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Q9P0M4

- IL17C_HUMAN

UniProt

Q9P0M4 - IL17C_HUMAN

Protein

Interleukin-17C

Gene

IL17C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.1 Publication

    GO - Molecular functioni

    1. cytokine activity Source: ProtInc

    GO - Biological processi

    1. cell-cell signaling Source: ProtInc
    2. cell surface receptor signaling pathway Source: ProtInc
    3. inflammatory response Source: ProtInc
    4. neutrophil differentiation Source: Ensembl
    5. positive regulation of cytokine production involved in inflammatory response Source: Ensembl

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Inflammatory response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-17C
    Short name:
    IL-17C
    Alternative name(s):
    Cytokine CX2
    Gene namesi
    Name:IL17C
    ORF Names:UNQ561/PRO1122
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:5983. IL17C.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: ProtInc

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29797.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 197179Interleukin-17CPRO_0000015429Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi129 ↔ 189By similarity
    Disulfide bondi134 ↔ 191By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ9P0M4.

    Expressioni

    Inductioni

    Up-regulated by bacterial stimuli, including by lipopolysaccharides (LPS) in gut epithelial cell lines. This up-regulation may be mediated by Toll-like receptors TLR2 and TLR5. Up-regulated by various proinflammatory cytokines, including TNF, IL1B and IL17F. Up-regulation by IL17A in colon epithelial cells has been observed in some cases (PubMed:21993849), but not in others (PubMed:21993848).2 Publications

    Gene expression databases

    BgeeiQ9P0M4.
    CleanExiHS_IL17C.
    GenevestigatoriQ9P0M4.

    Interactioni

    Subunit structurei

    Binds to a heterodimer formed by IL17RA and IL17RE.

    Protein-protein interaction databases

    STRINGi9606.ENSP00000244241.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9P0M4.
    SMRiQ9P0M4. Positions 102-194.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IL-17 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG45335.
    HOGENOMiHOG000113031.
    HOVERGENiHBG052096.
    InParanoidiQ9P0M4.
    KOiK05491.
    OMAiTCVLPRS.
    OrthoDBiEOG7KSX9Z.
    PhylomeDBiQ9P0M4.
    TreeFamiTF314701.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR020440. IL-17_chr.
    IPR010345. IL-17_fam.
    [Graphical view]
    PANTHERiPTHR21295. PTHR21295. 1 hit.
    PfamiPF06083. IL17. 1 hit.
    [Graphical view]
    PRINTSiPR01932. INTRLEUKIN17.
    SUPFAMiSSF57501. SSF57501. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9P0M4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTLLPGLLFL TWLHTCLAHH DPSLRGHPHS HGTPHCYSAE ELPLGQAPPH    50
    LLARGAKWGQ ALPVALVSSL EAASHRGRHE RPSATTQCPV LRPEEVLEAD 100
    THQRSISPWR YRVDTDEDRY PQKLAFAECL CRGCIDARTG RETAALNSVR 150
    LLQSLLVLRR RPCSRDGSGL PTPGAFAFHT EFIHVPVGCT CVLPRSV 197
    Length:197
    Mass (Da):21,765
    Last modified:October 1, 2000 - v1
    Checksum:iBAE0152E18DE7D08
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti50 – 501H → R in AAG27921. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti25 – 251R → G.
    Corresponds to variant rs11465492 [ dbSNP | Ensembl ].
    VAR_049598

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF152099 mRNA. Translation: AAF28105.1.
    AF142410 mRNA. Translation: AAG27921.1.
    AY358471 mRNA. Translation: AAQ88835.1.
    BC069152 mRNA. Translation: AAH69152.1.
    BC101835 mRNA. Translation: AAI01836.1.
    BC112196 mRNA. Translation: AAI12197.1.
    CCDSiCCDS42217.1.
    RefSeqiNP_037410.1. NM_013278.3.
    UniGeneiHs.278911.

    Genome annotation databases

    EnsembliENST00000244241; ENSP00000244241; ENSG00000124391.
    GeneIDi27189.
    KEGGihsa:27189.
    UCSCiuc002fla.3. human.

    Polymorphism databases

    DMDMi20138769.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Interleukin-17 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF152099 mRNA. Translation: AAF28105.1 .
    AF142410 mRNA. Translation: AAG27921.1 .
    AY358471 mRNA. Translation: AAQ88835.1 .
    BC069152 mRNA. Translation: AAH69152.1 .
    BC101835 mRNA. Translation: AAI01836.1 .
    BC112196 mRNA. Translation: AAI12197.1 .
    CCDSi CCDS42217.1.
    RefSeqi NP_037410.1. NM_013278.3.
    UniGenei Hs.278911.

    3D structure databases

    ProteinModelPortali Q9P0M4.
    SMRi Q9P0M4. Positions 102-194.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000244241.

    Polymorphism databases

    DMDMi 20138769.

    Proteomic databases

    PRIDEi Q9P0M4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000244241 ; ENSP00000244241 ; ENSG00000124391 .
    GeneIDi 27189.
    KEGGi hsa:27189.
    UCSCi uc002fla.3. human.

    Organism-specific databases

    CTDi 27189.
    GeneCardsi GC16P088705.
    HGNCi HGNC:5983. IL17C.
    MIMi 604628. gene.
    neXtProti NX_Q9P0M4.
    PharmGKBi PA29797.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45335.
    HOGENOMi HOG000113031.
    HOVERGENi HBG052096.
    InParanoidi Q9P0M4.
    KOi K05491.
    OMAi TCVLPRS.
    OrthoDBi EOG7KSX9Z.
    PhylomeDBi Q9P0M4.
    TreeFami TF314701.

    Miscellaneous databases

    GenomeRNAii 27189.
    NextBioi 50038.
    PROi Q9P0M4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9P0M4.
    CleanExi HS_IL17C.
    Genevestigatori Q9P0M4.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR020440. IL-17_chr.
    IPR010345. IL-17_fam.
    [Graphical view ]
    PANTHERi PTHR21295. PTHR21295. 1 hit.
    Pfami PF06083. IL17. 1 hit.
    [Graphical view ]
    PRINTSi PR01932. INTRLEUKIN17.
    SUPFAMi SSF57501. SSF57501. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family."
      Li H., Chen J., Huang A., Stinson J., Heldens S., Foster J., Dowd P., Gurney A.L., Wood W.I.
      Proc. Natl. Acad. Sci. U.S.A. 97:773-778(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Novel human cytokine CX2 with homology to IL-17."
      Zhang W., He L., Wan T., Yuan Z., Cao X.
      Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    5. "IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens."
      Song X., Zhu S., Shi P., Liu Y., Shi Y., Levin S.D., Qian Y.
      Nat. Immunol. 12:1151-1158(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    6. Cited for: FUNCTION, INTERACTION WITH IL17RA AND IL17RE, INDUCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiIL17C_HUMAN
    AccessioniPrimary (citable) accession number: Q9P0M4
    Secondary accession number(s): Q3MIG8, Q9HC75
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 31, 2002
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3