Disintegrin and metalloproteinase domain-containing protein 22 precursor

Names and origin

Protein names

Recommended name:
    Disintegrin and metalloproteinase domain-containing protein 22
      Short name=ADAM 22
Alternative name(s):
    Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2
    Metalloproteinase-disintegrin ADAM22-3

Gene names

Name:	ADAM22
Synonyms:	MDC2

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	906 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1. Ref.5 Ref.7 Ref.8
Subunit structure	Interacts with LGI1 and can bind to LGI4 By similarity. Interacts through its C-terminal region with YWHAB/14-3-3 beta and YWHAZ/14-3-3 zeta but not with YWHAE/14-3-3 epsilon or YWHAH/14-3-3 eta.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Highly expressed in the brain and in some high-grade but not low-grade gliomas. Detected slightly or not at all in other tissues. Ref.8
Post-translational modification	The precursor is cleaved by a furin endopeptidase By similarity.
Sequence similarities	Contains 1 disintegrin domain. Contains 1 EGF-like domain. Contains 1 peptidase M12B domain.

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Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	EGF-like domain Signal Transmembrane
Molecular function	Receptor
PTM	Cleavage on pair of basic residues Disulfide bond Glycoprotein Phosphoprotein
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW central nervous system development Ref.1 Traceable author statement. Source: ProtInc negative regulation of cell adhesion Ref.1 Non-traceable author statement. Source: UniProtKB proteolysis Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Ref.1 Non-traceable author statement. Source: UniProtKB
Molecular function	integrin binding Ref.1 Non-traceable author statement. Source: UniProtKB metalloendopeptidase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

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Binary interactions

With	Entry	#Exp.	IntAct	Notes
YWHAB	P31946	2	EBI-1567258,EBI-359815
YWHAB	P31946	1	EBI-1567267,EBI-359815
YWHAE	P62258	1	EBI-1567267,EBI-356498
Ywhag	P61982	1	EBI-1567267,EBI-359843	From a different organism.
YWHAH	Q04917	1	EBI-1567267,EBI-306940
YWHAQ	P27348	2	EBI-1567258,EBI-359854
YWHAQ	P27348	1	EBI-1567267,EBI-359854
YWHAZ	P63104	2	EBI-1567258,EBI-347088
YWHAZ	P63104	2	EBI-1567267,EBI-347088

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Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9P0K1-1) Also known as: Epsilon; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9P0K1-2) Also known as: Delta; The sequence of this isoform differs from the canonical sequence as follows: 768-803: Missing. 859-859: E → EYLNPWFKRDYNVAKWVEDVNKNTEEPYFR
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoform 3 (identifier: Q9P0K1-3) Also known as: Alpha; The sequence of this isoform differs from the canonical sequence as follows: 860-906: Missing.

Isoform 4 (identifier: Q9P0K1-4) Also known as: Beta; The sequence of this isoform differs from the canonical sequence as follows: 768-803: Missing. 860-906: Missing.

Isoform 5 (identifier: Q9P0K1-5) The sequence of this isoform differs from the canonical sequence as follows: 768-803: Missing.

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 25

25

Potential

Propeptide

26 – 222

197

By similarity

PRO_0000029112

Chain

223 – 906

684

Disintegrin and metalloproteinase domain-containing protein 22

PRO_0000029113

Regions

Topological domain

223 – 736

514

Extracellular Potential

Transmembrane

737 – 757

21

Potential

Topological domain

758 – 906

149

Cytoplasmic Potential

Domain

239 – 438

200

Peptidase M12B

Domain

444 – 531

88

Disintegrin

Domain

675 – 712

38

EGF-like

Compositional bias

532 – 678

147

Cys-rich

Amino acid modifications

Modified residue

834

1

Phosphoserine By similarity

Modified residue

866

1

Phosphoserine By similarity

Modified residue

868

1

Phosphoserine By similarity

Glycosylation

175

1

N-linked (GlcNAc...) Potential

Glycosylation

519

1

N-linked (GlcNAc...) Potential

Glycosylation

634

1

N-linked (GlcNAc...) Potential

Glycosylation

675

1

N-linked (GlcNAc...) Potential

Disulfide bond

349 ↔ 433

By similarity

Disulfide bond

392 ↔ 417

By similarity

Disulfide bond

394 ↔ 401

By similarity

Disulfide bond

503 ↔ 523

By similarity

Disulfide bond

679 ↔ 694

By similarity

Disulfide bond

688 ↔ 700

By similarity

Disulfide bond

702 ↔ 711

By similarity

Natural variations

Alternative sequence

768 – 803

36

Missing in isoform 2, isoform 4 and isoform 5.

VSP_005482

Alternative sequence

859

1

E → EYLNPWFKRDYNVAKWVEDV NKNTEEPYFR in isoform 2.

VSP_005484

Alternative sequence

860 – 906

47

Missing in isoform 3 and isoform 4.

VSP_005483

Natural variant

81

1

P → R: dbSNP rs2279542. Ref.3 Ref.4

VAR_020057

Natural variant

119

1

H → Y: dbSNP rs4728730.

VAR_051589

Natural variant

207

1

V → I: dbSNP rs17255978.

VAR_051590

Experimental info

Mutagenesis

834

1

S → A: Abolishes interactions with YWHAB and YWHAZ; when associated with A-857. Ref.5 Ref.7

Mutagenesis

857

1

S → A: Abolishes interactions with YWHAB and YWHAZ; when associated with A-834. Ref.5 Ref.7

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Sequences

Sequence		Length	Mass (Da)
Isoform 1 (Epsilon) [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 265ECCD0FA6C088B Show »	FASTA	906	100,433
10 20 30 40 50 60 MQAAVAVSVP FLLLCVLGTC PPARCGQAGD ASLMELEKRK ENRFVERQSI VPLRLIYRSG 70 80 90 100 110 120 GEDESRHDAL DTRVRGDLGG PQLTHVDQAS FQVDAFGTSF ILDVVLNHDL LSSEYIERHI 130 140 150 160 170 180 EHGGKTVEVK GGEHCYYQGH IRGNPDSFVA LSTCHGLHGM FYDGNHTYLI EPEENDTTQE 190 200 210 220 230 240 DFHFHSVYKS RLFEFSLDDL PSEFQQVNIT PSKFILKPRP KRSKRQLRRY PRNVEEETKY 250 260 270 280 290 300 IELMIVNDHL MFKKHRLSVV HTNTYAKSVV NMADLIYKDQ LKTRIVLVAM ETWATDNKFA 310 320 330 340 350 360 ISENPLITLR EFMKYRRDFI KEKSDAVHLF SGSQFESSRS GAAYIGGICS LLKGGGVNEF 370 380 390 400 410 420 GKTDLMAVTL AQSLAHNIGI ISDKRKLASG ECKCEDTWSG CIMGDTGYYL PKKFTQCNIE 430 440 450 460 470 480 EYHDFLNSGG GACLFNKPSK LLDPPECGNG FIETGEECDC GTPAECVLEG AECCKKCTLT 490 500 510 520 530 540 QDSQCSDGLC CKKCKFQPMG TVCREAVNDC DIRETCSGNS SQCAPNIHKM DGYSCDGVQG 550 560 570 580 590 600 ICFGGRCKTR DRQCKYIWGQ KVTASDKYCY EKLNIEGTEK GNCGKDKDTW IQCNKRDVLC 610 620 630 640 650 660 GYLLCTNIGN IPRLGELDGE ITSTLVVQQG RTLNCSGGHV KLEEDVDLGY VEDGTPCGPQ 670 680 690 700 710 720 MMCLEHRCLP VASFNFSTCL SSKEGTICSG NGVCSNELKC VCNRHWIGSD CNTYFPHNDD 730 740 750 760 770 780 AKTGITLSGN GVAGTNIIIG IIAGTILVLA LILGITAWGY KNYREQRQLP QGDYVKKPGD 790 800 810 820 830 840 GDSFYSDIPP GVSTNSASSS KKRSNGLSHS WSERIPDTKH ISDICENGRP RSNSWQGNLG 850 860 870 880 890 900 GNKKKIRGKR FRPRSNSTET LSPAKSPSSS TGSIASSRKY PYPMPPLPDE DKKVNRQSAR LWETSI « Hide
Isoform 2 (Delta). Checksum: 5AB89C260378DFD6 Show »	FASTA	899	100,341
10 20 30 40 50 60 MQAAVAVSVP FLLLCVLGTC PPARCGQAGD ASLMELEKRK ENRFVERQSI VPLRLIYRSG 70 80 90 100 110 120 GEDESRHDAL DTRVRGDLGG PQLTHVDQAS FQVDAFGTSF ILDVVLNHDL LSSEYIERHI 130 140 150 160 170 180 EHGGKTVEVK GGEHCYYQGH IRGNPDSFVA LSTCHGLHGM FYDGNHTYLI EPEENDTTQE 190 200 210 220 230 240 DFHFHSVYKS RLFEFSLDDL PSEFQQVNIT PSKFILKPRP KRSKRQLRRY PRNVEEETKY 250 260 270 280 290 300 IELMIVNDHL MFKKHRLSVV HTNTYAKSVV NMADLIYKDQ LKTRIVLVAM ETWATDNKFA 310 320 330 340 350 360 ISENPLITLR EFMKYRRDFI KEKSDAVHLF SGSQFESSRS GAAYIGGICS LLKGGGVNEF 370 380 390 400 410 420 GKTDLMAVTL AQSLAHNIGI ISDKRKLASG ECKCEDTWSG CIMGDTGYYL PKKFTQCNIE 430 440 450 460 470 480 EYHDFLNSGG GACLFNKPSK LLDPPECGNG FIETGEECDC GTPAECVLEG AECCKKCTLT 490 500 510 520 530 540 QDSQCSDGLC CKKCKFQPMG TVCREAVNDC DIRETCSGNS SQCAPNIHKM DGYSCDGVQG 550 560 570 580 590 600 ICFGGRCKTR DRQCKYIWGQ KVTASDKYCY EKLNIEGTEK GNCGKDKDTW IQCNKRDVLC 610 620 630 640 650 660 GYLLCTNIGN IPRLGELDGE ITSTLVVQQG RTLNCSGGHV KLEEDVDLGY VEDGTPCGPQ 670 680 690 700 710 720 MMCLEHRCLP VASFNFSTCL SSKEGTICSG NGVCSNELKC VCNRHWIGSD CNTYFPHNDD 730 740 750 760 770 780 AKTGITLSGN GVAGTNIIIG IIAGTILVLA LILGITAWGY KNYREQRSNG LSHSWSERIP 790 800 810 820 830 840 DTKHISDICE NGRPRSNSWQ GNLGGNKKKI RGKRFRPRSN STEYLNPWFK RDYNVAKWVE 850 860 870 880 890 DVNKNTEEPY FRTLSPAKSP SSSTGSIASS RKYPYPMPPL PDEDKKVNRQ SARLWETSI « Hide
Isoform 3 (Alpha). Checksum: 6105B681A1331D55 Show »	FASTA	859	95,288
10 20 30 40 50 60 MQAAVAVSVP FLLLCVLGTC PPARCGQAGD ASLMELEKRK ENRFVERQSI VPLRLIYRSG 70 80 90 100 110 120 GEDESRHDAL DTRVRGDLGG PQLTHVDQAS FQVDAFGTSF ILDVVLNHDL LSSEYIERHI 130 140 150 160 170 180 EHGGKTVEVK GGEHCYYQGH IRGNPDSFVA LSTCHGLHGM FYDGNHTYLI EPEENDTTQE 190 200 210 220 230 240 DFHFHSVYKS RLFEFSLDDL PSEFQQVNIT PSKFILKPRP KRSKRQLRRY PRNVEEETKY 250 260 270 280 290 300 IELMIVNDHL MFKKHRLSVV HTNTYAKSVV NMADLIYKDQ LKTRIVLVAM ETWATDNKFA 310 320 330 340 350 360 ISENPLITLR EFMKYRRDFI KEKSDAVHLF SGSQFESSRS GAAYIGGICS LLKGGGVNEF 370 380 390 400 410 420 GKTDLMAVTL AQSLAHNIGI ISDKRKLASG ECKCEDTWSG CIMGDTGYYL PKKFTQCNIE 430 440 450 460 470 480 EYHDFLNSGG GACLFNKPSK LLDPPECGNG FIETGEECDC GTPAECVLEG AECCKKCTLT 490 500 510 520 530 540 QDSQCSDGLC CKKCKFQPMG TVCREAVNDC DIRETCSGNS SQCAPNIHKM DGYSCDGVQG 550 560 570 580 590 600 ICFGGRCKTR DRQCKYIWGQ KVTASDKYCY EKLNIEGTEK GNCGKDKDTW IQCNKRDVLC 610 620 630 640 650 660 GYLLCTNIGN IPRLGELDGE ITSTLVVQQG RTLNCSGGHV KLEEDVDLGY VEDGTPCGPQ 670 680 690 700 710 720 MMCLEHRCLP VASFNFSTCL SSKEGTICSG NGVCSNELKC VCNRHWIGSD CNTYFPHNDD 730 740 750 760 770 780 AKTGITLSGN GVAGTNIIIG IIAGTILVLA LILGITAWGY KNYREQRQLP QGDYVKKPGD 790 800 810 820 830 840 GDSFYSDIPP GVSTNSASSS KKRSNGLSHS WSERIPDTKH ISDICENGRP RSNSWQGNLG 850 GNKKKIRGKR FRPRSNSTE « Hide
Isoform 4 (Beta). Checksum: E9FD1A9BA99DE0DB Show »	FASTA	823	91,492
