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Q9P055

- JKAMP_HUMAN

UniProt

Q9P055 - JKAMP_HUMAN

Protein

JNK1/MAPK8-associated membrane protein

Gene

JKAMP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 2 (07 Nov 2003)
      Previous versions | rss
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    Functioni

    May be a regulator of the duration of MAPK8 activity in response to various stress stimuli. Facilitates degradation of misfolded endoplasmic reticulum (ER) luminal proteins through the recruitment of components of the proteasome and endoplasmic reticulum-associated degradation (ERAD) system By similarity.By similarity

    GO - Molecular functioni

    1. ubiquitin protein ligase binding Source: UniProtKB

    GO - Biological processi

    1. ER-associated ubiquitin-dependent protein catabolic process Source: UniProtKB
    2. response to unfolded protein Source: UniProtKB-KW

    Keywords - Biological processi

    Unfolded protein response

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    JNK1/MAPK8-associated membrane protein
    Short name:
    JKAMP
    Alternative name(s):
    JNK1-associated membrane protein
    Short name:
    JAMP
    Medulloblastoma antigen MU-MB-50.4
    Gene namesi
    Name:JKAMP
    Synonyms:C14orf100, JAMP
    ORF Names:CDA06, HSPC213, HSPC327
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:20184. JKAMP.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165479069.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 326326JNK1/MAPK8-associated membrane proteinPRO_0000089903Add
    BLAST

    Post-translational modificationi

    Ubiquitinated by RNF5 via 'Lys-63'-linked ubiquitin linkage in a UBE2N-dependent manner. Ubiquitination decreases association with components of the proteasome and ERAD By similarity.By similarity

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    PaxDbiQ9P055.
    PRIDEiQ9P055.

    PTM databases

    PhosphoSiteiQ9P055.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9P055.
    BgeeiQ9P055.
    GenevestigatoriQ9P055.

    Organism-specific databases

    HPAiHPA031172.

    Interactioni

    Subunit structurei

    Interacts with RNF5 and MAPK8, but not with MAPK9. Binding to MAPK8 occurs before and after exposure to stress, such as UV irradiation. After exposure to stress, interacts with phosphorylated MAPK8. Competes with DUSP10 for MAPK8 binding. Associates with multiple components of the proteasome and with ERAD regulatory proteins including AMFR/GP78, CANX, PSMC1, PSMC2, PSMC3/TBP1, PSMC5, PSMC6, PSMD8, SEC61-ALPHA and UFD1L By similarity.By similarity

    Protein-protein interaction databases

    BioGridi119590. 9 interactions.
    MINTiMINT-4721513.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7272LumenalSequence AnalysisAdd
    BLAST
    Topological domaini94 – 1029CytoplasmicSequence Analysis
    Topological domaini124 – 16441LumenalSequence AnalysisAdd
    BLAST
    Topological domaini186 – 20318CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini225 – 2251LumenalSequence Analysis
    Topological domaini247 – 26519CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini287 – 2926LumenalSequence Analysis
    Topological domaini314 – 32613CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei73 – 9321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei103 – 12321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei165 – 18521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei204 – 22421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei226 – 24621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei266 – 28621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei293 – 31321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG262492.
    HOVERGENiHBG051016.
    InParanoidiQ9P055.
    OrthoDBiEOG747PJJ.
    PhylomeDBiQ9P055.
    TreeFamiTF314201.

    Family and domain databases

    InterProiIPR008485. DUF766.
    [Graphical view]
    PANTHERiPTHR12740. PTHR12740. 1 hit.
    PfamiPF05571. DUF766. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9P055-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MFGAAARSAD LALLEKNLQA AHGCLGLYCG KTLLFKNGST EIYGECGVCP    50
    RGQRTNAQKY CQPCTESPEL YDWLYLGFMA MLPLVLHWFF IEWYSGKKSS 100
    SALFQHITAL FECSMAAIIT LLVSDPVGVL YIRSCRVLML SDWYTMLYNP 150
    SPDYVTTVHC THEAVYPLYT IVFIYYAFCL VLMMLLRPLL VKKIACGLGK 200
    SDRFKSIYAA LYFFPILTVL QAVGGGLLYY AFPYIILVLS LVTLAVYMSA 250
    SEIENCYDLL VRKKRLIVLF SHWLLHAYGI ISISRVDKLE QDLPLLALVP 300
    TPALFYLFTA KFTEPSRILS EGANGH 326
    Length:326
    Mass (Da):36,751
    Last modified:November 7, 2003 - v2
    Checksum:i75B270100E3BC3C9
    GO
    Isoform 2 (identifier: Q9P055-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-78: Missing.

    Show »
    Length:248
    Mass (Da):28,212
    Checksum:i6918AC0A6414F401
    GO
    Isoform 3 (identifier: Q9P055-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-23: MFGAAARSADLALLEKNLQAAHG → MA

    Show »
    Length:305
    Mass (Da):34,615
    Checksum:i1047E4068BAC541A
    GO
    Isoform 4 (identifier: Q9P055-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-23: MFGAAARSADLALLEKNLQAAHG → MAVDIQPA

    Show »
    Length:311
    Mass (Da):35,239
    Checksum:iF294B4CAFDDCECE4
    GO
    Isoform 5 (identifier: Q9P055-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-23: MFGAAARSADLALLEKNLQAAHG → MKGEIQQSLGAWVLLT

    Show »
    Length:319
    Mass (Da):36,169
    Checksum:i91D42D3746B15413
    GO

    Sequence cautioni

    The sequence AAF36133.1 differs from that shown. Reason: Frameshift at positions 105 and 124.
    The sequence AAF29005.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti85 – 851V → A in BAB13874. (PubMed:14702039)Curated
    Sequence conflicti141 – 1411S → P in AAF36133. (PubMed:11042152)Curated
    Sequence conflicti149 – 1491N → S in AAF36133. (PubMed:11042152)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 7878Missing in isoform 2. 2 PublicationsVSP_008809Add
    BLAST
    Alternative sequencei1 – 2323MFGAA…QAAHG → MA in isoform 3. 5 PublicationsVSP_008810Add
    BLAST
    Alternative sequencei1 – 2323MFGAA…QAAHG → MAVDIQPA in isoform 4. 4 PublicationsVSP_008811Add
    BLAST
    Alternative sequencei1 – 2323MFGAA…QAAHG → MKGEIQQSLGAWVLLT in isoform 5. 1 PublicationVSP_008812Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF529304 mRNA. Translation: AAP85636.1.
    AF151047 mRNA. Translation: AAF36133.1. Frameshift.
    AF161445 mRNA. Translation: AAF29005.1. Different initiation.
    AL136696 mRNA. Translation: CAB66631.1.
    AK021683 mRNA. Translation: BAB13874.1.
    AK027591 mRNA. Translation: BAB55216.1.
    AK298209 mRNA. Translation: BAG60479.1.
    AF212245 mRNA. Translation: AAG41781.1.
    BX161501 mRNA. Translation: CAD61945.1.
    CR457163 mRNA. Translation: CAG33444.1.
    CR533510 mRNA. Translation: CAG38541.1.
    CH471061 Genomic DNA. Translation: EAW80753.1.
    BC005198 mRNA. Translation: AAH05198.1.
    BC010359 mRNA. Translation: AAH10359.1.
    CCDSiCCDS45116.1. [Q9P055-4]
    CCDS45117.1. [Q9P055-3]
    CCDS61463.1. [Q9P055-5]
    RefSeqiNP_001092095.1. NM_001098625.2. [Q9P055-3]
    NP_001271130.1. NM_001284201.1.
    NP_001271131.1. NM_001284202.1. [Q9P055-5]
    NP_001271132.1. NM_001284203.1. [Q9P055-2]
    NP_001271133.1. NM_001284204.1.
    NP_057559.2. NM_016475.4. [Q9P055-4]
    UniGeneiHs.446850.

    Genome annotation databases

    EnsembliENST00000261247; ENSP00000261247; ENSG00000050130. [Q9P055-4]
    ENST00000356057; ENSP00000348351; ENSG00000050130. [Q9P055-5]
    ENST00000425728; ENSP00000389699; ENSG00000050130. [Q9P055-3]
    GeneIDi51528.
    KEGGihsa:51528.
    UCSCiuc001xef.4. human. [Q9P055-4]
    uc001xeg.4. human. [Q9P055-5]
    uc001xeh.4. human. [Q9P055-3]
    uc001xej.4. human. [Q9P055-1]

