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Protein

GSK3-beta interaction protein

Gene

GSKIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
GSK3-beta interaction protein
Short name:
GSKIP
Gene namesi
Name:GSKIP
Synonyms:C14orf129
ORF Names:HSPC210
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:20343. GSKIP.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi130 – 1301L → P: Loss of interaction with GSK3B. 1 Publication

Organism-specific databases

PharmGKBiPA134987554.

Polymorphism and mutation databases

DMDMi34582343.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 139139GSK3-beta interaction proteinPRO_0000220951Add
BLAST

Proteomic databases

EPDiQ9P0R6.
MaxQBiQ9P0R6.
PaxDbiQ9P0R6.
PeptideAtlasiQ9P0R6.
PRIDEiQ9P0R6.

Expressioni

Tissue specificityi

Detected in heart, brain, placenta, liver, skeletal muscle, kidney, testis, lung and pancreas.1 Publication

Gene expression databases

BgeeiQ9P0R6.
CleanExiHS_C14orf129.
ExpressionAtlasiQ9P0R6. baseline and differential.
GenevisibleiQ9P0R6. HS.

Organism-specific databases

HPAiHPA043054.
HPA046782.

Interactioni

Subunit structurei

Interacts with GSK3B.1 Publication

Protein-protein interaction databases

BioGridi119589. 5 interactions.
IntActiQ9P0R6. 4 interactions.
STRINGi9606.ENSP00000412315.

Structurei

Secondary structure

1
139
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi10 – 134Combined sources
Helixi33 – 4412Combined sources
Helixi45 – 473Combined sources
Beta strandi48 – 536Combined sources
Beta strandi63 – 697Combined sources
Beta strandi75 – 817Combined sources
Beta strandi84 – 918Combined sources
Beta strandi103 – 1075Combined sources
Helixi108 – 1147Combined sources
Helixi116 – 13520Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1SGONMR-A1-139[»]
ProteinModelPortaliQ9P0R6.
SMRiQ9P0R6. Positions 1-139.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9P0R6.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni115 – 13925Interaction with GSK3BAdd
BLAST

Sequence similaritiesi

Belongs to the UPF0279 family.Curated

Phylogenomic databases

eggNOGiKOG3965. Eukaryota.
ENOG4111QBG. LUCA.
GeneTreeiENSGT00390000009517.
HOGENOMiHOG000007951.
HOVERGENiHBG051028.
InParanoidiQ9P0R6.
OMAiETREGNR.
OrthoDBiEOG783MXF.
PhylomeDBiQ9P0R6.
TreeFamiTF313906.

Family and domain databases

InterProiIPR007967. DUF727.
IPR023231. GSKIP_dom.
[Graphical view]
PANTHERiPTHR12490. PTHR12490. 1 hit.
PfamiPF05303. DUF727. 1 hit.
[Graphical view]
ProDomiPD080843. DUF727. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF103107. SSF103107. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9P0R6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METDCNPMEL SSMSGFEEGS ELNGFEGTDM KDMRLEAEAV VNDVLFAVNN
60 70 80 90 100
MFVSKSLRCA DDVAYINVET KERNRYCLEL TEAGLKVVGY AFDQVDDHLQ
110 120 130
TPYHETVYSL LDTLSPAYRE AFGNALLQRL EALKRDGQS
Length:139
Mass (Da):15,648
Last modified:September 9, 2003 - v2
Checksum:iA2D8BAF4B458B316
GO

Sequence cautioni

The sequence AAF36130.1 differs from that shown. Reason: Frameshift at position 132. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti46 – 461F → S in BAA91380 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151044 mRNA. Translation: AAF36130.1. Frameshift.
AK000796 mRNA. Translation: BAA91380.1.
AK094654 mRNA. Translation: BAG52902.1.
AL359240 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81634.1.
BC004818 mRNA. Translation: AAH04818.1.
CCDSiCCDS32153.1.
RefSeqiNP_001258833.1. NM_001271904.1.
NP_001258834.1. NM_001271905.1.
NP_001258835.1. NM_001271906.1.
NP_057556.2. NM_016472.4.
UniGeneiHs.4104.
Hs.745067.

