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Q9P055 (JKAMP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
JNK1/MAPK8-associated membrane protein

Short name=JKAMP
Alternative name(s):
JNK1-associated membrane protein
Short name=JAMP
Medulloblastoma antigen MU-MB-50.4
Gene names
Name:JKAMP
Synonyms:C14orf100, JAMP
ORF Names:CDA06, HSPC213, HSPC327
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length326 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be a regulator of the duration of MAPK8 activity in response to various stress stimuli. Facilitates degradation of misfolded endoplasmic reticulum (ER) luminal proteins through the recruitment of components of the proteasome and endoplasmic reticulum-associated degradation (ERAD) system By similarity.

Subunit structure

Interacts with RNF5 and MAPK8, but not with MAPK9. Binding to MAPK8 occurs before and after exposure to stress, such as UV irradiation. After exposure to stress, interacts with phosphorylated MAPK8. Competes with DUSP10 for MAPK8 binding. Associates with multiple components of the proteasome and with ERAD regulatory proteins including AMFR/GP78, CANX, PSMC1, PSMC2, PSMC3/TBP1, PSMC5, PSMC6, PSMD8, SEC61-ALPHA and UFD1L By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Post-translational modification

Ubiquitinated by RNF5 via 'Lys-63'-linked ubiquitin linkage in a UBE2N-dependent manner. Ubiquitination decreases association with components of the proteasome and ERAD By similarity.

Miscellaneous

Patients with cancer had 2 to 12-fold higher frequencies of antibodies against this antigen.

Sequence caution

The sequence AAF29005.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAF36133.1 differs from that shown. Reason: Frameshift at positions 105 and 124.

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9P055-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9P055-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-78: Missing.
Isoform 3 (identifier: Q9P055-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MFGAAARSADLALLEKNLQAAHG → MA
Isoform 4 (identifier: Q9P055-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MFGAAARSADLALLEKNLQAAHG → MAVDIQPA
Isoform 5 (identifier: Q9P055-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MFGAAARSADLALLEKNLQAAHG → MKGEIQQSLGAWVLLT

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 326326JNK1/MAPK8-associated membrane protein
PRO_0000089903

Regions

Topological domain1 – 7272Lumenal Potential
Transmembrane73 – 9321Helical; Potential
Topological domain94 – 1029Cytoplasmic Potential
Transmembrane103 – 12321Helical; Potential
Topological domain124 – 16441Lumenal Potential
Transmembrane165 – 18521Helical; Potential
Topological domain186 – 20318Cytoplasmic Potential
Transmembrane204 – 22421Helical; Potential
Topological domain2251Lumenal Potential
Transmembrane226 – 24621Helical; Potential
Topological domain247 – 26519Cytoplasmic Potential
Transmembrane266 – 28621Helical; Potential
Topological domain287 – 2926Lumenal Potential
Transmembrane293 – 31321Helical; Potential
Topological domain314 – 32613Cytoplasmic Potential

Natural variations

Alternative sequence1 – 7878Missing in isoform 2.
VSP_008809
Alternative sequence1 – 2323MFGAA…QAAHG → MA in isoform 3.
VSP_008810
Alternative sequence1 – 2323MFGAA…QAAHG → MAVDIQPA in isoform 4.
VSP_008811
Alternative sequence1 – 2323MFGAA…QAAHG → MKGEIQQSLGAWVLLT in isoform 5.
VSP_008812

Experimental info

Sequence conflict851V → A in BAB13874. Ref.4
Sequence conflict1411S → P in AAF36133. Ref.2
Sequence conflict1491N → S in AAF36133. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 7, 2003. Version 2.
Checksum: 75B270100E3BC3C9

FASTA32636,751
        10         20         30         40         50         60 
MFGAAARSAD LALLEKNLQA AHGCLGLYCG KTLLFKNGST EIYGECGVCP RGQRTNAQKY 

        70         80         90        100        110        120 
CQPCTESPEL YDWLYLGFMA MLPLVLHWFF IEWYSGKKSS SALFQHITAL FECSMAAIIT 

       130        140        150        160        170        180 
LLVSDPVGVL YIRSCRVLML SDWYTMLYNP SPDYVTTVHC THEAVYPLYT IVFIYYAFCL 

       190        200        210        220        230        240 
VLMMLLRPLL VKKIACGLGK SDRFKSIYAA LYFFPILTVL QAVGGGLLYY AFPYIILVLS 

       250        260        270        280        290        300 
LVTLAVYMSA SEIENCYDLL VRKKRLIVLF SHWLLHAYGI ISISRVDKLE QDLPLLALVP 

       310        320 
TPALFYLFTA KFTEPSRILS EGANGH 

« Hide

Isoform 2 [UniParc].

Checksum: 6918AC0A6414F401
Show »

FASTA24828,212
Isoform 3 [UniParc].

