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Protein

Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial

Gene

COX16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Enzyme and pathway databases

ReactomeiR-HSA-5628897. TP53 Regulates Metabolic Genes.
R-HSA-611105. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial
Gene namesi
Name:COX16
Synonyms:C14orf112
ORF Names:HSPC203, PTD019
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:20213. COX16.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei15 – 3723HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162382755.

Polymorphism and mutation databases

BioMutaiCOX16.
DMDMi68565330.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 106Cytochrome c oxidase assembly protein COX16 homolog, mitochondrialPRO_0000019556
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

EPDiQ9P0S2.
MaxQBiQ9P0S2.
PaxDbiQ9P0S2.
PeptideAtlasiQ9P0S2.
PRIDEiQ9P0S2.
TopDownProteomicsiQ9P0S2.

PTM databases

iPTMnetiQ9P0S2.
PhosphoSiteiQ9P0S2.

Expressioni

Gene expression databases

BgeeiQ9P0S2.
CleanExiHS_COX16.
ExpressionAtlasiQ9P0S2. baseline and differential.
GenevisibleiQ9P0S2. HS.

Organism-specific databases

HPAiHPA062659.

Interactioni

Protein-protein interaction databases

BioGridi119401. 6 interactions.
IntActiQ9P0S2. 1 interaction.
STRINGi9606.ENSP00000374562.

Structurei

3D structure databases

ProteinModelPortaliQ9P0S2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the COX16 family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J12X. Eukaryota.
ENOG411273P. LUCA.
GeneTreeiENSGT00520000055955.
HOGENOMiHOG000217274.
HOVERGENiHBG105488.
InParanoidiQ9P0S2.
KOiK18182.
OMAiPRPWEEQ.
OrthoDBiEOG7CNZJG.
PhylomeDBiQ9P0S2.
TreeFamiTF324420.

Family and domain databases

InterProiIPR020164. Cyt_c_Oxase_assmbl_COX16.
[Graphical view]
PfamiPF14138. COX16. 1 hit.
[Graphical view]
ProDomiPD076120. Cyt_c_Oxase_assmbl_COX16. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9P0S2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFAPAVMRAF RKNKTLGYGV PMLLLIVGGS FGLREFSQIR YDAVKSKMDP
60 70 80 90 100
ELEKKLKENK ISLESEYEKI KDSKFDDWKN IRGPRPWEDP DLLQGRNPES

LKTKTT
Length:106
Mass (Da):12,293
Last modified:October 1, 2000 - v1
Checksum:iEB84EE268DF62B07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF226729 mRNA. Translation: AAG09730.1.
AF151037 mRNA. Translation: AAF36123.1.
AK290743 mRNA. Translation: BAF83432.1.
CR457199 mRNA. Translation: CAG33480.1.
AL160191 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81031.1.
BC001702 mRNA. Translation: AAH01702.1.
CCDSiCCDS9802.1.
RefSeqiNP_057552.1. NM_016468.6.
UniGeneiHs.709581.

Genome annotation databases

EnsembliENST00000389912; ENSP00000374562; ENSG00000133983.
GeneIDi51241.
KEGGihsa:51241.
UCSCiuc001xmb.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF226729 mRNA. Translation: AAG09730.1.
AF151037 mRNA. Translation: AAF36123.1.
AK290743 mRNA. Translation: BAF83432.1.
CR457199 mRNA. Translation: CAG33480.1.
AL160191 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81031.1.
BC001702 mRNA. Translation: AAH01702.1.
CCDSiCCDS9802.1.
RefSeqiNP_057552.1. NM_016468.6.
UniGeneiHs.709581.

3D structure databases

ProteinModelPortaliQ9P0S2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119401. 6 interactions.
IntActiQ9P0S2. 1 interaction.
STRINGi9606.ENSP00000374562.

PTM databases

iPTMnetiQ9P0S2.
PhosphoSiteiQ9P0S2.

Polymorphism and mutation databases

BioMutaiCOX16.
DMDMi68565330.

Proteomic databases

EPDiQ9P0S2.
MaxQBiQ9P0S2.
PaxDbiQ9P0S2.
PeptideAtlasiQ9P0S2.
PRIDEiQ9P0S2.
TopDownProteomicsiQ9P0S2.

Protocols and materials databases

DNASUi51241.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389912; ENSP00000374562; ENSG00000133983.
GeneIDi51241.
KEGGihsa:51241.
UCSCiuc001xmb.3. human.

Organism-specific databases

CTDi51241.
GeneCardsiCOX16.
HGNCiHGNC:20213. COX16.
HPAiHPA062659.
neXtProtiNX_Q9P0S2.
PharmGKBiPA162382755.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J12X. Eukaryota.
ENOG411273P. LUCA.
GeneTreeiENSGT00520000055955.
HOGENOMiHOG000217274.
HOVERGENiHBG105488.
InParanoidiQ9P0S2.
KOiK18182.
OMAiPRPWEEQ.
OrthoDBiEOG7CNZJG.
PhylomeDBiQ9P0S2.
TreeFamiTF324420.

Enzyme and pathway databases

ReactomeiR-HSA-5628897. TP53 Regulates Metabolic Genes.
R-HSA-611105. Respiratory electron transport.

Miscellaneous databases

ChiTaRSiCOX16. human.
GenomeRNAii51241.
PROiQ9P0S2.

Gene expression databases

BgeeiQ9P0S2.
CleanExiHS_COX16.
ExpressionAtlasiQ9P0S2. baseline and differential.
GenevisibleiQ9P0S2. HS.

Family and domain databases

InterProiIPR020164. Cyt_c_Oxase_assmbl_COX16.
[Graphical view]
PfamiPF14138. COX16. 1 hit.
[Graphical view]
ProDomiPD076120. Cyt_c_Oxase_assmbl_COX16. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Xiao H., Song H., Gao G., Ren S., Chen Z., Han Z.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary tumor.
  2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Umbilical cord blood.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  8. "COX16 encodes a novel protein required for the assembly of cytochrome oxidase in Saccharomyces cerevisiae."
    Carlson C.G., Barrientos A., Tzagoloff A., Glerum D.M.
    J. Biol. Chem. 278:3770-3775(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  9. "Studies of COX16, COX19, and PET191 in human cytochrome-c oxidase deficiency."
    Tay S.K.H., Nesti C., Mancuso M., Schon E.A., Shanske S., Bonilla E., Davidson M.M., Dimauro S.
    Arch. Neurol. 61:1935-1937(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: LACK OF INVOLVEMENT IN COX DEFICIENCY.

Entry informationi

Entry nameiCOX16_HUMAN
AccessioniPrimary (citable) accession number: Q9P0S2
Secondary accession number(s): A6NDT5, A8K3X8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: October 1, 2000
Last modified: July 6, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

No COX16 mutations have been detected in patients with cytochrome c oxidase (COX) deficiency.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.