##gff-version 3
Q9P0N8	UniProtKB	Chain	1	246	.	.	.	ID=PRO_0000055925;Note=E3 ubiquitin-protein ligase MARCHF2	
Q9P0N8	UniProtKB	Transmembrane	138	158	.	.	.	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q9P0N8	UniProtKB	Transmembrane	175	195	.	.	.	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255	
Q9P0N8	UniProtKB	Zinc finger	56	116	.	.	.	Note=RING-CH-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00623	
Q9P0N8	UniProtKB	Region	56	116	.	.	.	Note=Required for inhibition of HIV-1 virus production and VSV G protein expression;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29573664;Dbxref=PMID:29573664	
Q9P0N8	UniProtKB	Region	121	246	.	.	.	Note=Required for interaction with IKBKG;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:32935379;Dbxref=PMID:32935379	
Q9P0N8	UniProtKB	Binding site	64	64	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00623	
Q9P0N8	UniProtKB	Binding site	67	67	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00623	
Q9P0N8	UniProtKB	Binding site	80	80	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00623	
Q9P0N8	UniProtKB	Binding site	82	82	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00623	
Q9P0N8	UniProtKB	Binding site	90	90	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00623	
Q9P0N8	UniProtKB	Binding site	93	93	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00623	
Q9P0N8	UniProtKB	Binding site	106	106	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00623	
Q9P0N8	UniProtKB	Binding site	109	109	.	.	.	Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00623	
Q9P0N8	UniProtKB	Alternative sequence	125	194	.	.	.	ID=VSP_041478;Note=In isoform 2. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305	
Q9P0N8	UniProtKB	Natural variant	54	54	.	.	.	ID=VAR_030303;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15489334;Dbxref=dbSNP:rs1133893,PMID:15489334	
Q9P0N8	UniProtKB	Natural variant	219	219	.	.	.	ID=VAR_053638;Note=R->P;Dbxref=dbSNP:rs34099346	
Q9P0N8	UniProtKB	Mutagenesis	64	64	.	.	.	Note=Abolishes ubiquitination of ERGIC3 and CFTR%2C and degradation of CFTR%3B when associated with S-67. Reduces ubiquitination of DLG1%3B when associated with S-67%2C S-106 and S-109. Reduces inhibition of HIV-1 virus production and VSVG protein expression%3B when associated with S-67. Abolishes ubiquitination of IKBKG/NEMO%3B when associated with S-67 and Q-90. C->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17980554,ECO:0000269|PubMed:23818989,ECO:0000269|PubMed:29573664,ECO:0000269|PubMed:31142615,ECO:0000269|PubMed:32935379;Dbxref=PMID:17980554,PMID:23818989,PMID:29573664,PMID:31142615,PMID:32935379	
Q9P0N8	UniProtKB	Mutagenesis	67	67	.	.	.	Note=Abolishes ubiquitination of ERGIC3 and CFTR%2C and degradation of CFTR%3B when associated with S-64. Reduces ubiquitination of DLG1%3B when associated with S-64%2C S-106 and S-109. Reduces inhibition of HIV-1 virus production and VSVG protein expression%3B when associated with S-64. Abolishes ubiquitination of IKBKG/NEMO%3B when associated with S-64 and Q-90. C->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:17980554,ECO:0000269|PubMed:23818989,ECO:0000269|PubMed:29573664,ECO:0000269|PubMed:31142615,ECO:0000269|PubMed:32935379;Dbxref=PMID:17980554,PMID:23818989,PMID:29573664,PMID:31142615,PMID:32935379	
Q9P0N8	UniProtKB	Mutagenesis	90	90	.	.	.	Note=Abolishes ubiquitination of IKBKG/NEMO%3B when associated with S-64 and S-67. H->Q	
Q9P0N8	UniProtKB	Mutagenesis	97	97	.	.	.	Note=Reduces ubiquitination of DLG1. No effect on interaction with DLG1. Abolishes ubiquitination of and interaction with DLG1%3B when associated with 243-E--V-246 DEL. W->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17980554;Dbxref=PMID:17980554	
Q9P0N8	UniProtKB	Mutagenesis	106	106	.	.	.	Note=Reduces ubiquitination of DLG1%3B when associated with S-64%2C S-67 and S-109. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17980554;Dbxref=PMID:17980554	
Q9P0N8	UniProtKB	Mutagenesis	109	109	.	.	.	Note=Reduces ubiquitination of DLG1%3B when associated with S-64%2C S-67 and S-106. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17980554;Dbxref=PMID:17980554	
Q9P0N8	UniProtKB	Mutagenesis	243	246	.	.	.	Note=Abolishes ubiquitination of and interaction with DLG1%3B when associated with A-97. ETPV->AAAA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17980554;Dbxref=PMID:17980554