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Protein

Zinc finger protein with KRAB and SCAN domains 7

Gene

ZKSCAN7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri383 – 405C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 433C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri439 – 461C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri467 – 489C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri495 – 517C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri523 – 545C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri551 – 573C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri579 – 601C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri607 – 629C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri635 – 657C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri663 – 685C2H2-type 11; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri691 – 713C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri719 – 741C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000144792-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein with KRAB and SCAN domains 7
Alternative name(s):
Zinc finger protein 167
Zinc finger protein 448
Zinc finger protein 64
Gene namesi
Name:ZKSCAN7
Synonyms:ZNF167, ZNF448, ZNF64
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:12955. ZKSCAN7.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55888.
OpenTargetsiENSG00000196345.
ENSG00000281894.
PharmGKBiPA37537.

Polymorphism and mutation databases

BioMutaiZKSCAN7.
DMDMi124078992.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474371 – 754Zinc finger protein with KRAB and SCAN domains 7Add BLAST754

Proteomic databases

MaxQBiQ9P0L1.
PaxDbiQ9P0L1.
PeptideAtlasiQ9P0L1.
PRIDEiQ9P0L1.

PTM databases

iPTMnetiQ9P0L1.
PhosphoSitePlusiQ9P0L1.

Expressioni

Gene expression databases

BgeeiENSG00000196345.
CleanExiHS_ZNF167.
ExpressionAtlasiQ9P0L1. baseline and differential.
GenevisibleiQ9P0L1. HS.

Organism-specific databases

HPAiHPA048312.
HPA049906.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SCAND1P570864EBI-743851,EBI-745846
ZKSCAN4Q969J23EBI-743851,EBI-2818641
ZNF446Q96AF53EBI-743851,EBI-740232
ZSCAN12O433093EBI-743851,EBI-1210440
ZSCAN21Q9Y5A63EBI-743851,EBI-10281938

Protein-protein interaction databases

BioGridi120978. 14 interactors.
IntActiQ9P0L1. 13 interactors.
STRINGi9606.ENSP00000273320.

Structurei

3D structure databases

ProteinModelPortaliQ9P0L1.
SMRiQ9P0L1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 136SCAN boxPROSITE-ProRule annotationAdd BLAST83
Domaini231 – 306KRABPROSITE-ProRule annotationAdd BLAST76

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri383 – 405C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 433C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri439 – 461C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri467 – 489C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri495 – 517C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri523 – 545C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri551 – 573C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri579 – 601C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri607 – 629C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri635 – 657C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri663 – 685C2H2-type 11; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri691 – 713C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri719 – 741C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133674.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ9P0L1.
KOiK09229.
OMAiDKYKEVG.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9P0L1.
TreeFamiTF350837.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 6 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P0L1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTTAGRGNLG LIPRSTAFQK QEGRLTVKQE PANQTWGQGS SLQKNYPPVC
60 70 80 90 100
EIFRLHFRQL CYHEMSGPQE ALSRLRELCR WWLMPEVHTK EQILELLVLE
110 120 130 140 150
QFLSILPGEL RTWVQLHHPE SGEEAVAVVE DFQRHLSGSE EVSAPAQKQE
160 170 180 190 200
MHFEETTALG TTKESPPTSP LSGGSAPGAH LEPPYDPGTH HLPSGDFAQC
210 220 230 240 250
TSPVPTLPQV GNSGDQAGAT VLRMVRPQDT VAYEDLSVDY TQKKWKSLTL
260 270 280 290 300
SQRALQWNMM PENHHSMASL AGENMMKGSE LTPKQEFFKG SESSNRTSGG
310 320 330 340 350
LFGVVPGAAE TGDVCEDTFK ELEGQTSDEE GSRLENDFLE ITDEDKKKST
360 370 380 390 400
KDRYDKYKEV GEHPPLSSSP VEHEGVLKGQ KSYRCDECGK AFNRSSHLIG
410 420 430 440 450
HQRIHTGEKP YECNECGKTF RQTSQLIVHL RTHTGEKPYE CSECGKAYRH
460 470 480 490 500
SSHLIQHQRL HNGEKPYKCN ECAKAFTQSS RLTDHQRTHT GEKPYECNEC
510 520 530 540 550
GEAFIRSKSL ARHQVLHTGK KPYKCNECGR AFCSNRNLID HQRIHTGEKP
560 570 580 590 600
YECSECGKAF SRSKCLIRHQ SLHTGEKPYK CSECGKAFNQ NSQLIEHERI
610 620 630 640 650
HTGEKPFECS ECGKAFGLSK CLIRHQRLHT GEKPYKCNEC GKSFNQNSHL
660 670 680 690 700
IIHQRIHTGE KPYECNECGK VFSYSSSLMV HQRTHTGEKP YKCNDCGKAF
710 720 730 740 750
SDSSQLIVHQ RVHTGEKPYE CSECGKAFSQ RSTFNHHQRT HTGEKSSGLA

WSVS
Length:754
Mass (Da):85,033
Last modified:January 23, 2007 - v2
Checksum:iB568F187A3ED2D1B
GO
Isoform 2 (identifier: Q9P0L1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     271-276: AGENMM → GWSTMA
     277-754: Missing.

Note: No experimental confirmation available.
Show »
Length:276
Mass (Da):30,787
Checksum:iF251589C8FFFA56F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti665C → Y in AAF72104 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05278224R → C.Corresponds to variant rs35696191dbSNPEnsembl.1
Natural variantiVAR_052783153F → S.Corresponds to variant rs13081859dbSNPEnsembl.1
Natural variantiVAR_052784342T → I.Corresponds to variant rs34396823dbSNPEnsembl.1
Natural variantiVAR_052785359E → K.Corresponds to variant rs34181686dbSNPEnsembl.1
Natural variantiVAR_052786432T → A.Corresponds to variant rs9835485dbSNPEnsembl.1
Natural variantiVAR_052787483T → I.2 PublicationsCorresponds to variant rs9873604dbSNPEnsembl.1
Natural variantiVAR_052788746S → F.Corresponds to variant rs34437520dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011955271 – 276AGENMM → GWSTMA in isoform 2. 1 Publication6
Alternative sequenceiVSP_011956277 – 754Missing in isoform 2. 1 PublicationAdd BLAST478

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF154846 mRNA. Translation: AAF72104.1.
AY280798 mRNA. Translation: AAQ16302.1.
AK291285 mRNA. Translation: BAF83974.1.
BC010555 mRNA. Translation: AAH10555.1.
BC063020 mRNA. Translation: AAH63020.1.
BC127640 mRNA. Translation: AAI27641.1.
CCDSiCCDS2714.1. [Q9P0L1-2]
CCDS2715.1. [Q9P0L1-1]
PIRiG45193.
RefSeqiNP_001275519.1. NM_001288590.1. [Q9P0L1-1]
NP_001275520.1. NM_001288591.1. [Q9P0L1-2]
NP_001275521.1. NM_001288592.1.
NP_061121.2. NM_018651.3. [Q9P0L1-1]
NP_079445.1. NM_025169.2. [Q9P0L1-2]
UniGeneiHs.529512.
Hs.696570.

Genome annotation databases

EnsembliENST00000273320; ENSP00000273320; ENSG00000196345. [Q9P0L1-1]
ENST00000341840; ENSP00000345404; ENSG00000196345. [Q9P0L1-2]
ENST00000426540; ENSP00000395524; ENSG00000196345. [Q9P0L1-1]
ENST00000431636; ENSP00000416681; ENSG00000196345. [Q9P0L1-2]
ENST00000625422; ENSP00000486331; ENSG00000281894. [Q9P0L1-2]
ENST00000626497; ENSP00000485942; ENSG00000281894. [Q9P0L1-1]
ENST00000629379; ENSP00000485948; ENSG00000281894. [Q9P0L1-1]
ENST00000629459; ENSP00000486642; ENSG00000281894. [Q9P0L1-2]
GeneIDi55888.
KEGGihsa:55888.
UCSCiuc003cni.5. human. [Q9P0L1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF154846 mRNA. Translation: AAF72104.1.
AY280798 mRNA. Translation: AAQ16302.1.
AK291285 mRNA. Translation: BAF83974.1.
BC010555 mRNA. Translation: AAH10555.1.
BC063020 mRNA. Translation: AAH63020.1.
BC127640 mRNA. Translation: AAI27641.1.
CCDSiCCDS2714.1. [Q9P0L1-2]
CCDS2715.1. [Q9P0L1-1]
PIRiG45193.
RefSeqiNP_001275519.1. NM_001288590.1. [Q9P0L1-1]
NP_001275520.1. NM_001288591.1. [Q9P0L1-2]
NP_001275521.1. NM_001288592.1.
NP_061121.2. NM_018651.3. [Q9P0L1-1]
NP_079445.1. NM_025169.2. [Q9P0L1-2]
UniGeneiHs.529512.
Hs.696570.

3D structure databases

ProteinModelPortaliQ9P0L1.
SMRiQ9P0L1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120978. 14 interactors.
IntActiQ9P0L1. 13 interactors.
STRINGi9606.ENSP00000273320.

PTM databases

iPTMnetiQ9P0L1.
PhosphoSitePlusiQ9P0L1.

Polymorphism and mutation databases

BioMutaiZKSCAN7.
DMDMi124078992.

Proteomic databases

MaxQBiQ9P0L1.
PaxDbiQ9P0L1.
PeptideAtlasiQ9P0L1.
PRIDEiQ9P0L1.

Protocols and materials databases

DNASUi55888.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000273320; ENSP00000273320; ENSG00000196345. [Q9P0L1-1]
ENST00000341840; ENSP00000345404; ENSG00000196345. [Q9P0L1-2]
ENST00000426540; ENSP00000395524; ENSG00000196345. [Q9P0L1-1]
ENST00000431636; ENSP00000416681; ENSG00000196345. [Q9P0L1-2]
ENST00000625422; ENSP00000486331; ENSG00000281894. [Q9P0L1-2]
ENST00000626497; ENSP00000485942; ENSG00000281894. [Q9P0L1-1]
ENST00000629379; ENSP00000485948; ENSG00000281894. [Q9P0L1-1]
ENST00000629459; ENSP00000486642; ENSG00000281894. [Q9P0L1-2]
GeneIDi55888.
KEGGihsa:55888.
UCSCiuc003cni.5. human. [Q9P0L1-1]

Organism-specific databases

CTDi55888.
DisGeNETi55888.
GeneCardsiZKSCAN7.
HGNCiHGNC:12955. ZKSCAN7.
HPAiHPA048312.
HPA049906.
neXtProtiNX_Q9P0L1.
OpenTargetsiENSG00000196345.
ENSG00000281894.
PharmGKBiPA37537.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133674.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ9P0L1.
KOiK09229.
OMAiDKYKEVG.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9P0L1.
TreeFamiTF350837.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000144792-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii55888.
PROiQ9P0L1.

Gene expression databases

BgeeiENSG00000196345.
CleanExiHS_ZNF167.
ExpressionAtlasiQ9P0L1. baseline and differential.
GenevisibleiQ9P0L1. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 6 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZKSC7_HUMAN
AccessioniPrimary (citable) accession number: Q9P0L1
Secondary accession number(s): A0PJV3
, A8K5H0, Q6WL09, Q96FQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.