10 20 30 40 50 60 MQAAVAVSVP FLLLCVLGTC PPARCGQAGD ASLMELEKRK ENRFVERQSI VPLRLIYRSG 70 80 90 100 110 120 GEDESRHDAL DTRVRGDLGG PQLTHVDQAS FQVDAFGTSF ILDVVLNHDL LSSEYIERHI 130 140 150 160 170 180 EHGGKTVEVK GGEHCYYQGH IRGNPDSFVA LSTCHGLHGM FYDGNHTYLI EPEENDTTQE 190 200 210 220 230 240 DFHFHSVYKS RLFEFSLDDL PSEFQQVNIT PSKFILKPRP KRSKRQLRRY PRNVEEETKY 250 260 270 280 290 300 IELMIVNDHL MFKKHRLSVV HTNTYAKSVV NMADLIYKDQ LKTRIVLVAM ETWATDNKFA 310 320 330 340 350 360 ISENPLITLR EFMKYRRDFI KEKSDAVHLF SGSQFESSRS GAAYIGGICS LLKGGGVNEF 370 380 390 400 410 420 GKTDLMAVTL AQSLAHNIGI ISDKRKLASG ECKCEDTWSG CIMGDTGYYL PKKFTQCNIE 430 440 450 460 470 480 EYHDFLNSGG GACLFNKPSK LLDPPECGNG FIETGEECDC GTPAECVLEG AECCKKCTLT 490 500 510 520 530 540 QDSQCSDGLC CKKCKFQPMG TVCREAVNDC DIRETCSGNS SQCAPNIHKM DGYSCDGVQG 550 560 570 580 590 600 ICFGGRCKTR DRQCKYIWGQ KVTASDKYCY EKLNIEGTEK GNCGKDKDTW IQCNKRDVLC 610 620 630 640 650 660 GYLLCTNIGN IPRLGELDGE ITSTLVVQQG RTLNCSGGHV KLEEDVDLGY VEDGTPCGPQ 670 680 690 700 710 720 MMCLEHRCLP VASFNFSTCL SSKEGTICSG NGVCSNELKC VCNRHWIGSD CNTYFPHNDD 730 740 750 760 770 780 AKTGITLSGN GVAGTNIIIG IIAGTILVLA LILGITAWGY KNYREQRSNG LSHSWSERIP 790 800 810 820 DTKHISDICE NGRPRSNSWQ GNLGGNKKKI RGKRFRPRSN STE « Hide
Isoform 5. Checksum: C236086AD0BCCA2F Show »	FASTA	870	96,637
10 20 30 40 50 60 MQAAVAVSVP FLLLCVLGTC PPARCGQAGD ASLMELEKRK ENRFVERQSI VPLRLIYRSG 70 80 90 100 110 120 GEDESRHDAL DTRVRGDLGG PQLTHVDQAS FQVDAFGTSF ILDVVLNHDL LSSEYIERHI 130 140 150 160 170 180 EHGGKTVEVK GGEHCYYQGH IRGNPDSFVA LSTCHGLHGM FYDGNHTYLI EPEENDTTQE 190 200 210 220 230 240 DFHFHSVYKS RLFEFSLDDL PSEFQQVNIT PSKFILKPRP KRSKRQLRRY PRNVEEETKY 250 260 270 280 290 300 IELMIVNDHL MFKKHRLSVV HTNTYAKSVV NMADLIYKDQ LKTRIVLVAM ETWATDNKFA 310 320 330 340 350 360 ISENPLITLR EFMKYRRDFI KEKSDAVHLF SGSQFESSRS GAAYIGGICS LLKGGGVNEF 370 380 390 400 410 420 GKTDLMAVTL AQSLAHNIGI ISDKRKLASG ECKCEDTWSG CIMGDTGYYL PKKFTQCNIE 430 440 450 460 470 480 EYHDFLNSGG GACLFNKPSK LLDPPECGNG FIETGEECDC GTPAECVLEG AECCKKCTLT 490 500 510 520 530 540 QDSQCSDGLC CKKCKFQPMG TVCREAVNDC DIRETCSGNS SQCAPNIHKM DGYSCDGVQG 550 560 570 580 590 600 ICFGGRCKTR DRQCKYIWGQ KVTASDKYCY EKLNIEGTEK GNCGKDKDTW IQCNKRDVLC 610 620 630 640 650 660 GYLLCTNIGN IPRLGELDGE ITSTLVVQQG RTLNCSGGHV KLEEDVDLGY VEDGTPCGPQ 670 680 690 700 710 720 MMCLEHRCLP VASFNFSTCL SSKEGTICSG NGVCSNELKC VCNRHWIGSD CNTYFPHNDD 730 740 750 760 770 780 AKTGITLSGN GVAGTNIIIG IIAGTILVLA LILGITAWGY KNYREQRSNG LSHSWSERIP 790 800 810 820 830 840 DTKHISDICE NGRPRSNSWQ GNLGGNKKKI RGKRFRPRSN STETLSPAKS PSSSTGSIAS 850 860 870 SRKYPYPMPP LPDEDKKVNR QSARLWETSI « Hide

