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Protein

Core histone macro-H2A.2

Gene

H2AFY2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Core histone macro-H2A.2
Short name:
Histone macroH2A2
Short name:
mH2A2
Gene namesi
Name:H2AFY2
Synonyms:MACROH2A2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000099284.13.
HGNCiHGNC:14453. H2AFY2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55506.
OpenTargetsiENSG00000099284.
PharmGKBiPA29118.

Polymorphism and mutation databases

BioMutaiH2AFY2.
DMDMi12585260.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000553201 – 372Core histone macro-H2A.2Add BLAST372

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki239Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)ND:

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ9P0M6.
MaxQBiQ9P0M6.
PaxDbiQ9P0M6.
PeptideAtlasiQ9P0M6.
PRIDEiQ9P0M6.

PTM databases

iPTMnetiQ9P0M6.
PhosphoSitePlusiQ9P0M6.

Expressioni

Gene expression databases

BgeeiENSG00000099284.
CleanExiHS_H2AFY2.
ExpressionAtlasiQ9P0M6. baseline and differential.
GenevisibleiQ9P0M6. HS.

Organism-specific databases

HPAiHPA035865.
HPA041189.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120686. 117 interactors.
DIPiDIP-48563N.
IntActiQ9P0M6. 9 interactors.
MINTiMINT-6609507.
STRINGi9606.ENSP00000362352.

Structurei

Secondary structure

1372
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi184 – 190ND:7
Beta strandi196 – 201ND:6
Helixi204 – 209ND:6
Beta strandi213 – 219ND:7
Helixi228 – 251ND:24
Beta strandi260 – 264ND:5
Beta strandi268 – 277ND:10
Helixi286 – 303ND:18
Beta strandi307 – 311ND:5
Helixi323 – 340ND:18
Beta strandi348 – 353ND:6
Helixi356 – 367ND:12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XD7X-ray2.09A/B/C/D177-369[»]
ProteinModelPortaliQ9P0M6.
SMRiQ9P0M6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9P0M6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 117Histone H2AAdd BLAST116
Domaini184 – 370MacroIEP:Add BLAST187

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi118 – 161Lys-richAdd BLAST44

Phylogenomic databases

eggNOGiENOG410IV3A. Eukaryota.
KOG1756. Eukaryota.
KOG2633. Eukaryota.
COG2110. LUCA.
COG5262. LUCA.
GeneTreeiENSGT00900000140854.
HOGENOMiHOG000234653.
HOVERGENiHBG009342.
InParanoidiQ9P0M6.
KOiK11251.
OMAiRMMRYLR.
OrthoDBiEOG091G0XGD.
PhylomeDBiQ9P0M6.
TreeFamiTF332276.

Family and domain databases

CDDicd00074. H2A. 1 hit.
cd02904. Macro_H2A_like. 1 hit.
InterProiView protein in InterPro
IPR021171. Core_histone_macro-H2A.
IPR009072. Histone-fold.
IPR002119. Histone_H2A.
IPR007125. Histone_H2A/H2B/H3.
IPR032454. Histone_H2A_C.
IPR002589. Macro_dom.
IPR035796. Macro_H2A.
PfamiView protein in Pfam
PF00125. Histone. 1 hit.
PF16211. Histone_H2A_C. 1 hit.
PF01661. Macro. 1 hit.
PIRSFiPIRSF037942. Core_histone_macro-H2A. 1 hit.
PRINTSiPR00620. HISTONEH2A.
SMARTiView protein in SMART
SM00506. A1pp. 1 hit.
SM00414. H2A. 1 hit.
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiView protein in PROSITE
PS51154. MACRO. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9P0M6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGRSGKKKM SKLSRSARAG VIFPVGRLMR YLKKGTFKYR ISVGAPVYMA
60 70 80 90 100
AVIEYLAAEI LELAGNAARD NKKARIAPRH ILLAVANDEE LNQLLKGVTI
110 120 130 140 150
ASGGVLPRIH PELLAKKRGT KGKSETILSP PPEKRGRKAT SGKKGGKKSK
160 170 180 190 200
AAKPRTSKKS KPKDSDKEGT SNSTSEDGPG DGFTILSSKS LVLGQKLSLT
210 220 230 240 250
QSDISHIGSM RVEGIVHPTT AEIDLKEDIG KALEKAGGKE FLETVKELRK
260 270 280 290 300
SQGPLEVAEA AVSQSSGLAA KFVIHCHIPQ WGSDKCEEQL EETIKNCLSA
310 320 330 340 350
AEDKKLKSVA FPPFPSGRNC FPKQTAAQVT LKAISAHFDD SSASSLKNVY
360 370
FLLFDSESIG IYVQEMAKLD AK
Length:372
Mass (Da):40,058
Last modified:January 23, 2007 - v3
Checksum:iC4B35CD156031AF1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF336304 mRNA. Translation: AAK52471.1.
AF151534 mRNA. Translation: AAF72101.1.
AK022776 mRNA. Translation: BAB14239.1.
AL731540 Genomic DNA. No translation available.
BC016172 mRNA. Translation: AAH16172.1.
CCDSiCCDS7296.1.
RefSeqiNP_061119.1. NM_018649.2.
UniGeneiHs.499953.

Genome annotation databases

EnsembliENST00000373255; ENSP00000362352; ENSG00000099284.
GeneIDi55506.
KEGGihsa:55506.
UCSCiuc001jqm.4. human.

Similar proteinsi

Entry informationi

Entry nameiH2AW_HUMAN
AccessioniPrimary (citable) accession number: Q9P0M6
Secondary accession number(s): Q5SQT2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 162 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references