Q9P0M4 (IL17C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-17C
Short name=IL-17C

Alternative name(s):
Cytokine CX2

Gene names

Name:	IL17C
ORF Names:	UNQ561/PRO1122

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	197 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases. Ref.6
Subunit structure	Binds to a heterodimer formed by IL17RA and IL17RE. Ref.6
Subcellular location	Secreted.
Induction	Up-regulated by bacterial stimuli, including by lipopolysaccharides (LPS) in gut epithelial cell lines. This up-regulation may be mediated by Toll-like receptors TLR2 and TLR5. Up-regulated by various proinflammatory cytokines, including TNF, IL1B and IL17F. Up-regulation by IL17A in colon epithelial cells has been observed in some cases (Ref.5), but not in others (Ref.6). Ref.5 Ref.6
Sequence similarities	Belongs to the IL-17 family.

Ontologies

Keywords
Biological process	Inflammatory response
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell surface receptor signaling pathway Traceable author statement Ref.1. Source: ProtInc cell-cell signaling Traceable author statement Ref.1. Source: ProtInc inflammatory response Traceable author statement Ref.1. Source: ProtInc neutrophil differentiation Inferred from electronic annotation. Source: Compara positive regulation of cytokine production involved in inflammatory response Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular space Traceable author statement Ref.1. Source: ProtInc
Molecular_function	cytokine activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 197	179	Interleukin-17C		PRO_0000015429
Amino acid modifications
	Disulfide bond	129 ↔ 189		By similarity
	Disulfide bond	134 ↔ 191		By similarity
Natural variations
	Natural variant	25	1	R → G. Corresponds to variant rs11465492 [ dbSNP | Ensembl ].		VAR_049598
Experimental info
	Sequence conflict	50	1	H → R in AAG27921. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9P0M4 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: BAE0152E18DE7D08	FASTA	197	21,765
	10 20 30 40 50 60 MTLLPGLLFL TWLHTCLAHH DPSLRGHPHS HGTPHCYSAE ELPLGQAPPH LLARGAKWGQ 70 80 90 100 110 120 ALPVALVSSL EAASHRGRHE RPSATTQCPV LRPEEVLEAD THQRSISPWR YRVDTDEDRY 130 140 150 160 170 180 PQKLAFAECL CRGCIDARTG RETAALNSVR LLQSLLVLRR RPCSRDGSGL PTPGAFAFHT 190 EFIHVPVGCT CVLPRSV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family." Li H., Chen J., Huang A., Stinson J., Heldens S., Foster J., Dowd P., Gurney A.L., Wood W.I. Proc. Natl. Acad. Sci. U.S.A. 97:773-778(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Novel human cytokine CX2 with homology to IL-17." Zhang W., He L., Wan T., Yuan Z., Cao X. Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[5]	"IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens." Song X., Zhu S., Shi P., Liu Y., Shi Y., Levin S.D., Qian Y. Nat. Immunol. 12:1151-1158(2011) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
[6]	"IL-17C regulates the innate immune function of epithelial cells in an autocrine manner." Ramirez-Carrozzi V., Sambandam A., Luis E., Lin Z., Jeet S., Lesch J., Hackney J., Kim J., Zhou M., Lai J., Modrusan Z., Sai T., Lee W., Xu M., Caplazi P., Diehl L., de Voss J., Balazs M. , Gonzalez L. Jr., Singh H., Ouyang W., Pappu R. Nat. Immunol. 12:1159-1166(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH IL17RA AND IL17RE, INDUCTION, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Web resources

Wikipedia

Interleukin-17 entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF152099 mRNA. Translation: AAF28105.1. AF142410 mRNA. Translation: AAG27921.1. AY358471 mRNA. Translation: AAQ88835.1. BC069152 mRNA. Translation: AAH69152.1. BC101835 mRNA. Translation: AAI01836.1. BC112196 mRNA. Translation: AAI12197.1.
IPI	IPI00002316.
RefSeq	NP_037410.1. NM_013278.3.
UniGene	Hs.278911.
3D structure databases
ProteinModelPortal	Q9P0M4.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000244241.
Polymorphism databases
DMDM	20138769.
Proteomic databases
PRIDE	Q9P0M4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000244241; ENSP00000244241; ENSG00000124391.
GeneID	27189.
KEGG	hsa:27189.
UCSC	uc002fla.3. human.
Organism-specific databases
CTD	27189.
GeneCards	GC16P088705.
HGNC	HGNC:5983. IL17C.
MIM	604628. gene.
neXtProt	NX_Q9P0M4.
PharmGKB	PA29797.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG45335.
HOGENOM	HOG000113031.
HOVERGEN	HBG052096.
InParanoid	Q9P0M4.
KO	K05491.
OMA	TCVLPRS.
OrthoDB	EOG4WWRKN.
Gene expression databases
Bgee	Q9P0M4.
CleanEx	HS_IL17C.
Genevestigator	Q9P0M4.
GermOnline	ENSG00000124391. Homo sapiens.
Family and domain databases
InterPro	IPR010345. Interleukin-17. IPR020440. Interleukin-17_chordata. [Graphical view]
PANTHER	PTHR21295. PTHR21295. 1 hit.
Pfam	PF06083. IL17. 1 hit. [Graphical view]
PRINTS	PR01932. INTRLEUKIN17.
ProtoNet	Search...
Other
GenomeRNAi	27189.
NextBio	50038.
SOURCE	Search...

Entry information

Entry name

IL17C_HUMAN

Accession

Primary (citable) accession number: Q9P0M4
Secondary accession number(s): Q3MIG8, Q9HC75

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 31, 2002
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.