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Q9P0I2

- EMC3_HUMAN

UniProt

Q9P0I2 - EMC3_HUMAN

Protein

ER membrane protein complex subunit 3

Gene

EMC3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ER membrane protein complex subunit 3
    Alternative name(s):
    Transmembrane protein 111
    Gene namesi
    Name:EMC3
    Synonyms:TMEM111
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:23999. EMC3.

    Subcellular locationi

    Membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. ER membrane protein complex Source: UniProtKB
    2. integral component of membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670762.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 261260ER membrane protein complex subunit 3PRO_0000211406Add
    BLAST

    Proteomic databases

    MaxQBiQ9P0I2.
    PaxDbiQ9P0I2.
    PRIDEiQ9P0I2.

    PTM databases

    PhosphoSiteiQ9P0I2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9P0I2.
    BgeeiQ9P0I2.
    CleanExiHS_TMEM111.
    GenevestigatoriQ9P0I2.

    Organism-specific databases

    HPAiHPA042372.

    Interactioni

    Subunit structurei

    Component of the ER membrane protein complex (EMC).1 Publication

    Protein-protein interaction databases

    BioGridi120936. 2 interactions.
    STRINGi9606.ENSP00000245046.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9P0I2.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei14 – 3421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei118 – 13821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the EMC3 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG306838.
    HOGENOMiHOG000158234.
    HOVERGENiHBG056099.
    InParanoidiQ9P0I2.
    OMAiNIRGWVF.
    OrthoDBiEOG708W0H.
    PhylomeDBiQ9P0I2.

    Family and domain databases

    InterProiIPR002809. DUF106_TM.
    IPR008568. UCP010045_TM_euk.
    [Graphical view]
    PANTHERiPTHR13116. PTHR13116. 1 hit.
    PfamiPF01956. DUF106. 1 hit.
    [Graphical view]
    PIRSFiPIRSF010045. DUF850_TM_euk. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9P0I2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGPELLLDS NIRLWVVLPI VIITFFVGMI RHYVSILLQS DKKLTQEQVS    50
    DSQVLIRSRV LRENGKYIPK QSFLTRKYYF NNPEDGFFKK TKRKVVPPSP 100
    MTDPTMLTDM MKGNVTNVLP MILIGGWINM TFSGFVTTKV PFPLTLRFKP 150
    MLQQGIELLT LDASWVSSAS WYFLNVFGLR SIYSLILGQD NAADQSRMMQ 200
    EQMTGAAMAM PADTNKAFKT EWEALELTDH QWALDDVEEE LMAKDLHFEG 250
    MFKKELQTSI F 261
    Length:261
    Mass (Da):29,952
    Last modified:January 23, 2007 - v3
    Checksum:i0FB279E54D6C1FCC
    GO
    Isoform 2 (identifier: Q9P0I2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         220-261: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:219
    Mass (Da):24,915
    Checksum:i2591071C7822CBBC
    GO

    Sequence cautioni

    The sequence BAD18807.1 differs from that shown. Reason: Erroneous termination at position 222. Translated as Trp.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti29 – 291M → T in BAD18807. (PubMed:14702039)Curated
    Sequence conflicti60 – 601V → I in BAD96673. 1 PublicationCurated
    Sequence conflicti172 – 1721Y → H in BAD18807. (PubMed:14702039)Curated
    Sequence conflicti250 – 2501G → D in BAD18807. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei220 – 26142Missing in isoform 2. 1 PublicationVSP_014886Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF157321 mRNA. Translation: AAF67487.1.
    AK172843 mRNA. Translation: BAD18807.1. Sequence problems.
    AK222953 mRNA. Translation: BAD96673.1.
    AK312008 mRNA. Translation: BAG34946.1.
    CH471055 Genomic DNA. Translation: EAW64047.1.
    BC022807 mRNA. Translation: AAH22807.1.
    CCDSiCCDS2594.1. [Q9P0I2-1]
    RefSeqiNP_060917.1. NM_018447.2. [Q9P0I2-1]
    UniGeneiHs.475392.

    Genome annotation databases

    EnsembliENST00000245046; ENSP00000245046; ENSG00000125037. [Q9P0I2-1]
    GeneIDi55831.
    KEGGihsa:55831.
    UCSCiuc003bun.3. human. [Q9P0I2-1]

    Polymorphism databases

    DMDMi71153383.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF157321 mRNA. Translation: AAF67487.1 .
    AK172843 mRNA. Translation: BAD18807.1 . Sequence problems.
    AK222953 mRNA. Translation: BAD96673.1 .
    AK312008 mRNA. Translation: BAG34946.1 .
    CH471055 Genomic DNA. Translation: EAW64047.1 .
    BC022807 mRNA. Translation: AAH22807.1 .
    CCDSi CCDS2594.1. [Q9P0I2-1 ]
    RefSeqi NP_060917.1. NM_018447.2. [Q9P0I2-1 ]
    UniGenei Hs.475392.

    3D structure databases

    ProteinModelPortali Q9P0I2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120936. 2 interactions.
    STRINGi 9606.ENSP00000245046.

    PTM databases

    PhosphoSitei Q9P0I2.

    Polymorphism databases

    DMDMi 71153383.

    Proteomic databases

    MaxQBi Q9P0I2.
    PaxDbi Q9P0I2.
    PRIDEi Q9P0I2.

    Protocols and materials databases

    DNASUi 55831.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000245046 ; ENSP00000245046 ; ENSG00000125037 . [Q9P0I2-1 ]
    GeneIDi 55831.
    KEGGi hsa:55831.
    UCSCi uc003bun.3. human. [Q9P0I2-1 ]

    Organism-specific databases

    CTDi 55831.
    GeneCardsi GC03M010007.
    HGNCi HGNC:23999. EMC3.
    HPAi HPA042372.
    neXtProti NX_Q9P0I2.
    PharmGKBi PA142670762.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG306838.
    HOGENOMi HOG000158234.
    HOVERGENi HBG056099.
    InParanoidi Q9P0I2.
    OMAi NIRGWVF.
    OrthoDBi EOG708W0H.
    PhylomeDBi Q9P0I2.

    Miscellaneous databases

    GenomeRNAii 55831.
    NextBioi 61045.
    PROi Q9P0I2.

    Gene expression databases

    ArrayExpressi Q9P0I2.
    Bgeei Q9P0I2.
    CleanExi HS_TMEM111.
    Genevestigatori Q9P0I2.

    Family and domain databases

    InterProi IPR002809. DUF106_TM.
    IPR008568. UCP010045_TM_euk.
    [Graphical view ]
    PANTHERi PTHR13116. PTHR13116. 1 hit.
    Pfami PF01956. DUF106. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF010045. DUF850_TM_euk. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Adrenal gland.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain and Stomach cancer.
    3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Small intestine.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    6. Bienvenut W.V.
      Submitted (JUN-2005) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-13; 140-147 AND 181-197, CLEAVAGE OF INITIATOR METHIONINE, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: B-cell lymphoma.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. Cited for: IDENTIFICATION IN THE EMC COMPLEX, SUBCELLULAR LOCATION.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiEMC3_HUMAN
    AccessioniPrimary (citable) accession number: Q9P0I2
    Secondary accession number(s): B2R4Z9, Q53GH8, Q6ZMC2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 96 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families
    3. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries

    External Data

    Dasty 3