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Q9P0M4 (IL17C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-17C

Short name=IL-17C
Alternative name(s):
Cytokine CX2
Gene names
Name:IL17C
ORF Names:UNQ561/PRO1122
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length197 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases. Ref.6

Subunit structure

Binds to a heterodimer formed by IL17RA and IL17RE. Ref.6

Subcellular location

Secreted.

Induction

Up-regulated by bacterial stimuli, including by lipopolysaccharides (LPS) in gut epithelial cell lines. This up-regulation may be mediated by Toll-like receptors TLR2 and TLR5. Up-regulated by various proinflammatory cytokines, including TNF, IL1B and IL17F. Up-regulation by IL17A in colon epithelial cells has been observed in some cases (Ref.5), but not in others (Ref.6). Ref.5 Ref.6

Sequence similarities

Belongs to the IL-17 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 197179Interleukin-17C
PRO_0000015429

Amino acid modifications

Disulfide bond129 ↔ 189 By similarity
Disulfide bond134 ↔ 191 By similarity

Natural variations

Natural variant251R → G.
Corresponds to variant rs11465492 [ dbSNP | Ensembl ].
VAR_049598

Experimental info

Sequence conflict501H → R in AAG27921. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9P0M4 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: BAE0152E18DE7D08

FASTA19721,765
        10         20         30         40         50         60 
MTLLPGLLFL TWLHTCLAHH DPSLRGHPHS HGTPHCYSAE ELPLGQAPPH LLARGAKWGQ 

        70         80         90        100        110        120 
ALPVALVSSL EAASHRGRHE RPSATTQCPV LRPEEVLEAD THQRSISPWR YRVDTDEDRY 

       130        140        150        160        170        180 
PQKLAFAECL CRGCIDARTG RETAALNSVR LLQSLLVLRR RPCSRDGSGL PTPGAFAFHT 

       190 
EFIHVPVGCT CVLPRSV 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family."
Li H., Chen J., Huang A., Stinson J., Heldens S., Foster J., Dowd P., Gurney A.L., Wood W.I.
Proc. Natl. Acad. Sci. U.S.A. 97:773-778(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Novel human cytokine CX2 with homology to IL-17."
Zhang W., He L., Wan T., Yuan Z., Cao X.
Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[5]"IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens."
Song X., Zhu S., Shi P., Liu Y., Shi Y., Levin S.D., Qian Y.
Nat. Immunol. 12:1151-1158(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[6]"IL-17C regulates the innate immune function of epithelial cells in an autocrine manner."
Ramirez-Carrozzi V., Sambandam A., Luis E., Lin Z., Jeet S., Lesch J., Hackney J., Kim J., Zhou M., Lai J., Modrusan Z., Sai T., Lee W., Xu M., Caplazi P., Diehl L., de Voss J., Balazs M. expand/collapse author list , Gonzalez L. Jr., Singh H., Ouyang W., Pappu R.
Nat. Immunol. 12:1159-1166(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH IL17RA AND IL17RE, INDUCTION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Web resources

Wikipedia

Interleukin-17 entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF152099 mRNA. Translation: AAF28105.1.
AF142410 mRNA. Translation: AAG27921.1.
AY358471 mRNA. Translation: AAQ88835.1.
BC069152 mRNA. Translation: AAH69152.1.
BC101835 mRNA. Translation: AAI01836.1.
BC112196 mRNA. Translation: AAI12197.1.
RefSeqNP_037410.1. NM_013278.3.
UniGeneHs.278911.

3D structure databases

ProteinModelPortalQ9P0M4.
SMRQ9P0M4. Positions 102-194.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000244241.

Polymorphism databases

DMDM20138769.

Proteomic databases

PRIDEQ9P0M4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000244241; ENSP00000244241; ENSG00000124391.
GeneID27189.
KEGGhsa:27189.
UCSCuc002fla.3. human.

Organism-specific databases

CTD27189.
GeneCardsGC16P088705.
HGNCHGNC:5983. IL17C.
MIM604628. gene.
neXtProtNX_Q9P0M4.
PharmGKBPA29797.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45335.
HOGENOMHOG000113031.
HOVERGENHBG052096.
InParanoidQ9P0M4.
KOK05491.
OMATCVLPRS.
OrthoDBEOG7KSX9Z.
PhylomeDBQ9P0M4.
TreeFamTF314701.

Gene expression databases

BgeeQ9P0M4.
CleanExHS_IL17C.
GenevestigatorQ9P0M4.

Family and domain databases

InterProIPR020440. IL-17_chr.
IPR010345. IL-17_fam.
[Graphical view]
PANTHERPTHR21295. PTHR21295. 1 hit.
PfamPF06083. IL17. 1 hit.
[Graphical view]
PRINTSPR01932. INTRLEUKIN17.
ProtoNetSearch...

Other

GenomeRNAi27189.
NextBio50038.
PROQ9P0M4.
SOURCESearch...

Entry information

Entry nameIL17C_HUMAN
AccessionPrimary (citable) accession number: Q9P0M4
Secondary accession number(s): Q3MIG8, Q9HC75
Entry history
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM