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Q9P0M4

- IL17C_HUMAN

UniProt

Q9P0M4 - IL17C_HUMAN

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Protein
Interleukin-17C
Gene
IL17C, UNQ561/PRO1122
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.1 Publication

GO - Molecular functioni

  1. cytokine activity Source: ProtInc
Complete GO annotation...

GO - Biological processi

  1. cell surface receptor signaling pathway Source: ProtInc
  2. cell-cell signaling Source: ProtInc
  3. inflammatory response Source: ProtInc
  4. neutrophil differentiation Source: Ensembl
  5. positive regulation of cytokine production involved in inflammatory response Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-17C
Short name:
IL-17C
Alternative name(s):
Cytokine CX2
Gene namesi
Name:IL17C
ORF Names:UNQ561/PRO1122
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:5983. IL17C.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29797.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Chaini19 – 197179Interleukin-17C
PRO_0000015429Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi129 ↔ 189 By similarity
Disulfide bondi134 ↔ 191 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ9P0M4.

Expressioni

Inductioni

Up-regulated by bacterial stimuli, including by lipopolysaccharides (LPS) in gut epithelial cell lines. This up-regulation may be mediated by Toll-like receptors TLR2 and TLR5. Up-regulated by various proinflammatory cytokines, including TNF, IL1B and IL17F. Up-regulation by IL17A in colon epithelial cells has been observed in some cases (1 Publication), but not in others (1 Publication).2 Publications

Gene expression databases

BgeeiQ9P0M4.
CleanExiHS_IL17C.
GenevestigatoriQ9P0M4.

Interactioni

Subunit structurei

Binds to a heterodimer formed by IL17RA and IL17RE.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000244241.

Structurei

3D structure databases

ProteinModelPortaliQ9P0M4.
SMRiQ9P0M4. Positions 102-194.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-17 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45335.
HOGENOMiHOG000113031.
HOVERGENiHBG052096.
InParanoidiQ9P0M4.
KOiK05491.
OMAiTCVLPRS.
OrthoDBiEOG7KSX9Z.
PhylomeDBiQ9P0M4.
TreeFamiTF314701.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020440. IL-17_chr.
IPR010345. IL-17_fam.
[Graphical view]
PANTHERiPTHR21295. PTHR21295. 1 hit.
PfamiPF06083. IL17. 1 hit.
[Graphical view]
PRINTSiPR01932. INTRLEUKIN17.
SUPFAMiSSF57501. SSF57501. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9P0M4-1 [UniParc]FASTAAdd to Basket

« Hide

MTLLPGLLFL TWLHTCLAHH DPSLRGHPHS HGTPHCYSAE ELPLGQAPPH    50
LLARGAKWGQ ALPVALVSSL EAASHRGRHE RPSATTQCPV LRPEEVLEAD 100
THQRSISPWR YRVDTDEDRY PQKLAFAECL CRGCIDARTG RETAALNSVR 150
LLQSLLVLRR RPCSRDGSGL PTPGAFAFHT EFIHVPVGCT CVLPRSV 197
Length:197
Mass (Da):21,765
Last modified:October 1, 2000 - v1
Checksum:iBAE0152E18DE7D08
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti25 – 251R → G.
Corresponds to variant rs11465492 [ dbSNP | Ensembl ].
VAR_049598

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti50 – 501H → R in AAG27921. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF152099 mRNA. Translation: AAF28105.1.
AF142410 mRNA. Translation: AAG27921.1.
AY358471 mRNA. Translation: AAQ88835.1.
BC069152 mRNA. Translation: AAH69152.1.
BC101835 mRNA. Translation: AAI01836.1.
BC112196 mRNA. Translation: AAI12197.1.
CCDSiCCDS42217.1.
RefSeqiNP_037410.1. NM_013278.3.
UniGeneiHs.278911.

Genome annotation databases

EnsembliENST00000244241; ENSP00000244241; ENSG00000124391.
GeneIDi27189.
KEGGihsa:27189.
UCSCiuc002fla.3. human.

Polymorphism databases

DMDMi20138769.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Interleukin-17 entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF152099 mRNA. Translation: AAF28105.1 .
AF142410 mRNA. Translation: AAG27921.1 .
AY358471 mRNA. Translation: AAQ88835.1 .
BC069152 mRNA. Translation: AAH69152.1 .
BC101835 mRNA. Translation: AAI01836.1 .
BC112196 mRNA. Translation: AAI12197.1 .
CCDSi CCDS42217.1.
RefSeqi NP_037410.1. NM_013278.3.
UniGenei Hs.278911.

3D structure databases

ProteinModelPortali Q9P0M4.
SMRi Q9P0M4. Positions 102-194.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000244241.

Polymorphism databases

DMDMi 20138769.

Proteomic databases

PRIDEi Q9P0M4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000244241 ; ENSP00000244241 ; ENSG00000124391 .
GeneIDi 27189.
KEGGi hsa:27189.
UCSCi uc002fla.3. human.

Organism-specific databases

CTDi 27189.
GeneCardsi GC16P088705.
HGNCi HGNC:5983. IL17C.
MIMi 604628. gene.
neXtProti NX_Q9P0M4.
PharmGKBi PA29797.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG45335.
HOGENOMi HOG000113031.
HOVERGENi HBG052096.
InParanoidi Q9P0M4.
KOi K05491.
OMAi TCVLPRS.
OrthoDBi EOG7KSX9Z.
PhylomeDBi Q9P0M4.
TreeFami TF314701.

Miscellaneous databases

GenomeRNAii 27189.
NextBioi 50038.
PROi Q9P0M4.
SOURCEi Search...

Gene expression databases

Bgeei Q9P0M4.
CleanExi HS_IL17C.
Genevestigatori Q9P0M4.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR020440. IL-17_chr.
IPR010345. IL-17_fam.
[Graphical view ]
PANTHERi PTHR21295. PTHR21295. 1 hit.
Pfami PF06083. IL17. 1 hit.
[Graphical view ]
PRINTSi PR01932. INTRLEUKIN17.
SUPFAMi SSF57501. SSF57501. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family."
    Li H., Chen J., Huang A., Stinson J., Heldens S., Foster J., Dowd P., Gurney A.L., Wood W.I.
    Proc. Natl. Acad. Sci. U.S.A. 97:773-778(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Novel human cytokine CX2 with homology to IL-17."
    Zhang W., He L., Wan T., Yuan Z., Cao X.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  5. "IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens."
    Song X., Zhu S., Shi P., Liu Y., Shi Y., Levin S.D., Qian Y.
    Nat. Immunol. 12:1151-1158(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  6. Cited for: FUNCTION, INTERACTION WITH IL17RA AND IL17RE, INDUCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiIL17C_HUMAN
AccessioniPrimary (citable) accession number: Q9P0M4
Secondary accession number(s): Q3MIG8, Q9HC75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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