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Q9P0J6

- RM36_HUMAN

UniProt

Q9P0J6 - RM36_HUMAN

Protein

39S ribosomal protein L36, mitochondrial

Gene

MRPL36

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Component of the large subunit of the mitochondrial ribosome.Curated

    GO - Molecular functioni

    1. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. translation Source: UniProtKB

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    39S ribosomal protein L36, mitochondrial
    Short name:
    L36mt
    Short name:
    MRP-L36
    Alternative name(s):
    BRCA1-interacting protein 1
    Gene namesi
    Name:MRPL36
    Synonyms:BRIP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:14490. MRPL36.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial large ribosomal subunit Source: UniProtKB

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30967.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 10339S ribosomal protein L36, mitochondrialPRO_0000030529
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Proteomic databases

    PRIDEiQ9P0J6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9P0J6.
    BgeeiQ9P0J6.
    CleanExiHS_BRIP1.
    HS_MRPL36.
    GenevestigatoriQ9P0J6.

    Organism-specific databases

    HPAiHPA047238.

    Interactioni

    Protein-protein interaction databases

    BioGridi122366. 4 interactions.
    IntActiQ9P0J6. 1 interaction.
    MINTiMINT-1526761.
    STRINGi9606.ENSP00000372093.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9P0J6.
    SMRiQ9P0J6. Positions 67-102.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L36P family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG267357.
    HOGENOMiHOG000111586.
    HOVERGENiHBG029144.
    InParanoidiQ9P0J6.
    KOiK02919.
    OMAiRVTHILV.
    OrthoDBiEOG79CZ1X.
    PhylomeDBiQ9P0J6.
    TreeFamiTF300275.

    Family and domain databases

    HAMAPiMF_00251. Ribosomal_L36.
    InterProiIPR000473. Ribosomal_L36.
    [Graphical view]
    PANTHERiPTHR18804. PTHR18804. 1 hit.
    PfamiPF00444. Ribosomal_L36. 1 hit.
    [Graphical view]
    SUPFAMiSSF57840. SSF57840. 1 hit.
    TIGRFAMsiTIGR01022. rpmJ_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9P0J6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANLFIRKMV NPLLYLSRHT VKPRALSTFL FGSIRGAAPV AVEPGAAVRS    50
    LLSPGLLPHL LPALGFKNKT VLKKRCKDCY LVKRRGRWYV YCKTHPRHKQ 100
    RQM 103
    Length:103
    Mass (Da):11,784
    Last modified:October 1, 2000 - v1
    Checksum:iCF1720639DE3C34B
    GO

    Sequence cautioni

    The sequence AAF04788.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti36 – 361G → S in AAF04788. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB049654 mRNA. Translation: BAB40859.1.
    AF151109 mRNA. Translation: AAF04788.1. Different initiation.
    EF036487 mRNA. Translation: ABO65073.1.
    AF155653 mRNA. Translation: AAF67010.1.
    AK312001 mRNA. Translation: BAG34939.1.
    CH471102 Genomic DNA. Translation: EAX08145.1.
    BC020642 mRNA. Translation: AAH20642.1.
    BC104652 mRNA. Translation: AAI04653.1.
    CCDSiCCDS3865.1.
    RefSeqiNP_115868.1. NM_032479.3.
    UniGeneiHs.719465.

    Genome annotation databases

    EnsembliENST00000382647; ENSP00000372093; ENSG00000171421.
    ENST00000505059; ENSP00000423152; ENSG00000171421.
    ENST00000505818; ENSP00000427152; ENSG00000171421.
    ENST00000508987; ENSP00000423399; ENSG00000171421.
    GeneIDi64979.
    KEGGihsa:64979.
    UCSCiuc003jcx.4. human.

    Polymorphism databases

    DMDMi24212267.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB049654 mRNA. Translation: BAB40859.1 .
    AF151109 mRNA. Translation: AAF04788.1 . Different initiation.
    EF036487 mRNA. Translation: ABO65073.1 .
    AF155653 mRNA. Translation: AAF67010.1 .
    AK312001 mRNA. Translation: BAG34939.1 .
    CH471102 Genomic DNA. Translation: EAX08145.1 .
    BC020642 mRNA. Translation: AAH20642.1 .
    BC104652 mRNA. Translation: AAI04653.1 .
    CCDSi CCDS3865.1.
    RefSeqi NP_115868.1. NM_032479.3.
    UniGenei Hs.719465.

    3D structure databases

    ProteinModelPortali Q9P0J6.
    SMRi Q9P0J6. Positions 67-102.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122366. 4 interactions.
    IntActi Q9P0J6. 1 interaction.
    MINTi MINT-1526761.
    STRINGi 9606.ENSP00000372093.

    Polymorphism databases

    DMDMi 24212267.

    Proteomic databases

    PRIDEi Q9P0J6.

    Protocols and materials databases

    DNASUi 64979.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000382647 ; ENSP00000372093 ; ENSG00000171421 .
    ENST00000505059 ; ENSP00000423152 ; ENSG00000171421 .
    ENST00000505818 ; ENSP00000427152 ; ENSG00000171421 .
    ENST00000508987 ; ENSP00000423399 ; ENSG00000171421 .
    GeneIDi 64979.
    KEGGi hsa:64979.
    UCSCi uc003jcx.4. human.

    Organism-specific databases

    CTDi 64979.
    GeneCardsi GC05M001851.
    HGNCi HGNC:14490. MRPL36.
    HPAi HPA047238.
    MIMi 611842. gene.
    neXtProti NX_Q9P0J6.
    PharmGKBi PA30967.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG267357.
    HOGENOMi HOG000111586.
    HOVERGENi HBG029144.
    InParanoidi Q9P0J6.
    KOi K02919.
    OMAi RVTHILV.
    OrthoDBi EOG79CZ1X.
    PhylomeDBi Q9P0J6.
    TreeFami TF300275.

    Miscellaneous databases

    GenomeRNAii 64979.
    NextBioi 67168.
    PROi Q9P0J6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9P0J6.
    Bgeei Q9P0J6.
    CleanExi HS_BRIP1.
    HS_MRPL36.
    Genevestigatori Q9P0J6.

    Family and domain databases

    HAMAPi MF_00251. Ribosomal_L36.
    InterProi IPR000473. Ribosomal_L36.
    [Graphical view ]
    PANTHERi PTHR18804. PTHR18804. 1 hit.
    Pfami PF00444. Ribosomal_L36. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57840. SSF57840. 1 hit.
    TIGRFAMsi TIGR01022. rpmJ_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria."
      Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K.
      J. Biol. Chem. 276:21724-21736(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "BRIP1, a candidate for BRCA1-interacting protein."
      Wang Q., Zhang H., Greene M.I.
      Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Searching for interaction partners of the transcription factor REST/NRSF by two-hybrid screening."
      Santana-Roman H., Curiel-Quesada E., Tapia-Ramirez J.
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Adrenal gland.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thalamus.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiRM36_HUMAN
    AccessioniPrimary (citable) accession number: Q9P0J6
    Secondary accession number(s): A4UCS0
    , B2R4Z2, Q3SWV6, Q9UKL7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2002
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. Ribosomal proteins
      Ribosomal proteins families and list of entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3