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Q9P0L1 (ZKSC7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein with KRAB and SCAN domains 7
Alternative name(s):
Zinc finger protein 167
Zinc finger protein 448
Zinc finger protein 64
Gene names
Name:ZKSCAN7
Synonyms:ZNF167, ZNF448, ZNF64
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length754 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Potential.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 13 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Contains 1 SCAN box domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranscription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9P0L1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9P0L1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     271-276: AGENMM → GWSTMA
     277-754: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 754754Zinc finger protein with KRAB and SCAN domains 7
PRO_0000047437

Regions

Domain54 – 13683SCAN box
Domain231 – 30676KRAB
Zinc finger383 – 40523C2H2-type 1
Zinc finger411 – 43323C2H2-type 2
Zinc finger439 – 46123C2H2-type 3
Zinc finger467 – 48923C2H2-type 4
Zinc finger495 – 51723C2H2-type 5
Zinc finger523 – 54523C2H2-type 6
Zinc finger551 – 57323C2H2-type 7
Zinc finger579 – 60123C2H2-type 8
Zinc finger607 – 62923C2H2-type 9
Zinc finger635 – 65723C2H2-type 10
Zinc finger663 – 68523C2H2-type 11; degenerate
Zinc finger691 – 71323C2H2-type 12
Zinc finger719 – 74123C2H2-type 13

Natural variations

Alternative sequence271 – 2766AGENMM → GWSTMA in isoform 2.
VSP_011955
Alternative sequence277 – 754478Missing in isoform 2.
VSP_011956
Natural variant241R → C.
Corresponds to variant rs35696191 [ dbSNP | Ensembl ].
VAR_052782
Natural variant1531F → S.
Corresponds to variant rs13081859 [ dbSNP | Ensembl ].
VAR_052783
Natural variant3421T → I.
Corresponds to variant rs34396823 [ dbSNP | Ensembl ].
VAR_052784
Natural variant3591E → K.
Corresponds to variant rs34181686 [ dbSNP | Ensembl ].
VAR_052785
Natural variant4321T → A.
Corresponds to variant rs9835485 [ dbSNP | Ensembl ].
VAR_052786
Natural variant4831T → I. Ref.1 Ref.3
Corresponds to variant rs9873604 [ dbSNP | Ensembl ].
VAR_052787
Natural variant7461S → F.
Corresponds to variant rs34437520 [ dbSNP | Ensembl ].
VAR_052788

Experimental info

Sequence conflict6651C → Y in AAF72104. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: B568F187A3ED2D1B

FASTA75485,033
        10         20         30         40         50         60 
MTTAGRGNLG LIPRSTAFQK QEGRLTVKQE PANQTWGQGS SLQKNYPPVC EIFRLHFRQL 

        70         80         90        100        110        120 
CYHEMSGPQE ALSRLRELCR WWLMPEVHTK EQILELLVLE QFLSILPGEL RTWVQLHHPE 

       130        140        150        160        170        180 
SGEEAVAVVE DFQRHLSGSE EVSAPAQKQE MHFEETTALG TTKESPPTSP LSGGSAPGAH 

       190        200        210        220        230        240 
LEPPYDPGTH HLPSGDFAQC TSPVPTLPQV GNSGDQAGAT VLRMVRPQDT VAYEDLSVDY 

       250        260        270        280        290        300 
TQKKWKSLTL SQRALQWNMM PENHHSMASL AGENMMKGSE LTPKQEFFKG SESSNRTSGG 

       310        320        330        340        350        360 
LFGVVPGAAE TGDVCEDTFK ELEGQTSDEE GSRLENDFLE ITDEDKKKST KDRYDKYKEV 

       370        380        390        400        410        420 
GEHPPLSSSP VEHEGVLKGQ KSYRCDECGK AFNRSSHLIG HQRIHTGEKP YECNECGKTF 

       430        440        450        460        470        480 
RQTSQLIVHL RTHTGEKPYE CSECGKAYRH SSHLIQHQRL HNGEKPYKCN ECAKAFTQSS 

