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Protein

Transmembrane protein 14C

Gene

TMEM14C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for normal heme biosynthesis.By similarity

GO - Biological processi

Keywordsi

Biological processHeme biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 14C
Gene namesi
Name:TMEM14C
Synonyms:C6orf53
ORF Names:HSPC194
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000111843.13
HGNCiHGNC:20952 TMEM14C
MIMi615318 gene
neXtProtiNX_Q9P0S9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Transmembranei32 – 52HelicalSequence analysisAdd BLAST21
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi51522
OpenTargetsiENSG00000111843
PharmGKBiPA134874746

Polymorphism and mutation databases

BioMutaiTMEM14C
DMDMi27734405

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002211731 – 112Transmembrane protein 14CAdd BLAST112

Proteomic databases

EPDiQ9P0S9
MaxQBiQ9P0S9
PaxDbiQ9P0S9
PeptideAtlasiQ9P0S9
PRIDEiQ9P0S9
TopDownProteomicsiQ9P0S9

PTM databases

iPTMnetiQ9P0S9
PhosphoSitePlusiQ9P0S9
SwissPalmiQ9P0S9

Expressioni

Gene expression databases

BgeeiENSG00000111843
CleanExiHS_TMEM14C
ExpressionAtlasiQ9P0S9 baseline and differential
GenevisibleiQ9P0S9 HS

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC155Q8N6L03EBI-2339195,EBI-749265

Protein-protein interaction databases

BioGridi119585, 9 interactors
IntActiQ9P0S9, 13 interactors
MINTiQ9P0S9
STRINGi9606.ENSP00000229563

Structurei

Secondary structure

1112
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 29Combined sources20
Helixi35 – 52Combined sources18
Beta strandi54 – 57Combined sources4
Helixi59 – 74Combined sources16
Beta strandi76 – 78Combined sources3
Beta strandi87 – 89Combined sources3
Helixi91 – 104Combined sources14
Beta strandi105 – 107Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LOSNMR-A1-112[»]
ProteinModelPortaliQ9P0S9
SMRiQ9P0S9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM14 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4267 Eukaryota
ENOG4112205 LUCA
GeneTreeiENSGT00390000013475
HOGENOMiHOG000211932
HOVERGENiHBG054211
InParanoidiQ9P0S9
OMAiGLQMMEK
OrthoDBiEOG091G0XXJ
PhylomeDBiQ9P0S9
TreeFamiTF323345

Family and domain databases

InterProiView protein in InterPro
IPR005349 TMEM14
PANTHERiPTHR12668 PTHR12668, 1 hit
PfamiView protein in Pfam
PF03647 Tmemb_14, 1 hit

Sequencei

Sequence statusi: Complete.

Q9P0S9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQDTGSVVPL HWFGFGYAAL VASGGIIGYV KAGSVPSLAA GLLFGSLAGL
60 70 80 90 100
GAYQLSQDPR NVWVFLATSG TLAGIMGMRF YHSGKFMPAG LIAGASLLMV
110
AKVGVSMFNR PH
Length:112
Mass (Da):11,565
Last modified:October 1, 2000 - v1
Checksum:i0C54AD12A50A96E0
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_046947106S → R. Corresponds to variant dbSNP:rs1045961Ensembl.1
Natural variantiVAR_046948108F → L. Corresponds to variant dbSNP:rs1045964Ensembl.1
Natural variantiVAR_046949109N → I. Corresponds to variant dbSNP:rs1045967Ensembl.1
Natural variantiVAR_046950112H → D. Corresponds to variant dbSNP:rs1045986Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151028 mRNA Translation: AAF36114.1
AL358777 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55271.1
BC002496 mRNA Translation: AAH02496.1
BC010086 mRNA Translation: AAH10086.1
CCDSiCCDS4514.1
RefSeqiNP_001158730.1, NM_001165258.1
NP_057546.1, NM_016462.3
UniGeneiHs.519557

Genome annotation databases

EnsembliENST00000229563; ENSP00000229563; ENSG00000111843
ENST00000541412; ENSP00000444561; ENSG00000111843
GeneIDi51522
KEGGihsa:51522
UCSCiuc003mzh.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTM14C_HUMAN
AccessioniPrimary (citable) accession number: Q9P0S9
Secondary accession number(s): Q5T4I6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health