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Q9P0M9

- RM27_HUMAN

UniProt

Q9P0M9 - RM27_HUMAN

Protein

39S ribosomal protein L27, mitochondrial

Gene

MRPL27

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. structural constituent of ribosome Source: UniProtKB

    GO - Biological processi

    1. translation Source: UniProtKB

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    39S ribosomal protein L27, mitochondrial
    Short name:
    L27mt
    Short name:
    MRP-L27
    Gene namesi
    Name:MRPL27
    ORF Names:HSPC250
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:14483. MRPL27.

    Subcellular locationi

    Mitochondrion 1 Publication

    GO - Cellular componenti

    1. mitochondrial large ribosomal subunit Source: UniProtKB

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30957.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14814839S ribosomal protein L27, mitochondrialPRO_0000181229Add
    BLAST

    Proteomic databases

    MaxQBiQ9P0M9.
    PaxDbiQ9P0M9.
    PRIDEiQ9P0M9.

    PTM databases

    PhosphoSiteiQ9P0M9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9P0M9.
    BgeeiQ9P0M9.
    CleanExiHS_MRPL27.
    GenevestigatoriQ9P0M9.

    Organism-specific databases

    HPAiHPA021416.

    Interactioni

    Protein-protein interaction databases

    BioGridi119418. 4 interactions.
    IntActiQ9P0M9. 2 interactions.
    MINTiMINT-3077897.
    STRINGi9606.ENSP00000225969.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9P0M9.
    SMRiQ9P0M9. Positions 38-135.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L27P family.Curated

    Phylogenomic databases

    eggNOGiNOG290823.
    HOGENOMiHOG000111610.
    HOVERGENiHBG018255.
    KOiK02899.
    OMAiHVVPAKP.
    OrthoDBiEOG7R834K.
    PhylomeDBiQ9P0M9.
    TreeFamiTF323523.

    Family and domain databases

    InterProiIPR001684. Ribosomal_L27.
    [Graphical view]
    PANTHERiPTHR15893. PTHR15893. 1 hit.
    PfamiPF01016. Ribosomal_L27. 1 hit.
    [Graphical view]
    PRINTSiPR00063. RIBOSOMALL27.
    ProDomiPD003114. Ribosomal_L27. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    Q9P0M9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASVVLALRT RTAVTSLLSP TPATALAVRY ASKKSGGSSK NLGGKSSGRR    50
    QGIKKMEGHY VHAGNIIATQ RHFRWHPGAH VGVGKNKCLY ALEEGIVRYT 100
    KEVYVPHPRN TEAVDLITRL PKGAVLYKTF VHVVPAKPEG TFKLVAML 148
    Length:148
    Mass (Da):16,073
    Last modified:October 1, 2000 - v1
    Checksum:i90945F471E80EFB6
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti24 – 241T → A.
    Corresponds to variant rs17776919 [ dbSNP | Ensembl ].
    VAR_052023

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB049647 mRNA. Translation: BAB40852.1.
    AF151084 mRNA. Translation: AAF36170.1.
    AK315758 mRNA. Translation: BAG38111.1.
    CH471109 Genomic DNA. Translation: EAW94623.1.
    BC001066 mRNA. Translation: AAH01066.1.
    BC021986 mRNA. Translation: AAH21986.1.
    CCDSiCCDS11564.1.
    RefSeqiNP_057588.1. NM_016504.2.
    UniGeneiHs.7736.

    Genome annotation databases

    EnsembliENST00000225969; ENSP00000225969; ENSG00000108826.
    GeneIDi51264.
    KEGGihsa:51264.
    UCSCiuc002iqq.3. human.

    Polymorphism databases

    DMDMi20139806.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB049647 mRNA. Translation: BAB40852.1 .
    AF151084 mRNA. Translation: AAF36170.1 .
    AK315758 mRNA. Translation: BAG38111.1 .
    CH471109 Genomic DNA. Translation: EAW94623.1 .
    BC001066 mRNA. Translation: AAH01066.1 .
    BC021986 mRNA. Translation: AAH21986.1 .
    CCDSi CCDS11564.1.
    RefSeqi NP_057588.1. NM_016504.2.
    UniGenei Hs.7736.

    3D structure databases

    ProteinModelPortali Q9P0M9.
    SMRi Q9P0M9. Positions 38-135.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119418. 4 interactions.
    IntActi Q9P0M9. 2 interactions.
    MINTi MINT-3077897.
    STRINGi 9606.ENSP00000225969.

    PTM databases

    PhosphoSitei Q9P0M9.

    Polymorphism databases

    DMDMi 20139806.

    Proteomic databases

    MaxQBi Q9P0M9.
    PaxDbi Q9P0M9.
    PRIDEi Q9P0M9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000225969 ; ENSP00000225969 ; ENSG00000108826 .
    GeneIDi 51264.
    KEGGi hsa:51264.
    UCSCi uc002iqq.3. human.

    Organism-specific databases

    CTDi 51264.
    GeneCardsi GC17M048445.
    HGNCi HGNC:14483. MRPL27.
    HPAi HPA021416.
    MIMi 611837. gene.
    neXtProti NX_Q9P0M9.
    PharmGKBi PA30957.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG290823.
    HOGENOMi HOG000111610.
    HOVERGENi HBG018255.
    KOi K02899.
    OMAi HVVPAKP.
    OrthoDBi EOG7R834K.
    PhylomeDBi Q9P0M9.
    TreeFami TF323523.

    Miscellaneous databases

    ChiTaRSi MRPL27. human.
    GenomeRNAii 51264.
    NextBioi 54441.
    PROi Q9P0M9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9P0M9.
    Bgeei Q9P0M9.
    CleanExi HS_MRPL27.
    Genevestigatori Q9P0M9.

    Family and domain databases

    InterProi IPR001684. Ribosomal_L27.
    [Graphical view ]
    PANTHERi PTHR15893. PTHR15893. 1 hit.
    Pfami PF01016. Ribosomal_L27. 1 hit.
    [Graphical view ]
    PRINTSi PR00063. RIBOSOMALL27.
    ProDomi PD003114. Ribosomal_L27. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria."
      Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K.
      J. Biol. Chem. 276:21724-21736(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
    2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
      Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
      , Gu J., Chen S.-J., Chen Z.
      Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Umbilical cord blood.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Trachea.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Lung.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRM27_HUMAN
    AccessioniPrimary (citable) accession number: Q9P0M9
    Secondary accession number(s): B2RE14
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 5, 2002
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Ribosomal proteins
      Ribosomal proteins families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3