Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9P0L4

- Q9P0L4_HUMAN

UniProt

Q9P0L4 - Q9P0L4_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name:

Bruton's tyrosine kinase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. protein tyrosine kinase activity Source: Ensembl

GO - Biological processi

  1. cell maturation Source: Ensembl
  2. histamine secretion by mast cell Source: Ensembl
  3. I-kappaB kinase/NF-kappaB signaling Source: Ensembl
  4. protein autophosphorylation Source: Ensembl
  5. response to organic substance Source: Ensembl
  6. response to reactive oxygen species Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Bruton's tyrosine kinaseImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cytoplasmic vesicle Source: Ensembl
  2. mast cell granule Source: GOC
  3. nucleus Source: Ensembl
  4. perinuclear region of cytoplasm Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ9P0L4.
ExpressionAtlasiQ9P0L4. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ9P0L4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 SH3 domain.UniRule annotation

Keywords - Domaini

SH3 domainUniRule annotation

Family and domain databases

InterProiIPR001452. SH3_domain.
[Graphical view]
PfamiPF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9P0L4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
CQILENRNGS LKPGSSHRKT KKPLPPTPEE DQILKKPLPP EPAAAPVSTS
60 70 80 90
ELKKVVALYD YMPMNANDLQ LRKGDEYFIL EESNLPWWRA RDKNG
Length:95
Mass (Da):10,797
Last modified:October 1, 2000 - v1
Checksum:iF2C0149F0433A891
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF153763 mRNA. Translation: AAF37340.1.
UniGeneiHs.159494.
Hs.733206.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF153763 mRNA. Translation: AAF37340.1 .
UniGenei Hs.159494.
Hs.733206.

3D structure databases

ProteinModelPortali Q9P0L4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Gene expression databases

Bgeei Q9P0L4.
ExpressionAtlasi Q9P0L4. baseline and differential.

Family and domain databases

InterProi IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00018. SH3_1. 1 hit.
[Graphical view ]
PRINTSi PR00452. SH3DOMAIN.
SMARTi SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
PROSITEi PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of nine novel mutations in the Bruton's tyrosine kinase gene in X-linked agammaglobulinaemia patients."
    Orlandi P., Ritis K., Moschese V., Angelini F., Sideras P., Plebani A., Rossi P.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9P0L4_HUMAN
AccessioniPrimary (citable) accession number: Q9P0L4
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.