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Q9P0L1

- ZKSC7_HUMAN

UniProt

Q9P0L1 - ZKSC7_HUMAN

Protein

Zinc finger protein with KRAB and SCAN domains 7

Gene

ZKSCAN7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri383 – 40523C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri411 – 43323C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri439 – 46123C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri467 – 48923C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri495 – 51723C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri523 – 54523C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri551 – 57323C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri579 – 60123C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri607 – 62923C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri635 – 65723C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri663 – 68523C2H2-type 11; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri691 – 71323C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri719 – 74123C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein with KRAB and SCAN domains 7
    Alternative name(s):
    Zinc finger protein 167
    Zinc finger protein 448
    Zinc finger protein 64
    Gene namesi
    Name:ZKSCAN7
    Synonyms:ZNF167, ZNF448, ZNF64
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:12955. ZKSCAN7.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37537.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 754754Zinc finger protein with KRAB and SCAN domains 7PRO_0000047437Add
    BLAST

    Proteomic databases

    MaxQBiQ9P0L1.
    PaxDbiQ9P0L1.
    PRIDEiQ9P0L1.

    PTM databases

    PhosphoSiteiQ9P0L1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9P0L1.
    BgeeiQ9P0L1.
    CleanExiHS_ZNF167.
    GenevestigatoriQ9P0L1.

    Organism-specific databases

    HPAiHPA048312.
    HPA049906.

    Interactioni

    Protein-protein interaction databases

    BioGridi120978. 8 interactions.
    IntActiQ9P0L1. 4 interactions.
    STRINGi9606.ENSP00000273320.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9P0L1.
    SMRiQ9P0L1. Positions 48-136, 346-748.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini54 – 13683SCAN boxPROSITE-ProRule annotationAdd
    BLAST
    Domaini231 – 30676KRABPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation
    Contains 1 SCAN box domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri383 – 40523C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri411 – 43323C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri439 – 46123C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri467 – 48923C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri495 – 51723C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri523 – 54523C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri551 – 57323C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri579 – 60123C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri607 – 62923C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri635 – 65723C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri663 – 68523C2H2-type 11; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri691 – 71323C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri719 – 74123C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234619.
    HOVERGENiHBG018163.
    InParanoidiQ9P0L1.
    KOiK09229.
    OMAiGTTKESP.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ9P0L1.
    TreeFamiTF350837.

    Family and domain databases

    Gene3Di3.30.160.60. 13 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR008916. Retrov_capsid_C.
    IPR003309. Tscrpt_reg_SCAN.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    PF02023. SCAN. 1 hit.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00431. SCAN. 1 hit.
    SM00355. ZnF_C2H2. 13 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    SSF47353. SSF47353. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS50804. SCAN_BOX. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 13 hits.
    PS50157. ZINC_FINGER_C2H2_2. 13 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9P0L1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTTAGRGNLG LIPRSTAFQK QEGRLTVKQE PANQTWGQGS SLQKNYPPVC    50
    EIFRLHFRQL CYHEMSGPQE ALSRLRELCR WWLMPEVHTK EQILELLVLE 100
    QFLSILPGEL RTWVQLHHPE SGEEAVAVVE DFQRHLSGSE EVSAPAQKQE 150
    MHFEETTALG TTKESPPTSP LSGGSAPGAH LEPPYDPGTH HLPSGDFAQC 200
    TSPVPTLPQV GNSGDQAGAT VLRMVRPQDT VAYEDLSVDY TQKKWKSLTL 250
    SQRALQWNMM PENHHSMASL AGENMMKGSE LTPKQEFFKG SESSNRTSGG 300
    LFGVVPGAAE TGDVCEDTFK ELEGQTSDEE GSRLENDFLE ITDEDKKKST 350
    KDRYDKYKEV GEHPPLSSSP VEHEGVLKGQ KSYRCDECGK AFNRSSHLIG 400
    HQRIHTGEKP YECNECGKTF RQTSQLIVHL RTHTGEKPYE CSECGKAYRH 450
    SSHLIQHQRL HNGEKPYKCN ECAKAFTQSS RLTDHQRTHT GEKPYECNEC 500
    GEAFIRSKSL ARHQVLHTGK KPYKCNECGR AFCSNRNLID HQRIHTGEKP 550
    YECSECGKAF SRSKCLIRHQ SLHTGEKPYK CSECGKAFNQ NSQLIEHERI 600
    HTGEKPFECS ECGKAFGLSK CLIRHQRLHT GEKPYKCNEC GKSFNQNSHL 650
    IIHQRIHTGE KPYECNECGK VFSYSSSLMV HQRTHTGEKP YKCNDCGKAF 700
    SDSSQLIVHQ RVHTGEKPYE CSECGKAFSQ RSTFNHHQRT HTGEKSSGLA 750
    WSVS 754
    Length:754
    Mass (Da):85,033
    Last modified:January 23, 2007 - v2
    Checksum:iB568F187A3ED2D1B
    GO
    Isoform 2 (identifier: Q9P0L1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         271-276: AGENMM → GWSTMA
         277-754: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:276
    Mass (Da):30,787
    Checksum:iF251589C8FFFA56F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti665 – 6651C → Y in AAF72104. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti24 – 241R → C.
    Corresponds to variant rs35696191 [ dbSNP | Ensembl ].
    VAR_052782
    Natural varianti153 – 1531F → S.
    Corresponds to variant rs13081859 [ dbSNP | Ensembl ].
    VAR_052783
    Natural varianti342 – 3421T → I.
    Corresponds to variant rs34396823 [ dbSNP | Ensembl ].
    VAR_052784
    Natural varianti359 – 3591E → K.
    Corresponds to variant rs34181686 [ dbSNP | Ensembl ].
    VAR_052785
    Natural varianti432 – 4321T → A.
    Corresponds to variant rs9835485 [ dbSNP | Ensembl ].
    VAR_052786
    Natural varianti483 – 4831T → I.2 Publications
    Corresponds to variant rs9873604 [ dbSNP | Ensembl ].
    VAR_052787
    Natural varianti746 – 7461S → F.
    Corresponds to variant rs34437520 [ dbSNP | Ensembl ].
    VAR_052788

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei271 – 2766AGENMM → GWSTMA in isoform 2. 1 PublicationVSP_011955
    Alternative sequencei277 – 754478Missing in isoform 2. 1 PublicationVSP_011956Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF154846 mRNA. Translation: AAF72104.1.
    AY280798 mRNA. Translation: AAQ16302.1.
    AK291285 mRNA. Translation: BAF83974.1.
    BC010555 mRNA. Translation: AAH10555.1.
    BC063020 mRNA. Translation: AAH63020.1.
    BC127640 mRNA. Translation: AAI27641.1.
    CCDSiCCDS2714.1. [Q9P0L1-2]
    CCDS2715.1. [Q9P0L1-1]
    PIRiG45193.
    RefSeqiNP_001275519.1. NM_001288590.1. [Q9P0L1-1]
    NP_001275520.1. NM_001288591.1. [Q9P0L1-2]
    NP_001275521.1. NM_001288592.1.
    NP_061121.2. NM_018651.3. [Q9P0L1-1]
    NP_079445.1. NM_025169.2. [Q9P0L1-2]
    UniGeneiHs.529512.
    Hs.696570.

    Genome annotation databases

    EnsembliENST00000273320; ENSP00000273320; ENSG00000196345. [Q9P0L1-1]
    ENST00000341840; ENSP00000345404; ENSG00000196345. [Q9P0L1-2]
    ENST00000426540; ENSP00000395524; ENSG00000196345. [Q9P0L1-1]
    ENST00000431636; ENSP00000416681; ENSG00000196345. [Q9P0L1-2]
    GeneIDi55888.
    KEGGihsa:55888.
    UCSCiuc003cni.3. human. [Q9P0L1-2]
    uc003cnj.3. human. [Q9P0L1-1]

