Q9P0L1 (ZKSC7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein with KRAB and SCAN domains 7

Alternative name(s):
Zinc finger protein 167
Zinc finger protein 448
Zinc finger protein 64

Gene names

Name:	ZKSCAN7
Synonyms:	ZNF167, ZNF448, ZNF64

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	754 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Potential.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 13 C2H2-type zinc fingers. Contains 1 KRAB domain. Contains 1 SCAN box domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW viral reproduction Inferred from electronic annotation. Source: InterPro
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9P0L1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9P0L1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     271-276: AGENMM → GWSTMA
     277-754: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 754	754	Zinc finger protein with KRAB and SCAN domains 7		PRO_0000047437
Regions
	Domain	54 – 136	83	SCAN box
	Domain	231 – 306	76	KRAB
	Zinc finger	383 – 405	23	C2H2-type 1
	Zinc finger	411 – 433	23	C2H2-type 2
	Zinc finger	439 – 461	23	C2H2-type 3
	Zinc finger	467 – 489	23	C2H2-type 4
	Zinc finger	495 – 517	23	C2H2-type 5
	Zinc finger	523 – 545	23	C2H2-type 6
	Zinc finger	551 – 573	23	C2H2-type 7
	Zinc finger	579 – 601	23	C2H2-type 8
	Zinc finger	607 – 629	23	C2H2-type 9
	Zinc finger	635 – 657	23	C2H2-type 10
	Zinc finger	663 – 685	23	C2H2-type 11; degenerate
	Zinc finger	691 – 713	23	C2H2-type 12
	Zinc finger	719 – 741	23	C2H2-type 13
Natural variations
	Alternative sequence	271 – 276	6	AGENMM → GWSTMA in isoform 2.		VSP_011955
	Alternative sequence	277 – 754	478	Missing in isoform 2.		VSP_011956
	Natural variant	24	1	R → C. Corresponds to variant rs35696191 [ dbSNP | Ensembl ].		VAR_052782
	Natural variant	153	1	F → S. Corresponds to variant rs13081859 [ dbSNP | Ensembl ].		VAR_052783
	Natural variant	342	1	T → I. Corresponds to variant rs34396823 [ dbSNP | Ensembl ].		VAR_052784
	Natural variant	359	1	E → K. Corresponds to variant rs34181686 [ dbSNP | Ensembl ].		VAR_052785
	Natural variant	432	1	T → A. Corresponds to variant rs9835485 [ dbSNP | Ensembl ].		VAR_052786
	Natural variant	483	1	T → I. Ref.1 Ref.3 Corresponds to variant rs9873604 [ dbSNP | Ensembl ].		VAR_052787
	Natural variant	746	1	S → F. Corresponds to variant rs34437520 [ dbSNP | Ensembl ].		VAR_052788
Experimental info
	Sequence conflict	665	1	C → Y in AAF72104. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: B568F187A3ED2D1B	FASTA	754	85,033
	10 20 30 40 50 60 MTTAGRGNLG LIPRSTAFQK QEGRLTVKQE PANQTWGQGS SLQKNYPPVC EIFRLHFRQL 70 80 90 100 110 120 CYHEMSGPQE ALSRLRELCR WWLMPEVHTK EQILELLVLE QFLSILPGEL RTWVQLHHPE 130 140 150 160 170 180 SGEEAVAVVE DFQRHLSGSE EVSAPAQKQE MHFEETTALG TTKESPPTSP LSGGSAPGAH 190 200 210 220 230 240 LEPPYDPGTH HLPSGDFAQC TSPVPTLPQV GNSGDQAGAT VLRMVRPQDT VAYEDLSVDY 250 260 270 280 290 300 TQKKWKSLTL SQRALQWNMM PENHHSMASL AGENMMKGSE LTPKQEFFKG SESSNRTSGG 310 320 330 340 350 360 LFGVVPGAAE TGDVCEDTFK ELEGQTSDEE GSRLENDFLE ITDEDKKKST KDRYDKYKEV 370 380 390 400 410 420 GEHPPLSSSP VEHEGVLKGQ KSYRCDECGK AFNRSSHLIG HQRIHTGEKP YECNECGKTF 430 440 450 460 470 480 RQTSQLIVHL RTHTGEKPYE CSECGKAYRH SSHLIQHQRL HNGEKPYKCN ECAKAFTQSS 490 500 510 520 530 540 RLTDHQRTHT GEKPYECNEC GEAFIRSKSL ARHQVLHTGK KPYKCNECGR AFCSNRNLID 550 560 570 580 590 600 HQRIHTGEKP YECSECGKAF SRSKCLIRHQ SLHTGEKPYK CSECGKAFNQ NSQLIEHERI 610 620 630 640 650 660 HTGEKPFECS ECGKAFGLSK CLIRHQRLHT GEKPYKCNEC GKSFNQNSHL IIHQRIHTGE 670 680 690 700 710 720 KPYECNECGK VFSYSSSLMV HQRTHTGEKP YKCNDCGKAF SDSSQLIVHQ RVHTGEKPYE 730 740 750 CSECGKAFSQ RSTFNHHQRT HTGEKSSGLA WSVS
