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Protein

39S ribosomal protein L36, mitochondrial

Gene

MRPL36

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L36, mitochondrial
Short name:
L36mt
Short name:
MRP-L36
Alternative name(s):
BRCA1-interacting protein 1
Mitochondrial large ribosomal subunit protein bL36m1 Publication
Gene namesi
Name:MRPL36
Synonyms:BRIP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:14490. MRPL36.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi64979.
OpenTargetsiENSG00000171421.
PharmGKBiPA30967.

Polymorphism and mutation databases

BioMutaiMRPL36.
DMDMi24212267.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000030529? – 10339S ribosomal protein L36, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

PaxDbiQ9P0J6.
PeptideAtlasiQ9P0J6.
PRIDEiQ9P0J6.
TopDownProteomicsiQ9P0J6.

Expressioni

Gene expression databases

BgeeiENSG00000171421.
CleanExiHS_BRIP1.
HS_MRPL36.
ExpressionAtlasiQ9P0J6. baseline and differential.
GenevisibleiQ9P0J6. HS.

Organism-specific databases

HPAiHPA047238.

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. bL36m has a zinc binding site.2 Publications

Protein-protein interaction databases

BioGridi122366. 2 interactors.
IntActiQ9P0J6. 1 interactor.
MINTiMINT-1526761.
STRINGi9606.ENSP00000372093.

Structurei

Secondary structure

1103
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi76 – 78Combined sources3
Beta strandi80 – 84Combined sources5
Beta strandi87 – 91Combined sources5
Helixi96 – 98Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.4041-103[»]
3J9Melectron microscopy3.5041-103[»]
ProteinModelPortaliQ9P0J6.
SMRiQ9P0J6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4122. Eukaryota.
COG0257. LUCA.
GeneTreeiENSGT00390000010866.
HOGENOMiHOG000111586.
HOVERGENiHBG029144.
InParanoidiQ9P0J6.
KOiK02919.
OMAiYVYCKTN.
OrthoDBiEOG091G14CM.
PhylomeDBiQ9P0J6.
TreeFamiTF300275.

Family and domain databases

HAMAPiMF_00251. Ribosomal_L36. 1 hit.
InterProiView protein in InterPro
IPR000473. Ribosomal_L36.
PfamiView protein in Pfam
PF00444. Ribosomal_L36. 1 hit.
SUPFAMiSSF57840. SSF57840. 1 hit.
TIGRFAMsiTIGR01022. rpmJ_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9P0J6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANLFIRKMV NPLLYLSRHT VKPRALSTFL FGSIRGAAPV AVEPGAAVRS
60 70 80 90 100
LLSPGLLPHL LPALGFKNKT VLKKRCKDCY LVKRRGRWYV YCKTHPRHKQ

RQM
Length:103
Mass (Da):11,784
Last modified:October 1, 2000 - v1
Checksum:iCF1720639DE3C34B
GO

Sequence cautioni

The sequence AAF04788 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti36G → S in AAF04788 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049654 mRNA. Translation: BAB40859.1.
AF151109 mRNA. Translation: AAF04788.1. Different initiation.
EF036487 mRNA. Translation: ABO65073.1.
AF155653 mRNA. Translation: AAF67010.1.
AK312001 mRNA. Translation: BAG34939.1.
CH471102 Genomic DNA. Translation: EAX08145.1.
BC020642 mRNA. Translation: AAH20642.1.
BC104652 mRNA. Translation: AAI04653.1.
CCDSiCCDS3865.1.
RefSeqiNP_115868.1. NM_032479.3.
XP_016865239.1. XM_017009750.1.
XP_016865240.1. XM_017009751.1.
XP_016865241.1. XM_017009752.1.
UniGeneiHs.719465.

Genome annotation databases

EnsembliENST00000382647; ENSP00000372093; ENSG00000171421.
ENST00000505059; ENSP00000423152; ENSG00000171421.
ENST00000505818; ENSP00000427152; ENSG00000171421.
ENST00000508987; ENSP00000423399; ENSG00000171421.
GeneIDi64979.
KEGGihsa:64979.
UCSCiuc003jcx.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049654 mRNA. Translation: BAB40859.1.
AF151109 mRNA. Translation: AAF04788.1. Different initiation.
EF036487 mRNA. Translation: ABO65073.1.
AF155653 mRNA. Translation: AAF67010.1.
AK312001 mRNA. Translation: BAG34939.1.
CH471102 Genomic DNA. Translation: EAX08145.1.
BC020642 mRNA. Translation: AAH20642.1.
BC104652 mRNA. Translation: AAI04653.1.
CCDSiCCDS3865.1.
RefSeqiNP_115868.1. NM_032479.3.
XP_016865239.1. XM_017009750.1.
XP_016865240.1. XM_017009751.1.
XP_016865241.1. XM_017009752.1.
UniGeneiHs.719465.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.4041-103[»]
3J9Melectron microscopy3.5041-103[»]
ProteinModelPortaliQ9P0J6.
SMRiQ9P0J6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122366. 2 interactors.
IntActiQ9P0J6. 1 interactor.
MINTiMINT-1526761.
STRINGi9606.ENSP00000372093.

Polymorphism and mutation databases

BioMutaiMRPL36.
DMDMi24212267.

Proteomic databases

PaxDbiQ9P0J6.
PeptideAtlasiQ9P0J6.
PRIDEiQ9P0J6.
TopDownProteomicsiQ9P0J6.

Protocols and materials databases

DNASUi64979.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382647; ENSP00000372093; ENSG00000171421.
ENST00000505059; ENSP00000423152; ENSG00000171421.
ENST00000505818; ENSP00000427152; ENSG00000171421.
ENST00000508987; ENSP00000423399; ENSG00000171421.
GeneIDi64979.
KEGGihsa:64979.
UCSCiuc003jcx.5. human.

Organism-specific databases

CTDi64979.
DisGeNETi64979.
GeneCardsiMRPL36.
HGNCiHGNC:14490. MRPL36.
HPAiHPA047238.
MIMi611842. gene.
neXtProtiNX_Q9P0J6.
OpenTargetsiENSG00000171421.
PharmGKBiPA30967.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4122. Eukaryota.
COG0257. LUCA.
GeneTreeiENSGT00390000010866.
HOGENOMiHOG000111586.
HOVERGENiHBG029144.
InParanoidiQ9P0J6.
KOiK02919.
OMAiYVYCKTN.
OrthoDBiEOG091G14CM.
PhylomeDBiQ9P0J6.
TreeFamiTF300275.

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Miscellaneous databases

ChiTaRSiMRPL36. human.
GenomeRNAii64979.
PROiPR:Q9P0J6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171421.
CleanExiHS_BRIP1.
HS_MRPL36.
ExpressionAtlasiQ9P0J6. baseline and differential.
GenevisibleiQ9P0J6. HS.

Family and domain databases

HAMAPiMF_00251. Ribosomal_L36. 1 hit.
InterProiView protein in InterPro
IPR000473. Ribosomal_L36.
PfamiView protein in Pfam
PF00444. Ribosomal_L36. 1 hit.
SUPFAMiSSF57840. SSF57840. 1 hit.
TIGRFAMsiTIGR01022. rpmJ_bact. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRM36_HUMAN
AccessioniPrimary (citable) accession number: Q9P0J6
Secondary accession number(s): A4UCS0
, B2R4Z2, Q3SWV6, Q9UKL7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 1, 2000
Last modified: April 12, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.