Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9P0J0

- NDUAD_HUMAN

UniProt

Q9P0J0 - NDUAD_HUMAN

Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

Gene

NDUFA13

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes.3 Publications

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB
    2. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB
    3. NADH dehydrogenase activity Source: UniProtKB
    4. protein binding Source: UniProtKB

    GO - Biological processi

    1. apoptotic signaling pathway Source: UniProtKB
    2. cellular metabolic process Source: Reactome
    3. cellular response to interferon-beta Source: ParkinsonsUK-UCL
    4. cellular response to retinoic acid Source: ParkinsonsUK-UCL
    5. extrinsic apoptotic signaling pathway Source: Ensembl
    6. negative regulation of cell growth Source: UniProtKB
    7. negative regulation of intrinsic apoptotic signaling pathway Source: UniProtKB
    8. negative regulation of transcription, DNA-templated Source: UniProtKB
    9. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: ParkinsonsUK-UCL
    10. positive regulation of peptidase activity Source: ParkinsonsUK-UCL
    11. positive regulation of protein catabolic process Source: ParkinsonsUK-UCL
    12. protein import into mitochondrial inner membrane Source: UniProtKB
    13. reactive oxygen species metabolic process Source: UniProtKB
    14. respiratory electron transport chain Source: Reactome
    15. small molecule metabolic process Source: Reactome

    Keywords - Biological processi

    Apoptosis, Electron transport, Respiratory chain, Transport

    Enzyme and pathway databases

    ReactomeiREACT_22393. Respiratory electron transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
    Alternative name(s):
    Cell death regulatory protein GRIM-19
    Complex I-B16.6
    Short name:
    CI-B16.6
    Gene associated with retinoic and interferon-induced mortality 19 protein
    Short name:
    GRIM-19
    Short name:
    Gene associated with retinoic and IFN-induced mortality 19 protein
    NADH-ubiquinone oxidoreductase B16.6 subunit
    Gene namesi
    Name:NDUFA13
    Synonyms:GRIM19
    ORF Names:CDA016, CGI-39
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:17194. NDUFA13.

    Subcellular locationi

    Mitochondrion inner membrane; Single-pass membrane protein; Matrix side. Nucleus
    Note: May be translocated into the nucleus upon IFN/RA treatment.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. extracellular vesicular exosome Source: UniProt
    3. integral component of membrane Source: UniProtKB-KW
    4. mitochondrial inner membrane Source: Reactome
    5. mitochondrial membrane Source: UniProtKB
    6. mitochondrial respiratory chain Source: UniProtKB
    7. mitochondrial respiratory chain complex I Source: UniProtKB
    8. mitochondrion Source: UniProtKB
    9. nucleoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane, Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Hurthle cell thyroid carcinoma (HCTC) [MIM:607464]: A rare type of thyroid cancer accounting for only about 3-10% of all differentiated thyroid cancers. These neoplasms are considered a variant of follicular carcinoma of the thyroid and are referred to as follicular carcinoma, oxyphilic type.1 Publication
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.

    Organism-specific databases

    MIMi607464. phenotype.
    Orphaneti146. Papillary or follicular thyroid carcinoma.
    PharmGKBiPA142671270.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 144143NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13PRO_0000118804Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9P0J0.
    PaxDbiQ9P0J0.
    PRIDEiQ9P0J0.

    PTM databases

    PhosphoSiteiQ9P0J0.

    Expressioni

    Tissue specificityi

    Widely expressed, with highest expression in heart, skeletal muscle, liver, kidney and placenta. In intestinal mucosa, down-regulated in areas involved in Crohn disease and ulcerative colitis.1 Publication

    Developmental stagei

    Expressed in numerous fetal tissues.

    Inductioni

    By IFNB1/IFN-beta combined with all-trans-retinoic acid (ATRA).

    Gene expression databases

    BgeeiQ9P0J0.
    CleanExiHS_NDUFA13.
    GenevestigatoriQ9P0J0.

    Organism-specific databases

    HPAiHPA041213.

    Interactioni

    Subunit structurei

    Complex I is composed of 45 different subunits. Interacts with CARD15, but not with CARD4. Interacts with STAT3, but not with STAT1, STAT2 and STAT5A. Interacts with HHV-8 IRF1, in the nucleus, with HPV-16 E6 and SV40 LT. Interacts with OLFM4.6 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    HTRA2O434646EBI-372742,EBI-517086

    Protein-protein interaction databases

    BioGridi119270. 10 interactions.
    DIPiDIP-31180N.
    IntActiQ9P0J0. 6 interactions.
    MINTiMINT-3077817.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9P0J0.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei30 – 5122HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni102 – 14443Important for inducing cell deathAdd
    BLAST

    Sequence similaritiesi

    Belongs to the complex I NDUFA13 subunit family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0062.
    HOGENOMiHOG000195836.
    HOVERGENiHBG019074.
    InParanoidiQ9P0J0.
    KOiK11353.
    PhylomeDBiQ9P0J0.
    TreeFamiTF315182.