       490        500        510        520        530        540 
RLTDHQRTHT GEKPYECNEC GEAFIRSKSL ARHQVLHTGK KPYKCNECGR AFCSNRNLID 

       550        560        570        580        590        600 
HQRIHTGEKP YECSECGKAF SRSKCLIRHQ SLHTGEKPYK CSECGKAFNQ NSQLIEHERI 

       610        620        630        640        650        660 
HTGEKPFECS ECGKAFGLSK CLIRHQRLHT GEKPYKCNEC GKSFNQNSHL IIHQRIHTGE 

       670        680        690        700        710        720 
KPYECNECGK VFSYSSSLMV HQRTHTGEKP YKCNDCGKAF SDSSQLIVHQ RVHTGEKPYE 

       730        740        750 
CSECGKAFSQ RSTFNHHQRT HTGEKSSGLA WSVS 

« Hide

Isoform 2 [UniParc].

Checksum: F251589C8FFFA56F
Show »

FASTA27630,787

References

« Hide 'large scale' references
[1]"Cloning and isolating human ZFP cDNA."
Zhou H.J., Huang X.W., Zhou Y., Hu S.L., Yuan J.G., Qiang B.Q.
Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ILE-483.
[2]"Cloning and characterization of a human novel znf gene."
Luo K.T., Yu L.
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-483.
Tissue: Teratocarcinoma.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF154846 mRNA. Translation: AAF72104.1.
AY280798 mRNA. Translation: AAQ16302.1.
AK291285 mRNA. Translation: BAF83974.1.
BC010555 mRNA. Translation: AAH10555.1.
BC063020 mRNA. Translation: AAH63020.1.
BC127640 mRNA. Translation: AAI27641.1.
PIRG45193.
RefSeqNP_001275519.1. NM_001288590.1.
NP_001275520.1. NM_001288591.1.
NP_001275521.1. NM_001288592.1.
NP_061121.2. NM_018651.3.
NP_079445.1. NM_025169.2.
UniGeneHs.529512.
Hs.696570.

3D structure databases

ProteinModelPortalQ9P0L1.
SMRQ9P0L1. Positions 48-136, 226-277, 359-748.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120978. 8 interactions.
IntActQ9P0L1. 4 interactions.
STRING9606.ENSP00000273320.

PTM databases

PhosphoSiteQ9P0L1.

Polymorphism databases

DMDM124078992.

Proteomic databases

PaxDbQ9P0L1.
PRIDEQ9P0L1.

Protocols and materials databases

DNASU55888.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000273320; ENSP00000273320; ENSG00000196345. [Q9P0L1-1]
ENST00000341840; ENSP00000345404; ENSG00000196345. [Q9P0L1-2]
ENST00000426540; ENSP00000395524; ENSG00000196345. [Q9P0L1-1]
ENST00000431636; ENSP00000416681; ENSG00000196345. [Q9P0L1-2]
GeneID55888.
KEGGhsa:55888.
UCSCuc003cni.3. human. [Q9P0L1-2]
uc003cnj.3. human. [Q9P0L1-1]

Organism-specific databases

CTD55888.
GeneCardsGC03P044597.
HGNCHGNC:12955. ZKSCAN7.
HPAHPA048312.
HPA049906.
neXtProtNX_Q9P0L1.
PharmGKBPA37537.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234619.
HOVERGENHBG018163.
InParanoidQ9P0L1.
KOK09229.
OMAGTTKESP.
OrthoDBEOG7KSX7Q.
PhylomeDBQ9P0L1.
TreeFamTF350837.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ9P0L1.
BgeeQ9P0L1.
CleanExHS_ZNF167.
GenevestigatorQ9P0L1.

Family and domain databases

Gene3D3.30.160.60. 13 hits.
InterProIPR001909. Krueppel-associated_box.
IPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSZNF167. human.
GenomeRNAi55888.
NextBio61218.
PROQ9P0L1.

Entry information

Entry nameZKSC7_HUMAN
AccessionPrimary (citable) accession number: Q9P0L1
Secondary accession number(s): A0PJV3 expand/collapse secondary AC list , A8K5H0, Q6WL09, Q96FQ2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: January 23, 2007
Last modified: March 19, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM