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Q9P055

- JKAMP_HUMAN

UniProt

Q9P055 - JKAMP_HUMAN

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Protein

JNK1/MAPK8-associated membrane protein

Gene

JKAMP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

May be a regulator of the duration of MAPK8 activity in response to various stress stimuli. Facilitates degradation of misfolded endoplasmic reticulum (ER) luminal proteins through the recruitment of components of the proteasome and endoplasmic reticulum-associated degradation (ERAD) system (By similarity).By similarity

GO - Molecular functioni

  1. ubiquitin protein ligase binding Source: UniProtKB

GO - Biological processi

  1. ER-associated ubiquitin-dependent protein catabolic process Source: UniProtKB
  2. response to unfolded protein Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Unfolded protein response

Names & Taxonomyi

Protein namesi
Recommended name:
JNK1/MAPK8-associated membrane protein
Short name:
JKAMP
Alternative name(s):
JNK1-associated membrane protein
Short name:
JAMP
Medulloblastoma antigen MU-MB-50.4
Gene namesi
Name:JKAMP
Synonyms:C14orf100, JAMP
ORF Names:CDA06, HSPC213, HSPC327
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:20184. JKAMP.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165479069.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326JNK1/MAPK8-associated membrane proteinPRO_0000089903Add
BLAST

Post-translational modificationi

Ubiquitinated by RNF5 via 'Lys-63'-linked ubiquitin linkage in a UBE2N-dependent manner. Ubiquitination decreases association with components of the proteasome and ERAD (By similarity).By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ9P055.
PRIDEiQ9P055.

PTM databases

PhosphoSiteiQ9P055.

Expressioni

Gene expression databases

BgeeiQ9P055.
ExpressionAtlasiQ9P055. baseline and differential.
GenevestigatoriQ9P055.

Organism-specific databases

HPAiHPA031172.

Interactioni

Subunit structurei

Interacts with RNF5 and MAPK8, but not with MAPK9. Binding to MAPK8 occurs before and after exposure to stress, such as UV irradiation. After exposure to stress, interacts with phosphorylated MAPK8. Competes with DUSP10 for MAPK8 binding. Associates with multiple components of the proteasome and with ERAD regulatory proteins including AMFR/GP78, CANX, PSMC1, PSMC2, PSMC3/TBP1, PSMC5, PSMC6, PSMD8, SEC61-ALPHA and UFD1L (By similarity).By similarity

Protein-protein interaction databases

BioGridi119590. 9 interactions.
MINTiMINT-4721513.

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7272LumenalSequence AnalysisAdd
BLAST
Topological domaini94 – 1029CytoplasmicSequence Analysis
Topological domaini124 – 16441LumenalSequence AnalysisAdd
BLAST
Topological domaini186 – 20318CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini225 – 2251LumenalSequence Analysis
Topological domaini247 – 26519CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini287 – 2926LumenalSequence Analysis
Topological domaini314 – 32613CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei73 – 9321HelicalSequence AnalysisAdd
BLAST
Transmembranei103 – 12321HelicalSequence AnalysisAdd
BLAST
Transmembranei165 – 18521HelicalSequence AnalysisAdd
BLAST
Transmembranei204 – 22421HelicalSequence AnalysisAdd
BLAST
Transmembranei226 – 24621HelicalSequence AnalysisAdd
BLAST
Transmembranei266 – 28621HelicalSequence AnalysisAdd
BLAST
Transmembranei293 – 31321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG262492.
GeneTreeiENSGT00390000018097.
HOVERGENiHBG051016.
InParanoidiQ9P055.
OrthoDBiEOG747PJJ.
PhylomeDBiQ9P055.
TreeFamiTF314201.

Family and domain databases

InterProiIPR008485. DUF766.
[Graphical view]
PANTHERiPTHR12740. PTHR12740. 1 hit.
PfamiPF05571. DUF766. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9P055-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFGAAARSAD LALLEKNLQA AHGCLGLYCG KTLLFKNGST EIYGECGVCP
60 70 80 90 100
RGQRTNAQKY CQPCTESPEL YDWLYLGFMA MLPLVLHWFF IEWYSGKKSS
110 120 130 140 150
SALFQHITAL FECSMAAIIT LLVSDPVGVL YIRSCRVLML SDWYTMLYNP
160 170 180 190 200
SPDYVTTVHC THEAVYPLYT IVFIYYAFCL VLMMLLRPLL VKKIACGLGK
210 220 230 240 250
SDRFKSIYAA LYFFPILTVL QAVGGGLLYY AFPYIILVLS LVTLAVYMSA
260 270 280 290 300
SEIENCYDLL VRKKRLIVLF SHWLLHAYGI ISISRVDKLE QDLPLLALVP
310 320
TPALFYLFTA KFTEPSRILS EGANGH
Length:326
Mass (Da):36,751
Last modified:November 7, 2003 - v2
Checksum:i75B270100E3BC3C9
GO
Isoform 2 (identifier: Q9P055-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-78: Missing.

