ID   Q9P0L4_HUMAN            Unreviewed;        95 AA.
AC   Q9P0L4;
DT   01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2000, sequence version 1.
DT   22-FEB-2023, entry version 85.
DE   SubName: Full=Bruton's tyrosine kinase {ECO:0000313|EMBL:AAF37340.1};
DE   Flags: Fragment;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAF37340.1};
RN   [1] {ECO:0000313|EMBL:AAF37340.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Orlandi P., Ritis K., Moschese V., Angelini F., Sideras P., Plebani A.,
RA   Rossi P.;
RT   "Identification of nine novel mutations in the Bruton's tyrosine kinase
RT   gene in X-linked agammaglobulinaemia patients.";
RL   Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AF153763; AAF37340.1; -; mRNA.
DR   AlphaFoldDB; Q9P0L4; -.
DR   PeptideAtlas; Q9P0L4; -.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   Pfam; PF00018; SH3_1; 1.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   2: Evidence at transcript level;
KW   Kinase {ECO:0000313|EMBL:AAF37340.1};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}; Transferase {ECO:0000313|EMBL:AAF37340.1}.
FT   DOMAIN          50..95
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   REGION          1..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAF37340.1"
SQ   SEQUENCE   95 AA;  10797 MW;  F2C0149F0433A891 CRC64;
     CQILENRNGS LKPGSSHRKT KKPLPPTPEE DQILKKPLPP EPAAAPVSTS ELKKVVALYD
     YMPMNANDLQ LRKGDEYFIL EESNLPWWRA RDKNG
//