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Q9P0K8

- FOXJ2_HUMAN

UniProt

Q9P0K8 - FOXJ2_HUMAN

Protein

Forkhead box protein J2

Gene

FOXJ2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Transcriptional activator. Able to bind to two different type of DNA binding sites. Isoform FOXJ2.L behaves as a more potent transactivator than FOXJ2.S.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi66 – 14378Fork-headPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
    2. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
    3. sequence-specific DNA binding Source: UniProtKB

    GO - Biological processi

    1. positive regulation of transcription, DNA-templated Source: UniProtKB
    2. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    SignaLinkiQ9P0K8.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Forkhead box protein J2
    Alternative name(s):
    Fork head homologous X
    Gene namesi
    Name:FOXJ2
    Synonyms:FHX
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:24818. FOXJ2.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleolus Source: HPA
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134982817.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 574573Forkhead box protein J2PRO_0000091853Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Modified residuei3 – 31Phosphoserine1 Publication
    Modified residuei161 – 1611Phosphoserine1 Publication
    Modified residuei172 – 1721Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9P0K8.
    PaxDbiQ9P0K8.
    PRIDEiQ9P0K8.

    PTM databases

    PhosphoSiteiQ9P0K8.

    Expressioni

    Tissue specificityi

    Widely expressed.

    Gene expression databases

    BgeeiQ9P0K8.
    CleanExiHS_FOXJ2.
    GenevestigatoriQ9P0K8.

    Organism-specific databases

    HPAiHPA008723.

    Interactioni

    Protein-protein interaction databases

    BioGridi120920. 3 interactions.
    IntActiQ9P0K8. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9P0K8.
    SMRiQ9P0K8. Positions 66-143.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi266 – 2705Poly-Ser
    Compositional biasi291 – 2944Poly-Gln
    Compositional biasi295 – 2984Poly-Pro
    Compositional biasi299 – 3068Poly-Gln
    Compositional biasi313 – 3219Poly-Gln
    Compositional biasi390 – 3956Poly-Pro

    Sequence similaritiesi

    Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5025.
    HOGENOMiHOG000231184.
    HOVERGENiHBG051648.
    InParanoidiQ9P0K8.
    KOiK09403.
    OMAiRHPPDDD.
    OrthoDBiEOG7RZ5RQ.
    PhylomeDBiQ9P0K8.
    TreeFamiTF333250.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00250. Fork_head. 1 hit.
    [Graphical view]
    PRINTSiPR00053. FORKHEAD.
    SMARTiSM00339. FH. 1 hit.
    [Graphical view]
    PROSITEiPS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform FOXJ2.L (identifier: Q9P0K8-1) [UniParc]FASTAAdd to Basket

    Also known as: FHX.L

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASDLESSLT SIDWLPQLTL RATIEKLGSA SQAGPPGSSR KCSPGSPTDP    50
    NATLSKDEAA VHQDGKPRYS YATLITYAIN SSPAKKMTLS EIYRWICDNF 100
    PYYKNAGIGW KNSIRHNLSL NKCFRKVPRP RDDPGKGSYW TIDTCPDISR 150
    KRRHPPDDDL SQDSPEQEAS KSPRGGVAGS GEASLPPEGN PQMSLQSPTS 200
    IASYSQGTGS VDGGAVAAGA SGRESAEGPP PLYNTNHDFK FSYSEINFQD 250
    LSWSFRNLYK SMLEKSSSSS QHGFSSLLGD IPPSNNYYMY QQQQPPPPQQ 300
    QQQQQQPPQP PPQQSQPQQQ QAPAQGPSAV GGAPPLHTPS TDGCTPPGGK 350
    QAGAEGYGPP PVMAMHPPPL QHGGYHPHQH HPHSHPAQQP PPPQPQAQGQ 400
    APINNTGFAF PSDWCSNIDS LKESFKMVNR LNWSSIEQSQ FSELMESLRQ 450
    AEQKNWTLDQ HHIANLCDSL NHFLTQTGHV PPQGGTHRPP APARIADSCA 500
    LTSGKQESAM SQVNSYGHPQ APHLYPGPSP MYPIPTQDSA GYNRPAHHMV 550
    PRPSVPPPGA NEEIPDDFDW DLIT 574
    Length:574
    Mass (Da):62,395
    Last modified:October 1, 2000 - v1
    Checksum:i258120EDAE4B11EB
    GO
    Isoform FOXJ2.S (identifier: Q9P0K8-2) [UniParc]FASTAAdd to Basket

    Also known as: FHX.S

    The sequence of this isoform differs from the canonical sequence as follows:
         513-574: VNSYGHPQAP...PDDFDWDLIT → GTAPSQLPWRWRLC

    Show »
    Length:526
    Mass (Da):57,220
    Checksum:i666CFE383030805D
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti229 – 2291P → R.
    Corresponds to variant rs35642012 [ dbSNP | Ensembl ].
    VAR_049162
    Natural varianti310 – 3101P → S.
    Corresponds to variant rs2277415 [ dbSNP | Ensembl ].
    VAR_021842

