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Q9P015

- RM15_HUMAN

UniProt

Q9P015 - RM15_HUMAN

Protein

39S ribosomal protein L15, mitochondrial

Gene

MRPL15

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. translation Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    39S ribosomal protein L15, mitochondrial
    Short name:
    L15mt
    Short name:
    MRP-L15
    Gene namesi
    Name:MRPL15
    ORF Names:HSPC145
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:14054. MRPL15.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. large ribosomal subunit Source: InterPro
    2. mitochondrion Source: LIFEdb

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30944.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2121MitochondrionBy similarityAdd
    BLAST
    Chaini22 – 29627539S ribosomal protein L15, mitochondrialPRO_0000257838Add
    BLAST

    Proteomic databases

    MaxQBiQ9P015.
    PaxDbiQ9P015.
    PeptideAtlasiQ9P015.
    PRIDEiQ9P015.

    PTM databases

    PhosphoSiteiQ9P015.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9P015.
    BgeeiQ9P015.
    CleanExiHS_MRPL15.
    GenevestigatoriQ9P015.

    Organism-specific databases

    HPAiHPA044425.

    Interactioni

    Protein-protein interaction databases

    BioGridi118857. 34 interactions.
    IntActiQ9P015. 5 interactions.
    MINTiMINT-3066248.
    STRINGi9606.ENSP00000260102.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9P015.
    SMRiQ9P015. Positions 22-177.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi38 – 6427Arg-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ribosomal protein L15P family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0200.
    HOGENOMiHOG000231264.
    HOVERGENiHBG088294.
    InParanoidiQ9P015.
    KOiK02876.
    OMAiHGAGNKG.
    OrthoDBiEOG7NKKNG.
    PhylomeDBiQ9P015.
    TreeFamiTF105918.

    Family and domain databases

    HAMAPiMF_01341. Ribosomal_L15.
    InterProiIPR005749. Ribosomal_L15_bac-type.
    IPR021131. Ribosomal_L18e/L15P.
    [Graphical view]
    PANTHERiPTHR12934. PTHR12934. 1 hit.
    PfamiPF00828. Ribosomal_L18e. 1 hit.
    [Graphical view]
    SUPFAMiSSF52080. SSF52080. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9P015-1 [UniParc]FASTAAdd to Basket

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    MAGPLQGGGA RALDLLRGLP RVSLANLKPN PGSKKPERRP RGRRRGRKCG    50
    RGHKGERQRG TRPRLGFEGG QTPFYIRIPK YGFNEGHSFR RQYKPLSLNR 100
    LQYLIDLGRV DPSQPIDLTQ LVNGRGVTIQ PLKRDYGVQL VEEGADTFTA 150
    KVNIEVQLAS ELAIAAIEKN GGVVTTAFYD PRSLDIVCKP VPFFLRGQPI 200
    PKRMLPPEEL VPYYTDAKNR GYLADPAKFP EARLELARKY GYILPDITKD 250
    ELFKMLCTRK DPRQIFFGLA PGWVVNMADK KILKPTDENL LKYYTS 296
    Length:296
    Mass (Da):33,420
    Last modified:October 1, 2000 - v1
    Checksum:iD7396086F808A72C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti96 – 961L → M in CAB66600. (PubMed:11230166)Curated
    Sequence conflicti96 – 961L → M in CAG38562. 1 PublicationCurated
    Sequence conflicti137 – 1371G → D in CAB66600. (PubMed:11230166)Curated
    Sequence conflicti137 – 1371G → D in CAG38562. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF161494 mRNA. Translation: AAF29109.1.
    AL136665 mRNA. Translation: CAB66600.1.
    CR533531 mRNA. Translation: CAG38562.1.
    BC000891 mRNA. Translation: AAH00891.1.
    AB051619 Genomic DNA. Translation: BAB54947.1.
    CCDSiCCDS6158.1.
    RefSeqiNP_054894.1. NM_014175.3.
    UniGeneiHs.18349.

    Genome annotation databases

    EnsembliENST00000260102; ENSP00000260102; ENSG00000137547.
    GeneIDi29088.
    KEGGihsa:29088.
    UCSCiuc003xsa.2. human.

    Polymorphism databases

    DMDMi74734761.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF161494 mRNA. Translation: AAF29109.1 .
    AL136665 mRNA. Translation: CAB66600.1 .
    CR533531 mRNA. Translation: CAG38562.1 .
    BC000891 mRNA. Translation: AAH00891.1 .
    AB051619 Genomic DNA. Translation: BAB54947.1 .
    CCDSi CCDS6158.1.
    RefSeqi NP_054894.1. NM_014175.3.
    UniGenei Hs.18349.

    3D structure databases

    ProteinModelPortali Q9P015.
    SMRi Q9P015. Positions 22-177.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118857. 34 interactions.
    IntActi Q9P015. 5 interactions.
    MINTi MINT-3066248.
    STRINGi 9606.ENSP00000260102.

    PTM databases

    PhosphoSitei Q9P015.

    Polymorphism databases

    DMDMi 74734761.

    Proteomic databases

    MaxQBi Q9P015.
    PaxDbi Q9P015.
    PeptideAtlasi Q9P015.
    PRIDEi Q9P015.

    Protocols and materials databases

    DNASUi 29088.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000260102 ; ENSP00000260102 ; ENSG00000137547 .
    GeneIDi 29088.
    KEGGi hsa:29088.
    UCSCi uc003xsa.2. human.

    Organism-specific databases

    CTDi 29088.
    GeneCardsi GC08P055097.
    HGNCi HGNC:14054. MRPL15.
    HPAi HPA044425.
    MIMi 611828. gene.
    neXtProti NX_Q9P015.
    PharmGKBi PA30944.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0200.
    HOGENOMi HOG000231264.
    HOVERGENi HBG088294.
    InParanoidi Q9P015.
    KOi K02876.
    OMAi HGAGNKG.
    OrthoDBi EOG7NKKNG.
    PhylomeDBi Q9P015.
    TreeFami TF105918.

    Miscellaneous databases

    ChiTaRSi MRPL15. human.
    GeneWikii MRPL15.
    GenomeRNAii 29088.
    NextBioi 52090.
    PROi Q9P015.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9P015.
    Bgeei Q9P015.
    CleanExi HS_MRPL15.
    Genevestigatori Q9P015.

    Family and domain databases

    HAMAPi MF_01341. Ribosomal_L15.
    InterProi IPR005749. Ribosomal_L15_bac-type.
    IPR021131. Ribosomal_L18e/L15P.
    [Graphical view ]
    PANTHERi PTHR12934. PTHR12934. 1 hit.
    Pfami PF00828. Ribosomal_L18e. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52080. SSF52080. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
      Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
      , Gu J., Chen S.-J., Chen Z.
      Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Blood.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Fetal brain.
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cervix.
    5. "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
      Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
      Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 259-296.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRM15_HUMAN
    AccessioniPrimary (citable) accession number: Q9P015
    Secondary accession number(s): Q96Q54, Q9H0Y1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. Ribosomal proteins
      Ribosomal proteins families and list of entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3