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Q9P0K8 (FOXJ2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Forkhead box protein J2
Alternative name(s):
Fork head homologous X
Gene names
Name:FOXJ2
Synonyms:FHX
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length574 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional activator. Able to bind to two different type of DNA binding sites. Isoform FOXJ2L behaves as a more potent transactivator than FOXJ2.S.

Subcellular location

Nucleus.

Tissue specificity

Widely expressed.

Sequence similarities

Contains 1 fork-head DNA-binding domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform FOXJ2.L (identifier: Q9P0K8-1)

Also known as: FHX.L;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform FOXJ2.S (identifier: Q9P0K8-2)

Also known as: FHX.S;

The sequence of this isoform differs from the canonical sequence as follows:
     513-574: VNSYGHPQAP...PDDFDWDLIT → GTAPSQLPWRWRLC

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.9
Chain2 – 574573Forkhead box protein J2
PRO_0000091853

Regions

DNA binding66 – 14378Fork-head
Compositional bias266 – 2705Poly-Ser
Compositional bias291 – 2944Poly-Gln
Compositional bias295 – 2984Poly-Pro
Compositional bias299 – 3068Poly-Gln
Compositional bias313 – 3219Poly-Gln
Compositional bias390 – 3956Poly-Pro

Amino acid modifications

Modified residue21N-acetylalanine Ref.9
Modified residue31Phosphoserine Ref.9
Modified residue1611Phosphoserine Ref.5
Modified residue1721Phosphoserine Ref.8

Natural variations

Alternative sequence513 – 57462VNSYG…WDLIT → GTAPSQLPWRWRLC in isoform FOXJ2.S.
VSP_001544
Natural variant2291P → R.
Corresponds to variant rs35642012 [ dbSNP | Ensembl ].
VAR_049162
Natural variant3101P → S.
Corresponds to variant rs2277415 [ dbSNP | Ensembl ].
VAR_021842

Sequences

Sequence LengthMass (Da)Tools
Isoform FOXJ2.L (FHX.L) [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 258120EDAE4B11EB

FASTA57462,395
        10         20         30         40         50         60 
MASDLESSLT SIDWLPQLTL RATIEKLGSA SQAGPPGSSR KCSPGSPTDP NATLSKDEAA 

        70         80         90        100        110        120 
VHQDGKPRYS YATLITYAIN SSPAKKMTLS EIYRWICDNF PYYKNAGIGW KNSIRHNLSL 

       130        140        150        160        170        180 
NKCFRKVPRP RDDPGKGSYW TIDTCPDISR KRRHPPDDDL SQDSPEQEAS KSPRGGVAGS 

       190        200        210        220        230        240 
GEASLPPEGN PQMSLQSPTS IASYSQGTGS VDGGAVAAGA SGRESAEGPP PLYNTNHDFK 

       250        260        270        280        290        300 
FSYSEINFQD LSWSFRNLYK SMLEKSSSSS QHGFSSLLGD IPPSNNYYMY QQQQPPPPQQ 

       310        320        330        340        350        360 
QQQQQQPPQP PPQQSQPQQQ QAPAQGPSAV GGAPPLHTPS TDGCTPPGGK QAGAEGYGPP 

       370        380        390        400        410        420 
PVMAMHPPPL QHGGYHPHQH HPHSHPAQQP PPPQPQAQGQ APINNTGFAF PSDWCSNIDS 

       430        440        450        460        470        480 
LKESFKMVNR LNWSSIEQSQ FSELMESLRQ AEQKNWTLDQ HHIANLCDSL NHFLTQTGHV 

       490        500        510        520        530        540 
PPQGGTHRPP APARIADSCA LTSGKQESAM SQVNSYGHPQ APHLYPGPSP MYPIPTQDSA 

       550        560        570 
GYNRPAHHMV PRPSVPPPGA NEEIPDDFDW DLIT 

« Hide

Isoform FOXJ2.S (FHX.S) [UniParc].

Checksum: 666CFE383030805D
Show »

FASTA52657,220

References

« Hide 'large scale' references
[1]"FHX, a novel fork head factor with a dual DNA binding specificity."
Perez-Sanchez C., Gomez-Ferreria M.A., de la Fuente C.A., Granadino B., Velasco G., Esteban A., Rey-Campos J.
J. Biol. Chem. 275:12909-12916(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM FOXJ2.L).
[2]"FHX.L and FHX.S, two isoforms of the human fork-head factor FHX (FOXJ2) with differential activity."
Perez-Sanchez C., de la Fuente C.A., Gomez-Ferreria M.A., Granadino B., Rey-Campos J.
J. Mol. Biol. 301:795-806(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM FOXJ2.S).
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM FOXJ2.L).
Tissue: Lung.
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 458-574 (ISOFORM FOXJ2.L).
Tissue: Melanoma.
[5]"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-161, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic kidney.
[6]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[7]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-172, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[9]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF155132 mRNA. Translation: AAF65927.1.
AF155133 mRNA. Translation: AAK49016.1.
BC126396 mRNA. Translation: AAI26397.1.
BC136305 mRNA. Translation: AAI36306.1.
AL161978 mRNA. Translation: CAB82315.1.
CCDSCCDS8587.1. [Q9P0K8-1]
PIRT47161.
RefSeqNP_060886.1. NM_018416.2. [Q9P0K8-1]
XP_005253487.1. XM_005253430.2. [Q9P0K8-1]
UniGeneHs.120844.

3D structure databases

ProteinModelPortalQ9P0K8.
SMRQ9P0K8. Positions 66-143.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120920. 3 interactions.
IntActQ9P0K8. 1 interaction.

PTM databases

PhosphoSiteQ9P0K8.

Polymorphism databases

DMDM13626933.

Proteomic databases

MaxQBQ9P0K8.
PaxDbQ9P0K8.
PRIDEQ9P0K8.

Protocols and materials databases

DNASU55810.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000162391; ENSP00000162391; ENSG00000065970. [Q9P0K8-1]
ENST00000428177; ENSP00000403411; ENSG00000065970. [Q9P0K8-2]
GeneID55810.
KEGGhsa:55810.
UCSCuc001qtt.1. human. [Q9P0K8-2]
uc001qtu.3. human. [Q9P0K8-1]

Organism-specific databases

CTD55810.
GeneCardsGC12P008185.
HGNCHGNC:24818. FOXJ2.
HPAHPA008723.
neXtProtNX_Q9P0K8.
PharmGKBPA134982817.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5025.
HOGENOMHOG000231184.
HOVERGENHBG051648.
InParanoidQ9P0K8.
KOK09403.
OMARHPPDDD.
OrthoDBEOG7RZ5RQ.
PhylomeDBQ9P0K8.
TreeFamTF333250.

Enzyme and pathway databases

SignaLinkQ9P0K8.

Gene expression databases

BgeeQ9P0K8.
CleanExHS_FOXJ2.
GenevestigatorQ9P0K8.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSPR00053. FORKHEAD.
SMARTSM00339. FH. 1 hit.
[Graphical view]
PROSITEPS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiFOXJ2.
GenomeRNAi55810.
NextBio60973.
PROQ9P0K8.

Entry information

Entry nameFOXJ2_HUMAN
AccessionPrimary (citable) accession number: Q9P0K8
Secondary accession number(s): A0AVK4 expand/collapse secondary AC list , B2RMP3, Q96PS9, Q9NSN5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM