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Protein

Mediator of RNA polymerase II transcription subunit 11

Gene

MED11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-1989781. PPARA activates gene expression.
R-HSA-381340. Transcriptional regulation of white adipocyte differentiation.

Names & Taxonomyi

Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 11
Alternative name(s):
Mediator complex subunit 11
Gene namesi
Name:MED11
ORF Names:HSPC296
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:32687. MED11.

Subcellular locationi

GO - Cellular componenti

  • mediator complex Source: MGI
  • ubiquitin ligase complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596413.

Polymorphism and mutation databases

BioMutaiMED11.
DMDMi158564056.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 117116Mediator of RNA polymerase II transcription subunit 11PRO_0000304308Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9P086.
MaxQBiQ9P086.
PaxDbiQ9P086.
PeptideAtlasiQ9P086.
PRIDEiQ9P086.
TopDownProteomicsiQ9P086.

PTM databases

iPTMnetiQ9P086.

Expressioni

Gene expression databases

BgeeiQ9P086.
CleanExiHS_MED11.
ExpressionAtlasiQ9P086. baseline and differential.
GenevisibleiQ9P086. HS.

Organism-specific databases

HPAiHPA056669.

Interactioni

Subunit structurei

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MED22Q155283EBI-394704,EBI-394687

Protein-protein interaction databases

BioGridi134637. 32 interactions.
IntActiQ9P086. 12 interactions.
STRINGi9606.ENSP00000293777.

Structurei

3D structure databases

ProteinModelPortaliQ9P086.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Mediator complex subunit 11 family.Curated

Phylogenomic databases

eggNOGiKOG4057. Eukaryota.
ENOG4111SCB. LUCA.
GeneTreeiENSGT00390000010184.
HOGENOMiHOG000006725.
HOVERGENiHBG108126.
InParanoidiQ9P086.
KOiK15131.
OMAiYSARKDC.
PhylomeDBiQ9P086.
TreeFamiTF318328.

Family and domain databases

InterProiIPR019404. Mediator_Med11.
[Graphical view]
PfamiPF10280. Med11. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9P086-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATYSLANER LRALEDIERE IGAILQNAGT VILELSKEKT NERLLDRQAA
60 70 80 90 100
AFTASVQHVE AELSAQIRYL TQVATGQPHE GSSYSSRKDC QMALKRVDYA
110
RLKLSDVART CEQMLEN
Length:117
Mass (Da):13,129
Last modified:September 11, 2007 - v2
Checksum:iD01CAA8D211D6FC7
GO

Sequence cautioni

The sequence AAF28974.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti112 – 1121E → G in AAF28974 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161414 mRNA. Translation: AAF28974.1. Different initiation.
CH471108 Genomic DNA. Translation: EAW90417.1.
BC070377 mRNA. Translation: AAH70377.1.
CCDSiCCDS32533.1.
RefSeqiNP_001001683.1. NM_001001683.3.
NP_001291929.1. NM_001305000.1.
UniGeneiHs.513885.

Genome annotation databases

EnsembliENST00000293777; ENSP00000293777; ENSG00000161920.
GeneIDi400569.
KEGGihsa:400569.
UCSCiuc002fyp.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161414 mRNA. Translation: AAF28974.1. Different initiation.
CH471108 Genomic DNA. Translation: EAW90417.1.
BC070377 mRNA. Translation: AAH70377.1.
CCDSiCCDS32533.1.
RefSeqiNP_001001683.1. NM_001001683.3.
NP_001291929.1. NM_001305000.1.
UniGeneiHs.513885.

3D structure databases

ProteinModelPortaliQ9P086.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi134637. 32 interactions.
IntActiQ9P086. 12 interactions.
STRINGi9606.ENSP00000293777.

PTM databases

iPTMnetiQ9P086.

Polymorphism and mutation databases

BioMutaiMED11.
DMDMi158564056.

Proteomic databases

EPDiQ9P086.
MaxQBiQ9P086.
PaxDbiQ9P086.
PeptideAtlasiQ9P086.
PRIDEiQ9P086.
TopDownProteomicsiQ9P086.

Protocols and materials databases

DNASUi400569.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293777; ENSP00000293777; ENSG00000161920.
GeneIDi400569.
KEGGihsa:400569.
UCSCiuc002fyp.4. human.

Organism-specific databases

CTDi400569.
GeneCardsiMED11.
HGNCiHGNC:32687. MED11.
HPAiHPA056669.
MIMi612383. gene.
neXtProtiNX_Q9P086.
PharmGKBiPA144596413.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4057. Eukaryota.
ENOG4111SCB. LUCA.
GeneTreeiENSGT00390000010184.
HOGENOMiHOG000006725.
HOVERGENiHBG108126.
InParanoidiQ9P086.
KOiK15131.
OMAiYSARKDC.
PhylomeDBiQ9P086.
TreeFamiTF318328.

Enzyme and pathway databases

ReactomeiR-HSA-1989781. PPARA activates gene expression.
R-HSA-381340. Transcriptional regulation of white adipocyte differentiation.

Miscellaneous databases

ChiTaRSiMED11. human.
GenomeRNAii400569.
PROiQ9P086.
SOURCEiSearch...

Gene expression databases

BgeeiQ9P086.
CleanExiHS_MED11.
ExpressionAtlasiQ9P086. baseline and differential.
GenevisibleiQ9P086. HS.

Family and domain databases

InterProiIPR019404. Mediator_Med11.
[Graphical view]
PfamiPF10280. Med11. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human partial CDS from CD34+ stem cells."
    Ye M., Zhang Q.-H., Zhou J., Shen Y., Wu X.-Y., Guan Z.Q., Wang L., Fan H.-Y., Mao Y.-F., Dai M., Huang Q.-H., Chen S.-J., Chen Z.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Umbilical cord blood.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3."
    Sato S., Tomomori-Sato C., Banks C.A.S., Sorokina I., Parmely T.J., Kong S.E., Jin J., Cai Y., Lane W.S., Brower C.S., Conaway R.C., Conaway J.W.
    J. Biol. Chem. 278:15123-15127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MED10 AND MED22.
  5. "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology."
    Sato S., Tomomori-Sato C., Parmely T.J., Florens L., Zybailov B., Swanson S.K., Banks C.A.S., Jin J., Cai Y., Washburn M.P., Conaway J.W., Conaway R.C.
    Mol. Cell 14:685-691(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE MEDIATOR COMPLEX.
  6. "MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription."
    Zhang X., Krutchinsky A., Fukuda A., Chen W., Yamamura S., Chait B.T., Roeder R.G.
    Mol. Cell 19:89-100(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE MEDIATOR COMPLEX, ASSOCIATION OF THE MEDIATOR COMPLEX WITH RNA POLYMERASE II.
  7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMED11_HUMAN
AccessioniPrimary (citable) accession number: Q9P086
Secondary accession number(s): Q6NS89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: July 6, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.