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Q9P0M9

- RM27_HUMAN

UniProt

Q9P0M9 - RM27_HUMAN

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Protein

39S ribosomal protein L27, mitochondrial

Gene

MRPL27

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  1. translation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L27, mitochondrial
Short name:
L27mt
Short name:
MRP-L27
Gene namesi
Name:MRPL27
ORF Names:HSPC250
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:14483. MRPL27.

Subcellular locationi

Mitochondrion 1 Publication

GO - Cellular componenti

  1. mitochondrial large ribosomal subunit Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30957.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14814839S ribosomal protein L27, mitochondrialPRO_0000181229Add
BLAST

Proteomic databases

MaxQBiQ9P0M9.
PaxDbiQ9P0M9.
PRIDEiQ9P0M9.

PTM databases

PhosphoSiteiQ9P0M9.

Expressioni

Gene expression databases

BgeeiQ9P0M9.
CleanExiHS_MRPL27.
ExpressionAtlasiQ9P0M9. baseline and differential.
GenevestigatoriQ9P0M9.

Organism-specific databases

HPAiHPA021416.

Interactioni

Protein-protein interaction databases

BioGridi119418. 15 interactions.
IntActiQ9P0M9. 2 interactions.
MINTiMINT-3077897.
STRINGi9606.ENSP00000225969.

Structurei

3D structure databases

ProteinModelPortaliQ9P0M9.
SMRiQ9P0M9. Positions 38-135.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L27P family.Curated

Phylogenomic databases

eggNOGiNOG290823.
GeneTreeiENSGT00390000014660.
HOGENOMiHOG000111610.
HOVERGENiHBG018255.
InParanoidiQ9P0M9.
KOiK02899.
OMAiHVVPAKP.
OrthoDBiEOG7R834K.
PhylomeDBiQ9P0M9.
TreeFamiTF323523.

Family and domain databases

InterProiIPR001684. Ribosomal_L27.
[Graphical view]
PANTHERiPTHR15893. PTHR15893. 1 hit.
PfamiPF01016. Ribosomal_L27. 1 hit.
[Graphical view]
PRINTSiPR00063. RIBOSOMALL27.
ProDomiPD003114. Ribosomal_L27. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q9P0M9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASVVLALRT RTAVTSLLSP TPATALAVRY ASKKSGGSSK NLGGKSSGRR
60 70 80 90 100
QGIKKMEGHY VHAGNIIATQ RHFRWHPGAH VGVGKNKCLY ALEEGIVRYT
110 120 130 140
KEVYVPHPRN TEAVDLITRL PKGAVLYKTF VHVVPAKPEG TFKLVAML
Length:148
Mass (Da):16,073
Last modified:October 1, 2000 - v1
Checksum:i90945F471E80EFB6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti24 – 241T → A.
Corresponds to variant rs17776919 [ dbSNP | Ensembl ].
VAR_052023

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB049647 mRNA. Translation: BAB40852.1.
AF151084 mRNA. Translation: AAF36170.1.
AK315758 mRNA. Translation: BAG38111.1.
CH471109 Genomic DNA. Translation: EAW94623.1.
BC001066 mRNA. Translation: AAH01066.1.
BC021986 mRNA. Translation: AAH21986.1.
CCDSiCCDS11564.1.
RefSeqiNP_057588.1. NM_016504.2.
UniGeneiHs.7736.

Genome annotation databases

EnsembliENST00000225969; ENSP00000225969; ENSG00000108826.
GeneIDi51264.
KEGGihsa:51264.
UCSCiuc002iqq.3. human.

Polymorphism databases

DMDMi20139806.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB049647 mRNA. Translation: BAB40852.1 .
AF151084 mRNA. Translation: AAF36170.1 .
AK315758 mRNA. Translation: BAG38111.1 .
CH471109 Genomic DNA. Translation: EAW94623.1 .
BC001066 mRNA. Translation: AAH01066.1 .
BC021986 mRNA. Translation: AAH21986.1 .
CCDSi CCDS11564.1.
RefSeqi NP_057588.1. NM_016504.2.
UniGenei Hs.7736.

3D structure databases

ProteinModelPortali Q9P0M9.
SMRi Q9P0M9. Positions 38-135.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119418. 15 interactions.
IntActi Q9P0M9. 2 interactions.
MINTi MINT-3077897.
STRINGi 9606.ENSP00000225969.

PTM databases

PhosphoSitei Q9P0M9.

Polymorphism databases

DMDMi 20139806.

Proteomic databases

MaxQBi Q9P0M9.
PaxDbi Q9P0M9.
PRIDEi Q9P0M9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000225969 ; ENSP00000225969 ; ENSG00000108826 .
GeneIDi 51264.
KEGGi hsa:51264.
UCSCi uc002iqq.3. human.

Organism-specific databases

CTDi 51264.
GeneCardsi GC17M048445.
HGNCi HGNC:14483. MRPL27.
HPAi HPA021416.
MIMi 611837. gene.
neXtProti NX_Q9P0M9.
PharmGKBi PA30957.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG290823.
GeneTreei ENSGT00390000014660.
HOGENOMi HOG000111610.
HOVERGENi HBG018255.
InParanoidi Q9P0M9.
KOi K02899.
OMAi HVVPAKP.
OrthoDBi EOG7R834K.
PhylomeDBi Q9P0M9.
TreeFami TF323523.

Miscellaneous databases

ChiTaRSi MRPL27. human.
GenomeRNAii 51264.
NextBioi 54441.
PROi Q9P0M9.
SOURCEi Search...

Gene expression databases

Bgeei Q9P0M9.
CleanExi HS_MRPL27.
ExpressionAtlasi Q9P0M9. baseline and differential.
Genevestigatori Q9P0M9.

Family and domain databases

InterProi IPR001684. Ribosomal_L27.
[Graphical view ]
PANTHERi PTHR15893. PTHR15893. 1 hit.
Pfami PF01016. Ribosomal_L27. 1 hit.
[Graphical view ]
PRINTSi PR00063. RIBOSOMALL27.
ProDomi PD003114. Ribosomal_L27. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria."
    Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K.
    J. Biol. Chem. 276:21724-21736(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
  2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Umbilical cord blood.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Trachea.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Lung.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRM27_HUMAN
AccessioniPrimary (citable) accession number: Q9P0M9
Secondary accession number(s): B2RE14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Ribosomal proteins
    Ribosomal proteins families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3