Reviewed, UniProtKB/Swiss-Prot Q9P031 (TAP26_HUMAN)

Names and origin

Protein names

Recommended name:
    Thyroid transcription factor 1-associated protein 26
      Short name=TTF-1-associated protein 26
Alternative name(s):
    TTF-1-associated protein BR2
    Coiled-coil domain-containing protein 59

Gene names

Name:	CCDC59
Synonyms:	BR22, TAP26
ORF Names:	HSPC128

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	241 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities. Ref.5 Ref.6
Subunit structure	Interacts with NKX2-1. Ref.1
Subcellular location	Nucleus Probable.
Tissue specificity	Ubiquitously expressed. In lung, expression is restricted to the alveolar epithelial cells. Ref.1
Sequence similarities	Belongs to the TAP26 family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Ref.1 Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CDC20	Q12834	1	EBI-1047110,EBI-367462
DEDD	O75618	1	EBI-1047110,EBI-1043164
MAGED1	Q9Y5V3	1	EBI-1047110,EBI-716006
MOBKL3	Q9Y3A3	1	EBI-1047110,EBI-713935
NKX2-1	P43699	3	EBI-1047110,EBI-1391923
PAK7	Q9P286	1	EBI-1047110,EBI-1051061
RNF167	Q9H6Y7	1	EBI-1047110,EBI-1055214
VHL	P40337	1	EBI-1047110,EBI-301246

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 241	241	Thyroid transcription factor 1-associated protein 26		PRO_0000298941
Experimental info
	Sequence conflict	136	1	E → G in BAA91524. Ref.4
	Sequence conflict	160	1	P → S in AAF29092. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9P031-1 [UniParc]. Last modified August 21, 2007. Version 2. Checksum: A9012048D32A87AE	FASTA	241	28,670
	10 20 30 40 50 60 MAPVRRSAKW RPGGIEARGE GVSTVGYRNK NVRQKTWRPN HPQAFVGSVR EGQGFAFRRK 70 80 90 100 110 120 LKIQQSYKKL LRKEKKAQTS LESQFTDRYP DNLKHLYLAE EERHRKQARK VDHPLSEQVH 130 140 150 160 170 180 QPLLEEQCSI DEPLFEDQCS FDQPQPEEQC IKTVNSFTIP KKNKKKTSNQ KAQEEYEQIQ 190 200 210 220 230 240 AKRAAKKQEF ERRKQEREEA QRQYKKKKME VFKILNKKTK KGQPNLNVQM EYLLQKIQEK C

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"BR22, a novel protein, interacts with thyroid transcription factor-1 and activates the human surfactant protein B promoter." Yang Y.-S., Yang M.-C., Wang B., Weissler J.C. Am. J. Respir. Cell Mol. Biol. 24:30-37(2001) [PubMed: 11152647] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH NKX2-1.
[2]	"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. , Gu J., Chen S.-J., Chen Z. Genome Res. 10:1546-1560(2000) [PubMed: 11042152] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Umbilical cord blood.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-160.
[5]	"BR22, a 26 kDa thyroid transcription factor-1 associated protein (TAP26), is expressed in human lung cells." Yang M.-C., Wang B., Weissler J.C., Margraf L.R., Yang Y.-S. Eur. Respir. J. 22:28-34(2003) [PubMed: 12882447] [Abstract] Cited for: FUNCTION.
[6]	"The TTF-1/TAP26 complex differentially modulates surfactant protein-B (SFTPB) and -C (SFTPBC) promoters in lung cells." Yang M.-C., Guo Y., Liu C.-C., Weissler J.C., Yang Y.-S. Biochem. Biophys. Res. Commun. 344:484-490(2006) [PubMed: 16630564] [Abstract] Cited for: FUNCTION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF213377 mRNA. Translation: AAG43569.1. AF161477 mRNA. Translation: AAF29092.1. BC020647 mRNA. Translation: AAH20647.1. AK001156 mRNA. Translation: BAA91524.1.
IPI	IPI00329594.
RefSeq	NP_054886.2.
UniGene	Hs.582627
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9P031. 17 interactions.
PTM databases
PhosphoSite	Q9P031.
Proteomic databases
PRIDE	Q9P031.
Genome annotation databases
Ensembl	ENSG00000133773. Homo sapiens. [Contig view]
GeneID	29080.
KEGG	hsa:29080.
UCSC	uc001szp.2. human.
Organism-specific databases
GeneCards	GC12M081270.
HGNC	HGNC:25005. CCDC59.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q9P031.
OMA	Q9P031. QMEYLLK.
Gene expression databases
ArrayExpress	Q9P031.
Bgee	Q9P031.
CleanEx	HS_CCDC59.
Family and domain databases
InterPro	IPR009149. BR22. [Graphical view]
PANTHER	PTHR15657. BR22. 1 hit.
PRINTS	PR01854. BR22PROTEIN.
ProtoNet	Search...
Other Resources
NextBio	52050.

Entry information

Entry name

TAP26_HUMAN

Accession

Primary (citable) accession number: Q9P031
Secondary accession number(s): Q9H2V5, Q9NW62

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 21, 2007
Last sequence update:	August 21, 2007
Last modified:	July 7, 2009
This is version 42 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)