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Protein

Mediator of RNA polymerase II transcription subunit 11

Gene

MED11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-1989781. PPARA activates gene expression.
R-HSA-381340. Transcriptional regulation of white adipocyte differentiation.

Names & Taxonomyi

Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 11
Alternative name(s):
Mediator complex subunit 11
Gene namesi
Name:MED11
ORF Names:HSPC296
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000161920.9.
HGNCiHGNC:32687. MED11.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000161920.
PharmGKBiPA144596413.

Polymorphism and mutation databases

BioMutaiMED11.
DMDMi158564056.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00003043082 – 117Mediator of RNA polymerase II transcription subunit 11Add BLAST116

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9P086.
MaxQBiQ9P086.
PaxDbiQ9P086.
PeptideAtlasiQ9P086.
PRIDEiQ9P086.
TopDownProteomicsiQ9P086.

PTM databases

iPTMnetiQ9P086.
PhosphoSitePlusiQ9P086.

Expressioni

Gene expression databases

BgeeiENSG00000161920.
CleanExiHS_MED11.
ExpressionAtlasiQ9P086. baseline and differential.
GenevisibleiQ9P086. HS.

Organism-specific databases

HPAiHPA056669.

Interactioni

Subunit structurei

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MED22Q155283EBI-394704,EBI-394687

Protein-protein interaction databases

BioGridi134637. 32 interactors.
CORUMiQ9P086.
IntActiQ9P086. 12 interactors.
STRINGi9606.ENSP00000293777.

Structurei

3D structure databases

ProteinModelPortaliQ9P086.
SMRiQ9P086.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Mediator complex subunit 11 family.Curated

Phylogenomic databases

eggNOGiKOG4057. Eukaryota.
ENOG4111SCB. LUCA.
GeneTreeiENSGT00390000010184.
HOGENOMiHOG000006725.
HOVERGENiHBG108126.
InParanoidiQ9P086.
KOiK15131.
OMAiMTPPMER.
OrthoDBiEOG091G0YZ0.
PhylomeDBiQ9P086.
TreeFamiTF318328.

Family and domain databases

InterProiView protein in InterPro
IPR019404. Mediator_Med11.
PfamiView protein in Pfam
PF10280. Med11. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9P086-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATYSLANER LRALEDIERE IGAILQNAGT VILELSKEKT NERLLDRQAA
60 70 80 90 100
AFTASVQHVE AELSAQIRYL TQVATGQPHE GSSYSSRKDC QMALKRVDYA
110
RLKLSDVART CEQMLEN
Length:117
Mass (Da):13,129
Last modified:September 11, 2007 - v2
Checksum:iD01CAA8D211D6FC7
GO

Sequence cautioni

The sequence AAF28974 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti112E → G in AAF28974 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161414 mRNA. Translation: AAF28974.1. Different initiation.
CH471108 Genomic DNA. Translation: EAW90417.1.
BC070377 mRNA. Translation: AAH70377.1.
CCDSiCCDS32533.1.
RefSeqiNP_001001683.1. NM_001001683.3.
NP_001291929.1. NM_001305000.1.
UniGeneiHs.513885.

Genome annotation databases

EnsembliENST00000293777; ENSP00000293777; ENSG00000161920.
GeneIDi400569.
KEGGihsa:400569.
UCSCiuc002fyp.4. human.

Similar proteinsi

Entry informationi

Entry nameiMED11_HUMAN
AccessioniPrimary (citable) accession number: Q9P086
Secondary accession number(s): Q6NS89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: September 27, 2017
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families