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Protein

Thyroid transcription factor 1-associated protein 26

Gene

CCDC59

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities.2 Publications

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-5683826. Surfactant metabolism.
R-HSA-5688031. Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS).

Names & Taxonomyi

Protein namesi
Recommended name:
Thyroid transcription factor 1-associated protein 26
Short name:
TTF-1-associated protein 26
Alternative name(s):
Coiled-coil domain-containing protein 59
TTF-1-associated protein BR2
Gene namesi
Name:CCDC59
Synonyms:BR22, TAP26
ORF Names:HSPC128
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:25005. CCDC59.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485412.

Polymorphism and mutation databases

BioMutaiCCDC59.
DMDMi156633647.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 241241Thyroid transcription factor 1-associated protein 26PRO_0000298941Add
BLAST

Proteomic databases

EPDiQ9P031.
MaxQBiQ9P031.
PaxDbiQ9P031.
PRIDEiQ9P031.

PTM databases

iPTMnetiQ9P031.

Expressioni

Tissue specificityi

Ubiquitously expressed. In lung, expression is restricted to the alveolar epithelial cells.1 Publication

Gene expression databases

BgeeiQ9P031.
CleanExiHS_CCDC59.
ExpressionAtlasiQ9P031. baseline and differential.
GenevisibleiQ9P031. HS.

Organism-specific databases

HPAiHPA038555.
HPA057578.

Interactioni

Subunit structurei

Interacts with NKX2-1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NKX2-1P436994EBI-1047110,EBI-1391923

Protein-protein interaction databases

BioGridi118850. 53 interactions.
IntActiQ9P031. 5 interactions.
MINTiMINT-5010053.
STRINGi9606.ENSP00000256151.

Structurei

3D structure databases

ProteinModelPortaliQ9P031.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TAP26 family.Curated

Phylogenomic databases

eggNOGiKOG3777. Eukaryota.
KOG4819. Eukaryota.
ENOG4111ZBH. LUCA.
GeneTreeiENSGT00390000006546.
HOGENOMiHOG000154507.
HOVERGENiHBG108545.
InParanoidiQ9P031.
OMAiKIQQNYK.
PhylomeDBiQ9P031.
TreeFamiTF324429.

Family and domain databases

InterProiIPR013730. Fyv7/TAP26.
[Graphical view]
PANTHERiPTHR15657. PTHR15657. 1 hit.
PfamiPF08524. rRNA_processing. 1 hit.
[Graphical view]
PRINTSiPR01854. BR22PROTEIN.

Sequencei

Sequence statusi: Complete.

Q9P031-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPVRRSAKW RPGGIEARGE GVSTVGYRNK NVRQKTWRPN HPQAFVGSVR
60 70 80 90 100
EGQGFAFRRK LKIQQSYKKL LRKEKKAQTS LESQFTDRYP DNLKHLYLAE
110 120 130 140 150
EERHRKQARK VDHPLSEQVH QPLLEEQCSI DEPLFEDQCS FDQPQPEEQC
160 170 180 190 200
IKTVNSFTIP KKNKKKTSNQ KAQEEYEQIQ AKRAAKKQEF ERRKQEREEA
210 220 230 240
QRQYKKKKME VFKILNKKTK KGQPNLNVQM EYLLQKIQEK C
Length:241
Mass (Da):28,670
Last modified:August 21, 2007 - v2
Checksum:iA9012048D32A87AE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti136 – 1361E → G in BAA91524 (PubMed:14702039).Curated
Sequence conflicti160 – 1601P → S in AAF29092 (PubMed:11042152).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF213377 mRNA. Translation: AAG43569.1.
AF161477 mRNA. Translation: AAF29092.1.
BC020647 mRNA. Translation: AAH20647.1.
AK001156 mRNA. Translation: BAA91524.1.
CCDSiCCDS9023.1.
RefSeqiNP_054886.2. NM_014167.4.
UniGeneiHs.582627.

Genome annotation databases

EnsembliENST00000256151; ENSP00000256151; ENSG00000133773.
GeneIDi29080.
KEGGihsa:29080.
UCSCiuc001szp.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF213377 mRNA. Translation: AAG43569.1.
AF161477 mRNA. Translation: AAF29092.1.
BC020647 mRNA. Translation: AAH20647.1.
AK001156 mRNA. Translation: BAA91524.1.
CCDSiCCDS9023.1.
RefSeqiNP_054886.2. NM_014167.4.
UniGeneiHs.582627.

3D structure databases

ProteinModelPortaliQ9P031.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118850. 53 interactions.
IntActiQ9P031. 5 interactions.
MINTiMINT-5010053.
STRINGi9606.ENSP00000256151.

PTM databases

iPTMnetiQ9P031.

Polymorphism and mutation databases

BioMutaiCCDC59.
DMDMi156633647.

Proteomic databases

EPDiQ9P031.
MaxQBiQ9P031.
PaxDbiQ9P031.
PRIDEiQ9P031.

Protocols and materials databases

DNASUi29080.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256151; ENSP00000256151; ENSG00000133773.
GeneIDi29080.
KEGGihsa:29080.
UCSCiuc001szp.5. human.

Organism-specific databases

CTDi29080.
GeneCardsiCCDC59.
H-InvDBHIX0010851.
HGNCiHGNC:25005. CCDC59.
HPAiHPA038555.
HPA057578.
neXtProtiNX_Q9P031.
PharmGKBiPA143485412.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3777. Eukaryota.
KOG4819. Eukaryota.
ENOG4111ZBH. LUCA.
GeneTreeiENSGT00390000006546.
HOGENOMiHOG000154507.
HOVERGENiHBG108545.
InParanoidiQ9P031.
OMAiKIQQNYK.
PhylomeDBiQ9P031.
TreeFamiTF324429.

Enzyme and pathway databases

ReactomeiR-HSA-5683826. Surfactant metabolism.
R-HSA-5688031. Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS).

Miscellaneous databases

GenomeRNAii29080.
NextBioi52050.
PROiQ9P031.

Gene expression databases

BgeeiQ9P031.
CleanExiHS_CCDC59.
ExpressionAtlasiQ9P031. baseline and differential.
GenevisibleiQ9P031. HS.

Family and domain databases

InterProiIPR013730. Fyv7/TAP26.
[Graphical view]
PANTHERiPTHR15657. PTHR15657. 1 hit.
PfamiPF08524. rRNA_processing. 1 hit.
[Graphical view]
PRINTSiPR01854. BR22PROTEIN.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "BR22, a novel protein, interacts with thyroid transcription factor-1 and activates the human surfactant protein B promoter."
    Yang Y.-S., Yang M.-C., Wang B., Weissler J.C.
    Am. J. Respir. Cell Mol. Biol. 24:30-37(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH NKX2-1.
  2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Umbilical cord blood.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-160.
  5. "BR22, a 26 kDa thyroid transcription factor-1 associated protein (TAP26), is expressed in human lung cells."
    Yang M.-C., Wang B., Weissler J.C., Margraf L.R., Yang Y.-S.
    Eur. Respir. J. 22:28-34(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "The TTF-1/TAP26 complex differentially modulates surfactant protein-B (SFTPB) and -C (SFTPBC) promoters in lung cells."
    Yang M.-C., Guo Y., Liu C.-C., Weissler J.C., Yang Y.-S.
    Biochem. Biophys. Res. Commun. 344:484-490(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiTAP26_HUMAN
AccessioniPrimary (citable) accession number: Q9P031
Secondary accession number(s): Q9H2V5, Q9NW62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: May 11, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.