Q9P0L9 (PK2L1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Polycystic kidney disease 2-like 1 protein

Alternative name(s):
Polycystin-2 homolog
Polycystin-2L1
Polycystin-L
Polycystin-L1

Gene names

Name:	PKD2L1
Synonyms:	PKD2L, PKDL

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	805 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May function as a subunit of an ion channel and act as a transducer of calcium-mediated signaling. Ref.8
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Tissue specificity	Expressed in adult heart, skeletal muscle, brain, spleen, testis, retina and liver. According to Ref.1, expressed at high levels in fetal tissues, including kidney and liver, and down-regulated in adult tissues. According to Ref.7, expressed in fetal brain, but not expressed in fetal lung, liver or kidney. Isoform 4 appears to be expressed only in transformed lymphoblasts. Ref.1 Ref.7
Sequence similarities	Belongs to the polycystin family.

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Transmembrane Transmembrane helix
Ligand	Calcium
Molecular function	Ion channel
PTM	Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular response to acidity Inferred from sequence or structural similarity. Source: BHF-UCL detection of chemical stimulus involved in sensory perception of sour taste Inferred from sequence or structural similarity. Source: BHF-UCL detection of mechanical stimulus Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular_component	cell surface Inferred from electronic annotation. Source: Ensembl endoplasmic reticulum Inferred from sequence or structural similarity. Source: BHF-UCL integral to membrane Non-traceable author statement Ref.6. Source: UniProtKB plasma membrane Inferred from mutant phenotype PubMed 17944866. Source: BHF-UCL
Molecular_function	calcium channel activity Inferred from Biological aspect of Ancestor. Source: RefGenome calcium ion binding Inferred from sequence or structural similarity. Source: BHF-UCL calcium-activated potassium channel activity Inferred from direct assay Ref.8. Source: BHF-UCL identical protein binding Inferred from sequence or structural similarity. Source: BHF-UCL sodium channel activity Inferred from direct assay Ref.8. Source: BHF-UCL sour taste receptor activity Inferred from electronic annotation. Source: Ensembl
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q9P0L9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9P0L9-2)

Also known as: PKDLdel15;

The sequence of this isoform differs from the canonical sequence as follows:
     751-760: KEQAIWKHPQ → RFPIKEKRKP
     761-805: Missing.

Isoform 3 (identifier: Q9P0L9-3)

Also known as: PKDLdel5;

The sequence of this isoform differs from the canonical sequence as follows:
     245-319: Missing.

Isoform 4 (identifier: Q9P0L9-4)

Also known as: PKDLdel456;

The sequence of this isoform differs from the canonical sequence as follows:
     225-344: Missing.

Note: Unusual intron exon spliced junction.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 805

805

Polycystic kidney disease 2-like 1 protein

PRO_0000164360

Regions

Topological domain

1 – 103

103

Cytoplasmic Potential

Transmembrane

104 – 124

21

Helical; Potential

Topological domain

125 – 313

189

Extracellular Potential

Transmembrane

314 – 334

21

Helical; Potential

Topological domain

335 – 347

13

Cytoplasmic Potential

Transmembrane

348 – 368

21

Helical; Potential

Topological domain

369 – 384

16

Extracellular Potential

Transmembrane

385 – 405

21

Helical; Potential

Topological domain

406 – 476

71

Cytoplasmic Potential

Transmembrane

477 – 497

21

Helical; Potential

Topological domain

498 – 539

42

Extracellular Potential

Transmembrane

540 – 560

21

Helical; Potential

Topological domain

561 – 805

245

Cytoplasmic Potential

Coiled coil

650 – 686

37

Potential

Motif

195 – 207

13

Polycystin motif

Amino acid modifications

Glycosylation

177

1

N-linked (GlcNAc...) Potential

Glycosylation

207

1

N-linked (GlcNAc...) Potential

Glycosylation

241

1

N-linked (GlcNAc...) Potential

Glycosylation

505

1

N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence

225 – 344

120

Missing in isoform 4.

