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Q9P0L1

- ZKSC7_HUMAN

UniProt

Q9P0L1 - ZKSC7_HUMAN

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Protein
Zinc finger protein with KRAB and SCAN domains 7
Gene
ZKSCAN7, ZNF167, ZNF448, ZNF64
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri383 – 40523C2H2-type 1
Add
BLAST
Zinc fingeri411 – 43323C2H2-type 2
Add
BLAST
Zinc fingeri439 – 46123C2H2-type 3
Add
BLAST
Zinc fingeri467 – 48923C2H2-type 4
Add
BLAST
Zinc fingeri495 – 51723C2H2-type 5
Add
BLAST
Zinc fingeri523 – 54523C2H2-type 6
Add
BLAST
Zinc fingeri551 – 57323C2H2-type 7
Add
BLAST
Zinc fingeri579 – 60123C2H2-type 8
Add
BLAST
Zinc fingeri607 – 62923C2H2-type 9
Add
BLAST
Zinc fingeri635 – 65723C2H2-type 10
Add
BLAST
Zinc fingeri663 – 68523C2H2-type 11; degenerate
Add
BLAST
Zinc fingeri691 – 71323C2H2-type 12
Add
BLAST
Zinc fingeri719 – 74123C2H2-type 13
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein with KRAB and SCAN domains 7
Alternative name(s):
Zinc finger protein 167
Zinc finger protein 448
Zinc finger protein 64
Gene namesi
Name:ZKSCAN7
Synonyms:ZNF167, ZNF448, ZNF64
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:12955. ZKSCAN7.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37537.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 754754Zinc finger protein with KRAB and SCAN domains 7
PRO_0000047437Add
BLAST

Proteomic databases

MaxQBiQ9P0L1.
PaxDbiQ9P0L1.
PRIDEiQ9P0L1.

PTM databases

PhosphoSiteiQ9P0L1.

Expressioni

Gene expression databases

ArrayExpressiQ9P0L1.
BgeeiQ9P0L1.
CleanExiHS_ZNF167.
GenevestigatoriQ9P0L1.

Organism-specific databases

HPAiHPA048312.
HPA049906.

Interactioni

Protein-protein interaction databases

BioGridi120978. 8 interactions.
IntActiQ9P0L1. 4 interactions.
STRINGi9606.ENSP00000273320.

Structurei

3D structure databases

ProteinModelPortaliQ9P0L1.
SMRiQ9P0L1. Positions 48-136, 346-748.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 13683SCAN box
Add
BLAST
Domaini231 – 30676KRAB
Add
BLAST

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.
Contains 1 KRAB domain.
Contains 1 SCAN box domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ9P0L1.
KOiK09229.
OMAiGTTKESP.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9P0L1.
TreeFamiTF350837.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9P0L1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MTTAGRGNLG LIPRSTAFQK QEGRLTVKQE PANQTWGQGS SLQKNYPPVC    50
EIFRLHFRQL CYHEMSGPQE ALSRLRELCR WWLMPEVHTK EQILELLVLE 100
QFLSILPGEL RTWVQLHHPE SGEEAVAVVE DFQRHLSGSE EVSAPAQKQE 150
MHFEETTALG TTKESPPTSP LSGGSAPGAH LEPPYDPGTH HLPSGDFAQC 200
TSPVPTLPQV GNSGDQAGAT VLRMVRPQDT VAYEDLSVDY TQKKWKSLTL 250
SQRALQWNMM PENHHSMASL AGENMMKGSE LTPKQEFFKG SESSNRTSGG 300
LFGVVPGAAE TGDVCEDTFK ELEGQTSDEE GSRLENDFLE ITDEDKKKST 350
KDRYDKYKEV GEHPPLSSSP VEHEGVLKGQ KSYRCDECGK AFNRSSHLIG 400
HQRIHTGEKP YECNECGKTF RQTSQLIVHL RTHTGEKPYE CSECGKAYRH 450
SSHLIQHQRL HNGEKPYKCN ECAKAFTQSS RLTDHQRTHT GEKPYECNEC 500
GEAFIRSKSL ARHQVLHTGK KPYKCNECGR AFCSNRNLID HQRIHTGEKP 550
YECSECGKAF SRSKCLIRHQ SLHTGEKPYK CSECGKAFNQ NSQLIEHERI 600
HTGEKPFECS ECGKAFGLSK CLIRHQRLHT GEKPYKCNEC GKSFNQNSHL 650
IIHQRIHTGE KPYECNECGK VFSYSSSLMV HQRTHTGEKP YKCNDCGKAF 700
SDSSQLIVHQ RVHTGEKPYE CSECGKAFSQ RSTFNHHQRT HTGEKSSGLA 750
WSVS 754
Length:754
Mass (Da):85,033
Last modified:January 23, 2007 - v2
Checksum:iB568F187A3ED2D1B
GO
Isoform 2 (identifier: Q9P0L1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     271-276: AGENMM → GWSTMA
     277-754: Missing.

Note: No experimental confirmation available.