    Family and domain databases

    InterProiIPR009346. GRIM-19.
    [Graphical view]
    PANTHERiPTHR12966. PTHR12966. 1 hit.
    PfamiPF06212. GRIM-19. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9P0J0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAASKVKQDM PPPGGYGPID YKRNLPRRGL SGYSMLAIGI GTLIYGHWSI    50
    MKWNRERRRL QIEDFEARIA LLPLLQAETD RRTLQMLREN LEEEAIIMKD 100
    VPDWKVGESV FHTTRWVPPL IGELYGLRTT EEALHASHGF MWYT 144
    Length:144
    Mass (Da):16,698
    Last modified:January 23, 2007 - v3
    Checksum:i058F608B235FF856
    GO
    Isoform 2 (identifier: Q9P0J0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         143-144: YT → ALELQPPLAD...AAARGAVRSC

    Note: No experimental confirmation available.

    Show »
    Length:222
    Mass (Da):24,882
    Checksum:iDE2128E0367CD4D9
    GO

    Sequence cautioni

    The sequence AAD27748.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAG44670.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH00589.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2 – 21A → P(PubMed:10810093)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti5 – 51K → N in a Hurthle cell variant of papillary carcinoma sample. 1 Publication
    VAR_045984
    Natural varianti115 – 1151R → P in a Hurthle cell variant of papillary carcinoma sample. 1 Publication
    VAR_045985

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei143 – 1442YT → ALELQPPLADMGRAELSSNA TTSLVQRRKQAWGRQSWLEQ IWNAGPVCQRLHRGGSRPGA GAAGGLSLWAAAARGAVRSC in isoform 2. 1 PublicationVSP_056644

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF286697 mRNA. Translation: AAG28167.1.
    AF155662 mRNA. Translation: AAF67481.1.
    AF132973 mRNA. Translation: AAD27748.1. Different initiation.
    AF261134 mRNA. Translation: AAG44670.1. Different initiation.
    AK293965 mRNA. Translation: BAG57337.1.
    AC011448 Genomic DNA. No translation available.
    BC000589 mRNA. Translation: AAH00589.2. Different initiation.
    BC009189 mRNA. Translation: AAH09189.1.
    CCDSiCCDS12404.2.
    RefSeqiNP_057049.5. NM_015965.6.
    UniGeneiHs.534453.

    Genome annotation databases

    EnsembliENST00000507754; ENSP00000423673; ENSG00000186010.
    ENST00000512771; ENSP00000465471; ENSG00000186010.
    GeneIDi51079.
    KEGGihsa:51079.
    UCSCiuc021uqu.1. human.

    Polymorphism databases

    DMDMi20139242.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF286697 mRNA. Translation: AAG28167.1 .
    AF155662 mRNA. Translation: AAF67481.1 .
    AF132973 mRNA. Translation: AAD27748.1 . Different initiation.
    AF261134 mRNA. Translation: AAG44670.1 . Different initiation.
    AK293965 mRNA. Translation: BAG57337.1 .
    AC011448 Genomic DNA. No translation available.
    BC000589 mRNA. Translation: AAH00589.2 . Different initiation.
    BC009189 mRNA. Translation: AAH09189.1 .
    CCDSi CCDS12404.2.
    RefSeqi NP_057049.5. NM_015965.6.
    UniGenei Hs.534453.

    3D structure databases

    ProteinModelPortali Q9P0J0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119270. 10 interactions.
    DIPi DIP-31180N.
    IntActi Q9P0J0. 6 interactions.
    MINTi MINT-3077817.

    Chemistry

    ChEMBLi CHEMBL2363065.
    DrugBanki DB00157. NADH.

    PTM databases

    PhosphoSitei Q9P0J0.

    Polymorphism databases

    DMDMi 20139242.

    Proteomic databases

    MaxQBi Q9P0J0.
    PaxDbi Q9P0J0.
    PRIDEi Q9P0J0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000507754 ; ENSP00000423673 ; ENSG00000186010 .
    ENST00000512771 ; ENSP00000465471 ; ENSG00000186010 .
    GeneIDi 51079.
    KEGGi hsa:51079.
    UCSCi uc021uqu.1. human.

    Organism-specific databases

    CTDi 51079.
    GeneCardsi GC19P019626.
    H-InvDB HIX0213010.
    HGNCi HGNC:17194. NDUFA13.
    HPAi HPA041213.
    MIMi 607464. phenotype.
    609435. gene.
    neXtProti NX_Q9P0J0.
    Orphaneti 146. Papillary or follicular thyroid carcinoma.
    PharmGKBi PA142671270.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0062.
    HOGENOMi HOG000195836.
    HOVERGENi HBG019074.
    InParanoidi Q9P0J0.
    KOi K11353.
    PhylomeDBi Q9P0J0.
    TreeFami TF315182.

    Enzyme and pathway databases

    Reactomei REACT_22393. Respiratory electron transport.

    Miscellaneous databases

    ChiTaRSi NDUFA13. human.
    GeneWikii NDUFA13.
    GenomeRNAii 51079.
    NextBioi 53719.
    PROi Q9P0J0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9P0J0.
    CleanExi HS_NDUFA13.
    Genevestigatori Q9P0J0.

    Family and domain databases

    InterProi IPR009346. GRIM-19.
    [Graphical view ]
    PANTHERi PTHR12966. PTHR12966. 1 hit.
    Pfami PF06212. GRIM-19. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of GRIM-19, a novel cell death-regulatory gene induced by the interferon-beta and retinoic acid combination, using a genetic approach."
      Angell J.E., Lindner D.J., Shapiro P.S., Hofmann E.R., Kalvakolanu D.V.
      J. Biol. Chem. 275:33416-33426(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Tissue: Mammary carcinoma.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Adrenal gland.
    3. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
      Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
      Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "A novel gene expressed in human pheochromocytoma."
      Xu X., Yang Y., Gao G., Xiao H., Chen Z., Han Z.
      Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Pheochromocytoma.
    5. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Cerebellum.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta and Skin.
    8. "Viral interferon regulatory factor 1 of Kaposi's sarcoma-associated herpesvirus interacts with a cell death regulator, GRIM19, and inhibits interferon/retinoic acid-induced cell death."
      Seo T., Lee D., Shim Y.S., Angell J.E., Chidambaram N.V., Kalvakolanu D.V., Choe J.
      J. Virol. 76:8797-8807(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HHV-8 IRF1; HPV-16 E6 AND SV40 LT.
    9. "GRIM-19, a death-regulatory gene product, suppresses Stat3 activity via functional interaction."
      Lufei C., Ma J., Huang G., Zhang T., Novotny-Diermayr V., Ong C.T., Cao X.
      EMBO J. 22:1325-1335(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH STAT3, SUBCELLULAR LOCATION.
    10. "The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification."
      Murray J., Zhang B., Taylor S.W., Oglesbee D., Fahy E., Marusich M.F., Ghosh S.S., Capaldi R.A.
      J. Biol. Chem. 278:13619-13622(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE NADH-UBIQUINONE OXIDOREDUCTASE COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
    11. "The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3."
      Zhang J., Yang J., Roy S.K., Tininini S., Hu J., Bromberg J.F., Poli V., Stark G.R., Kalvakolanu D.V.
      Proc. Natl. Acad. Sci. U.S.A. 100:9342-9347(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH STAT3.
    12. "GRIM-19, a cell death regulatory protein, is essential for assembly and function of mitochondrial complex I."
      Huang G., Lu H., Hao A., Ng D.C.H., Ponniah S., Guo K., Lufei C., Zeng Q., Cao X.
      Mol. Cell. Biol. 24:8447-8456(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    13. "GW112, a novel antiapoptotic protein that promotes tumor growth."
      Zhang X., Huang Q., Yang Z., Li Y., Li C.-Y.
      Cancer Res. 64:2474-2481(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH OLFM4.
    14. "GRIM-19 interacts with nucleotide oligomerization domain 2 and serves as downstream effector of anti-bacterial function in intestinal epithelial cells."
      Barnich N., Hisamatsu T., Aguirre J.E., Xavier R., Reinecker H.-C., Podolsky D.K.
      J. Biol. Chem. 280:19021-19026(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CARD15.
    15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich (Hurthle cell) tumours of the thyroid."
      Maximo V., Botelho T., Capela J., Soares P., Lima J., Taveira A., Amaro T., Barbosa A.P., Preto A., Harach H.R., Williams D., Sobrinho-Simoes M.
      Br. J. Cancer 92:1892-1898(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS ASN-5 AND PRO-115, INVOLVEMENT IN SUSCEPTIBILITY TO HURTHLE CELL THYROID CARCINOMA.

    Entry informationi

    Entry nameiNDUAD_HUMAN
    AccessioniPrimary (citable) accession number: Q9P0J0
    Secondary accession number(s): B4DF76
    , K7EK58, Q6PKI0, Q9H2L3, Q9Y327
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 27, 2002
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 138 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3