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Q9P0M6

- H2AW_HUMAN

UniProt

Q9P0M6 - H2AW_HUMAN

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Protein

Core histone macro-H2A.2

Gene

H2AFY2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.1 Publication

GO - Molecular functioni

  1. chromatin DNA binding Source: UniProt
  2. transcription regulatory region DNA binding Source: UniProt

GO - Biological processi

  1. brain development Source: UniProt
  2. chromatin modification Source: UniProtKB-KW
  3. dosage compensation Source: MGI
  4. establishment of protein localization to chromatin Source: UniProt
  5. negative regulation of gene expression, epigenetic Source: UniProt
  6. negative regulation of transcription from RNA polymerase II promoter Source: UniProt
  7. negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter Source: UniProt
  8. nucleosome assembly Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Core histone macro-H2A.2
Short name:
Histone macroH2A2
Short name:
mH2A2
Gene namesi
Name:H2AFY2
Synonyms:MACROH2A2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:14453. H2AFY2.

Subcellular locationi

Nucleus. Chromosome
Note: Enriched in inactive X chromosome chromatin and in senescence-associated heterochromatin.

GO - Cellular componenti

  1. Barr body Source: MGI
  2. extracellular vesicular exosome Source: UniProtKB
  3. nuclear chromatin Source: UniProt
  4. nucleosome Source: UniProtKB-KW
  5. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29118.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 372372Core histone macro-H2A.2PRO_0000055320Add
BLAST

Proteomic databases

MaxQBiQ9P0M6.
PaxDbiQ9P0M6.
PRIDEiQ9P0M6.

PTM databases

PhosphoSiteiQ9P0M6.

Expressioni

Gene expression databases

BgeeiQ9P0M6.
CleanExiHS_H2AFY2.
ExpressionAtlasiQ9P0M6. baseline and differential.
GenevestigatoriQ9P0M6.

Organism-specific databases

HPAiHPA035865.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.

Protein-protein interaction databases

BioGridi120686. 13 interactions.
DIPiDIP-48563N.
IntActiQ9P0M6. 2 interactions.
MINTiMINT-6609507.
STRINGi9606.ENSP00000362352.

Structurei

Secondary structure

1
372
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi184 – 1907Combined sources
Beta strandi196 – 2016Combined sources
Helixi204 – 2096Combined sources
Beta strandi213 – 2197Combined sources
Helixi228 – 25124Combined sources
Beta strandi260 – 2645Combined sources
Beta strandi268 – 27710Combined sources
Helixi286 – 30318Combined sources
Beta strandi307 – 3115Combined sources
Helixi323 – 34018Combined sources
Beta strandi348 – 3536Combined sources
Helixi356 – 36712Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2XD7X-ray2.09A/B/C/D177-369[»]
ProteinModelPortaliQ9P0M6.
SMRiQ9P0M6. Positions 12-117, 177-369.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9P0M6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 117116Histone H2AAdd
BLAST
Domaini184 – 370187MacroPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi118 – 16144Lys-richAdd
BLAST

Sequence similaritiesi

Contains 1 histone H2A domain.Curated
Contains 1 Macro domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG2110.
GeneTreeiENSGT00760000119217.
HOGENOMiHOG000234653.
HOVERGENiHBG009342.
InParanoidiQ9P0M6.
KOiK11251.
OMAiKVEGIVH.
OrthoDBiEOG71G9VP.
PhylomeDBiQ9P0M6.
TreeFamiTF332276.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR021171. Core_histone_macro-H2A.
IPR009072. Histone-fold.
IPR007125. Histone_core_D.
IPR002119. Histone_H2A.
IPR002589. Macro_dom.
[Graphical view]
PfamiPF00125. Histone. 1 hit.
PF01661. Macro. 1 hit.
[Graphical view]
PIRSFiPIRSF037942. Core_histone_macro-H2A. 1 hit.
PRINTSiPR00620. HISTONEH2A.
SMARTiSM00414. H2A. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS51154. MACRO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P0M6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGRSGKKKM SKLSRSARAG VIFPVGRLMR YLKKGTFKYR ISVGAPVYMA
60 70 80 90 100
AVIEYLAAEI LELAGNAARD NKKARIAPRH ILLAVANDEE LNQLLKGVTI
110 120 130 140 150
ASGGVLPRIH PELLAKKRGT KGKSETILSP PPEKRGRKAT SGKKGGKKSK
160 170 180 190 200
AAKPRTSKKS KPKDSDKEGT SNSTSEDGPG DGFTILSSKS LVLGQKLSLT
210 220 230 240 250
QSDISHIGSM RVEGIVHPTT AEIDLKEDIG KALEKAGGKE FLETVKELRK
260 270 280 290 300
SQGPLEVAEA AVSQSSGLAA KFVIHCHIPQ WGSDKCEEQL EETIKNCLSA
310 320 330 340 350
AEDKKLKSVA FPPFPSGRNC FPKQTAAQVT LKAISAHFDD SSASSLKNVY
360 370
FLLFDSESIG IYVQEMAKLD AK
Length:372
Mass (Da):40,058
Last modified:January 23, 2007 - v3
Checksum:iC4B35CD156031AF1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF336304 mRNA. Translation: AAK52471.1.
AF151534 mRNA. Translation: AAF72101.1.
AK022776 mRNA. Translation: BAB14239.1.
AL731540 Genomic DNA. Translation: CAI13683.1.
BC016172 mRNA. Translation: AAH16172.1.
CCDSiCCDS7296.1.
RefSeqiNP_061119.1. NM_018649.2.
UniGeneiHs.499953.

Genome annotation databases

EnsembliENST00000373255; ENSP00000362352; ENSG00000099284.
GeneIDi55506.
KEGGihsa:55506.
UCSCiuc001jqm.3. human.

Polymorphism databases

DMDMi12585260.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF336304 mRNA. Translation: AAK52471.1 .
AF151534 mRNA. Translation: AAF72101.1 .
AK022776 mRNA. Translation: BAB14239.1 .
AL731540 Genomic DNA. Translation: CAI13683.1 .
BC016172 mRNA. Translation: AAH16172.1 .
CCDSi CCDS7296.1.
RefSeqi NP_061119.1. NM_018649.2.
UniGenei Hs.499953.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2XD7 X-ray 2.09 A/B/C/D 177-369 [» ]
ProteinModelPortali Q9P0M6.
SMRi Q9P0M6. Positions 12-117, 177-369.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120686. 13 interactions.
DIPi DIP-48563N.
IntActi Q9P0M6. 2 interactions.
MINTi MINT-6609507.
STRINGi 9606.ENSP00000362352.

PTM databases

PhosphoSitei Q9P0M6.

Polymorphism databases

DMDMi 12585260.

Proteomic databases

MaxQBi Q9P0M6.
PaxDbi Q9P0M6.
PRIDEi Q9P0M6.

Protocols and materials databases

DNASUi 55506.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000373255 ; ENSP00000362352 ; ENSG00000099284 .
GeneIDi 55506.
KEGGi hsa:55506.
UCSCi uc001jqm.3. human.

Organism-specific databases

CTDi 55506.
GeneCardsi GC10P071812.
H-InvDB HIX0008890.
HGNCi HGNC:14453. H2AFY2.
HPAi HPA035865.
neXtProti NX_Q9P0M6.
PharmGKBi PA29118.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2110.
GeneTreei ENSGT00760000119217.
HOGENOMi HOG000234653.
HOVERGENi HBG009342.
InParanoidi Q9P0M6.
KOi K11251.
OMAi KVEGIVH.
OrthoDBi EOG71G9VP.
PhylomeDBi Q9P0M6.
TreeFami TF332276.

Miscellaneous databases

ChiTaRSi H2AFY2. human.
EvolutionaryTracei Q9P0M6.
GeneWikii H2AFY2.
GenomeRNAii 55506.
NextBioi 59903.
PROi Q9P0M6.

Gene expression databases

Bgeei Q9P0M6.
CleanExi HS_H2AFY2.
ExpressionAtlasi Q9P0M6. baseline and differential.
Genevestigatori Q9P0M6.

Family and domain databases

Gene3Di 1.10.20.10. 1 hit.
InterProi IPR021171. Core_histone_macro-H2A.
IPR009072. Histone-fold.
IPR007125. Histone_core_D.
IPR002119. Histone_H2A.
IPR002589. Macro_dom.
[Graphical view ]
Pfami PF00125. Histone. 1 hit.
PF01661. Macro. 1 hit.
[Graphical view ]
PIRSFi PIRSF037942. Core_histone_macro-H2A. 1 hit.
PRINTSi PR00620. HISTONEH2A.
SMARTi SM00414. H2A. 1 hit.
[Graphical view ]
SUPFAMi SSF47113. SSF47113. 1 hit.
PROSITEi PS51154. MACRO. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant."
    Chadwick B.P., Willard H.F.
    Hum. Mol. Genet. 10:1101-1113(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
  2. "MACROH2A2, a new member of the MACROH2A core histone family."
    Costanzi C., Pehrson J.R.
    J. Biol. Chem. 276:21776-21784(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  6. "Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA."
    Zhang R., Poustovoitov M.V., Ye X., Santos H.A., Chen W., Daganzo S.M., Erzberger J.P., Serebriiskii I.G., Canutescu A.A., Dunbrack R.L., Pehrson J.R., Berger J.M., Kaufman P.D., Adams P.D.
    Dev. Cell 8:19-30(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiH2AW_HUMAN
AccessioniPrimary (citable) accession number: Q9P0M6
Secondary accession number(s): Q5SQT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3