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Protein

Interleukin-17C

Gene

IL17C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.1 Publication

GO - Molecular functioni

  • cytokine activity Source: ProtInc

GO - Biological processi

  • cell-cell signaling Source: ProtInc
  • cell surface receptor signaling pathway Source: ProtInc
  • inflammatory response Source: ProtInc
  • interleukin-17-mediated signaling pathway Source: Reactome

Keywordsi

Molecular functionCytokine
Biological processInflammatory response

Enzyme and pathway databases

ReactomeiR-HSA-448424 Interleukin-17 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-17C
Short name:
IL-17C
Alternative name(s):
Cytokine CX2
Gene namesi
Name:IL17C
ORF Names:UNQ561/PRO1122
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000124391.4
HGNCiHGNC:5983 IL17C
MIMi604628 gene
neXtProtiNX_Q9P0M4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi27189
OpenTargetsiENSG00000124391
PharmGKBiPA29797

Polymorphism and mutation databases

BioMutaiIL17C
DMDMi20138769

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001542919 – 197Interleukin-17CAdd BLAST179

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi129 ↔ 189By similarity
Disulfide bondi134 ↔ 191By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9P0M4
PeptideAtlasiQ9P0M4
PRIDEiQ9P0M4

Expressioni

Inductioni

Up-regulated by bacterial stimuli, including by lipopolysaccharides (LPS) in gut epithelial cell lines. This up-regulation may be mediated by Toll-like receptors TLR2 and TLR5. Up-regulated by various proinflammatory cytokines, including TNF, IL1B and IL17F. Up-regulation by IL17A in colon epithelial cells has been observed in some cases (PubMed:21993849), but not in others (PubMed:21993848).2 Publications

Gene expression databases

BgeeiENSG00000124391
CleanExiHS_IL17C
GenevisibleiQ9P0M4 HS

Organism-specific databases

HPAiHPA065051

Interactioni

Subunit structurei

Binds to a heterodimer formed by IL17RA and IL17RE.

GO - Molecular functioni

  • cytokine activity Source: ProtInc

Protein-protein interaction databases

STRINGi9606.ENSP00000244241

Structurei

3D structure databases

ProteinModelPortaliQ9P0M4
SMRiQ9P0M4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-17 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZ2K Eukaryota
ENOG4111VTD LUCA
GeneTreeiENSGT00730000110824
HOGENOMiHOG000113031
HOVERGENiHBG052096
InParanoidiQ9P0M4
KOiK05491
OMAiTCVLPRS
OrthoDBiEOG091G17O0
PhylomeDBiQ9P0M4
TreeFamiTF314701

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR020440 IL-17_chr
IPR010345 IL-17_fam
PfamiView protein in Pfam
PF06083 IL17, 1 hit
PRINTSiPR01932 INTRLEUKIN17
SUPFAMiSSF57501 SSF57501, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9P0M4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLLPGLLFL TWLHTCLAHH DPSLRGHPHS HGTPHCYSAE ELPLGQAPPH
60 70 80 90 100
LLARGAKWGQ ALPVALVSSL EAASHRGRHE RPSATTQCPV LRPEEVLEAD
110 120 130 140 150
THQRSISPWR YRVDTDEDRY PQKLAFAECL CRGCIDARTG RETAALNSVR
160 170 180 190
LLQSLLVLRR RPCSRDGSGL PTPGAFAFHT EFIHVPVGCT CVLPRSV
Length:197
Mass (Da):21,765
Last modified:October 1, 2000 - v1
Checksum:iBAE0152E18DE7D08
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti50H → R in AAG27921 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04959825R → G. Corresponds to variant dbSNP:rs11465492Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF152099 mRNA Translation: AAF28105.1
AF142410 mRNA Translation: AAG27921.1
AY358471 mRNA Translation: AAQ88835.1
BC069152 mRNA Translation: AAH69152.1
BC101835 mRNA Translation: AAI01836.1
BC112196 mRNA Translation: AAI12197.1
CCDSiCCDS42217.1
RefSeqiNP_037410.1, NM_013278.3
UniGeneiHs.278911

Genome annotation databases

EnsembliENST00000244241; ENSP00000244241; ENSG00000124391
GeneIDi27189
KEGGihsa:27189
UCSCiuc002fla.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIL17C_HUMAN
AccessioniPrimary (citable) accession number: Q9P0M4
Secondary accession number(s): Q3MIG8, Q9HC75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: October 1, 2000
Last modified: February 28, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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