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Protein
Submitted name:

Bruton's tyrosine kinase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Bruton's tyrosine kinaseImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PaxDbiQ9P0L4.

Expressioni

Gene expression databases

BgeeiQ9P0L4.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000308176.

Chemistry

BindingDBiQ9P0L4.

Structurei

3D structure databases

ProteinModelPortaliQ9P0L4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini50 – 9546SH3InterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 SH3 domain.UniRule annotation

Keywords - Domaini

SH3 domainUniRule annotation

Phylogenomic databases

eggNOGiCOG0515. LUCA.
KOG0197. Eukaryota.

Family and domain databases

InterProiIPR001452. SH3_domain.
[Graphical view]
PfamiPF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9P0L4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
CQILENRNGS LKPGSSHRKT KKPLPPTPEE DQILKKPLPP EPAAAPVSTS
60 70 80 90
ELKKVVALYD YMPMNANDLQ LRKGDEYFIL EESNLPWWRA RDKNG
Length:95
Mass (Da):10,797
Last modified:October 1, 2000 - v1
Checksum:iF2C0149F0433A891
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF153763 mRNA. Translation: AAF37340.1.
UniGeneiHs.159494.
Hs.733206.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF153763 mRNA. Translation: AAF37340.1.
UniGeneiHs.159494.
Hs.733206.

3D structure databases

ProteinModelPortaliQ9P0L4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000308176.

Chemistry

BindingDBiQ9P0L4.

Proteomic databases

PaxDbiQ9P0L4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiCOG0515. LUCA.
KOG0197. Eukaryota.

Gene expression databases

BgeeiQ9P0L4.

Family and domain databases

InterProiIPR001452. SH3_domain.
[Graphical view]
PfamiPF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of nine novel mutations in the Bruton's tyrosine kinase gene in X-linked agammaglobulinaemia patients."
    Orlandi P., Ritis K., Moschese V., Angelini F., Sideras P., Plebani A., Rossi P.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9P0L4_HUMAN
AccessioniPrimary (citable) accession number: Q9P0L4
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: December 9, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.