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Protein

Cysteine-rich PDZ-binding protein

Gene

CRIPT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses.By similarity

GO - Molecular functioni

  • microtubule binding Source: UniProtKB
  • PDZ domain binding Source: UniProtKB
  • protein complex binding Source: UniProtKB
  • scaffold protein binding Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000119878-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich PDZ-binding protein
Alternative name(s):
Cysteine-rich interactor of PDZ three
Short name:
Cysteine-rich interactor of PDZ3
Gene namesi
Name:CRIPT
ORF Names:HSPC139
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:14312. CRIPT.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Synapse

Pathology & Biotechi

Involvement in diseasei

Short stature with microcephaly and distinctive facies (SSMF)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by dwarfism, microcephaly, and distinctive facial dysmorphism involving frontal bossing, high forehead, sparse hair and eyebrows, telecanthus, mild proptosis, anteverted nares, and flat nasal bridge.
See also OMIM:615789

Keywords - Diseasei

Dwarfism

Organism-specific databases

DisGeNETi9419.
MalaCardsiCRIPT.
MIMi615789. phenotype.
OpenTargetsiENSG00000119878.
PharmGKBiPA145149101.

Polymorphism and mutation databases

DMDMi74734765.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003145631 – 101Cysteine-rich PDZ-binding proteinAdd BLAST101

Proteomic databases

EPDiQ9P021.
MaxQBiQ9P021.
PaxDbiQ9P021.
PeptideAtlasiQ9P021.
PRIDEiQ9P021.
TopDownProteomicsiQ9P021.

PTM databases

iPTMnetiQ9P021.
PhosphoSitePlusiQ9P021.

Expressioni

Gene expression databases

BgeeiENSG00000119878.
CleanExiHS_CRIPT.
GenevisibleiQ9P021. HS.

Organism-specific databases

HPAiHPA046080.
HPA056765.

Interactioni

Subunit structurei

Interacts with TUBB1. Interacts strongly with the PDZ3 domain of members of the DLG4 family. Associates with microtubules (By similarity). Interacts with DLG4.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Dlg3Q629365EBI-946968,EBI-349596From a different organism.
DLG4P783524EBI-946968,EBI-80389
Dlg4P310162EBI-946968,EBI-375655From a different organism.

GO - Molecular functioni

  • microtubule binding Source: UniProtKB
  • PDZ domain binding Source: UniProtKB
  • protein complex binding Source: UniProtKB
  • scaffold protein binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi114812. 16 interactors.
DIPiDIP-41219N.
IntActiQ9P021. 13 interactors.
MINTiMINT-1900575.
STRINGi9606.ENSP00000238892.

Structurei

3D structure databases

ProteinModelPortaliQ9P021.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni95 – 101Sufficient for interaction with DLG41 Publication7
Regioni98 – 101PDZ3-binding4

Sequence similaritiesi

Belongs to the CRIPT family.Curated

Phylogenomic databases

eggNOGiKOG3476. Eukaryota.
ENOG4111RAI. LUCA.
GeneTreeiENSGT00390000002260.
HOGENOMiHOG000242625.
HOVERGENiHBG097641.
InParanoidiQ9P021.
OMAiPNPWRTS.
OrthoDBiEOG091G0YCT.
PhylomeDBiQ9P021.
TreeFamiTF300144.

Family and domain databases

InterProiIPR019367. PDZ-binding_CRIPT.
[Graphical view]
PfamiPF10235. Cript. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9P021-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVCEKCEKKL GTVITPDTWK DGARNTTESG GRKLNENKAL TSKKARFDPY
60 70 80 90 100
GKNKFSTCRI CKSSVHQPGS HYCQGCAYKK GICAMCGKKV LDTKNYKQTS

V
Length:101
Mass (Da):11,216
Last modified:October 1, 2000 - v1
Checksum:i161B0F4CA87DFBAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161488 mRNA. Translation: AAF29103.1.
AK291298 mRNA. Translation: BAF83987.1.
AC018682 Genomic DNA. Translation: AAY14836.1.
CH471053 Genomic DNA. Translation: EAX00239.1.
BC006980 mRNA. Translation: AAH06980.1.
BC018653 mRNA. Translation: AAH18653.1.
CCDSiCCDS1829.1.
RefSeqiNP_054890.1. NM_014171.5.
UniGeneiHs.133998.
Hs.634293.

Genome annotation databases

EnsembliENST00000238892; ENSP00000238892; ENSG00000119878.
GeneIDi9419.
KEGGihsa:9419.
UCSCiuc002rve.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161488 mRNA. Translation: AAF29103.1.
AK291298 mRNA. Translation: BAF83987.1.
AC018682 Genomic DNA. Translation: AAY14836.1.
CH471053 Genomic DNA. Translation: EAX00239.1.
BC006980 mRNA. Translation: AAH06980.1.
BC018653 mRNA. Translation: AAH18653.1.
CCDSiCCDS1829.1.
RefSeqiNP_054890.1. NM_014171.5.
UniGeneiHs.133998.
Hs.634293.

3D structure databases

ProteinModelPortaliQ9P021.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114812. 16 interactors.
DIPiDIP-41219N.
IntActiQ9P021. 13 interactors.
MINTiMINT-1900575.
STRINGi9606.ENSP00000238892.

PTM databases

iPTMnetiQ9P021.
PhosphoSitePlusiQ9P021.

Polymorphism and mutation databases

DMDMi74734765.

Proteomic databases

EPDiQ9P021.
MaxQBiQ9P021.
PaxDbiQ9P021.
PeptideAtlasiQ9P021.
PRIDEiQ9P021.
TopDownProteomicsiQ9P021.

Protocols and materials databases

DNASUi9419.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000238892; ENSP00000238892; ENSG00000119878.
GeneIDi9419.
KEGGihsa:9419.
UCSCiuc002rve.5. human.

Organism-specific databases

CTDi9419.
DisGeNETi9419.
GeneCardsiCRIPT.
HGNCiHGNC:14312. CRIPT.
HPAiHPA046080.
HPA056765.
MalaCardsiCRIPT.
MIMi604594. gene.
615789. phenotype.
neXtProtiNX_Q9P021.
OpenTargetsiENSG00000119878.
PharmGKBiPA145149101.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3476. Eukaryota.
ENOG4111RAI. LUCA.
GeneTreeiENSGT00390000002260.
HOGENOMiHOG000242625.
HOVERGENiHBG097641.
InParanoidiQ9P021.
OMAiPNPWRTS.
OrthoDBiEOG091G0YCT.
PhylomeDBiQ9P021.
TreeFamiTF300144.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000119878-MONOMER.

Miscellaneous databases

ChiTaRSiCRIPT. human.
GeneWikiiCRIPT.
GenomeRNAii9419.
PROiQ9P021.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000119878.
CleanExiHS_CRIPT.
GenevisibleiQ9P021. HS.

Family and domain databases

InterProiIPR019367. PDZ-binding_CRIPT.
[Graphical view]
PfamiPF10235. Cript. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRIPT_HUMAN
AccessioniPrimary (citable) accession number: Q9P021
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.