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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

Gene

NDUFA13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes.3 Publications

GO - Molecular functioni

  • ATP binding Source: UniProtKB
  • NADH dehydrogenase (ubiquinone) activity Source: UniProtKB
  • NADH dehydrogenase activity Source: UniProtKB

GO - Biological processi

  • apoptotic signaling pathway Source: UniProtKB
  • cellular metabolic process Source: Reactome
  • cellular response to interferon-beta Source: ParkinsonsUK-UCL
  • cellular response to retinoic acid Source: ParkinsonsUK-UCL
  • negative regulation of cell growth Source: UniProtKB
  • negative regulation of intrinsic apoptotic signaling pathway Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: ParkinsonsUK-UCL
  • positive regulation of peptidase activity Source: ParkinsonsUK-UCL
  • positive regulation of protein catabolic process Source: ParkinsonsUK-UCL
  • protein import into mitochondrial inner membrane Source: UniProtKB
  • reactive oxygen species metabolic process Source: UniProtKB
  • respiratory electron transport chain Source: Reactome
  • small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiREACT_22393. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
Alternative name(s):
Cell death regulatory protein GRIM-19
Complex I-B16.6
Short name:
CI-B16.6
Gene associated with retinoic and interferon-induced mortality 19 protein
Short name:
GRIM-19
Short name:
Gene associated with retinoic and IFN-induced mortality 19 protein
NADH-ubiquinone oxidoreductase B16.6 subunit
Gene namesi
Name:NDUFA13
Synonyms:GRIM19
ORF Names:CDA016, CGI-39
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:17194. NDUFA13.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei30 – 5122HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: Reactome
  • mitochondrial membrane Source: UniProtKB
  • mitochondrial respiratory chain Source: UniProtKB
  • mitochondrial respiratory chain complex I Source: UniProtKB
  • mitochondrion Source: UniProtKB
  • nucleoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane, Nucleus

Pathology & Biotechi

Involvement in diseasei

Hurthle cell thyroid carcinoma (HCTC)1 Publication

Disease susceptibility is associated with variations affecting the gene represented in this entry.

Disease descriptionA rare type of thyroid cancer accounting for only about 3-10% of all differentiated thyroid cancers. These neoplasms are considered a variant of follicular carcinoma of the thyroid and are referred to as follicular carcinoma, oxyphilic type.

See also OMIM:607464

Organism-specific databases

MIMi607464. phenotype.
Orphaneti146. Papillary or follicular thyroid carcinoma.
PharmGKBiPA142671270.

Polymorphism and mutation databases

BioMutaiNDUFA13.
DMDMi20139242.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 144144NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13PRO_0000118804Add
BLAST

Proteomic databases

MaxQBiQ9P0J0.
PaxDbiQ9P0J0.
PRIDEiQ9P0J0.

PTM databases

PhosphoSiteiQ9P0J0.

Expressioni

Tissue specificityi

Widely expressed, with highest expression in heart, skeletal muscle, liver, kidney and placenta. In intestinal mucosa, down-regulated in areas involved in Crohn disease and ulcerative colitis.1 Publication

Developmental stagei

Expressed in numerous fetal tissues.

Inductioni

By IFNB1/IFN-beta combined with all-trans-retinoic acid (ATRA).

Gene expression databases

BgeeiQ9P0J0.
CleanExiHS_NDUFA13.
ExpressionAtlasiQ9P0J0. baseline.
GenevestigatoriQ9P0J0.

Organism-specific databases

HPAiHPA041213.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits. Interacts with CARD15, but not with CARD4. Interacts with STAT3, but not with STAT1, STAT2 and STAT5A. Interacts with HHV-8 IRF1, in the nucleus, with HPV-16 E6 and SV40 LT. Interacts with OLFM4.6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HTRA2O434646EBI-372742,EBI-517086

Protein-protein interaction databases

BioGridi119270. 10 interactions.
DIPiDIP-31180N.
IntActiQ9P0J0. 6 interactions.
MINTiMINT-3077817.

Structurei

3D structure databases

ProteinModelPortaliQ9P0J0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni102 – 14443Important for inducing cell deathAdd
BLAST

Sequence similaritiesi

Belongs to the complex I NDUFA13 subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0062.
GeneTreeiENSGT00390000000719.
HOGENOMiHOG000195836.
HOVERGENiHBG019074.
InParanoidiQ9P0J0.
KOiK11353.
PhylomeDBiQ9P0J0.
TreeFamiTF315182.