Show »
Length:276
Mass (Da):30,787
Checksum:iF251589C8FFFA56F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti24 – 241R → C.
Corresponds to variant rs35696191 [ dbSNP | Ensembl ].
VAR_052782
Natural varianti153 – 1531F → S.
Corresponds to variant rs13081859 [ dbSNP | Ensembl ].
VAR_052783
Natural varianti342 – 3421T → I.
Corresponds to variant rs34396823 [ dbSNP | Ensembl ].
VAR_052784
Natural varianti359 – 3591E → K.
Corresponds to variant rs34181686 [ dbSNP | Ensembl ].
VAR_052785
Natural varianti432 – 4321T → A.
Corresponds to variant rs9835485 [ dbSNP | Ensembl ].
VAR_052786
Natural varianti483 – 4831T → I.2 Publications
Corresponds to variant rs9873604 [ dbSNP | Ensembl ].
VAR_052787
Natural varianti746 – 7461S → F.
Corresponds to variant rs34437520 [ dbSNP | Ensembl ].
VAR_052788

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei271 – 2766AGENMM → GWSTMA in isoform 2.
VSP_011955
Alternative sequencei277 – 754478Missing in isoform 2.
VSP_011956Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti665 – 6651C → Y in AAF72104. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF154846 mRNA. Translation: AAF72104.1.
AY280798 mRNA. Translation: AAQ16302.1.
AK291285 mRNA. Translation: BAF83974.1.
BC010555 mRNA. Translation: AAH10555.1.
BC063020 mRNA. Translation: AAH63020.1.
BC127640 mRNA. Translation: AAI27641.1.
CCDSiCCDS2714.1. [Q9P0L1-2]
CCDS2715.1. [Q9P0L1-1]
PIRiG45193.
RefSeqiNP_001275519.1. NM_001288590.1. [Q9P0L1-1]
NP_001275520.1. NM_001288591.1. [Q9P0L1-2]
NP_001275521.1. NM_001288592.1.
NP_061121.2. NM_018651.3. [Q9P0L1-1]
NP_079445.1. NM_025169.2. [Q9P0L1-2]
UniGeneiHs.529512.
Hs.696570.

Genome annotation databases

EnsembliENST00000273320; ENSP00000273320; ENSG00000196345. [Q9P0L1-1]
ENST00000341840; ENSP00000345404; ENSG00000196345. [Q9P0L1-2]
ENST00000426540; ENSP00000395524; ENSG00000196345. [Q9P0L1-1]
ENST00000431636; ENSP00000416681; ENSG00000196345. [Q9P0L1-2]
GeneIDi55888.
KEGGihsa:55888.
UCSCiuc003cni.3. human. [Q9P0L1-2]
uc003cnj.3. human. [Q9P0L1-1]

Polymorphism databases

DMDMi124078992.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF154846 mRNA. Translation: AAF72104.1 .
AY280798 mRNA. Translation: AAQ16302.1 .
AK291285 mRNA. Translation: BAF83974.1 .
BC010555 mRNA. Translation: AAH10555.1 .
BC063020 mRNA. Translation: AAH63020.1 .
BC127640 mRNA. Translation: AAI27641.1 .
CCDSi CCDS2714.1. [Q9P0L1-2 ]
CCDS2715.1. [Q9P0L1-1 ]
PIRi G45193.
RefSeqi NP_001275519.1. NM_001288590.1. [Q9P0L1-1 ]
NP_001275520.1. NM_001288591.1. [Q9P0L1-2 ]
NP_001275521.1. NM_001288592.1.
NP_061121.2. NM_018651.3. [Q9P0L1-1 ]
NP_079445.1. NM_025169.2. [Q9P0L1-2 ]
UniGenei Hs.529512.
Hs.696570.

3D structure databases

ProteinModelPortali Q9P0L1.
SMRi Q9P0L1. Positions 48-136, 346-748.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120978. 8 interactions.
IntActi Q9P0L1. 4 interactions.
STRINGi 9606.ENSP00000273320.

PTM databases

PhosphoSitei Q9P0L1.

Polymorphism databases

DMDMi 124078992.

Proteomic databases

MaxQBi Q9P0L1.
PaxDbi Q9P0L1.
PRIDEi Q9P0L1.

Protocols and materials databases

DNASUi 55888.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000273320 ; ENSP00000273320 ; ENSG00000196345 . [Q9P0L1-1 ]
ENST00000341840 ; ENSP00000345404 ; ENSG00000196345 . [Q9P0L1-2 ]
ENST00000426540 ; ENSP00000395524 ; ENSG00000196345 . [Q9P0L1-1 ]
ENST00000431636 ; ENSP00000416681 ; ENSG00000196345 . [Q9P0L1-2 ]
GeneIDi 55888.
KEGGi hsa:55888.
UCSCi uc003cni.3. human. [Q9P0L1-2 ]
uc003cnj.3. human. [Q9P0L1-1 ]

Organism-specific databases

CTDi 55888.
GeneCardsi GC03P044597.
HGNCi HGNC:12955. ZKSCAN7.
HPAi HPA048312.
HPA049906.
neXtProti NX_Q9P0L1.
PharmGKBi PA37537.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000234619.
HOVERGENi HBG018163.
InParanoidi Q9P0L1.
KOi K09229.
OMAi GTTKESP.
OrthoDBi EOG7KSX7Q.
PhylomeDBi Q9P0L1.
TreeFami TF350837.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSi ZNF167. human.
GenomeRNAii 55888.
NextBioi 61218.
PROi Q9P0L1.

Gene expression databases

ArrayExpressi Q9P0L1.
Bgeei Q9P0L1.
CleanExi HS_ZNF167.
Genevestigatori Q9P0L1.

Family and domain databases

Gene3Di 3.30.160.60. 13 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and isolating human ZFP cDNA."
    Zhou H.J., Huang X.W., Zhou Y., Hu S.L., Yuan J.G., Qiang B.Q.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ILE-483.
  2. "Cloning and characterization of a human novel znf gene."
    Luo K.T., Yu L.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-483.
    Tissue: Teratocarcinoma.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.

Entry informationi

Entry nameiZKSC7_HUMAN
AccessioniPrimary (citable) accession number: Q9P0L1
Secondary accession number(s): A0PJV3
, A8K5H0, Q6WL09, Q96FQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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