Genome annotation databases

EnsembliENST00000438650; ENSP00000412315; ENSG00000100744.
ENST00000554182; ENSP00000451384; ENSG00000100744.
ENST00000555181; ENSP00000450420; ENSG00000100744.
ENST00000556095; ENSP00000451188; ENSG00000100744.
GeneIDi51527.
KEGGihsa:51527.
UCSCiuc001yfj.6. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151044 mRNA. Translation: AAF36130.1. Frameshift.
AK000796 mRNA. Translation: BAA91380.1.
AK094654 mRNA. Translation: BAG52902.1.
AL359240 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW81634.1.
BC004818 mRNA. Translation: AAH04818.1.
CCDSiCCDS32153.1.
RefSeqiNP_001258833.1. NM_001271904.1.
NP_001258834.1. NM_001271905.1.
NP_001258835.1. NM_001271906.1.
NP_057556.2. NM_016472.4.
UniGeneiHs.4104.
Hs.745067.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1SGONMR-A1-139[»]
ProteinModelPortaliQ9P0R6.
SMRiQ9P0R6. Positions 1-139.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119589. 5 interactions.
IntActiQ9P0R6. 4 interactions.
STRINGi9606.ENSP00000412315.

Polymorphism and mutation databases

DMDMi34582343.

Proteomic databases

EPDiQ9P0R6.
MaxQBiQ9P0R6.
PaxDbiQ9P0R6.
PeptideAtlasiQ9P0R6.
PRIDEiQ9P0R6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000438650; ENSP00000412315; ENSG00000100744.
ENST00000554182; ENSP00000451384; ENSG00000100744.
ENST00000555181; ENSP00000450420; ENSG00000100744.
ENST00000556095; ENSP00000451188; ENSG00000100744.
GeneIDi51527.
KEGGihsa:51527.
UCSCiuc001yfj.6. human.

Organism-specific databases

CTDi51527.
GeneCardsiGSKIP.
H-InvDBHIX0011950.
HGNCiHGNC:20343. GSKIP.
HPAiHPA043054.
HPA046782.
MIMi616605. gene.
neXtProtiNX_Q9P0R6.
PharmGKBiPA134987554.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3965. Eukaryota.
ENOG4111QBG. LUCA.
GeneTreeiENSGT00390000009517.
HOGENOMiHOG000007951.
HOVERGENiHBG051028.
InParanoidiQ9P0R6.
OMAiETREGNR.
OrthoDBiEOG783MXF.
PhylomeDBiQ9P0R6.
TreeFamiTF313906.

Miscellaneous databases

EvolutionaryTraceiQ9P0R6.
GenomeRNAii51527.
PROiQ9P0R6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9P0R6.
CleanExiHS_C14orf129.
ExpressionAtlasiQ9P0R6. baseline and differential.
GenevisibleiQ9P0R6. HS.

Family and domain databases

InterProiIPR007967. DUF727.
IPR023231. GSKIP_dom.
[Graphical view]
PANTHERiPTHR12490. PTHR12490. 1 hit.
PfamiPF05303. DUF727. 1 hit.
[Graphical view]
ProDomiPD080843. DUF727. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF103107. SSF103107. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Umbilical cord blood.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala and Colon.
  3. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  6. "GSKIP is homologous to the axin GSK3beta interaction domain and functions as a negative regulator of GSK3beta."
    Chou H.-Y., Howng S.-L., Cheng T.-S., Hsiao Y.-L., Lieu A.-S., Loh J.-K., Hwang S.-L., Lin C.-C., Hsu C.-M., Wang C., Lee C.-I., Lu P.-J., Chou C.-K., Huang C.-Y., Hong Y.-R.
    Biochemistry 45:11379-11389(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GSK3B, SUBCELLULAR LOCATION, MUTAGENESIS OF LEU-130, TISSUE SPECIFICITY.
  7. "NMR structure of the human C14orf129 gene product, HSPC210. Northeast structural genomics target HR969."
    Northeast structural genomics consortium (NESG)
    Submitted (JAN-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiGSKIP_HUMAN
AccessioniPrimary (citable) accession number: Q9P0R6
Secondary accession number(s): B3KSZ0, Q9BST1, Q9NWK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 9, 2003
Last sequence update: September 9, 2003
Last modified: July 6, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.