Q9P031 (TAP26_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thyroid transcription factor 1-associated protein 26
Short name=TTF-1-associated protein 26

Alternative name(s):
Coiled-coil domain-containing protein 59
TTF-1-associated protein BR2

Gene names

Name:	CCDC59
Synonyms:	BR22, TAP26
ORF Names:	HSPC128

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	241 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities. Ref.5 Ref.6
Subunit structure	Interacts with NKX2-1. Ref.1
Subcellular location	Nucleus Probable.
Tissue specificity	Ubiquitously expressed. In lung, expression is restricted to the alveolar epithelial cells. Ref.1
Sequence similarities	Belongs to the TAP26 family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from physical interaction Ref.1. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
NKX2-1	P43699	4	EBI-1047110,EBI-1391923

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 241	241	Thyroid transcription factor 1-associated protein 26		PRO_0000298941
Experimental info
	Sequence conflict	136	1	E → G in BAA91524. Ref.4
	Sequence conflict	160	1	P → S in AAF29092. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9P031 [UniParc]. Last modified August 21, 2007. Version 2. Checksum: A9012048D32A87AE	FASTA	241	28,670
	10 20 30 40 50 60 MAPVRRSAKW RPGGIEARGE GVSTVGYRNK NVRQKTWRPN HPQAFVGSVR EGQGFAFRRK 70 80 90 100 110 120 LKIQQSYKKL LRKEKKAQTS LESQFTDRYP DNLKHLYLAE EERHRKQARK VDHPLSEQVH 130 140 150 160 170 180 QPLLEEQCSI DEPLFEDQCS FDQPQPEEQC IKTVNSFTIP KKNKKKTSNQ KAQEEYEQIQ 190 200 210 220 230 240 AKRAAKKQEF ERRKQEREEA QRQYKKKKME VFKILNKKTK KGQPNLNVQM EYLLQKIQEK C

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"BR22, a novel protein, interacts with thyroid transcription factor-1 and activates the human surfactant protein B promoter." Yang Y.-S., Yang M.-C., Wang B., Weissler J.C. Am. J. Respir. Cell Mol. Biol. 24:30-37(2001) [PubMed: 11152647] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH NKX2-1.
[2]	"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. , Gu J., Chen S.-J., Chen Z. Genome Res. 10:1546-1560(2000) [PubMed: 11042152] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Umbilical cord blood.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-160.
[5]	"BR22, a 26 kDa thyroid transcription factor-1 associated protein (TAP26), is expressed in human lung cells." Yang M.-C., Wang B., Weissler J.C., Margraf L.R., Yang Y.-S. Eur. Respir. J. 22:28-34(2003) [PubMed: 12882447] [Abstract] Cited for: FUNCTION.
[6]	"The TTF-1/TAP26 complex differentially modulates surfactant protein-B (SFTPB) and -C (SFTPBC) promoters in lung cells." Yang M.-C., Guo Y., Liu C.-C., Weissler J.C., Yang Y.-S. Biochem. Biophys. Res. Commun. 344:484-490(2006) [PubMed: 16630564] [Abstract] Cited for: FUNCTION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF213377 mRNA. Translation: AAG43569.1. AF161477 mRNA. Translation: AAF29092.1. BC020647 mRNA. Translation: AAH20647.1. AK001156 mRNA. Translation: BAA91524.1.
IPI	IPI00329594.
RefSeq	NP_054886.2. NM_014167.4.
UniGene	Hs.582627.
3D structure databases
ProteinModelPortal	Q9P031.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9P031. 2 interactions.
STRING	Q9P031.
Polymorphism databases
DMDM	156633647.
Proteomic databases
PRIDE	Q9P031.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000256151; ENSP00000256151; ENSG00000133773.
GeneID	29080.
KEGG	hsa:29080.
UCSC	uc001szp.2. human.
Organism-specific databases
CTD	29080.
GeneCards	GC12M082617.
H-InvDB	HIX0010851.
HGNC	HGNC:25005. CCDC59.
HPA	HPA038555.
neXtProt	NX_Q9P031.
PharmGKB	PA143485412.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG12616.
GeneTree	ENSGT00390000006546.
HOGENOM	HBG278685.
HOVERGEN	HBG108545.
InParanoid	Q9P031.
OMA	IQQSYKK.
OrthoDB	EOG4BK54S.
PhylomeDB	Q9P031.
Gene expression databases
ArrayExpress	Q9P031.
Bgee	Q9P031.
CleanEx	HS_CCDC59.
Genevestigator	Q9P031.
Family and domain databases
InterPro	IPR009149. BR22. IPR013730. rRNA_processing. [Graphical view]
PANTHER	PTHR15657. BR22. 1 hit.
Pfam	PF08524. rRNA_processing. 1 hit. [Graphical view]
PRINTS	PR01854. BR22PROTEIN.
ProtoNet	Search...
Other
NextBio	52050.

Entry information

Entry name

TAP26_HUMAN

Accession

Primary (citable) accession number: Q9P031
Secondary accession number(s): Q9H2V5, Q9NW62

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 21, 2007
Last sequence update:	August 21, 2007
Last modified:	January 25, 2012
This is version 68 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.