    Polymorphism databases

    DMDMi38257782.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF529304 mRNA. Translation: AAP85636.1 .
    AF151047 mRNA. Translation: AAF36133.1 . Frameshift.
    AF161445 mRNA. Translation: AAF29005.1 . Different initiation.
    AL136696 mRNA. Translation: CAB66631.1 .
    AK021683 mRNA. Translation: BAB13874.1 .
    AK027591 mRNA. Translation: BAB55216.1 .
    AK298209 mRNA. Translation: BAG60479.1 .
    AF212245 mRNA. Translation: AAG41781.1 .
    BX161501 mRNA. Translation: CAD61945.1 .
    CR457163 mRNA. Translation: CAG33444.1 .
    CR533510 mRNA. Translation: CAG38541.1 .
    CH471061 Genomic DNA. Translation: EAW80753.1 .
    BC005198 mRNA. Translation: AAH05198.1 .
    BC010359 mRNA. Translation: AAH10359.1 .
    CCDSi CCDS45116.1. [Q9P055-4 ]
    CCDS45117.1. [Q9P055-3 ]
    CCDS61463.1. [Q9P055-5 ]
    RefSeqi NP_001092095.1. NM_001098625.2. [Q9P055-3 ]
    NP_001271130.1. NM_001284201.1.
    NP_001271131.1. NM_001284202.1. [Q9P055-5 ]
    NP_001271132.1. NM_001284203.1. [Q9P055-2 ]
    NP_001271133.1. NM_001284204.1.
    NP_057559.2. NM_016475.4. [Q9P055-4 ]
    UniGenei Hs.446850.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119590. 9 interactions.
    MINTi MINT-4721513.

    PTM databases

    PhosphoSitei Q9P055.

    Polymorphism databases

    DMDMi 38257782.

    Proteomic databases

    PaxDbi Q9P055.
    PRIDEi Q9P055.

    Protocols and materials databases

    DNASUi 51528.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000261247 ; ENSP00000261247 ; ENSG00000050130 . [Q9P055-4 ]
    ENST00000356057 ; ENSP00000348351 ; ENSG00000050130 . [Q9P055-5 ]
    ENST00000425728 ; ENSP00000389699 ; ENSG00000050130 . [Q9P055-3 ]
    GeneIDi 51528.
    KEGGi hsa:51528.
    UCSCi uc001xef.4. human. [Q9P055-4 ]
    uc001xeg.4. human. [Q9P055-5 ]
    uc001xeh.4. human. [Q9P055-3 ]
    uc001xej.4. human. [Q9P055-1 ]

    Organism-specific databases

    CTDi 51528.
    GeneCardsi GC14P059952.
    H-InvDB HIX0011705.
    HGNCi HGNC:20184. JKAMP.
    HPAi HPA031172.
    MIMi 611176. gene.
    neXtProti NX_Q9P055.
    PharmGKBi PA165479069.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG262492.
    HOVERGENi HBG051016.
    InParanoidi Q9P055.
    OrthoDBi EOG747PJJ.
    PhylomeDBi Q9P055.
    TreeFami TF314201.

    Miscellaneous databases

    GeneWikii JKAMP.
    GenomeRNAii 51528.
    NextBioi 55244.
    PROi Q9P055.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9P055.
    Bgeei Q9P055.
    Genevestigatori Q9P055.

    Family and domain databases

    InterProi IPR008485. DUF766.
    [Graphical view ]
    PANTHERi PTHR12740. PTHR12740. 1 hit.
    Pfami PF05571. DUF766. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Medulloblastoma.
    2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
      Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
      , Gu J., Chen S.-J., Chen Z.
      Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Umbilical cord blood.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Fetal brain.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4).
      Tissue: Embryo and Teratocarcinoma.
    5. "A novel gene expressed in human pheochromocytoma."
      Li Y., Huang Q., Peng Y., Song H., Yu Y., Xu S., Ren S., Chen Z., Han Z.
      Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Pheochromocytoma.
    6. "Full-length cDNA libraries and normalization."
      Li W.B., Gruber C., Jessee J., Polayes D.
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
      Tissue: Cervix carcinoma.
    7. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
      Tissue: Bone marrow.

    Entry informationi

    Entry nameiJKAMP_HUMAN
    AccessioniPrimary (citable) accession number: Q9P055
    Secondary accession number(s): B4DP67
    , Q6FIB6, Q6IAJ2, Q7Z5D4, Q86SY6, Q9H0Q6, Q9H2W0, Q9HAH5, Q9P0R3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 7, 2003
    Last sequence update: November 7, 2003
    Last modified: October 1, 2014
    This is version 113 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Patients with cancer had 2 to 12-fold higher frequencies of antibodies against this antigen.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3