VSP_004728

Alternative sequence

245 – 319

75

Missing in isoform 3.

VSP_004729

Alternative sequence

751 – 760

10

KEQAIWKHPQ → RFPIKEKRKP in isoform 2.

VSP_004730

Alternative sequence

761 – 805

45

Missing in isoform 2.

VSP_004731

Natural variant

278

1

R → Q.
Corresponds to variant rs17112895 [ dbSNP | Ensembl ].

VAR_050555

Natural variant

378

1

R → W.
Corresponds to variant rs7909153 [ dbSNP | Ensembl ].

VAR_050556

Natural variant

393

1

V → I. Ref.1
Corresponds to variant rs2278842 [ dbSNP | Ensembl ].

VAR_024569

Natural variant

681

1

R → L.
Corresponds to variant rs6584356 [ dbSNP | Ensembl ].

VAR_024570

Natural variant

788

1

A → D.
Corresponds to variant rs12782963 [ dbSNP | Ensembl ].

VAR_050557

Experimental info

Sequence conflict

13

1

Q → H in AAD41638. Ref.1

Secondary structure

1

.

.

.

.

.

805

Helix Strand Turn

Details...

Helix

704 – 731

28

Helix

734 – 741

8

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 3714C07F4B71F9C6	FASTA	805	91,982
	10 20 30 40 50 60 MNAVGSPEGQ ELQKLGSGAW DNPAYSGPPS PHGTLRVCTI SSTGPLQPQP KKPEDEPQET 70 80 90 100 110 120 AYRTQVSSCC LHICQGIRGL WGTTLTENTA ENRELYIKTT LRELLVYIVF LVDICLLTYG 130 140 150 160 170 180 MTSSSAYYYT KVMSELFLHT PSDTGVSFQA ISSMADFWDF AQGPLLDSLY WTKWYNNQSL 190 200 210 220 230 240 GHGSHSFIYY ENMLLGVPRL RQLKVRNDSC VVHEDFREDI LSCYDVYSPD KEEQLPFGPF 250 260 270 280 290 300 NGTAWTYHSQ DELGGFSHWG RLTSYSGGGY YLDLPGSRQG SAEALRALQE GLWLDRGTRV 310 320 330 340 350 360 VFIDFSVYNA NINLFCVLRL VVEFPATGGA IPSWQIRTVK LIRYVSNWDF FIVGCEVIFC 370 380 390 400 410 420 VFIFYYVVEE ILELHIHRLR YLSSIWNILD LVVILLSIVA VGFHIFRTLE VNRLMGKLLQ 430 440 450 460 470 480 QPNTYADFEF LAFWQTQYNN MNAVNLFFAW IKIFKYISFN KTMTQLSSTL ARCAKDILGF 490 500 510 520 530 540 AVMFFIVFFA YAQLGYLLFG TQVENFSTFI KCIFTQFRII LGDFDYNAID NANRILGPAY 550 560 570 580 590 600 FVTYVFFVFF VLLNMFLAII NDTYSEVKEE LAGQKDELQL SDLLKQGYNK TLLRLRLRKE 610 620 630 640 650 660 RVSDVQKVLQ GGEQEIQFED FTNTLRELGH AEHEITELTA TFTKFDRDGN RILDEKEQEK 670 680 690 700 710 720 MRQDLEEERV ALNTEIEKLG RSIVSSPQGK SGPEAARAGG WVSGEEFYML TRRVLQLETV 730 740 750 760 770 780 LEGVVSQIDA VGSKLKMLER KGWLAPSPGV KEQAIWKHPQ PAPAVTPDPW GVQGGQESEV 790 800 PYKREEEALE ERRLSRGEIP TLQRS
	Isoform 2 (PKDLdel15) [UniParc]. Checksum: 203D20F881C40055	FASTA	760	86,988
	10 20 30 40 50 60 MNAVGSPEGQ ELQKLGSGAW DNPAYSGPPS PHGTLRVCTI SSTGPLQPQP KKPEDEPQET 70 80 90 100 110 120 AYRTQVSSCC LHICQGIRGL WGTTLTENTA ENRELYIKTT LRELLVYIVF LVDICLLTYG 130 140 150 160 170 180 MTSSSAYYYT KVMSELFLHT PSDTGVSFQA ISSMADFWDF AQGPLLDSLY WTKWYNNQSL 190 200 210 220 230 240 GHGSHSFIYY ENMLLGVPRL RQLKVRNDSC VVHEDFREDI LSCYDVYSPD KEEQLPFGPF 250 260 270 280 290 300 NGTAWTYHSQ DELGGFSHWG RLTSYSGGGY YLDLPGSRQG SAEALRALQE GLWLDRGTRV 310 320 330 340 350 360 VFIDFSVYNA NINLFCVLRL VVEFPATGGA IPSWQIRTVK LIRYVSNWDF FIVGCEVIFC 370 380 390 400 410 420 VFIFYYVVEE ILELHIHRLR YLSSIWNILD LVVILLSIVA VGFHIFRTLE VNRLMGKLLQ 430 440 450 460 470 480 QPNTYADFEF LAFWQTQYNN MNAVNLFFAW IKIFKYISFN KTMTQLSSTL ARCAKDILGF 490 500 510 520 530 540 AVMFFIVFFA YAQLGYLLFG TQVENFSTFI KCIFTQFRII LGDFDYNAID NANRILGPAY 550 560 570 580 590 600 FVTYVFFVFF VLLNMFLAII NDTYSEVKEE LAGQKDELQL SDLLKQGYNK TLLRLRLRKE 610 620 630 640 650 660 RVSDVQKVLQ GGEQEIQFED FTNTLRELGH AEHEITELTA TFTKFDRDGN RILDEKEQEK 670 680 690 700 710 720 MRQDLEEERV ALNTEIEKLG RSIVSSPQGK SGPEAARAGG WVSGEEFYML TRRVLQLETV 730 740 750 760 LEGVVSQIDA VGSKLKMLER KGWLAPSPGV RFPIKEKRKP
	Isoform 3 (PKDLdel5) [UniParc]. Checksum: 02ABA835A71B32AD	FASTA	730	83,511
	10 20 30 40 50 60 MNAVGSPEGQ ELQKLGSGAW DNPAYSGPPS PHGTLRVCTI SSTGPLQPQP KKPEDEPQET 70 80 90 100 110 120 AYRTQVSSCC LHICQGIRGL WGTTLTENTA ENRELYIKTT LRELLVYIVF LVDICLLTYG 130 140 150 160 170 180 MTSSSAYYYT KVMSELFLHT PSDTGVSFQA ISSMADFWDF AQGPLLDSLY WTKWYNNQSL 190 200 210 220 230 240 GHGSHSFIYY ENMLLGVPRL RQLKVRNDSC VVHEDFREDI LSCYDVYSPD KEEQLPFGPF 250 260 270 280 290 300 NGTALVVEFP ATGGAIPSWQ IRTVKLIRYV SNWDFFIVGC EVIFCVFIFY YVVEEILELH 310 320 330 340 350 360 IHRLRYLSSI WNILDLVVIL LSIVAVGFHI FRTLEVNRLM GKLLQQPNTY ADFEFLAFWQ 370 380 390 400 410 420 TQYNNMNAVN LFFAWIKIFK YISFNKTMTQ LSSTLARCAK DILGFAVMFF IVFFAYAQLG 430 440 450 460 470 480 YLLFGTQVEN FSTFIKCIFT QFRIILGDFD YNAIDNANRI LGPAYFVTYV FFVFFVLLNM 490 500 510 520 530 540 FLAIINDTYS EVKEELAGQK DELQLSDLLK QGYNKTLLRL RLRKERVSDV QKVLQGGEQE 550 560 570 580 590 600 IQFEDFTNTL RELGHAEHEI TELTATFTKF DRDGNRILDE KEQEKMRQDL EEERVALNTE 610 620 630 640 650 660 IEKLGRSIVS SPQGKSGPEA ARAGGWVSGE EFYMLTRRVL QLETVLEGVV SQIDAVGSKL 670 680 690 700 710 720 KMLERKGWLA PSPGVKEQAI WKHPQPAPAV TPDPWGVQGG QESEVPYKRE EEALEERRLS 730 RGEIPTLQRS
	Isoform 4 (PKDLdel456) [UniParc]. Checksum: E805D32F37E6F54E	FASTA	685	78,520
	10 20 30 40 50 60 MNAVGSPEGQ ELQKLGSGAW DNPAYSGPPS PHGTLRVCTI SSTGPLQPQP KKPEDEPQET 70 80 90 100 110 120 AYRTQVSSCC LHICQGIRGL WGTTLTENTA ENRELYIKTT LRELLVYIVF LVDICLLTYG 130 140 150 160 170 180 MTSSSAYYYT KVMSELFLHT PSDTGVSFQA ISSMADFWDF AQGPLLDSLY WTKWYNNQSL 190 200 210 220 230 240 GHGSHSFIYY ENMLLGVPRL RQLKVRNDSC VVHEDFREDI LSCYVSNWDF FIVGCEVIFC 250 260 270 280 290 300 VFIFYYVVEE ILELHIHRLR YLSSIWNILD LVVILLSIVA VGFHIFRTLE VNRLMGKLLQ 310 320 330 340 350 360 QPNTYADFEF LAFWQTQYNN MNAVNLFFAW IKIFKYISFN KTMTQLSSTL ARCAKDILGF 370 380 390 400 410 420 AVMFFIVFFA YAQLGYLLFG TQVENFSTFI KCIFTQFRII LGDFDYNAID NANRILGPAY 430 440 450 460 470 480 FVTYVFFVFF VLLNMFLAII NDTYSEVKEE LAGQKDELQL SDLLKQGYNK TLLRLRLRKE 490 500 510 520 530 540 RVSDVQKVLQ GGEQEIQFED FTNTLRELGH AEHEITELTA TFTKFDRDGN RILDEKEQEK 550 560 570 580 590 600 MRQDLEEERV ALNTEIEKLG RSIVSSPQGK SGPEAARAGG WVSGEEFYML TRRVLQLETV 610 620 630 640 650 660 LEGVVSQIDA VGSKLKMLER KGWLAPSPGV KEQAIWKHPQ PAPAVTPDPW GVQGGQESEV 670 680 PYKREEEALE ERRLSRGEIP TLQRS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of PKDL, a novel polycystic kidney disease 2-like gene whose murine homologue is deleted in mice with kidney and retinal defects." Nomura H., Turco A.E., Pei Y., Kalaydjieva L., Schiavello T., Weremowicz S., Ji W., Morton C.C., Meisler M., Reeders S.T., Zhou J. J. Biol. Chem. 273:25967-25973(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1), TISSUE SPECIFICITY, VARIANT ILE-393. Tissue: Retina.
[2]	"The human polycystic kidney disease 2-like (PKDL) gene: exon/intron structure and evidence for a novel splicing mechanism." Guo L., Chen M., Basora N., Zhou J. Mamm. Genome 11:46-50(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 2; 3 AND 4).
[3]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[6]	"Identification of PKD2L, a human PKD2-related gene: tissue-specific expression and mapping to chromosome 10q25." Wu G., Hayashi T., Park J.-H., Dixit M., Reynolds D.M., Li L., Maeda Y., Cai Y., Coca-Prados M., Somlo S. Genomics 54:564-568(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 96-805 (ISOFORM 1). Tissue: Retina.
[7]	"Genes homologous to the autosomal dominant polycystic kidney disease genes (PKD1 and PKD2)." Veldhuisen B., Spruit L., Dauwerse H.G., Breuning M.H., Peters D.J.M. Eur. J. Hum. Genet. 7:860-872(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 43-805 (ISOFORMS 1 AND 4), TISSUE SPECIFICITY. Tissue: Testis.
[8]	"Polycystin-L is a calcium-regulated cation channel permeable to calcium ions." Chen X.-Z., Vassilev P.M., Basora N., Peng J.-B., Nomura H., Segal Y., Brown E.M., Reeders S.T., Hediger M.A., Zhou J. Nature 401:383-386(1999) [PubMed] [Europe PMC] [Abstract] Cited for: PROBABLE FUNCTION.
[9]	"Polycystin channels and kidney disease." Stayner C., Zhou J. Trends Pharmacol. Sci. 22:543-546(2001) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF073481 mRNA. Translation: AAD41638.1.
AF153474 , AF153459, AF153460, AF153461, AF153462, AF153463, AF153464, AF153465, AF153466, AF153467, AF153468, AF153469, AF153470, AF153471, AF153472, AF153473 Genomic DNA. Translation: AAF28108.1.
AL139819 Genomic DNA. Translation: CAH72822.1.
CH471066 Genomic DNA. Translation: EAW49833.1.
BC025665 mRNA. Translation: AAH25665.1.
AF094827 mRNA. Translation: AAD08695.1.
AF053316 mRNA. Translation: AAD51859.1.

IPI

IPI00103744.
IPI00219270.
IPI00219271.
IPI00219272.

RefSeq

NP_001240766.1. NM_001253837.1.
NP_057196.2. NM_016112.2.

UniGene

Hs.159241.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3TE3	X-ray	2.69	A/B/C/D/E/F	699-737	[»]
4GIF	X-ray	2.80	A	699-743	[»]

ProteinModelPortal

Q9P0L9.

SMR

Q9P0L9. Positions 597-675, 699-736.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9P0L9. 1 interaction.

MINT

MINT-3973148.

STRING

9606.ENSP00000325296.

Chemistry

ChEMBL

CHEMBL1628480.

GuidetoPHARMACOLOGY

505.

Polymorphism databases

DMDM

23821938.

Proteomic databases

PaxDb

Q9P0L9.

PRIDE

Q9P0L9.

Protocols and materials databases

DNASU

9033.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000318222; ENSP00000325296; ENSG00000107593.
ENST00000338519; ENSP00000345068; ENSG00000107593.
ENST00000353274; ENSP00000266049; ENSG00000107593.

GeneID

9033.

KEGG

hsa:9033.

UCSC

uc001kqx.1. human.

Organism-specific databases

CTD

9033.

GeneCards

GC10M102037.

HGNC

HGNC:9011. PKD2L1.

HPA

CAB022621.

MIM

604532. gene.

neXtProt

NX_Q9P0L9.

PharmGKB

PA33344.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG325704.

HOGENOM

HOG000230858.

HOVERGEN

HBG014945.

InParanoid

Q9P0L9.

KO

K04990.

OMA

FSTFVKC.

OrthoDB

EOG7N8ZTW.

PhylomeDB

Q9P0L9.

Gene expression databases

ArrayExpress

Q9P0L9.

Bgee

Q9P0L9.

CleanEx

HS_PKD2L1.

Genevestigator

Q9P0L9.

Family and domain databases

Gene3D

1.10.238.10. 1 hit.

InterPro

IPR011992. EF-hand-dom_pair.
IPR013122. PKD1_2_channel.
IPR003915. PKD_2.
[Graphical view]

Pfam

PF08016. PKD_channel. 1 hit.
[Graphical view]

PRINTS

PR01433. POLYCYSTIN2.

PROSITE

PS00018. EF_HAND_1. False negative.
[Graphical view]

ProtoNet

Search...

Other

GeneWiki

PKD2L1.

GenomeRNAi

9033.

NextBio

33843.

PRO

Q9P0L9.

SOURCE

Search...

Entry information

Entry name

PK2L1_HUMAN

Accession

Primary (citable) accession number: Q9P0L9
Secondary accession number(s): O75972 , Q5W039, Q9UP35, Q9UPA2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2002
Last sequence update:	October 1, 2000
Last modified:	December 11, 2013
This is version 117 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.