Show »
Length:248
Mass (Da):28,212
Checksum:i6918AC0A6414F401
GO
Isoform 3 (identifier: Q9P055-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MFGAAARSADLALLEKNLQAAHG → MA

Show »
Length:305
Mass (Da):34,615
Checksum:i1047E4068BAC541A
GO
Isoform 4 (identifier: Q9P055-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MFGAAARSADLALLEKNLQAAHG → MAVDIQPA

Show »
Length:311
Mass (Da):35,239
Checksum:iF294B4CAFDDCECE4
GO
Isoform 5 (identifier: Q9P055-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MFGAAARSADLALLEKNLQAAHG → MKGEIQQSLGAWVLLT

Show »
Length:319
Mass (Da):36,169
Checksum:i91D42D3746B15413
GO

Sequence cautioni

The sequence AAF36133.1 differs from that shown. Reason: Frameshift at positions 105 and 124.
The sequence AAF29005.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti85 – 851V → A in BAB13874. (PubMed:14702039)Curated
Sequence conflicti141 – 1411S → P in AAF36133. (PubMed:11042152)Curated
Sequence conflicti149 – 1491N → S in AAF36133. (PubMed:11042152)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7878Missing in isoform 2. 2 PublicationsVSP_008809Add
BLAST
Alternative sequencei1 – 2323MFGAA…QAAHG → MA in isoform 3. 5 PublicationsVSP_008810Add
BLAST
Alternative sequencei1 – 2323MFGAA…QAAHG → MAVDIQPA in isoform 4. 4 PublicationsVSP_008811Add
BLAST
Alternative sequencei1 – 2323MFGAA…QAAHG → MKGEIQQSLGAWVLLT in isoform 5. 1 PublicationVSP_008812Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF529304 mRNA. Translation: AAP85636.1.
AF151047 mRNA. Translation: AAF36133.1. Frameshift.
AF161445 mRNA. Translation: AAF29005.1. Different initiation.
AL136696 mRNA. Translation: CAB66631.1.
AK021683 mRNA. Translation: BAB13874.1.
AK027591 mRNA. Translation: BAB55216.1.
AK298209 mRNA. Translation: BAG60479.1.
AF212245 mRNA. Translation: AAG41781.1.
BX161501 mRNA. Translation: CAD61945.1.
CR457163 mRNA. Translation: CAG33444.1.
CR533510 mRNA. Translation: CAG38541.1.
CH471061 Genomic DNA. Translation: EAW80753.1.
BC005198 mRNA. Translation: AAH05198.1.
BC010359 mRNA. Translation: AAH10359.1.
CCDSiCCDS45116.1. [Q9P055-4]
CCDS45117.1. [Q9P055-3]
CCDS61463.1. [Q9P055-5]
RefSeqiNP_001092095.1. NM_001098625.2. [Q9P055-3]
NP_001271130.1. NM_001284201.1.
NP_001271131.1. NM_001284202.1. [Q9P055-5]
NP_001271132.1. NM_001284203.1. [Q9P055-2]
NP_001271133.1. NM_001284204.1.
NP_057559.2. NM_016475.4. [Q9P055-4]
UniGeneiHs.446850.

