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Protein

Thymocyte nuclear protein 1

Gene

THYN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Thymocyte nuclear protein 1
Alternative name(s):
Thymocyte protein Thy28
Gene namesi
Name:THYN1
Synonyms:THY28
ORF Names:HSPC144, MDS012, My0054
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:29560. THYN1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • nucleolus Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394653.

Polymorphism and mutation databases

BioMutaiTHYN1.
DMDMi74734762.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 225225Thymocyte nuclear protein 1PRO_0000262564Add
BLAST

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9P016.
MaxQBiQ9P016.
PaxDbiQ9P016.
PeptideAtlasiQ9P016.
PRIDEiQ9P016.

PTM databases

iPTMnetiQ9P016.
PhosphoSiteiQ9P016.

Expressioni

Gene expression databases

BgeeiENSG00000151500.
CleanExiHS_THYN1.
ExpressionAtlasiQ9P016. baseline and differential.
GenevisibleiQ9P016. HS.

Organism-specific databases

HPAiHPA038732.
HPA038733.

Interactioni

Protein-protein interaction databases

BioGridi118856. 8 interactions.
IntActiQ9P016. 2 interactions.
MINTiMINT-4776940.
STRINGi9606.ENSP00000341657.

Structurei

Secondary structure

1
225
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi56 – 649Combined sources
Beta strandi67 – 726Combined sources
Helixi78 – 814Combined sources
Helixi84 – 863Combined sources
Beta strandi87 – 893Combined sources
Helixi96 – 1049Combined sources
Beta strandi110 – 1156Combined sources
Beta strandi118 – 1203Combined sources
Beta strandi122 – 13514Combined sources
Helixi137 – 1393Combined sources
Beta strandi159 – 17416Combined sources
Helixi175 – 18814Combined sources
Turni191 – 1944Combined sources
Helixi196 – 1994Combined sources
Beta strandi204 – 2085Combined sources
Helixi210 – 2189Combined sources
Helixi219 – 2213Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3EOPX-ray2.30A/B55-221[»]
5J3EX-ray2.60A/B1-225[»]
ProteinModelPortaliQ9P016.
SMRiQ9P016. Positions 55-223.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9P016.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi5 – 106Nuclear localization signalBy similarity

Phylogenomic databases

eggNOGiKOG3383. Eukaryota.
COG2947. LUCA.
GeneTreeiENSGT00390000013297.
HOGENOMiHOG000263533.
HOVERGENiHBG054408.
InParanoidiQ9P016.
OMAiMTLFTRQ.
OrthoDBiEOG091G0MPN.
PhylomeDBiQ9P016.
TreeFamiTF332126.

Family and domain databases

Gene3Di3.10.590.10. 1 hit.
InterProiIPR002740. EVE_domain.
IPR015947. PUA-like_domain.
[Graphical view]
PfamiPF01878. EVE. 1 hit.
[Graphical view]
SUPFAMiSSF88697. SSF88697. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P016-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRPRKRLAG TSGSDKGLSG KRTKTENSGE ALAKVEDSNP QKTSATKNCL
60 70 80 90 100
KNLSSHWLMK SEPESRLEKG VDVKFSIEDL KAQPKQTTCW DGVRNYQARN
110 120 130 140 150
FLRAMKLGEE AFFYHSNCKE PGIAGLMKIV KEAYPDHTQF EKNNPHYDPS
160 170 180 190 200
SKEDNPKWSM VDVQFVRMMK RFIPLAELKS YHQAHKATGG PLKNMVLFTR
210 220
QRLSIQPLTQ EEFDFVLSLE EKEPS
Length:225
Mass (Da):25,697
Last modified:October 1, 2000 - v1
Checksum:i76E6034A6404C962
GO
Isoform 2 (identifier: Q9P016-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     161-225: VDVQFVRMMKRFIPLAELKSYHQAHKATGGPLKNMVLFTRQRLSIQPLTQEEFDFVLSLEEKEPS → KSLILF

Show »
Length:166
Mass (Da):18,812
Checksum:i444349B36A982256
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti29 – 291G → V in AAH93074 (PubMed:15489334).Curated
Sequence conflicti223 – 2231E → G in AAG43118 (Ref. 2) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei161 – 22565VDVQF…EKEPS → KSLILF in isoform 2. 2 PublicationsVSP_021789Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087886 mRNA. Translation: AAP97185.1.
AF059619 mRNA. Translation: AAG43118.1.
AF182413 mRNA. Translation: AAG14949.1.
AF161493 mRNA. Translation: AAF29108.1.
BC006978 mRNA. Translation: AAH06978.1.
BC093074 mRNA. Translation: AAH93074.1.
CCDSiCCDS8496.1. [Q9P016-1]
CCDS8497.1. [Q9P016-2]
RefSeqiNP_001032381.1. NM_001037304.1. [Q9P016-2]
NP_001032382.1. NM_001037305.1. [Q9P016-1]
NP_054893.1. NM_014174.2. [Q9P016-1]
NP_954994.1. NM_199297.1. [Q9P016-2]
NP_954995.1. NM_199298.1. [Q9P016-1]
UniGeneiHs.13645.

Genome annotation databases

EnsembliENST00000341541; ENSP00000341657; ENSG00000151500. [Q9P016-1]
ENST00000352327; ENSP00000341452; ENSG00000151500. [Q9P016-2]
ENST00000392594; ENSP00000376373; ENSG00000151500. [Q9P016-1]
ENST00000392595; ENSP00000376374; ENSG00000151500. [Q9P016-1]
GeneIDi29087.
KEGGihsa:29087.
UCSCiuc001qhf.4. human. [Q9P016-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087886 mRNA. Translation: AAP97185.1.
AF059619 mRNA. Translation: AAG43118.1.
AF182413 mRNA. Translation: AAG14949.1.
AF161493 mRNA. Translation: AAF29108.1.
BC006978 mRNA. Translation: AAH06978.1.
BC093074 mRNA. Translation: AAH93074.1.
CCDSiCCDS8496.1. [Q9P016-1]
CCDS8497.1. [Q9P016-2]
RefSeqiNP_001032381.1. NM_001037304.1. [Q9P016-2]
NP_001032382.1. NM_001037305.1. [Q9P016-1]
NP_054893.1. NM_014174.2. [Q9P016-1]
NP_954994.1. NM_199297.1. [Q9P016-2]
NP_954995.1. NM_199298.1. [Q9P016-1]
UniGeneiHs.13645.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3EOPX-ray2.30A/B55-221[»]
5J3EX-ray2.60A/B1-225[»]
ProteinModelPortaliQ9P016.
SMRiQ9P016. Positions 55-223.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118856. 8 interactions.
IntActiQ9P016. 2 interactions.
MINTiMINT-4776940.
STRINGi9606.ENSP00000341657.

PTM databases

iPTMnetiQ9P016.
PhosphoSiteiQ9P016.

Polymorphism and mutation databases

BioMutaiTHYN1.
DMDMi74734762.

Proteomic databases

EPDiQ9P016.
MaxQBiQ9P016.
PaxDbiQ9P016.
PeptideAtlasiQ9P016.
PRIDEiQ9P016.

Protocols and materials databases

DNASUi29087.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341541; ENSP00000341657; ENSG00000151500. [Q9P016-1]
ENST00000352327; ENSP00000341452; ENSG00000151500. [Q9P016-2]
ENST00000392594; ENSP00000376373; ENSG00000151500. [Q9P016-1]
ENST00000392595; ENSP00000376374; ENSG00000151500. [Q9P016-1]
GeneIDi29087.
KEGGihsa:29087.
UCSCiuc001qhf.4. human. [Q9P016-1]

Organism-specific databases

CTDi29087.
GeneCardsiTHYN1.
HGNCiHGNC:29560. THYN1.
HPAiHPA038732.
HPA038733.
MIMi613739. gene.
neXtProtiNX_Q9P016.
PharmGKBiPA128394653.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3383. Eukaryota.
COG2947. LUCA.
GeneTreeiENSGT00390000013297.
HOGENOMiHOG000263533.
HOVERGENiHBG054408.
InParanoidiQ9P016.
OMAiMTLFTRQ.
OrthoDBiEOG091G0MPN.
PhylomeDBiQ9P016.
TreeFamiTF332126.

Miscellaneous databases

EvolutionaryTraceiQ9P016.
GeneWikiiTHYN1.
GenomeRNAii29087.
PROiQ9P016.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000151500.
CleanExiHS_THYN1.
ExpressionAtlasiQ9P016. baseline and differential.
GenevisibleiQ9P016. HS.

Family and domain databases

Gene3Di3.10.590.10. 1 hit.
InterProiIPR002740. EVE_domain.
IPR015947. PUA-like_domain.
[Graphical view]
PfamiPF01878. EVE. 1 hit.
[Graphical view]
SUPFAMiSSF88697. SSF88697. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTHYN1_HUMAN
AccessioniPrimary (citable) accession number: Q9P016
Secondary accession number(s): Q567Q2, Q9H3L4, Q9HC20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.