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Q9P015

- RM15_HUMAN

UniProt

Q9P015 - RM15_HUMAN

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Protein

39S ribosomal protein L15, mitochondrial

Gene

MRPL15

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L15, mitochondrial
Short name:
L15mt
Short name:
MRP-L15
Gene namesi
Name:MRPL15
ORF Names:HSPC145
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:14054. MRPL15.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. large ribosomal subunit Source: InterPro
  2. mitochondrion Source: LIFEdb
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30944.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2121MitochondrionBy similarityAdd
BLAST
Chaini22 – 29627539S ribosomal protein L15, mitochondrialPRO_0000257838Add
BLAST

Proteomic databases

MaxQBiQ9P015.
PaxDbiQ9P015.
PeptideAtlasiQ9P015.
PRIDEiQ9P015.

PTM databases

PhosphoSiteiQ9P015.

Expressioni

Gene expression databases

BgeeiQ9P015.
CleanExiHS_MRPL15.
ExpressionAtlasiQ9P015. baseline and differential.
GenevestigatoriQ9P015.

Organism-specific databases

HPAiHPA044425.

Interactioni

Protein-protein interaction databases

BioGridi118857. 41 interactions.
IntActiQ9P015. 5 interactions.
MINTiMINT-3066248.
STRINGi9606.ENSP00000260102.

Structurei

3D structure databases

ProteinModelPortaliQ9P015.
SMRiQ9P015. Positions 22-223.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi38 – 6427Arg-richAdd
BLAST

Sequence similaritiesi

Belongs to the ribosomal protein L15P family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0200.
GeneTreeiENSGT00390000009040.
HOGENOMiHOG000231264.
HOVERGENiHBG088294.
InParanoidiQ9P015.
KOiK02876.
OMAiHGAGNKG.
OrthoDBiEOG7NKKNG.
PhylomeDBiQ9P015.
TreeFamiTF105918.

Family and domain databases

HAMAPiMF_01341. Ribosomal_L15.
InterProiIPR005749. Ribosomal_L15_bac-type.
IPR021131. Ribosomal_L18e/L15P.
[Graphical view]
PANTHERiPTHR12934. PTHR12934. 1 hit.
PfamiPF00828. Ribosomal_L18e. 1 hit.
[Graphical view]
SUPFAMiSSF52080. SSF52080. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9P015-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGPLQGGGA RALDLLRGLP RVSLANLKPN PGSKKPERRP RGRRRGRKCG
60 70 80 90 100
RGHKGERQRG TRPRLGFEGG QTPFYIRIPK YGFNEGHSFR RQYKPLSLNR
110 120 130 140 150
LQYLIDLGRV DPSQPIDLTQ LVNGRGVTIQ PLKRDYGVQL VEEGADTFTA
160 170 180 190 200
KVNIEVQLAS ELAIAAIEKN GGVVTTAFYD PRSLDIVCKP VPFFLRGQPI
210 220 230 240 250
PKRMLPPEEL VPYYTDAKNR GYLADPAKFP EARLELARKY GYILPDITKD
260 270 280 290
ELFKMLCTRK DPRQIFFGLA PGWVVNMADK KILKPTDENL LKYYTS
Length:296
Mass (Da):33,420
Last modified:October 1, 2000 - v1
Checksum:iD7396086F808A72C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti96 – 961L → M in CAB66600. (PubMed:11230166)Curated
Sequence conflicti96 – 961L → M in CAG38562. 1 PublicationCurated
Sequence conflicti137 – 1371G → D in CAB66600. (PubMed:11230166)Curated
Sequence conflicti137 – 1371G → D in CAG38562. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF161494 mRNA. Translation: AAF29109.1.
AL136665 mRNA. Translation: CAB66600.1.
CR533531 mRNA. Translation: CAG38562.1.
BC000891 mRNA. Translation: AAH00891.1.
AB051619 Genomic DNA. Translation: BAB54947.1.
CCDSiCCDS6158.1.
RefSeqiNP_054894.1. NM_014175.3.
UniGeneiHs.18349.

Genome annotation databases

EnsembliENST00000260102; ENSP00000260102; ENSG00000137547.
GeneIDi29088.
KEGGihsa:29088.
UCSCiuc003xsa.2. human.

Polymorphism databases

DMDMi74734761.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF161494 mRNA. Translation: AAF29109.1 .
AL136665 mRNA. Translation: CAB66600.1 .
CR533531 mRNA. Translation: CAG38562.1 .
BC000891 mRNA. Translation: AAH00891.1 .
AB051619 Genomic DNA. Translation: BAB54947.1 .
CCDSi CCDS6158.1.
RefSeqi NP_054894.1. NM_014175.3.
UniGenei Hs.18349.

3D structure databases

ProteinModelPortali Q9P015.
SMRi Q9P015. Positions 22-223.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118857. 41 interactions.
IntActi Q9P015. 5 interactions.
MINTi MINT-3066248.
STRINGi 9606.ENSP00000260102.

PTM databases

PhosphoSitei Q9P015.

Polymorphism databases

DMDMi 74734761.

Proteomic databases

MaxQBi Q9P015.
PaxDbi Q9P015.
PeptideAtlasi Q9P015.
PRIDEi Q9P015.

Protocols and materials databases

DNASUi 29088.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000260102 ; ENSP00000260102 ; ENSG00000137547 .
GeneIDi 29088.
KEGGi hsa:29088.
UCSCi uc003xsa.2. human.

Organism-specific databases

CTDi 29088.
GeneCardsi GC08P055097.
HGNCi HGNC:14054. MRPL15.
HPAi HPA044425.
MIMi 611828. gene.
neXtProti NX_Q9P015.
PharmGKBi PA30944.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0200.
GeneTreei ENSGT00390000009040.
HOGENOMi HOG000231264.
HOVERGENi HBG088294.
InParanoidi Q9P015.
KOi K02876.
OMAi HGAGNKG.
OrthoDBi EOG7NKKNG.
PhylomeDBi Q9P015.
TreeFami TF105918.

Miscellaneous databases

ChiTaRSi MRPL15. human.
GeneWikii MRPL15.
GenomeRNAii 29088.
NextBioi 52090.
PROi Q9P015.
SOURCEi Search...

Gene expression databases

Bgeei Q9P015.
CleanExi HS_MRPL15.
ExpressionAtlasi Q9P015. baseline and differential.
Genevestigatori Q9P015.

Family and domain databases

HAMAPi MF_01341. Ribosomal_L15.
InterProi IPR005749. Ribosomal_L15_bac-type.
IPR021131. Ribosomal_L18e/L15P.
[Graphical view ]
PANTHERi PTHR12934. PTHR12934. 1 hit.
Pfami PF00828. Ribosomal_L18e. 1 hit.
[Graphical view ]
SUPFAMi SSF52080. SSF52080. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Blood.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal brain.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cervix.
  5. "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
    Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
    Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 259-296.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRM15_HUMAN
AccessioniPrimary (citable) accession number: Q9P015
Secondary accession number(s): Q96Q54, Q9H0Y1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3