Genome annotation databases

EnsembliENST00000261247; ENSP00000261247; ENSG00000050130. [Q9P055-4]
ENST00000356057; ENSP00000348351; ENSG00000050130. [Q9P055-5]
ENST00000425728; ENSP00000389699; ENSG00000050130. [Q9P055-3]
GeneIDi51528.
KEGGihsa:51528.
UCSCiuc001xef.4. human. [Q9P055-4]
uc001xeg.4. human. [Q9P055-5]
uc001xeh.4. human. [Q9P055-3]
uc001xej.4. human. [Q9P055-1]

Polymorphism databases

DMDMi38257782.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF529304 mRNA. Translation: AAP85636.1 .
AF151047 mRNA. Translation: AAF36133.1 . Frameshift.
AF161445 mRNA. Translation: AAF29005.1 . Different initiation.
AL136696 mRNA. Translation: CAB66631.1 .
AK021683 mRNA. Translation: BAB13874.1 .
AK027591 mRNA. Translation: BAB55216.1 .
AK298209 mRNA. Translation: BAG60479.1 .
AF212245 mRNA. Translation: AAG41781.1 .
BX161501 mRNA. Translation: CAD61945.1 .
CR457163 mRNA. Translation: CAG33444.1 .
CR533510 mRNA. Translation: CAG38541.1 .
CH471061 Genomic DNA. Translation: EAW80753.1 .
BC005198 mRNA. Translation: AAH05198.1 .
BC010359 mRNA. Translation: AAH10359.1 .
CCDSi CCDS45116.1. [Q9P055-4 ]
CCDS45117.1. [Q9P055-3 ]
CCDS61463.1. [Q9P055-5 ]
RefSeqi NP_001092095.1. NM_001098625.2. [Q9P055-3 ]
NP_001271130.1. NM_001284201.1.
NP_001271131.1. NM_001284202.1. [Q9P055-5 ]
NP_001271132.1. NM_001284203.1. [Q9P055-2 ]
NP_001271133.1. NM_001284204.1.
NP_057559.2. NM_016475.4. [Q9P055-4 ]
UniGenei Hs.446850.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119590. 9 interactions.
MINTi MINT-4721513.

PTM databases

PhosphoSitei Q9P055.

Polymorphism databases

DMDMi 38257782.

Proteomic databases

PaxDbi Q9P055.
PRIDEi Q9P055.

Protocols and materials databases

DNASUi 51528.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000261247 ; ENSP00000261247 ; ENSG00000050130 . [Q9P055-4 ]
ENST00000356057 ; ENSP00000348351 ; ENSG00000050130 . [Q9P055-5 ]
ENST00000425728 ; ENSP00000389699 ; ENSG00000050130 . [Q9P055-3 ]
GeneIDi 51528.
KEGGi hsa:51528.
UCSCi uc001xef.4. human. [Q9P055-4 ]
uc001xeg.4. human. [Q9P055-5 ]
uc001xeh.4. human. [Q9P055-3 ]
uc001xej.4. human. [Q9P055-1 ]

Organism-specific databases

CTDi 51528.
GeneCardsi GC14P059952.
H-InvDB HIX0011705.
HGNCi HGNC:20184. JKAMP.
HPAi HPA031172.
MIMi 611176. gene.
neXtProti NX_Q9P055.
PharmGKBi PA165479069.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG262492.
GeneTreei ENSGT00390000018097.
HOVERGENi HBG051016.
InParanoidi Q9P055.
OrthoDBi EOG747PJJ.
PhylomeDBi Q9P055.
TreeFami TF314201.

Miscellaneous databases

GeneWikii JKAMP.
GenomeRNAii 51528.
NextBioi 55244.
PROi Q9P055.
SOURCEi Search...

Gene expression databases

Bgeei Q9P055.
ExpressionAtlasi Q9P055. baseline and differential.
Genevestigatori Q9P055.

Family and domain databases

InterProi IPR008485. DUF766.
[Graphical view ]
PANTHERi PTHR12740. PTHR12740. 1 hit.
Pfami PF05571. DUF766. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Medulloblastoma.
  2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Umbilical cord blood.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Fetal brain.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4).
    Tissue: Embryo and Teratocarcinoma.
  5. "A novel gene expressed in human pheochromocytoma."
    Li Y., Huang Q., Peng Y., Song H., Yu Y., Xu S., Ren S., Chen Z., Han Z.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Pheochromocytoma.
  6. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
    Tissue: Cervix carcinoma.
  7. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
    Tissue: Bone marrow.

Entry informationi

Entry nameiJKAMP_HUMAN
AccessioniPrimary (citable) accession number: Q9P055
Secondary accession number(s): B4DP67
, Q6FIB6, Q6IAJ2, Q7Z5D4, Q86SY6, Q9H0Q6, Q9H2W0, Q9HAH5, Q9P0R3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: November 7, 2003
Last modified: October 29, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Patients with cancer had 2 to 12-fold higher frequencies of antibodies against this antigen.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3