	Isoform 2 [UniParc]. Checksum: F251589C8FFFA56F	FASTA	276	30,787
	10 20 30 40 50 60 MTTAGRGNLG LIPRSTAFQK QEGRLTVKQE PANQTWGQGS SLQKNYPPVC EIFRLHFRQL 70 80 90 100 110 120 CYHEMSGPQE ALSRLRELCR WWLMPEVHTK EQILELLVLE QFLSILPGEL RTWVQLHHPE 130 140 150 160 170 180 SGEEAVAVVE DFQRHLSGSE EVSAPAQKQE MHFEETTALG TTKESPPTSP LSGGSAPGAH 190 200 210 220 230 240 LEPPYDPGTH HLPSGDFAQC TSPVPTLPQV GNSGDQAGAT VLRMVRPQDT VAYEDLSVDY 250 260 270 TQKKWKSLTL SQRALQWNMM PENHHSMASL GWSTMA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and isolating human ZFP cDNA." Zhou H.J., Huang X.W., Zhou Y., Hu S.L., Yuan J.G., Qiang B.Q. Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ILE-483.
[2]	"Cloning and characterization of a human novel znf gene." Luo K.T., Yu L. Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-483. Tissue: Teratocarcinoma.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF154846 mRNA. Translation: AAF72104.1. AY280798 mRNA. Translation: AAQ16302.1. AK291285 mRNA. Translation: BAF83974.1. BC010555 mRNA. Translation: AAH10555.1. BC063020 mRNA. Translation: AAH63020.1. BC127640 mRNA. Translation: AAI27641.1.
IPI	IPI00396512. IPI00479927.
PIR	G45193.
RefSeq	NP_061121.2. NM_018651.2. NP_079445.1. NM_025169.1.
UniGene	Hs.529512. Hs.696570.
3D structure databases
ProteinModelPortal	Q9P0L1.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9P0L1. 4 interactions.
STRING	9606.ENSP00000273320.
PTM databases
PhosphoSite	Q9P0L1.
Polymorphism databases
DMDM	124078992.
Proteomic databases
PaxDb	Q9P0L1.
PRIDE	Q9P0L1.
Protocols and materials databases
DNASU	55888.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000273320; ENSP00000273320; ENSG00000196345. ENST00000341840; ENSP00000345404; ENSG00000196345. ENST00000426540; ENSP00000395524; ENSG00000196345. ENST00000431636; ENSP00000416681; ENSG00000196345.
GeneID	55888.
KEGG	hsa:55888.
UCSC	uc003cni.3. human. uc003cnj.3. human.
Organism-specific databases
CTD	55888.
GeneCards	GC03P044572.
HGNC	HGNC:12955. ZKSCAN7.
HPA	HPA048312. HPA049906.
neXtProt	NX_Q9P0L1.
PharmGKB	PA37537.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000234619.
HOVERGEN	HBG018163.
InParanoid	Q9P0L1.
KO	K09229.
OMA	TQSSRLI.
OrthoDB	EOG4FJ884.
PhylomeDB	Q9P0L1.
Enzyme and pathway databases
Reactome	REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	Q9P0L1.
Bgee	Q9P0L1.
CleanEx	HS_ZNF167.
Genevestigator	Q9P0L1.
GermOnline	ENSG00000196345. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 13 hits.
InterPro	IPR001909. Krueppel-associated_box. IPR008916. Retrov_capsid_C. IPR003309. Tscrpt_reg_SCAN. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF01352. KRAB. 1 hit. PF02023. SCAN. 1 hit. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00431. SCAN. 1 hit. SM00355. ZnF_C2H2. 13 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit. SSF47353. Retrov_capsid_C. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS50804. SCAN_BOX. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 13 hits. PS50157. ZINC_FINGER_C2H2_2. 13 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ZNF167. human.
GenomeRNAi	55888.
NextBio	61218.

Entry information

Entry name

ZKSC7_HUMAN

Accession

Primary (citable) accession number: Q9P0L1
Secondary accession number(s): A0PJV3 , A8K5H0, Q6WL09, Q96FQ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 23, 2004
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 105 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.