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Protein

Core histone macro-H2A.2

Gene

H2AFY2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.1 Publication

GO - Molecular functioni

  • chromatin DNA binding Source: UniProtKB
  • protein heterodimerization activity Source: InterPro
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: UniProtKB
  • transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  • brain development Source: UniProtKB
  • chromatin silencing Source: GO_Central
  • dosage compensation Source: MGI
  • establishment of protein localization to chromatin Source: UniProtKB
  • negative regulation of gene expression, epigenetic Source: UniProtKB
  • negative regulation of transcription by RNA polymerase II Source: UniProtKB
  • negative regulation of transcription of nucleolar large rRNA by RNA polymerase I Source: UniProtKB
  • nucleosome assembly Source: InterPro
  • positive regulation of keratinocyte differentiation Source: UniProtKB

Keywordsi

Molecular functionChromatin regulator, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Core histone macro-H2A.2
Short name:
Histone macroH2A2
Short name:
mH2A2
Gene namesi
Name:H2AFY2
Synonyms:MACROH2A2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000099284.13
HGNCiHGNC:14453 H2AFY2
MIMi616141 gene
neXtProtiNX_Q9P0M6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55506
OpenTargetsiENSG00000099284
PharmGKBiPA29118

Polymorphism and mutation databases

BioMutaiH2AFY2
DMDMi12585260

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000553201 – 372Core histone macro-H2A.2Add BLAST372

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki239Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ9P0M6
MaxQBiQ9P0M6
PaxDbiQ9P0M6
PeptideAtlasiQ9P0M6
PRIDEiQ9P0M6

PTM databases

iPTMnetiQ9P0M6
PhosphoSitePlusiQ9P0M6

Expressioni

Gene expression databases

BgeeiENSG00000099284
CleanExiHS_H2AFY2
ExpressionAtlasiQ9P0M6 baseline and differential
GenevisibleiQ9P0M6 HS

Organism-specific databases

HPAiHPA035865
HPA041189

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120686, 119 interactors
DIPiDIP-48563N
IntActiQ9P0M6, 9 interactors
MINTiQ9P0M6
STRINGi9606.ENSP00000362352

Structurei

Secondary structure

1372
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi184 – 190Combined sources7
Beta strandi196 – 201Combined sources6
Helixi204 – 209Combined sources6
Beta strandi213 – 219Combined sources7
Helixi228 – 251Combined sources24
Beta strandi260 – 264Combined sources5
Beta strandi268 – 277Combined sources10
Helixi286 – 303Combined sources18
Beta strandi307 – 311Combined sources5
Helixi323 – 340Combined sources18
Beta strandi348 – 353Combined sources6
Helixi356 – 367Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XD7X-ray2.09A/B/C/D177-369[»]
6FY5X-ray1.65A/B178-372[»]
ProteinModelPortaliQ9P0M6
SMRiQ9P0M6
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9P0M6

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 117Histone H2AAdd BLAST116
Domaini184 – 370MacroPROSITE-ProRule annotationAdd BLAST187

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi118 – 161Lys-richAdd BLAST44

Phylogenomic databases

eggNOGiENOG410IV3A Eukaryota
KOG1756 Eukaryota
KOG2633 Eukaryota
COG2110 LUCA
COG5262 LUCA
GeneTreeiENSGT00910000143981
HOGENOMiHOG000234653
HOVERGENiHBG009342
InParanoidiQ9P0M6
KOiK11251
OMAiMKVEGIV
OrthoDBiEOG091G0XGD
PhylomeDBiQ9P0M6
TreeFamiTF332276

Family and domain databases

CDDicd00074 H2A, 1 hit
cd02904 Macro_H2A_like, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR021171 Core_histone_macro-H2A
IPR009072 Histone-fold
IPR002119 Histone_H2A
IPR007125 Histone_H2A/H2B/H3
IPR032454 Histone_H2A_C
IPR002589 Macro_dom
IPR035796 Macro_H2A
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PF16211 Histone_H2A_C, 1 hit
PF01661 Macro, 1 hit
PIRSFiPIRSF037942 Core_histone_macro-H2A, 1 hit
PRINTSiPR00620 HISTONEH2A
SMARTiView protein in SMART
SM00506 A1pp, 1 hit
SM00414 H2A, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS51154 MACRO, 1 hit

Sequencei

Sequence statusi: Complete.

Q9P0M6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRSGKKKM SKLSRSARAG VIFPVGRLMR YLKKGTFKYR ISVGAPVYMA
60 70 80 90 100
AVIEYLAAEI LELAGNAARD NKKARIAPRH ILLAVANDEE LNQLLKGVTI
110 120 130 140 150
ASGGVLPRIH PELLAKKRGT KGKSETILSP PPEKRGRKAT SGKKGGKKSK
160 170 180 190 200
AAKPRTSKKS KPKDSDKEGT SNSTSEDGPG DGFTILSSKS LVLGQKLSLT
210 220 230 240 250
QSDISHIGSM RVEGIVHPTT AEIDLKEDIG KALEKAGGKE FLETVKELRK
260 270 280 290 300
SQGPLEVAEA AVSQSSGLAA KFVIHCHIPQ WGSDKCEEQL EETIKNCLSA
310 320 330 340 350
AEDKKLKSVA FPPFPSGRNC FPKQTAAQVT LKAISAHFDD SSASSLKNVY
360 370
FLLFDSESIG IYVQEMAKLD AK
Length:372
Mass (Da):40,058
Last modified:January 23, 2007 - v3
Checksum:iC4B35CD156031AF1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF336304 mRNA Translation: AAK52471.1
AF151534 mRNA Translation: AAF72101.1
AK022776 mRNA Translation: BAB14239.1
AL731540 Genomic DNA No translation available.
BC016172 mRNA Translation: AAH16172.1
CCDSiCCDS7296.1
RefSeqiNP_061119.1, NM_018649.2
UniGeneiHs.499953

Genome annotation databases

EnsembliENST00000373255; ENSP00000362352; ENSG00000099284
GeneIDi55506
KEGGihsa:55506
UCSCiuc001jqm.4 human

Similar proteinsi

Entry informationi

Entry nameiH2AW_HUMAN
AccessioniPrimary (citable) accession number: Q9P0M6
Secondary accession number(s): Q5SQT2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 166 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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