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Protein

Ankycorbin

Gene

RAI14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ankycorbin
Alternative name(s):
Ankyrin repeat and coiled-coil structure-containing protein
Novel retinal pigment epithelial cell protein
Retinoic acid-induced protein 14
Gene namesi
Name:RAI14
Synonyms:KIAA1334, NORPEG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:14873. RAI14.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi26064.
OpenTargetsiENSG00000039560.
PharmGKBiPA34189.

Polymorphism and mutation databases

BioMutaiRAI14.
DMDMi108860920.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002396301 – 980AnkycorbinAdd BLAST980

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei11PhosphoserineCombined sources1
Modified residuei249PhosphothreonineCombined sources1
Modified residuei281PhosphoserineCombined sources1
Modified residuei286PhosphoserineCombined sources1
Modified residuei293PhosphoserineCombined sources1
Modified residuei295PhosphothreonineCombined sources1
Modified residuei297PhosphothreonineCombined sources1
Modified residuei300PhosphoserineCombined sources1
Modified residuei304PhosphoserineBy similarity1
Modified residuei318PhosphoserineBy similarity1
Modified residuei327PhosphoserineCombined sources1
Modified residuei329PhosphoserineCombined sources1
Modified residuei340PhosphoserineCombined sources1
Modified residuei341PhosphoserineCombined sources1
Modified residuei350PhosphoserineCombined sources1
Modified residuei358PhosphoserineCombined sources1
Modified residuei419PhosphoserineCombined sources1
Modified residuei512PhosphoserineCombined sources1
Modified residuei515PhosphoserineCombined sources1
Modified residuei667PhosphoserineCombined sources1
Modified residuei915PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9P0K7.
MaxQBiQ9P0K7.
PaxDbiQ9P0K7.
PeptideAtlasiQ9P0K7.
PRIDEiQ9P0K7.

PTM databases

iPTMnetiQ9P0K7.
PhosphoSitePlusiQ9P0K7.
SwissPalmiQ9P0K7.

Expressioni

Tissue specificityi

Highly expressed in placenta, muscle, kidney and testis. Moderately expressed in heart, brain, lung, liver and intestine. Isoform 2 is widely expressed and expressed in fetal and adult testes, and spermatozoa.3 Publications

Inductioni

Up-regulated by all-trans-retinoic acid (ATRA) in retinal pigment epithelial cells (ARPE-19).1 Publication

Gene expression databases

BgeeiENSG00000039560.
CleanExiHS_RAI14.
ExpressionAtlasiQ9P0K7. baseline and differential.
GenevisibleiQ9P0K7. HS.

Organism-specific databases

HPAiHPA036949.
HPA036950.

Interactioni

Subunit structurei

Doesn't bind directly to F-actin.By similarity

Protein-protein interaction databases

BioGridi117526. 66 interactors.
IntActiQ9P0K7. 47 interactors.
MINTiMINT-1138088.
STRINGi9606.ENSP00000427123.

Structurei

3D structure databases

ProteinModelPortaliQ9P0K7.
SMRiQ9P0K7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati18 – 51ANK 1Add BLAST34
Repeati52 – 81ANK 2Add BLAST30
Repeati85 – 114ANK 3Add BLAST30
Repeati118 – 147ANK 4Add BLAST30
Repeati151 – 180ANK 5Add BLAST30
Repeati184 – 213ANK 6Add BLAST30
Repeati217 – 247ANK 7Add BLAST31

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili349 – 374Sequence analysisAdd BLAST26
Coiled coili425 – 947Sequence analysisAdd BLAST523

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi270 – 276Nuclear localization signal1 Publication7

Sequence similaritiesi

Contains 7 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IEWD. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00530000063369.
HOGENOMiHOG000154070.
HOVERGENiHBG093886.
InParanoidiQ9P0K7.
OMAiEDMKEAM.
OrthoDBiEOG091G025R.
PhylomeDBiQ9P0K7.
TreeFamiTF331274.

Family and domain databases

Gene3Di1.25.40.20. 3 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P0K7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKSLKAKFRK SDTNEWNKND DRLLQAVENG DAEKVASLLG KKGASATKHD
60 70 80 90 100
SEGKTAFHLA AAKGHVECLR VMITHGVDVT AQDTTGHSAL HLAAKNSHHE
110 120 130 140 150
CIRKLLQSKC PAESVDSSGK TALHYAAAQG CLQAVQILCE HKSPINLKDL
160 170 180 190 200
DGNIPLLLAV QNGHSEICHF LLDHGADVNS RNKSGRTALM LACEIGSSNA
210 220 230 240 250
VEALIKKGAD LNLVDSLGYN ALHYSKLSEN AGIQSLLLSK ISQDADLKTP
260 270 280 290 300
TKPKQHDQVS KISSERSGTP KKRKAPPPPI SPTQLSDVSS PRSITSTPLS
310 320 330 340 350
GKESVFFAEP PFKAEISSIR ENKDRLSDST TGADSLLDIS SEADQQDLLS
360 370 380 390 400
LLQAKVASLT LHNKELQDKL QAKSPKEAEA DLSFDSYHST QTDLGPSLGK
410 420 430 440 450
PGETSPPDSK SSPSVLIHSL GKSTTDNDVR IQQLQEILQD LQKRLESSEA
460 470 480 490 500
ERKQLQVELQ SRRAELVCLN NTEISENSSD LSQKLKETQS KYEEAMKEVL
510 520 530 540 550
SVQKQMKLGL VSPESMDNYS HFHELRVTEE EINVLKQDLQ NALEESERNK
560 570 580 590 600
EKVRELEEKL VEREKGTVIK PPVEEYEEMK SSYCSVIENM NKEKAFLFEK
610 620 630 640 650
YQEAQEEIMK LKDTLKSQMT QEASDEAEDM KEAMNRMIDE LNKQVSELSQ
660 670 680 690 700
LYKEAQAELE DYRKRKSLED VTAEYIHKAE HEKLMQLTNV SRAKAEDALS
710 720 730 740 750
EMKSQYSKVL NELTQLKQLV DAQKENSVSI TEHLQVITTL RTAAKEMEEK
760 770 780 790 800
ISNLKEHLAS KEVEVAKLEK QLLEEKAAMT DAMVPRSSYE KLQSSLESEV
810 820 830 840 850
SVLASKLKES VKEKEKVHSE VVQIRSEVSQ VKREKENIQT LLKSKEQEVN
860 870 880 890 900
ELLQKFQQAQ EELAEMKRYA ESSSKLEEDK DKKINEMSKE VTKLKEALNS
910 920 930 940 950
LSQLSYSTSS SKRQSQQLEA LQQQVKQLQN QLAECKKQHQ EVISVYRMHL
960 970 980
LYAVQGQMDE DVQKVLKQIL TMCKNQSQKK
Length:980
Mass (Da):110,041
Last modified:June 13, 2006 - v2
Checksum:iDFCF4B7913B30B69
GO
Isoform 2 (identifier: Q9P0K7-2) [UniParc]FASTAAdd to basket
Also known as: sNORPEG

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MKSLKAKFRKSD → MQPTYLPWLSAKEKK

Show »
Length:983
Mass (Da):110,423
Checksum:i9B18E2F9DBFF5A6D
GO
Isoform 3 (identifier: Q9P0K7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MKSLKAKFRKSD → MEAK

Show »
Length:972
Mass (Da):109,080
Checksum:i5862375423E1C605
GO
Isoform 4 (identifier: Q9P0K7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     255-283: Missing.

Note: No experimental confirmation available.
Show »
Length:951
Mass (Da):106,905
Checksum:iF5CB369061C23BB6
GO

Sequence cautioni

The sequence BAA92572 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB43236 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104K → R in AAF44722 (PubMed:11042181).Curated1
Sequence conflicti272K → T in AAF44722 (PubMed:11042181).Curated1
Sequence conflicti272K → T in AAQ63889 (Ref. 3) Curated1
Sequence conflicti434L → P in AAQ63889 (Ref. 3) Curated1
Sequence conflicti491K → Q in AAQ63889 (Ref. 3) Curated1
Sequence conflicti602Q → P in AAQ63889 (Ref. 3) Curated1
Sequence conflicti607E → G in AAQ63889 (Ref. 3) Curated1
Sequence conflicti610K → E in AAQ63889 (Ref. 3) Curated1
Sequence conflicti636R → G in CAB43236 (PubMed:17974005).Curated1
Sequence conflicti766A → L in AAQ63889 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02667344A → T.Corresponds to variant rs17521570dbSNPEnsembl.1
Natural variantiVAR_05551745S → N.Corresponds to variant rs35941954dbSNPEnsembl.1
Natural variantiVAR_055518499V → L.Corresponds to variant rs10472941dbSNPEnsembl.1
Natural variantiVAR_055519870A → S.2 PublicationsCorresponds to variant rs1048944dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0192481 – 12MKSLK…FRKSD → MQPTYLPWLSAKEKK in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_0192491 – 12MKSLK…FRKSD → MEAK in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_045814255 – 283Missing in isoform 4. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155135 mRNA. Translation: AAF44722.1.
AY317139 mRNA. Translation: AAP84319.1.
AY354204 mRNA. Translation: AAQ63889.2.
AB037755 mRNA. Translation: BAA92572.1. Different initiation.
AK314379 mRNA. No translation available.
AC016602 Genomic DNA. No translation available.
AC025754 Genomic DNA. No translation available.
AC026801 Genomic DNA. No translation available.
BC052988 mRNA. Translation: AAH52988.1.
AL050011 mRNA. Translation: CAB43236.2. Different initiation.
CCDSiCCDS34142.1. [Q9P0K7-1]
CCDS54837.1. [Q9P0K7-4]
CCDS54838.1. [Q9P0K7-3]
CCDS54839.1. [Q9P0K7-2]
PIRiT08700.
RefSeqiNP_001138992.1. NM_001145520.1. [Q9P0K7-1]
NP_001138993.1. NM_001145521.1. [Q9P0K7-1]
NP_001138994.1. NM_001145522.1. [Q9P0K7-4]
NP_001138995.1. NM_001145523.1. [Q9P0K7-3]
NP_001138997.1. NM_001145525.1. [Q9P0K7-2]
NP_056392.2. NM_015577.2. [Q9P0K7-1]
XP_006714532.1. XM_006714469.2. [Q9P0K7-1]
XP_011512319.1. XM_011514017.2. [Q9P0K7-1]
XP_011512320.1. XM_011514018.1. [Q9P0K7-1]
XP_011512321.1. XM_011514019.1. [Q9P0K7-1]
XP_011512322.1. XM_011514020.1. [Q9P0K7-1]
XP_011512323.1. XM_011514021.1. [Q9P0K7-1]
XP_011512324.1. XM_011514022.1. [Q9P0K7-1]
XP_016864824.1. XM_017009335.1. [Q9P0K7-4]
UniGeneiHs.431400.

Genome annotation databases

EnsembliENST00000265109; ENSP00000265109; ENSG00000039560. [Q9P0K7-1]
ENST00000428746; ENSP00000388725; ENSG00000039560. [Q9P0K7-1]
ENST00000503673; ENSP00000422942; ENSG00000039560. [Q9P0K7-1]
ENST00000506376; ENSP00000423854; ENSG00000039560. [Q9P0K7-3]
ENST00000512629; ENSP00000422377; ENSG00000039560. [Q9P0K7-4]
ENST00000515799; ENSP00000427123; ENSG00000039560. [Q9P0K7-2]
GeneIDi26064.
KEGGihsa:26064.
UCSCiuc003jir.4. human. [Q9P0K7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155135 mRNA. Translation: AAF44722.1.
AY317139 mRNA. Translation: AAP84319.1.
AY354204 mRNA. Translation: AAQ63889.2.
AB037755 mRNA. Translation: BAA92572.1. Different initiation.
AK314379 mRNA. No translation available.
AC016602 Genomic DNA. No translation available.
AC025754 Genomic DNA. No translation available.
AC026801 Genomic DNA. No translation available.
BC052988 mRNA. Translation: AAH52988.1.
AL050011 mRNA. Translation: CAB43236.2. Different initiation.
CCDSiCCDS34142.1. [Q9P0K7-1]
CCDS54837.1. [Q9P0K7-4]
CCDS54838.1. [Q9P0K7-3]
CCDS54839.1. [Q9P0K7-2]
PIRiT08700.
RefSeqiNP_001138992.1. NM_001145520.1. [Q9P0K7-1]
NP_001138993.1. NM_001145521.1. [Q9P0K7-1]
NP_001138994.1. NM_001145522.1. [Q9P0K7-4]
NP_001138995.1. NM_001145523.1. [Q9P0K7-3]
NP_001138997.1. NM_001145525.1. [Q9P0K7-2]
NP_056392.2. NM_015577.2. [Q9P0K7-1]
XP_006714532.1. XM_006714469.2. [Q9P0K7-1]
XP_011512319.1. XM_011514017.2. [Q9P0K7-1]
XP_011512320.1. XM_011514018.1. [Q9P0K7-1]
XP_011512321.1. XM_011514019.1. [Q9P0K7-1]
XP_011512322.1. XM_011514020.1. [Q9P0K7-1]
XP_011512323.1. XM_011514021.1. [Q9P0K7-1]
XP_011512324.1. XM_011514022.1. [Q9P0K7-1]
XP_016864824.1. XM_017009335.1. [Q9P0K7-4]
UniGeneiHs.431400.

3D structure databases

ProteinModelPortaliQ9P0K7.
SMRiQ9P0K7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117526. 66 interactors.
IntActiQ9P0K7. 47 interactors.
MINTiMINT-1138088.
STRINGi9606.ENSP00000427123.

PTM databases

iPTMnetiQ9P0K7.
PhosphoSitePlusiQ9P0K7.
SwissPalmiQ9P0K7.

Polymorphism and mutation databases

BioMutaiRAI14.
DMDMi108860920.

Proteomic databases

EPDiQ9P0K7.
MaxQBiQ9P0K7.
PaxDbiQ9P0K7.
PeptideAtlasiQ9P0K7.
PRIDEiQ9P0K7.

Protocols and materials databases

DNASUi26064.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265109; ENSP00000265109; ENSG00000039560. [Q9P0K7-1]
ENST00000428746; ENSP00000388725; ENSG00000039560. [Q9P0K7-1]
ENST00000503673; ENSP00000422942; ENSG00000039560. [Q9P0K7-1]
ENST00000506376; ENSP00000423854; ENSG00000039560. [Q9P0K7-3]
ENST00000512629; ENSP00000422377; ENSG00000039560. [Q9P0K7-4]
ENST00000515799; ENSP00000427123; ENSG00000039560. [Q9P0K7-2]
GeneIDi26064.
KEGGihsa:26064.
UCSCiuc003jir.4. human. [Q9P0K7-1]

Organism-specific databases

CTDi26064.
DisGeNETi26064.
GeneCardsiRAI14.
HGNCiHGNC:14873. RAI14.
HPAiHPA036949.
HPA036950.
MIMi606586. gene.
neXtProtiNX_Q9P0K7.
OpenTargetsiENSG00000039560.
PharmGKBiPA34189.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEWD. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00530000063369.
HOGENOMiHOG000154070.
HOVERGENiHBG093886.
InParanoidiQ9P0K7.
OMAiEDMKEAM.
OrthoDBiEOG091G025R.
PhylomeDBiQ9P0K7.
TreeFamiTF331274.

Miscellaneous databases

ChiTaRSiRAI14. human.
GeneWikiiRAI14.
GenomeRNAii26064.
PROiQ9P0K7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000039560.
CleanExiHS_RAI14.
ExpressionAtlasiQ9P0K7. baseline and differential.
GenevisibleiQ9P0K7. HS.

Family and domain databases

Gene3Di1.25.40.20. 3 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAI14_HUMAN
AccessioniPrimary (citable) accession number: Q9P0K7
Secondary accession number(s): E9PED3
, Q6V1W9, Q7Z5I4, Q7Z733, Q9P2L2, Q9Y3T5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: November 2, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.