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Q9P0K8

- FOXJ2_HUMAN

UniProt

Q9P0K8 - FOXJ2_HUMAN

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Protein
Forkhead box protein J2
Gene
FOXJ2, FHX
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcriptional activator. Able to bind to two different type of DNA binding sites. Isoform FOXJ2.L behaves as a more potent transactivator than FOXJ2.S.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi66 – 14378Fork-head
Add
BLAST

GO - Molecular functioni

  1. DNA binding, bending Source: RefGenome
  2. sequence-specific DNA binding Source: UniProtKB
  3. sequence-specific DNA binding transcription factor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. pattern specification process Source: RefGenome
  2. positive regulation of transcription, DNA-templated Source: UniProtKB
  3. tissue development Source: RefGenome
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

SignaLinkiQ9P0K8.

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein J2
Alternative name(s):
Fork head homologous X
Gene namesi
Name:FOXJ2
Synonyms:FHX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:24818. FOXJ2.

Subcellular locationi

GO - Cellular componenti

  1. nucleolus Source: HPA
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134982817.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 574573Forkhead box protein J2
PRO_0000091853Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei3 – 31Phosphoserine1 Publication
Modified residuei161 – 1611Phosphoserine1 Publication
Modified residuei172 – 1721Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9P0K8.
PaxDbiQ9P0K8.
PRIDEiQ9P0K8.

PTM databases

PhosphoSiteiQ9P0K8.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiQ9P0K8.
CleanExiHS_FOXJ2.
GenevestigatoriQ9P0K8.

Organism-specific databases

HPAiHPA008723.

Interactioni

Protein-protein interaction databases

BioGridi120920. 3 interactions.
IntActiQ9P0K8. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9P0K8.
SMRiQ9P0K8. Positions 66-143.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi266 – 2705Poly-Ser
Compositional biasi291 – 2944Poly-Gln
Compositional biasi295 – 2984Poly-Pro
Compositional biasi299 – 3068Poly-Gln
Compositional biasi313 – 3219Poly-Gln
Compositional biasi390 – 3956Poly-Pro

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5025.
HOGENOMiHOG000231184.
HOVERGENiHBG051648.
InParanoidiQ9P0K8.
KOiK09403.
OMAiRHPPDDD.
OrthoDBiEOG7RZ5RQ.
PhylomeDBiQ9P0K8.
TreeFamiTF333250.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform FOXJ2.L (identifier: Q9P0K8-1) [UniParc]FASTAAdd to Basket

Also known as: FHX.L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MASDLESSLT SIDWLPQLTL RATIEKLGSA SQAGPPGSSR KCSPGSPTDP    50
NATLSKDEAA VHQDGKPRYS YATLITYAIN SSPAKKMTLS EIYRWICDNF 100
PYYKNAGIGW KNSIRHNLSL NKCFRKVPRP RDDPGKGSYW TIDTCPDISR 150
KRRHPPDDDL SQDSPEQEAS KSPRGGVAGS GEASLPPEGN PQMSLQSPTS 200
IASYSQGTGS VDGGAVAAGA SGRESAEGPP PLYNTNHDFK FSYSEINFQD 250
LSWSFRNLYK SMLEKSSSSS QHGFSSLLGD IPPSNNYYMY QQQQPPPPQQ 300
QQQQQQPPQP PPQQSQPQQQ QAPAQGPSAV GGAPPLHTPS TDGCTPPGGK 350
QAGAEGYGPP PVMAMHPPPL QHGGYHPHQH HPHSHPAQQP PPPQPQAQGQ 400
APINNTGFAF PSDWCSNIDS LKESFKMVNR LNWSSIEQSQ FSELMESLRQ 450
AEQKNWTLDQ HHIANLCDSL NHFLTQTGHV PPQGGTHRPP APARIADSCA 500
LTSGKQESAM SQVNSYGHPQ APHLYPGPSP MYPIPTQDSA GYNRPAHHMV 550
PRPSVPPPGA NEEIPDDFDW DLIT 574
Length:574
Mass (Da):62,395
Last modified:October 1, 2000 - v1
Checksum:i258120EDAE4B11EB
GO
Isoform FOXJ2.S (identifier: Q9P0K8-2) [UniParc]FASTAAdd to Basket

Also known as: FHX.S

The sequence of this isoform differs from the canonical sequence as follows:
     513-574: VNSYGHPQAP...PDDFDWDLIT → GTAPSQLPWRWRLC

Show »
Length:526
Mass (Da):57,220
Checksum:i666CFE383030805D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti229 – 2291P → R.
Corresponds to variant rs35642012 [ dbSNP | Ensembl ].
VAR_049162
Natural varianti310 – 3101P → S.
Corresponds to variant rs2277415 [ dbSNP | Ensembl ].
VAR_021842

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei513 – 57462VNSYG…WDLIT → GTAPSQLPWRWRLC in isoform FOXJ2.S.
VSP_001544Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF155132 mRNA. Translation: AAF65927.1.
AF155133 mRNA. Translation: AAK49016.1.
BC126396 mRNA. Translation: AAI26397.1.
BC136305 mRNA. Translation: AAI36306.1.
AL161978 mRNA. Translation: CAB82315.1.
CCDSiCCDS8587.1. [Q9P0K8-1]
PIRiT47161.
RefSeqiNP_060886.1. NM_018416.2. [Q9P0K8-1]
XP_005253487.1. XM_005253430.2. [Q9P0K8-1]
UniGeneiHs.120844.

Genome annotation databases

EnsembliENST00000162391; ENSP00000162391; ENSG00000065970. [Q9P0K8-1]
ENST00000428177; ENSP00000403411; ENSG00000065970. [Q9P0K8-2]
GeneIDi55810.
KEGGihsa:55810.
UCSCiuc001qtt.1. human. [Q9P0K8-2]
uc001qtu.3. human. [Q9P0K8-1]

Polymorphism databases

DMDMi13626933.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF155132 mRNA. Translation: AAF65927.1 .
AF155133 mRNA. Translation: AAK49016.1 .
BC126396 mRNA. Translation: AAI26397.1 .
BC136305 mRNA. Translation: AAI36306.1 .
AL161978 mRNA. Translation: CAB82315.1 .
CCDSi CCDS8587.1. [Q9P0K8-1 ]
PIRi T47161.
RefSeqi NP_060886.1. NM_018416.2. [Q9P0K8-1 ]
XP_005253487.1. XM_005253430.2. [Q9P0K8-1 ]
UniGenei Hs.120844.

3D structure databases

ProteinModelPortali Q9P0K8.
SMRi Q9P0K8. Positions 66-143.
ModBasei Search...

Protein-protein interaction databases

BioGridi 120920. 3 interactions.
IntActi Q9P0K8. 1 interaction.

PTM databases

PhosphoSitei Q9P0K8.

Polymorphism databases

DMDMi 13626933.

Proteomic databases

MaxQBi Q9P0K8.
PaxDbi Q9P0K8.
PRIDEi Q9P0K8.

Protocols and materials databases

DNASUi 55810.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000162391 ; ENSP00000162391 ; ENSG00000065970 . [Q9P0K8-1 ]
ENST00000428177 ; ENSP00000403411 ; ENSG00000065970 . [Q9P0K8-2 ]
GeneIDi 55810.
KEGGi hsa:55810.
UCSCi uc001qtt.1. human. [Q9P0K8-2 ]
uc001qtu.3. human. [Q9P0K8-1 ]

Organism-specific databases

CTDi 55810.
GeneCardsi GC12P008185.
HGNCi HGNC:24818. FOXJ2.
HPAi HPA008723.
neXtProti NX_Q9P0K8.
PharmGKBi PA134982817.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5025.
HOGENOMi HOG000231184.
HOVERGENi HBG051648.
InParanoidi Q9P0K8.
KOi K09403.
OMAi RHPPDDD.
OrthoDBi EOG7RZ5RQ.
PhylomeDBi Q9P0K8.
TreeFami TF333250.

Enzyme and pathway databases

SignaLinki Q9P0K8.

Miscellaneous databases

GeneWikii FOXJ2.
GenomeRNAii 55810.
NextBioi 60973.
PROi Q9P0K8.

Gene expression databases

Bgeei Q9P0K8.
CleanExi HS_FOXJ2.
Genevestigatori Q9P0K8.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00250. Fork_head. 1 hit.
[Graphical view ]
PRINTSi PR00053. FORKHEAD.
SMARTi SM00339. FH. 1 hit.
[Graphical view ]
PROSITEi PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM FOXJ2.L).
  2. "FHX.L and FHX.S, two isoforms of the human fork-head factor FHX (FOXJ2) with differential activity."
    Perez-Sanchez C., de la Fuente C.A., Gomez-Ferreria M.A., Granadino B., Rey-Campos J.
    J. Mol. Biol. 301:795-806(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM FOXJ2.S).
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM FOXJ2.L).
    Tissue: Lung.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 458-574 (ISOFORM FOXJ2.L).
    Tissue: Melanoma.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-161, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-172, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiFOXJ2_HUMAN
AccessioniPrimary (citable) accession number: Q9P0K8
Secondary accession number(s): A0AVK4
, B2RMP3, Q96PS9, Q9NSN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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