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei513 – 57462VNSYG…WDLIT → GTAPSQLPWRWRLC in isoform FOXJ2.S. 1 PublicationVSP_001544Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF155132 mRNA. Translation: AAF65927.1.
    AF155133 mRNA. Translation: AAK49016.1.
    BC126396 mRNA. Translation: AAI26397.1.
    BC136305 mRNA. Translation: AAI36306.1.
    AL161978 mRNA. Translation: CAB82315.1.
    CCDSiCCDS8587.1. [Q9P0K8-1]
    PIRiT47161.
    RefSeqiNP_060886.1. NM_018416.2. [Q9P0K8-1]
    XP_005253487.1. XM_005253430.2. [Q9P0K8-1]
    UniGeneiHs.120844.

    Genome annotation databases

    EnsembliENST00000162391; ENSP00000162391; ENSG00000065970. [Q9P0K8-1]
    ENST00000428177; ENSP00000403411; ENSG00000065970. [Q9P0K8-2]
    GeneIDi55810.
    KEGGihsa:55810.
    UCSCiuc001qtt.1. human. [Q9P0K8-2]
    uc001qtu.3. human. [Q9P0K8-1]

    Polymorphism databases

    DMDMi13626933.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF155132 mRNA. Translation: AAF65927.1 .
    AF155133 mRNA. Translation: AAK49016.1 .
    BC126396 mRNA. Translation: AAI26397.1 .
    BC136305 mRNA. Translation: AAI36306.1 .
    AL161978 mRNA. Translation: CAB82315.1 .
    CCDSi CCDS8587.1. [Q9P0K8-1 ]
    PIRi T47161.
    RefSeqi NP_060886.1. NM_018416.2. [Q9P0K8-1 ]
    XP_005253487.1. XM_005253430.2. [Q9P0K8-1 ]
    UniGenei Hs.120844.

    3D structure databases

    ProteinModelPortali Q9P0K8.
    SMRi Q9P0K8. Positions 66-143.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120920. 3 interactions.
    IntActi Q9P0K8. 1 interaction.

    PTM databases

    PhosphoSitei Q9P0K8.

    Polymorphism databases

    DMDMi 13626933.

    Proteomic databases

    MaxQBi Q9P0K8.
    PaxDbi Q9P0K8.
    PRIDEi Q9P0K8.

    Protocols and materials databases

    DNASUi 55810.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000162391 ; ENSP00000162391 ; ENSG00000065970 . [Q9P0K8-1 ]
    ENST00000428177 ; ENSP00000403411 ; ENSG00000065970 . [Q9P0K8-2 ]
    GeneIDi 55810.
    KEGGi hsa:55810.
    UCSCi uc001qtt.1. human. [Q9P0K8-2 ]
    uc001qtu.3. human. [Q9P0K8-1 ]

    Organism-specific databases

    CTDi 55810.
    GeneCardsi GC12P008185.
    HGNCi HGNC:24818. FOXJ2.
    HPAi HPA008723.
    neXtProti NX_Q9P0K8.
    PharmGKBi PA134982817.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5025.
    HOGENOMi HOG000231184.
    HOVERGENi HBG051648.
    InParanoidi Q9P0K8.
    KOi K09403.
    OMAi RHPPDDD.
    OrthoDBi EOG7RZ5RQ.
    PhylomeDBi Q9P0K8.
    TreeFami TF333250.

    Enzyme and pathway databases

    SignaLinki Q9P0K8.

    Miscellaneous databases

    GeneWikii FOXJ2.
    GenomeRNAii 55810.
    NextBioi 60973.
    PROi Q9P0K8.

    Gene expression databases

    Bgeei Q9P0K8.
    CleanExi HS_FOXJ2.
    Genevestigatori Q9P0K8.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00250. Fork_head. 1 hit.
    [Graphical view ]
    PRINTSi PR00053. FORKHEAD.
    SMARTi SM00339. FH. 1 hit.
    [Graphical view ]
    PROSITEi PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM FOXJ2.L).
    2. "FHX.L and FHX.S, two isoforms of the human fork-head factor FHX (FOXJ2) with differential activity."
      Perez-Sanchez C., de la Fuente C.A., Gomez-Ferreria M.A., Granadino B., Rey-Campos J.
      J. Mol. Biol. 301:795-806(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM FOXJ2.S).
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM FOXJ2.L).
      Tissue: Lung.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 458-574 (ISOFORM FOXJ2.L).
      Tissue: Melanoma.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-161, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-172, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiFOXJ2_HUMAN
    AccessioniPrimary (citable) accession number: Q9P0K8
    Secondary accession number(s): A0AVK4
    , B2RMP3, Q96PS9, Q9NSN5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 126 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3