Family and domain databases

InterProiIPR009346. GRIM-19.
[Graphical view]
PANTHERiPTHR12966. PTHR12966. 1 hit.
PfamiPF06212. GRIM-19. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P0J0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASKVKQDM PPPGGYGPID YKRNLPRRGL SGYSMLAIGI GTLIYGHWSI
60 70 80 90 100
MKWNRERRRL QIEDFEARIA LLPLLQAETD RRTLQMLREN LEEEAIIMKD
110 120 130 140
VPDWKVGESV FHTTRWVPPL IGELYGLRTT EEALHASHGF MWYT
Length:144
Mass (Da):16,698
Last modified:January 23, 2007 - v3
Checksum:i058F608B235FF856
GO
Isoform 2 (identifier: Q9P0J0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     143-144: YT → ALELQPPLAD...AAARGAVRSC

Note: No experimental confirmation available.

Show »
Length:222
Mass (Da):24,882
Checksum:iDE2128E0367CD4D9
GO

Sequence cautioni

The sequence AAD27748.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAG44670.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAH00589.2 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21A → P (PubMed:10810093).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti5 – 51K → N in a Hurthle cell variant of papillary carcinoma sample. 1 Publication
VAR_045984
Natural varianti115 – 1151R → P in a Hurthle cell variant of papillary carcinoma sample. 1 Publication
VAR_045985

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei143 – 1442YT → ALELQPPLADMGRAELSSNA TTSLVQRRKQAWGRQSWLEQ IWNAGPVCQRLHRGGSRPGA GAAGGLSLWAAAARGAVRSC in isoform 2. 1 PublicationVSP_056644

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF286697 mRNA. Translation: AAG28167.1.
AF155662 mRNA. Translation: AAF67481.1.
AF132973 mRNA. Translation: AAD27748.1. Different initiation.
AF261134 mRNA. Translation: AAG44670.1. Different initiation.
AK293965 mRNA. Translation: BAG57337.1.
AC011448 Genomic DNA. No translation available.
BC000589 mRNA. Translation: AAH00589.2. Different initiation.
BC009189 mRNA. Translation: AAH09189.1.
CCDSiCCDS12404.2. [Q9P0J0-1]
RefSeqiNP_057049.5. NM_015965.6. [Q9P0J0-1]
UniGeneiHs.534453.

Genome annotation databases

EnsembliENST00000507754; ENSP00000423673; ENSG00000186010. [Q9P0J0-1]
GeneIDi51079.
KEGGihsa:51079.
UCSCiuc021uqu.1. human. [Q9P0J0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF286697 mRNA. Translation: AAG28167.1.
AF155662 mRNA. Translation: AAF67481.1.
AF132973 mRNA. Translation: AAD27748.1. Different initiation.
AF261134 mRNA. Translation: AAG44670.1. Different initiation.
AK293965 mRNA. Translation: BAG57337.1.
AC011448 Genomic DNA. No translation available.
BC000589 mRNA. Translation: AAH00589.2. Different initiation.
BC009189 mRNA. Translation: AAH09189.1.
CCDSiCCDS12404.2. [Q9P0J0-1]
RefSeqiNP_057049.5. NM_015965.6. [Q9P0J0-1]
UniGeneiHs.534453.

3D structure databases

ProteinModelPortaliQ9P0J0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119270. 10 interactions.
DIPiDIP-31180N.
IntActiQ9P0J0. 6 interactions.
MINTiMINT-3077817.

Chemistry

ChEMBLiCHEMBL2363065.

PTM databases

PhosphoSiteiQ9P0J0.

Polymorphism and mutation databases

BioMutaiNDUFA13.
DMDMi20139242.

Proteomic databases

MaxQBiQ9P0J0.
PaxDbiQ9P0J0.
PRIDEiQ9P0J0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000507754; ENSP00000423673; ENSG00000186010. [Q9P0J0-1]
GeneIDi51079.
KEGGihsa:51079.
UCSCiuc021uqu.1. human. [Q9P0J0-1]

Organism-specific databases

CTDi51079.
GeneCardsiGC19P019626.
H-InvDBHIX0213010.
HGNCiHGNC:17194. NDUFA13.
HPAiHPA041213.
MIMi607464. phenotype.
609435. gene.
neXtProtiNX_Q9P0J0.
Orphaneti146. Papillary or follicular thyroid carcinoma.
PharmGKBiPA142671270.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0062.
GeneTreeiENSGT00390000000719.
HOGENOMiHOG000195836.
HOVERGENiHBG019074.
InParanoidiQ9P0J0.
KOiK11353.
PhylomeDBiQ9P0J0.
TreeFamiTF315182.

Enzyme and pathway databases

ReactomeiREACT_22393. Respiratory electron transport.

Miscellaneous databases

ChiTaRSiNDUFA13. human.
GeneWikiiNDUFA13.
GenomeRNAii51079.
NextBioi35471427.
PROiQ9P0J0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9P0J0.
CleanExiHS_NDUFA13.
ExpressionAtlasiQ9P0J0. baseline.
GenevestigatoriQ9P0J0.

Family and domain databases

InterProiIPR009346. GRIM-19.
[Graphical view]
PANTHERiPTHR12966. PTHR12966. 1 hit.
PfamiPF06212. GRIM-19. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of GRIM-19, a novel cell death-regulatory gene induced by the interferon-beta and retinoic acid combination, using a genetic approach."
    Angell J.E., Lindner D.J., Shapiro P.S., Hofmann E.R., Kalvakolanu D.V.
    J. Biol. Chem. 275:33416-33426(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Mammary carcinoma.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Adrenal gland.
  3. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "A novel gene expressed in human pheochromocytoma."
    Xu X., Yang Y., Gao G., Xiao H., Chen Z., Han Z.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Pheochromocytoma.
  5. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Cerebellum.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta and Skin.
  8. "Viral interferon regulatory factor 1 of Kaposi's sarcoma-associated herpesvirus interacts with a cell death regulator, GRIM19, and inhibits interferon/retinoic acid-induced cell death."
    Seo T., Lee D., Shim Y.S., Angell J.E., Chidambaram N.V., Kalvakolanu D.V., Choe J.
    J. Virol. 76:8797-8807(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HHV-8 IRF1; HPV-16 E6 AND SV40 LT.
  9. "GRIM-19, a death-regulatory gene product, suppresses Stat3 activity via functional interaction."
    Lufei C., Ma J., Huang G., Zhang T., Novotny-Diermayr V., Ong C.T., Cao X.
    EMBO J. 22:1325-1335(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH STAT3, SUBCELLULAR LOCATION.
  10. "The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification."
    Murray J., Zhang B., Taylor S.W., Oglesbee D., Fahy E., Marusich M.F., Ghosh S.S., Capaldi R.A.
    J. Biol. Chem. 278:13619-13622(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE NADH-UBIQUINONE OXIDOREDUCTASE COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  11. "The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3."
    Zhang J., Yang J., Roy S.K., Tininini S., Hu J., Bromberg J.F., Poli V., Stark G.R., Kalvakolanu D.V.
    Proc. Natl. Acad. Sci. U.S.A. 100:9342-9347(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH STAT3.
  12. "GRIM-19, a cell death regulatory protein, is essential for assembly and function of mitochondrial complex I."
    Huang G., Lu H., Hao A., Ng D.C.H., Ponniah S., Guo K., Lufei C., Zeng Q., Cao X.
    Mol. Cell. Biol. 24:8447-8456(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  13. "GW112, a novel antiapoptotic protein that promotes tumor growth."
    Zhang X., Huang Q., Yang Z., Li Y., Li C.-Y.
    Cancer Res. 64:2474-2481(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, INTERACTION WITH OLFM4.
  14. "GRIM-19 interacts with nucleotide oligomerization domain 2 and serves as downstream effector of anti-bacterial function in intestinal epithelial cells."
    Barnich N., Hisamatsu T., Aguirre J.E., Xavier R., Reinecker H.-C., Podolsky D.K.
    J. Biol. Chem. 280:19021-19026(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CARD15.
  15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich (Hurthle cell) tumours of the thyroid."
    Maximo V., Botelho T., Capela J., Soares P., Lima J., Taveira A., Amaro T., Barbosa A.P., Preto A., Harach H.R., Williams D., Sobrinho-Simoes M.
    Br. J. Cancer 92:1892-1898(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS ASN-5 AND PRO-115, INVOLVEMENT IN SUSCEPTIBILITY TO HURTHLE CELL THYROID CARCINOMA.

Entry informationi

Entry nameiNDUAD_HUMAN
AccessioniPrimary (citable) accession number: Q9P0J0
Secondary accession number(s): B4DF76
, K7EK58, Q6PKI0, Q9H2L3, Q9Y327
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: January 23, 2007
Last modified: May 27, 2015
This is version 144 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.