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Protein

Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial

Gene

COX16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase (PubMed:29355485, PubMed:29381136). Promotes the insertion of copper into the active site of cytochrome c oxidase subunit II (MT-CO2/COX2) (PubMed:29355485, PubMed:29381136). Interacts specifically with newly synthesized MT-CO2/COX and its copper center-forming metallochaperones SCO1, SCO2 and COA6 (PubMed:29381136). Probably facilitates MT-CO2/COX2 association with the MITRAC assembly intermediate containing MT-CO1/COX1, thereby participating in merging the MT-CO1/COX1 and MT-CO2/COX2 assembly lines (PubMed:29381136).2 Publications

Miscellaneous

No COX16 mutations have been detected in patients with cytochrome c oxidase (COX) deficiency.1 Publication

GO - Biological processi

  • mitochondrial respiratory chain complex IV assembly Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-611105 Respiratory electron transport

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase assembly protein COX16 homolog, mitochondrialCurated
Short name:
hCOX161 Publication
Gene namesi
Name:COX162 PublicationsImported
Synonyms:C14orf112Imported
ORF Names:HSPC2031 Publication, PTD0191 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000133983.14
HGNCiHGNC:20213 COX16
neXtProtiNX_Q9P0S2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 14Mitochondrial matrix2 PublicationsAdd BLAST14
Transmembranei15 – 37HelicalSequence analysisAdd BLAST23
Topological domaini38 – 106Mitochondrial intermembrane2 PublicationsAdd BLAST69

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi51241
OpenTargetsiENSG00000133983
PharmGKBiPA162382755

Polymorphism and mutation databases

BioMutaiCOX16
DMDMi68565330

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000195561 – 106Cytochrome c oxidase assembly protein COX16 homolog, mitochondrialAdd BLAST106

Proteomic databases

EPDiQ9P0S2
MaxQBiQ9P0S2
PaxDbiQ9P0S2
PeptideAtlasiQ9P0S2
PRIDEiQ9P0S2
TopDownProteomicsiQ9P0S2

PTM databases

iPTMnetiQ9P0S2
PhosphoSitePlusiQ9P0S2

Expressioni

Tissue specificityi

Widely expressed. Expressed at higher level in skeletal muscle, heart and liver.1 Publication

Gene expression databases

BgeeiENSG00000133983
CleanExiHS_COX16
ExpressionAtlasiQ9P0S2 baseline and differential
GenevisibleiQ9P0S2 HS

Organism-specific databases

HPAiHPA062659

Interactioni

Subunit structurei

Associates with the MITRAC complex (PubMed:29381136). Interacts with MT-CO2/COX; specifically interacts with newly synthesized MT-CO2/COX (PubMed:29355485, PubMed:29381136). Interacts with SCO1, SCO2 and COA6 (PubMed:29381136).2 Publications

Protein-protein interaction databases

BioGridi119401, 9 interactors
CORUMiQ9P0S2
IntActiQ9P0S2, 2 interactors
STRINGi9606.ENSP00000374562

Structurei

3D structure databases

ProteinModelPortaliQ9P0S2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the COX16 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J12X Eukaryota
ENOG411273P LUCA
GeneTreeiENSGT00520000055955
HOGENOMiHOG000217274
HOVERGENiHBG105488
InParanoidiQ9P0S2
KOiK18182
OMAiIDNWENK
OrthoDBiEOG091G0G6P
PhylomeDBiQ9P0S2
TreeFamiTF324420

Family and domain databases

InterProiView protein in InterPro
IPR020164 Cyt_c_Oxase_assmbl_COX16
PfamiView protein in Pfam
PF14138 COX16, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD076120 Cyt_c_Oxase_assmbl_COX16, 1 hit

Sequencei

Sequence statusi: Complete.

Q9P0S2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFAPAVMRAF RKNKTLGYGV PMLLLIVGGS FGLREFSQIR YDAVKSKMDP
60 70 80 90 100
ELEKKLKENK ISLESEYEKI KDSKFDDWKN IRGPRPWEDP DLLQGRNPES

LKTKTT
Length:106
Mass (Da):12,293
Last modified:October 1, 2000 - v1
Checksum:iEB84EE268DF62B07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ460510 mRNA Translation: ACJ76681.1
FJ460511 mRNA Translation: ACJ76682.1
AF226729 mRNA Translation: AAG09730.1
AF151037 mRNA Translation: AAF36123.1
AK290743 mRNA Translation: BAF83432.1
CR457199 mRNA Translation: CAG33480.1
AL160191 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81031.1
BC001702 mRNA Translation: AAH01702.1
CCDSiCCDS9802.1
RefSeqiNP_001191019.1, NM_001204090.1
NP_057552.1, NM_016468.6
UniGeneiHs.709581

Genome annotation databases

EnsembliENST00000389912; ENSP00000374562; ENSG00000133983
GeneIDi51241
KEGGihsa:51241
UCSCiuc001xmb.3 human

Similar proteinsi

Entry informationi

Entry nameiCOX16_HUMAN
AccessioniPrimary (citable) accession number: Q9P0S2
Secondary accession number(s): A6NDT5, A8K3X8, B8XYC5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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