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Protein

Zinc finger protein with KRAB and SCAN domains 7

Gene

ZKSCAN7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri383 – 40523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri411 – 43323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri439 – 46123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri467 – 48923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri495 – 51723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri523 – 54523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri551 – 57323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri579 – 60123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri607 – 62923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri635 – 65723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri663 – 68523C2H2-type 11; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri691 – 71323C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri719 – 74123C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein with KRAB and SCAN domains 7
Alternative name(s):
Zinc finger protein 167
Zinc finger protein 448
Zinc finger protein 64
Gene namesi
Name:ZKSCAN7
Synonyms:ZNF167, ZNF448, ZNF64
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:12955. ZKSCAN7.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37537.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 754754Zinc finger protein with KRAB and SCAN domains 7PRO_0000047437Add
BLAST

Proteomic databases

MaxQBiQ9P0L1.
PaxDbiQ9P0L1.
PRIDEiQ9P0L1.

PTM databases

PhosphoSiteiQ9P0L1.

Expressioni

Gene expression databases

BgeeiQ9P0L1.
CleanExiHS_ZNF167.
ExpressionAtlasiQ9P0L1. baseline and differential.
GenevestigatoriQ9P0L1.

Organism-specific databases

HPAiHPA048312.
HPA049906.

Interactioni

Protein-protein interaction databases

BioGridi120978. 12 interactions.
IntActiQ9P0L1. 4 interactions.
STRINGi9606.ENSP00000273320.

Structurei

3D structure databases

ProteinModelPortaliQ9P0L1.
SMRiQ9P0L1. Positions 48-136, 346-748.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 13683SCAN boxPROSITE-ProRule annotationAdd
BLAST
Domaini231 – 30676KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri383 – 40523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri411 – 43323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri439 – 46123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri467 – 48923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri495 – 51723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri523 – 54523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri551 – 57323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri579 – 60123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri607 – 62923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri635 – 65723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri663 – 68523C2H2-type 11; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri691 – 71323C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri719 – 74123C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00770000120459.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ9P0L1.
KOiK09229.
OMAiGTTKESP.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9P0L1.
TreeFamiTF350837.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9P0L1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTTAGRGNLG LIPRSTAFQK QEGRLTVKQE PANQTWGQGS SLQKNYPPVC
60 70 80 90 100
EIFRLHFRQL CYHEMSGPQE ALSRLRELCR WWLMPEVHTK EQILELLVLE
110 120 130 140 150
QFLSILPGEL RTWVQLHHPE SGEEAVAVVE DFQRHLSGSE EVSAPAQKQE
160 170 180 190 200
MHFEETTALG TTKESPPTSP LSGGSAPGAH LEPPYDPGTH HLPSGDFAQC
210 220 230 240 250
TSPVPTLPQV GNSGDQAGAT VLRMVRPQDT VAYEDLSVDY TQKKWKSLTL
260 270 280 290 300
SQRALQWNMM PENHHSMASL AGENMMKGSE LTPKQEFFKG SESSNRTSGG
310 320 330 340 350
LFGVVPGAAE TGDVCEDTFK ELEGQTSDEE GSRLENDFLE ITDEDKKKST
360 370 380 390 400
KDRYDKYKEV GEHPPLSSSP VEHEGVLKGQ KSYRCDECGK AFNRSSHLIG
410 420 430 440 450
HQRIHTGEKP YECNECGKTF RQTSQLIVHL RTHTGEKPYE CSECGKAYRH
460 470 480 490 500
SSHLIQHQRL HNGEKPYKCN ECAKAFTQSS RLTDHQRTHT GEKPYECNEC
510 520 530 540 550
GEAFIRSKSL ARHQVLHTGK KPYKCNECGR AFCSNRNLID HQRIHTGEKP
560 570 580 590 600
YECSECGKAF SRSKCLIRHQ SLHTGEKPYK CSECGKAFNQ NSQLIEHERI
610 620 630 640 650
HTGEKPFECS ECGKAFGLSK CLIRHQRLHT GEKPYKCNEC GKSFNQNSHL
660 670 680 690 700
IIHQRIHTGE KPYECNECGK VFSYSSSLMV HQRTHTGEKP YKCNDCGKAF
710 720 730 740 750
SDSSQLIVHQ RVHTGEKPYE CSECGKAFSQ RSTFNHHQRT HTGEKSSGLA

WSVS
Length:754
Mass (Da):85,033
Last modified:January 23, 2007 - v2
Checksum:iB568F187A3ED2D1B
GO
Isoform 2 (identifier: Q9P0L1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     271-276: AGENMM → GWSTMA
     277-754: Missing.

Note: No experimental confirmation available.