    Polymorphism databases

    DMDMi124078992.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF154846 mRNA. Translation: AAF72104.1 .
    AY280798 mRNA. Translation: AAQ16302.1 .
    AK291285 mRNA. Translation: BAF83974.1 .
    BC010555 mRNA. Translation: AAH10555.1 .
    BC063020 mRNA. Translation: AAH63020.1 .
    BC127640 mRNA. Translation: AAI27641.1 .
    CCDSi CCDS2714.1. [Q9P0L1-2 ]
    CCDS2715.1. [Q9P0L1-1 ]
    PIRi G45193.
    RefSeqi NP_001275519.1. NM_001288590.1. [Q9P0L1-1 ]
    NP_001275520.1. NM_001288591.1. [Q9P0L1-2 ]
    NP_001275521.1. NM_001288592.1.
    NP_061121.2. NM_018651.3. [Q9P0L1-1 ]
    NP_079445.1. NM_025169.2. [Q9P0L1-2 ]
    UniGenei Hs.529512.
    Hs.696570.

    3D structure databases

    ProteinModelPortali Q9P0L1.
    SMRi Q9P0L1. Positions 48-136, 346-748.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120978. 8 interactions.
    IntActi Q9P0L1. 4 interactions.
    STRINGi 9606.ENSP00000273320.

    PTM databases

    PhosphoSitei Q9P0L1.

    Polymorphism databases

    DMDMi 124078992.

    Proteomic databases

    MaxQBi Q9P0L1.
    PaxDbi Q9P0L1.
    PRIDEi Q9P0L1.

    Protocols and materials databases

    DNASUi 55888.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000273320 ; ENSP00000273320 ; ENSG00000196345 . [Q9P0L1-1 ]
    ENST00000341840 ; ENSP00000345404 ; ENSG00000196345 . [Q9P0L1-2 ]
    ENST00000426540 ; ENSP00000395524 ; ENSG00000196345 . [Q9P0L1-1 ]
    ENST00000431636 ; ENSP00000416681 ; ENSG00000196345 . [Q9P0L1-2 ]
    GeneIDi 55888.
    KEGGi hsa:55888.
    UCSCi uc003cni.3. human. [Q9P0L1-2 ]
    uc003cnj.3. human. [Q9P0L1-1 ]

    Organism-specific databases

    CTDi 55888.
    GeneCardsi GC03P044597.
    HGNCi HGNC:12955. ZKSCAN7.
    HPAi HPA048312.
    HPA049906.
    neXtProti NX_Q9P0L1.
    PharmGKBi PA37537.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234619.
    HOVERGENi HBG018163.
    InParanoidi Q9P0L1.
    KOi K09229.
    OMAi GTTKESP.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q9P0L1.
    TreeFami TF350837.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.

    Miscellaneous databases

    ChiTaRSi ZNF167. human.
    GenomeRNAii 55888.
    NextBioi 61218.
    PROi Q9P0L1.

    Gene expression databases

    ArrayExpressi Q9P0L1.
    Bgeei Q9P0L1.
    CleanExi HS_ZNF167.
    Genevestigatori Q9P0L1.

    Family and domain databases

    Gene3Di 3.30.160.60. 13 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR008916. Retrov_capsid_C.
    IPR003309. Tscrpt_reg_SCAN.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    PF02023. SCAN. 1 hit.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00431. SCAN. 1 hit.
    SM00355. ZnF_C2H2. 13 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    SSF47353. SSF47353. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS50804. SCAN_BOX. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 13 hits.
    PS50157. ZINC_FINGER_C2H2_2. 13 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and isolating human ZFP cDNA."
      Zhou H.J., Huang X.W., Zhou Y., Hu S.L., Yuan J.G., Qiang B.Q.
      Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ILE-483.
    2. "Cloning and characterization of a human novel znf gene."
      Luo K.T., Yu L.
      Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-483.
      Tissue: Teratocarcinoma.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.

    Entry informationi

    Entry nameiZKSC7_HUMAN
    AccessioniPrimary (citable) accession number: Q9P0L1
    Secondary accession number(s): A0PJV3
    , A8K5H0, Q6WL09, Q96FQ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 23, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3