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Protein

39S ribosomal protein L27, mitochondrial

Gene

MRPL27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_267634. Mitochondrial translation initiation.
REACT_268133. Mitochondrial translation elongation.
REACT_268261. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L27, mitochondrial
Short name:
L27mt
Short name:
MRP-L27
Gene namesi
Name:MRPL27
ORF Names:HSPC250
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:14483. MRPL27.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: Reactome
  • mitochondrial large ribosomal subunit Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30957.

Polymorphism and mutation databases

BioMutaiMRPL27.
DMDMi20139806.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14814839S ribosomal protein L27, mitochondrialPRO_0000181229Add
BLAST

Proteomic databases

MaxQBiQ9P0M9.
PaxDbiQ9P0M9.
PRIDEiQ9P0M9.

PTM databases

PhosphoSiteiQ9P0M9.

Expressioni

Gene expression databases

BgeeiQ9P0M9.
CleanExiHS_MRPL27.
ExpressionAtlasiQ9P0M9. baseline and differential.
GenevisibleiQ9P0M9. HS.

Organism-specific databases

HPAiHPA021416.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FHL3Q136433EBI-5325236,EBI-741101

Protein-protein interaction databases

BioGridi119418. 15 interactions.
IntActiQ9P0M9. 3 interactions.
MINTiMINT-3077897.
STRINGi9606.ENSP00000225969.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40W1-148[»]
3J9Melectron microscopy3.50W1-148[»]
ProteinModelPortaliQ9P0M9.
SMRiQ9P0M9. Positions 42-148.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L27P family.Curated

Phylogenomic databases

eggNOGiNOG290823.
GeneTreeiENSGT00390000014660.
HOGENOMiHOG000111610.
HOVERGENiHBG018255.
InParanoidiQ9P0M9.
KOiK02899.
OMAiHVVPAKP.
OrthoDBiEOG7R834K.
PhylomeDBiQ9P0M9.
TreeFamiTF323523.

Family and domain databases

InterProiIPR001684. Ribosomal_L27.
[Graphical view]
PANTHERiPTHR15893. PTHR15893. 1 hit.
PfamiPF01016. Ribosomal_L27. 1 hit.
[Graphical view]
PRINTSiPR00063. RIBOSOMALL27.
ProDomiPD003114. Ribosomal_L27. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q9P0M9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVVLALRT RTAVTSLLSP TPATALAVRY ASKKSGGSSK NLGGKSSGRR
60 70 80 90 100
QGIKKMEGHY VHAGNIIATQ RHFRWHPGAH VGVGKNKCLY ALEEGIVRYT
110 120 130 140
KEVYVPHPRN TEAVDLITRL PKGAVLYKTF VHVVPAKPEG TFKLVAML
Length:148
Mass (Da):16,073
Last modified:October 1, 2000 - v1
Checksum:i90945F471E80EFB6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti24 – 241T → A.
Corresponds to variant rs17776919 [ dbSNP | Ensembl ].
VAR_052023

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049647 mRNA. Translation: BAB40852.1.
AF151084 mRNA. Translation: AAF36170.1.
AK315758 mRNA. Translation: BAG38111.1.
CH471109 Genomic DNA. Translation: EAW94623.1.
BC001066 mRNA. Translation: AAH01066.1.
BC021986 mRNA. Translation: AAH21986.1.
CCDSiCCDS11564.1.
RefSeqiNP_057588.1. NM_016504.2.
UniGeneiHs.7736.

Genome annotation databases

EnsembliENST00000225969; ENSP00000225969; ENSG00000108826.
GeneIDi51264.
KEGGihsa:51264.
UCSCiuc002iqq.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049647 mRNA. Translation: BAB40852.1.
AF151084 mRNA. Translation: AAF36170.1.
AK315758 mRNA. Translation: BAG38111.1.
CH471109 Genomic DNA. Translation: EAW94623.1.
BC001066 mRNA. Translation: AAH01066.1.
BC021986 mRNA. Translation: AAH21986.1.
CCDSiCCDS11564.1.
RefSeqiNP_057588.1. NM_016504.2.
UniGeneiHs.7736.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40W1-148[»]
3J9Melectron microscopy3.50W1-148[»]
ProteinModelPortaliQ9P0M9.
SMRiQ9P0M9. Positions 42-148.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119418. 15 interactions.
IntActiQ9P0M9. 3 interactions.
MINTiMINT-3077897.
STRINGi9606.ENSP00000225969.

PTM databases

PhosphoSiteiQ9P0M9.

Polymorphism and mutation databases

BioMutaiMRPL27.
DMDMi20139806.

Proteomic databases

MaxQBiQ9P0M9.
PaxDbiQ9P0M9.
PRIDEiQ9P0M9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000225969; ENSP00000225969; ENSG00000108826.
GeneIDi51264.
KEGGihsa:51264.
UCSCiuc002iqq.3. human.

Organism-specific databases

CTDi51264.
GeneCardsiGC17M048445.
HGNCiHGNC:14483. MRPL27.
HPAiHPA021416.
MIMi611837. gene.
neXtProtiNX_Q9P0M9.
PharmGKBiPA30957.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG290823.
GeneTreeiENSGT00390000014660.
HOGENOMiHOG000111610.
HOVERGENiHBG018255.
InParanoidiQ9P0M9.
KOiK02899.
OMAiHVVPAKP.
OrthoDBiEOG7R834K.
PhylomeDBiQ9P0M9.
TreeFamiTF323523.

Enzyme and pathway databases

ReactomeiREACT_267634. Mitochondrial translation initiation.
REACT_268133. Mitochondrial translation elongation.
REACT_268261. Mitochondrial translation termination.

Miscellaneous databases

ChiTaRSiMRPL27. human.
GenomeRNAii51264.
NextBioi54441.
PROiQ9P0M9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9P0M9.
CleanExiHS_MRPL27.
ExpressionAtlasiQ9P0M9. baseline and differential.
GenevisibleiQ9P0M9. HS.

Family and domain databases

InterProiIPR001684. Ribosomal_L27.
[Graphical view]
PANTHERiPTHR15893. PTHR15893. 1 hit.
PfamiPF01016. Ribosomal_L27. 1 hit.
[Graphical view]
PRINTSiPR00063. RIBOSOMALL27.
ProDomiPD003114. Ribosomal_L27. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria."
    Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K.
    J. Biol. Chem. 276:21724-21736(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
  2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Umbilical cord blood.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Trachea.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Lung.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRM27_HUMAN
AccessioniPrimary (citable) accession number: Q9P0M9
Secondary accession number(s): B2RE14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: October 1, 2000
Last modified: June 24, 2015
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.