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Protein

39S ribosomal protein L27, mitochondrial

Gene

MRPL27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L27, mitochondrial
Short name:
L27mt
Short name:
MRP-L27
Alternative name(s):
Mitochondrial large ribosomal subunit protein bL27m1 Publication
Gene namesi
Name:MRPL27
ORF Names:HSPC250
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:14483. MRPL27.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: Reactome
  • mitochondrial large ribosomal subunit Source: UniProtKB

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000108826.
PharmGKBiPA30957.

Polymorphism and mutation databases

BioMutaiMRPL27.
DMDMi20139806.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 30MitochondrionBy similarityAdd BLAST30
ChainiPRO_000018122931 – 14839S ribosomal protein L27, mitochondrialAdd BLAST118

Proteomic databases

EPDiQ9P0M9.
MaxQBiQ9P0M9.
PaxDbiQ9P0M9.
PeptideAtlasiQ9P0M9.
PRIDEiQ9P0M9.
TopDownProteomicsiQ9P0M9.

PTM databases

iPTMnetiQ9P0M9.
PhosphoSitePlusiQ9P0M9.

Expressioni

Gene expression databases

BgeeiENSG00000108826.
CleanExiHS_MRPL27.
ExpressionAtlasiQ9P0M9. baseline and differential.
GenevisibleiQ9P0M9. HS.

Organism-specific databases

HPAiHPA021416.

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FHL3Q136435EBI-5325236,EBI-741101

Protein-protein interaction databases

BioGridi119418. 38 interactors.
IntActiQ9P0M9. 5 interactors.
MINTiMINT-3077897.
STRINGi9606.ENSP00000225969.

Structurei

Secondary structure

1148
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi52 – 55Combined sources4
Beta strandi66 – 69Combined sources4
Beta strandi74 – 77Combined sources4
Beta strandi81 – 83Combined sources3
Beta strandi89 – 102Combined sources14
Helixi111 – 119Combined sources9
Beta strandi128 – 135Combined sources8
Beta strandi144 – 148Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40W1-148[»]
3J9Melectron microscopy3.50W1-148[»]
ProteinModelPortaliQ9P0M9.
SMRiQ9P0M9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4600. Eukaryota.
COG0211. LUCA.
GeneTreeiENSGT00390000014660.
HOGENOMiHOG000111610.
HOVERGENiHBG018255.
InParanoidiQ9P0M9.
KOiK02899.
OMAiHQRFRLV.
OrthoDBiEOG091G17I3.
PhylomeDBiQ9P0M9.
TreeFamiTF323523.

Family and domain databases

InterProiView protein in InterPro
IPR001684. Ribosomal_L27.
PANTHERiPTHR15893. PTHR15893. 1 hit.
PfamiView protein in Pfam
PF01016. Ribosomal_L27. 1 hit.
PRINTSiPR00063. RIBOSOMALL27.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003114. Ribosomal_L27. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9P0M9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVVLALRT RTAVTSLLSP TPATALAVRY ASKKSGGSSK NLGGKSSGRR
60 70 80 90 100
QGIKKMEGHY VHAGNIIATQ RHFRWHPGAH VGVGKNKCLY ALEEGIVRYT
110 120 130 140
KEVYVPHPRN TEAVDLITRL PKGAVLYKTF VHVVPAKPEG TFKLVAML
Length:148
Mass (Da):16,073
Last modified:October 1, 2000 - v1
Checksum:i90945F471E80EFB6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05202324T → A. Corresponds to variant dbSNP:rs17776919Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049647 mRNA. Translation: BAB40852.1.
AF151084 mRNA. Translation: AAF36170.1.
AK315758 mRNA. Translation: BAG38111.1.
CH471109 Genomic DNA. Translation: EAW94623.1.
BC001066 mRNA. Translation: AAH01066.1.
BC021986 mRNA. Translation: AAH21986.1.
CCDSiCCDS11564.1.
RefSeqiNP_057588.1. NM_016504.2.
UniGeneiHs.7736.

Genome annotation databases

EnsembliENST00000225969; ENSP00000225969; ENSG00000108826.
GeneIDi51264.
KEGGihsa:51264.
UCSCiuc002iqq.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRM27_HUMAN
AccessioniPrimary (citable) accession number: Q9P0M9
Secondary accession number(s): B2RE14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: October 1, 2000
Last modified: June 7, 2017
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families