Show »
Length:276
Mass (Da):30,787
Checksum:iF251589C8FFFA56F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti665 – 6651C → Y in AAF72104. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti24 – 241R → C.
Corresponds to variant rs35696191 [ dbSNP | Ensembl ].
VAR_052782
Natural varianti153 – 1531F → S.
Corresponds to variant rs13081859 [ dbSNP | Ensembl ].
VAR_052783
Natural varianti342 – 3421T → I.
Corresponds to variant rs34396823 [ dbSNP | Ensembl ].
VAR_052784
Natural varianti359 – 3591E → K.
Corresponds to variant rs34181686 [ dbSNP | Ensembl ].
VAR_052785
Natural varianti432 – 4321T → A.
Corresponds to variant rs9835485 [ dbSNP | Ensembl ].
VAR_052786
Natural varianti483 – 4831T → I.2 Publications
Corresponds to variant rs9873604 [ dbSNP | Ensembl ].
VAR_052787
Natural varianti746 – 7461S → F.
Corresponds to variant rs34437520 [ dbSNP | Ensembl ].
VAR_052788

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei271 – 2766AGENMM → GWSTMA in isoform 2. 1 PublicationVSP_011955
Alternative sequencei277 – 754478Missing in isoform 2. 1 PublicationVSP_011956Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF154846 mRNA. Translation: AAF72104.1.
AY280798 mRNA. Translation: AAQ16302.1.
AK291285 mRNA. Translation: BAF83974.1.
BC010555 mRNA. Translation: AAH10555.1.
BC063020 mRNA. Translation: AAH63020.1.
BC127640 mRNA. Translation: AAI27641.1.
CCDSiCCDS2714.1. [Q9P0L1-2]
CCDS2715.1. [Q9P0L1-1]
PIRiG45193.
RefSeqiNP_001275519.1. NM_001288590.1. [Q9P0L1-1]
NP_001275520.1. NM_001288591.1. [Q9P0L1-2]
NP_001275521.1. NM_001288592.1.
NP_061121.2. NM_018651.3. [Q9P0L1-1]
NP_079445.1. NM_025169.2. [Q9P0L1-2]
UniGeneiHs.529512.
Hs.696570.

Genome annotation databases

EnsembliENST00000273320; ENSP00000273320; ENSG00000196345. [Q9P0L1-1]
ENST00000341840; ENSP00000345404; ENSG00000196345. [Q9P0L1-2]
ENST00000426540; ENSP00000395524; ENSG00000196345. [Q9P0L1-1]
ENST00000431636; ENSP00000416681; ENSG00000196345. [Q9P0L1-2]
GeneIDi55888.
KEGGihsa:55888.
UCSCiuc003cni.3. human. [Q9P0L1-2]
uc003cnj.3. human. [Q9P0L1-1]

Polymorphism databases

DMDMi124078992.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF154846 mRNA. Translation: AAF72104.1.
AY280798 mRNA. Translation: AAQ16302.1.
AK291285 mRNA. Translation: BAF83974.1.
BC010555 mRNA. Translation: AAH10555.1.
BC063020 mRNA. Translation: AAH63020.1.
BC127640 mRNA. Translation: AAI27641.1.
CCDSiCCDS2714.1. [Q9P0L1-2]
CCDS2715.1. [Q9P0L1-1]
PIRiG45193.
RefSeqiNP_001275519.1. NM_001288590.1. [Q9P0L1-1]
NP_001275520.1. NM_001288591.1. [Q9P0L1-2]
NP_001275521.1. NM_001288592.1.
NP_061121.2. NM_018651.3. [Q9P0L1-1]
NP_079445.1. NM_025169.2. [Q9P0L1-2]
UniGeneiHs.529512.
Hs.696570.

3D structure databases

ProteinModelPortaliQ9P0L1.
SMRiQ9P0L1. Positions 48-136, 346-748.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120978. 12 interactions.
IntActiQ9P0L1. 4 interactions.
STRINGi9606.ENSP00000273320.

PTM databases

PhosphoSiteiQ9P0L1.

Polymorphism databases

DMDMi124078992.

Proteomic databases

MaxQBiQ9P0L1.
PaxDbiQ9P0L1.
PRIDEiQ9P0L1.

Protocols and materials databases

DNASUi55888.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000273320; ENSP00000273320; ENSG00000196345. [Q9P0L1-1]
ENST00000341840; ENSP00000345404; ENSG00000196345. [Q9P0L1-2]
ENST00000426540; ENSP00000395524; ENSG00000196345. [Q9P0L1-1]
ENST00000431636; ENSP00000416681; ENSG00000196345. [Q9P0L1-2]
GeneIDi55888.
KEGGihsa:55888.
UCSCiuc003cni.3. human. [Q9P0L1-2]
uc003cnj.3. human. [Q9P0L1-1]

Organism-specific databases

CTDi55888.
GeneCardsiGC03P044597.
HGNCiHGNC:12955. ZKSCAN7.
HPAiHPA048312.
HPA049906.
neXtProtiNX_Q9P0L1.
PharmGKBiPA37537.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00770000120459.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ9P0L1.
KOiK09229.
OMAiGTTKESP.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9P0L1.
TreeFamiTF350837.

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii55888.
NextBioi61218.
PROiQ9P0L1.

Gene expression databases

BgeeiQ9P0L1.
CleanExiHS_ZNF167.
ExpressionAtlasiQ9P0L1. baseline and differential.
GenevestigatoriQ9P0L1.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and isolating human ZFP cDNA."
    Zhou H.J., Huang X.W., Zhou Y., Hu S.L., Yuan J.G., Qiang B.Q.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ILE-483.
  2. "Cloning and characterization of a human novel znf gene."
    Luo K.T., Yu L.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-483.
    Tissue: Teratocarcinoma.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.

Entry informationi

Entry nameiZKSC7_HUMAN
AccessioniPrimary (citable) accession number: Q9P0L1
Secondary accession number(s): A0PJV3
, A8K5H0, Q6WL09, Q96FQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: January 23, 2007
Last modified: February 4, 2015
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.