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References

[1]	"Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain." Sagane K., Ohya Y., Hasegawa Y., Tanaka I. Biochem. J. 334:93-98(1998) [PubMed: 9693107] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4). Tissue: Brain.
[2]	"The specific expression of three novel splice variant forms of human metalloprotease-like disintegrin-like cysteine-rich protein 2 gene in brain tissues and gliomas." Harada T., Nishie A., Torigoe K., Ikezaki K., Shono T., Maehara Y., Kuwano M., Wada M. Jpn. J. Cancer Res. 91:1001-1006(2000) [PubMed: 11050470] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[3]	"Isolation and tissue specific expression of novel ADAM family from 7q21.1 region." Wada M., Torigoe K., Harada T., Kuwano M. Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), VARIANT ARG-81. Tissue: Brain.
[4]	"The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries." Poindexter K., Nelson N., DuBose R.F., Black R.A., Cerretti D.P. Gene 237:61-70(1999) [PubMed: 10524237] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 40-906 (ISOFORM 1), VARIANT ARG-81. Tissue: Cerebellum.
[5]	"The interaction between ADAM 22 and 14-3-3zeta: regulation of cell adhesion and spreading." Zhu P., Sun Y., Xu R., Sang Y., Zhao J., Liu G., Cai L., Li C., Zhao S. Biochem. Biophys. Res. Commun. 301:991-999(2003) [PubMed: 12589811] [Abstract] Cited for: FUNCTION, INTERACTION WITH YWHAZ, MUTAGENESIS OF SER-834 AND SER-857.
[6]	"An unappreciated role for RNA surveillance." Hillman R.T., Green R.E., Brenner S.E. Genome Biol. 5:RESEARCH008.1-RESEARCH008.16(2004) [PubMed: 14759258] [Abstract] Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
[7]	"ADAM22 plays an important role in cell adhesion and spreading with the assistance of 14-3-3." Zhu P., Sang Y., Xu H., Zhao J., Xu R., Sun Y., Xu T., Wang X., Chen L., Feng H., Li C., Zhao S. Biochem. Biophys. Res. Commun. 331:938-946(2005) [PubMed: 15882968] [Abstract] Cited for: FUNCTION, INTERACTION WITH YWHAB, MUTAGENESIS OF SER-834 AND SER-857.
[8]	"ADAM22, expressed in normal brain but not in high-grade gliomas, inhibits cellular proliferation via the disintegrin domain." D'Abaco G.M., Ng K., Paradiso L., Godde N.J., Kaye A., Novak U. Neurosurgery 58:179-186(2006) [PubMed: 16385342] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

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Cross-references

Sequence databases

AB009671 mRNA. Translation: BAA32349.1.
AB009671 mRNA. Translation: BAA32350.1.
AF155381 mRNA. Translation: AAF73288.1.
AF155382 mRNA. Translation: AAF73289.1.
AF073291 mRNA. Translation: AAF22476.2.
AF158637 mRNA. Translation: AAD55251.1.

IPI

IPI00000779.
IPI00220631.
IPI00220632.
IPI00220634.
IPI00220635.

RefSeq

NP_004185.1.
NP_057435.2.
NP_068367.1.
NP_068368.2.
NP_068369.1.

UniGene

Hs.592282

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3G5C	X-ray	2.36	A/B	233-736	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9P0K1. 9 interactions.

STRING

Q9P0K1.

Protein family/group databases

MEROPS

M12.978.

PTM databases

PhosphoSite

Q9P0K1.

Proteomic databases

PRIDE

Q9P0K1.

Genome annotation databases

Ensembl

GeneID

53616.

KEGG

hsa:53616.

UCSC

uc003ujk.1. human.
uc003ujl.1. human.
uc003ujn.1. human.
uc003ujo.1. human.

Organism-specific databases

CTD

53616.

GeneCards

GC07P087401.

H-InvDB

HIX0025260.
HIX0039022.

HGNC

HGNC:201. ADAM22.

MIM

603709. gene.

PharmGKB

PA24518.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

Q9P0K1.

HOVERGEN

Q9P0K1.

Gene expression databases

ArrayExpress

Q9P0K1.

Bgee

Q9P0K1.

CleanEx

HS_ADAM22.

Genevestigator

Q9P0K1.

GermOnline

ENSG00000008277. Homo sapiens.

Family and domain databases

InterPro

IPR006586. ADAM_Cys-rich.
IPR001762. Blood-coag_inhib_Disintegrin.
IPR018358. Disintegrin_CS.
IPR006210. EGF-like.
IPR013032. EGF-like_reg_CS.
IPR013111. EGF_extracell.
IPR006025. Pept_M_Zn_BS.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]

Gene3D

G3DSA:4.10.70.10. Blood-coag_inhib_Disintegrin. 1 hit.

Pfam

PF08516. ADAM_CR. 1 hit.
PF00200. Disintegrin. 1 hit.
PF07974. EGF_2. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]

PRINTS

PR00289. DISINTEGRIN.

ProDom

PD000664. Disintegrin. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SMART

SM00608. ACR. 1 hit.
SM00050. DISIN. 1 hit.
SM00181. EGF. 1 hit.
[Graphical view]

PROSITE

PS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. False negative.
PS50026. EGF_3. False negative.
PS00142. ZINC_PROTEASE. False negative.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

56096.

SOURCE

Search...

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Entry information

Entry name

ADA22_HUMAN

Accession

Primary (citable) accession number: Q9P0K1
Secondary accession number(s): O75075

Q9UKK2

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	October 1, 2000
Last modified:	November 3, 2009
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Human chromosome 7: entries, gene names and cross-references to MIM

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List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents