Q9P055B4DP67Q6FIB6Q6IAJ2Q7Z5D4Q86SY6Q9H0Q6Q9H2W0Q9HAH5Q9P0R3JKAMP_HUMANJNK1/MAPK8-associated membrane proteinJKAMPJNK1-associated membrane proteinJAMPMedulloblastoma antigen MU-MB-50.4JKAMPC14orf100JAMPCDA06HSPC213HSPC327Homo sapiensHumanEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomoNovel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries.NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)Complete sequencing and characterization of 21,243 full-length human cDNAs.NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3)A novel gene expressed in human pheochromocytoma.NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)Full-length cDNA libraries and normalization.NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)JAMP optimizes ERAD to protect cells from unfolded proteins.FUNCTIONSUBCELLULAR LOCATIONINDUCTIONINTERACTION WITH DERL1Regulates the duration of MAPK8 activity in response to various stress stimuli (By similarity). Facilitates degradation of misfolded endoplasmic reticulum (ER) proteins through the recruitment of components of the proteasome and endoplasmic reticulum-associated degradation (ERAD) system (PubMed:18784250).Interacts with RNF5 and MAPK8, but not with MAPK9. Binding to MAPK8 occurs before and after exposure to stress, such as UV irradiation. After exposure to stress, interacts with phosphorylated MAPK8. Competes with DUSP10 for MAPK8 binding. Associates with multiple components of the proteasome and with ERAD regulatory proteins including AMFR/GP78, CANX, PSMC1, PSMC2, PSMC3/TBP1, PSMC5, PSMC6, PSMD8, SEC61-ALPHA and UFD1 (By similarity). Interacts with DERL1 (in the presence of misfolded protein CFTR(F508del)) (PubMed:18784250).Q9P055-4Q96EC8false3Endoplasmic reticulum membraneMulti-pass membrane proteinQ9P055-41Q9P055-22Q9P055-33Q9P055-54Basal expression under nonstress conditions; expression increases transiently after endoplasmic reticulum (ER) stress.Ubiquitinated by RNF5 via 'Lys-63'-linked ubiquitin linkage in a UBE2N-dependent manner. Ubiquitination decreases association with components of the proteasome and ERAD.Elevated expression in medulloblastomas (PubMed:12800201). Patients with cancer had 2 to 12-fold higher frequencies of antibodies against this antigen (PubMed:12800201).Alternative splicingEndoplasmic reticulumGlycoproteinMembraneReference proteomeTransmembraneTransmembrane helixUbl conjugationUnfolded protein responseMAVDIQPAMKGEIQQSLGAWVLLTMAVDIQPMVASPNSMAVDIQPACLGLYCGKTLLFKNGSTEIYGECGVCPRGQRTNAQKYCQPCTESPELYDWLYLGFMAMLPLVLHWFFIEWYSGKKSSSALFQHITALFECSMAAIITLLVSDPVGVLYIRSCRVLMLSDWYTMLYNPSPDYVTTVHCTHEAVYPLYTIVFIYYAFCLVLMMLLRPLLVKKIACGLGKSDRFKSIYAALYFFPILTVLQAVGGGLLYYAFPYIILVLSLVTLAVYMSASEIENCYDLLVRKKRLIVLFSHWLLHAYGIISISRVDKLEQDLPLLALVPTPALFYLFTAKFTEPSRILSEGANGH
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