NM_016462.3.
UniGeneiHs.519557.

Genome annotation databases

EnsembliENST00000229563; ENSP00000229563; ENSG00000111843.
ENST00000541412; ENSP00000444561; ENSG00000111843.
GeneIDi51522.
KEGGihsa:51522.
UCSCiuc003mzh.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151028 mRNA. Translation: AAF36114.1.
AL358777 Genomic DNA. Translation: CAI14003.1.
CH471087 Genomic DNA. Translation: EAW55271.1.
BC002496 mRNA. Translation: AAH02496.1.
BC010086 mRNA. Translation: AAH10086.1.
CCDSiCCDS4514.1.
RefSeqiNP_001158730.1. NM_001165258.1.
NP_057546.1. NM_016462.3.
UniGeneiHs.519557.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LOSNMR-A1-112[»]
ProteinModelPortaliQ9P0S9.
SMRiQ9P0S9. Positions 1-112.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119585. 8 interactions.
IntActiQ9P0S9. 5 interactions.
STRINGi9606.ENSP00000229563.

PTM databases

PhosphoSiteiQ9P0S9.
SwissPalmiQ9P0S9.

Polymorphism and mutation databases

BioMutaiTMEM14C.
DMDMi27734405.

Proteomic databases

EPDiQ9P0S9.
MaxQBiQ9P0S9.
PaxDbiQ9P0S9.
PRIDEiQ9P0S9.
TopDownProteomicsiQ9P0S9.

Protocols and materials databases

DNASUi51522.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000229563; ENSP00000229563; ENSG00000111843.
ENST00000541412; ENSP00000444561; ENSG00000111843.
GeneIDi51522.
KEGGihsa:51522.
UCSCiuc003mzh.4. human.

Organism-specific databases

CTDi51522.
GeneCardsiTMEM14C.
HGNCiHGNC:20952. TMEM14C.
MIMi615318. gene.
neXtProtiNX_Q9P0S9.
PharmGKBiPA134874746.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4267. Eukaryota.
ENOG4112205. LUCA.
GeneTreeiENSGT00390000013475.
HOGENOMiHOG000211932.
HOVERGENiHBG054211.
InParanoidiQ9P0S9.
OMAiRILCRAF.
OrthoDBiEOG7NKKP0.
PhylomeDBiQ9P0S9.
TreeFamiTF323345.

Miscellaneous databases

ChiTaRSiTMEM14C. human.
GenomeRNAii51522.
NextBioi55224.
PROiQ9P0S9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9P0S9.
CleanExiHS_TMEM14C.
ExpressionAtlasiQ9P0S9. baseline and differential.
GenevisibleiQ9P0S9. HS.

Family and domain databases

InterProiIPR005349. TMEM14.
[Graphical view]
PANTHERiPTHR12668. PTHR12668. 1 hit.
PfamiPF03647. Tmemb_14. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Umbilical cord blood.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta and Skin.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiTM14C_HUMAN
AccessioniPrimary (citable) accession number: Q9P0S9
Secondary accession number(s): Q5T4I6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: October 1, 2000
Last modified: April 13, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.