Checksum: 1047E4068BAC541A
Show »

FASTA30534,615
Isoform 4 [UniParc].

Checksum: F294B4CAFDDCECE4
Show »

FASTA31135,239
Isoform 5 [UniParc].

Checksum: 91D42D3746B15413
Show »

FASTA31936,169

References

« Hide 'large scale' references
[1]"Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries."
Behrends U., Schneider I., Roessler S., Frauenknecht H., Golbeck A., Lechner B., Eigenstetter G., Zobywalski C., Mueller-Weihrich S., Graubner U., Schmid I., Sackerer D., Spaeth M., Goetz C., Prantl F., Asmuss H.-P., Bise K., Mautner J.
Int. J. Cancer 106:244-251(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Tissue: Medulloblastoma.
[2]"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. expand/collapse author list , Gu J., Chen S.-J., Chen Z.
Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
Tissue: Umbilical cord blood.
[3]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
Tissue: Fetal brain.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4).
Tissue: Embryo and Teratocarcinoma.
[5]"A novel gene expressed in human pheochromocytoma."
Li Y., Huang Q., Peng Y., Song H., Yu Y., Xu S., Ren S., Chen Z., Han Z.
Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Pheochromocytoma.
[6]"Full-length cDNA libraries and normalization."
Li W.B., Gruber C., Jessee J., Polayes D.
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
Tissue: Cervix carcinoma.
[7]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
[8]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
Tissue: Bone marrow.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF529304 mRNA. Translation: AAP85636.1.
AF151047 mRNA. Translation: AAF36133.1. Frameshift.
AF161445 mRNA. Translation: AAF29005.1. Different initiation.
AL136696 mRNA. Translation: CAB66631.1.
AK021683 mRNA. Translation: BAB13874.1.
AK027591 mRNA. Translation: BAB55216.1.
AK298209 mRNA. Translation: BAG60479.1.
AF212245 mRNA. Translation: AAG41781.1.
BX161501 mRNA. Translation: CAD61945.1.
CR457163 mRNA. Translation: CAG33444.1.
CR533510 mRNA. Translation: CAG38541.1.
CH471061 Genomic DNA. Translation: EAW80753.1.
BC005198 mRNA. Translation: AAH05198.1.
BC010359 mRNA. Translation: AAH10359.1.
CCDSCCDS45116.1. [Q9P055-4]
CCDS45117.1. [Q9P055-3]
CCDS61463.1. [Q9P055-5]
RefSeqNP_001092095.1. NM_001098625.2. [Q9P055-3]
NP_001271130.1. NM_001284201.1.
NP_001271131.1. NM_001284202.1. [Q9P055-5]
NP_001271132.1. NM_001284203.1. [Q9P055-2]
NP_001271133.1. NM_001284204.1.
NP_057559.2. NM_016475.4. [Q9P055-4]
UniGeneHs.446850.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119590. 9 interactions.
MINTMINT-4721513.

PTM databases

PhosphoSiteQ9P055.

Polymorphism databases

DMDM38257782.

Proteomic databases

PaxDbQ9P055.
PRIDEQ9P055.

Protocols and materials databases

DNASU51528.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000261247; ENSP00000261247; ENSG00000050130. [Q9P055-4]
ENST00000356057; ENSP00000348351; ENSG00000050130. [Q9P055-5]
ENST00000425728; ENSP00000389699; ENSG00000050130. [Q9P055-3]
GeneID51528.
KEGGhsa:51528.
UCSCuc001xef.4. human. [Q9P055-4]
uc001xeg.4. human. [Q9P055-5]
uc001xeh.4. human. [Q9P055-3]
uc001xej.4. human. [Q9P055-1]

Organism-specific databases

CTD51528.
GeneCardsGC14P059952.
H-InvDBHIX0011705.
HGNCHGNC:20184. JKAMP.
HPAHPA031172.
MIM611176. gene.
neXtProtNX_Q9P055.
PharmGKBPA165479069.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG262492.
HOVERGENHBG051016.
InParanoidQ9P055.
OrthoDBEOG747PJJ.
PhylomeDBQ9P055.
TreeFamTF314201.

Gene expression databases

ArrayExpressQ9P055.
BgeeQ9P055.
GenevestigatorQ9P055.

Family and domain databases

InterProIPR008485. DUF766.
[Graphical view]
PANTHERPTHR12740. PTHR12740. 1 hit.
PfamPF05571. DUF766. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiJKAMP.
GenomeRNAi51528.
NextBio55244.
PROQ9P055.
SOURCESearch...

Entry information

Entry nameJKAMP_HUMAN
AccessionPrimary (citable) accession number: Q9P055
Secondary accession number(s): B4DP67 expand/collapse secondary AC list , Q6FIB6, Q6IAJ2, Q7Z5D4, Q86SY6, Q9H0Q6, Q9H2W0, Q9HAH5, Q9P0R3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: November 7, 2003
Last modified: July 9, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM