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Q9P0L4

- Q9P0L4_HUMAN

UniProt

Q9P0L4 - Q9P0L4_HUMAN

Protein
Submitted name:

Bruton's tyrosine kinase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Molecular functioni

    1. protein tyrosine kinase activity Source: Ensembl

    GO - Biological processi

    1. cell maturation Source: Ensembl
    2. histamine secretion by mast cell Source: Ensembl
    3. I-kappaB kinase/NF-kappaB signaling Source: Ensembl
    4. protein autophosphorylation Source: Ensembl
    5. response to organic substance Source: Ensembl
    6. response to reactive oxygen species Source: Ensembl

    Keywords - Molecular functioni

    KinaseImported, Transferase

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Bruton's tyrosine kinaseImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasmic vesicle Source: Ensembl
    2. mast cell granule Source: GOC
    3. nucleus Source: Ensembl
    4. perinuclear region of cytoplasm Source: Ensembl

    Expressioni

    Gene expression databases

    ArrayExpressiQ9P0L4.
    BgeeiQ9P0L4.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9P0L4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 SH3 domain.UniRule annotation

    Keywords - Domaini

    SH3 domainUniRule annotation

    Family and domain databases

    InterProiIPR001452. SH3_domain.
    [Graphical view]
    PfamiPF00018. SH3_1. 1 hit.
    [Graphical view]
    PRINTSiPR00452. SH3DOMAIN.
    SMARTiSM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    PROSITEiPS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q9P0L4-1 [UniParc]FASTAAdd to Basket

    « Hide

    CQILENRNGS LKPGSSHRKT KKPLPPTPEE DQILKKPLPP EPAAAPVSTS   50
    ELKKVVALYD YMPMNANDLQ LRKGDEYFIL EESNLPWWRA RDKNG 95
    Length:95
    Mass (Da):10,797
    Last modified:October 1, 2000 - v1
    Checksum:iF2C0149F0433A891
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF153763 mRNA. Translation: AAF37340.1.
    UniGeneiHs.159494.
    Hs.733206.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF153763 mRNA. Translation: AAF37340.1 .
    UniGenei Hs.159494.
    Hs.733206.

    3D structure databases

    ProteinModelPortali Q9P0L4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Gene expression databases

    ArrayExpressi Q9P0L4.
    Bgeei Q9P0L4.

    Family and domain databases

    InterProi IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF00018. SH3_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00452. SH3DOMAIN.
    SMARTi SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    PROSITEi PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of nine novel mutations in the Bruton's tyrosine kinase gene in X-linked agammaglobulinaemia patients."
      Orlandi P., Ritis K., Moschese V., Angelini F., Sideras P., Plebani A., Rossi P.
      Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ9P0L4_HUMAN
    AccessioniPrimary (citable) accession number: Q9P0L4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 1, 2000
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.