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Protein
Submitted name:

Bruton's tyrosine kinase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. protein tyrosine kinase activity Source: Ensembl

GO - Biological processi

  1. cell maturation Source: Ensembl
  2. cellular response to molecule of fungal origin Source: Ensembl
  3. cellular response to reactive oxygen species Source: Ensembl
  4. histamine secretion by mast cell Source: Ensembl
  5. I-kappaB kinase/NF-kappaB signaling Source: Ensembl
  6. protein autophosphorylation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Bruton's tyrosine kinaseImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cytoplasmic vesicle Source: Ensembl
  2. mast cell granule Source: Ensembl
  3. nucleus Source: Ensembl
  4. perinuclear region of cytoplasm Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ9P0L4.
ExpressionAtlasiQ9P0L4. baseline and differential.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ9P0L4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 SH3 domain.UniRule annotation

Keywords - Domaini

SH3 domainUniRule annotation

Family and domain databases

InterProiIPR001452. SH3_domain.
[Graphical view]
PfamiPF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9P0L4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
CQILENRNGS LKPGSSHRKT KKPLPPTPEE DQILKKPLPP EPAAAPVSTS
60 70 80 90
ELKKVVALYD YMPMNANDLQ LRKGDEYFIL EESNLPWWRA RDKNG
Length:95
Mass (Da):10,797
Last modified:October 1, 2000 - v1
Checksum:iF2C0149F0433A891
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF153763 mRNA. Translation: AAF37340.1.
UniGeneiHs.159494.
Hs.733206.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF153763 mRNA. Translation: AAF37340.1.
UniGeneiHs.159494.
Hs.733206.

3D structure databases

ProteinModelPortaliQ9P0L4.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiQ9P0L4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Gene expression databases

BgeeiQ9P0L4.
ExpressionAtlasiQ9P0L4. baseline and differential.

Family and domain databases

InterProiIPR001452. SH3_domain.
[Graphical view]
PfamiPF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of nine novel mutations in the Bruton's tyrosine kinase gene in X-linked agammaglobulinaemia patients."
    Orlandi P., Ritis K., Moschese V., Angelini F., Sideras P., Plebani A., Rossi P.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9P0L4_HUMAN
AccessioniPrimary (citable) accession number: Q9P0L4
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: November 26, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.