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Protein

39S ribosomal protein L15, mitochondrial

Gene

MRPL15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137547-MONOMER.
ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L15, mitochondrial
Short name:
L15mt
Short name:
MRP-L15
Gene namesi
Name:MRPL15
ORF Names:HSPC145
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:14054. MRPL15.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000137547.
PharmGKBiPA30944.

Polymorphism and mutation databases

BioMutaiMRPL15.
DMDMi74734761.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 21MitochondrionBy similarityAdd BLAST21
ChainiPRO_000025783822 – 29639S ribosomal protein L15, mitochondrialAdd BLAST275

Proteomic databases

EPDiQ9P015.
MaxQBiQ9P015.
PaxDbiQ9P015.
PeptideAtlasiQ9P015.
PRIDEiQ9P015.

PTM databases

iPTMnetiQ9P015.
PhosphoSitePlusiQ9P015.
SwissPalmiQ9P015.

Expressioni

Gene expression databases

BgeeiENSG00000137547.
CleanExiHS_MRPL15.
ExpressionAtlasiQ9P015. baseline and differential.
GenevisibleiQ9P015. HS.

Organism-specific databases

HPAiHPA044425.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CCNDBP1O952736EBI-2371967,EBI-748961
RUNDC3AQ59EK93EBI-2371967,EBI-747225

Protein-protein interaction databases

BioGridi118857. 58 interactors.
IntActiQ9P015. 12 interactors.
MINTiMINT-3066248.
STRINGi9606.ENSP00000260102.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40M1-296[»]
3J9Melectron microscopy3.50M1-296[»]
ProteinModelPortaliQ9P015.
SMRiQ9P015.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi38 – 64Arg-richAdd BLAST27

Sequence similaritiesi

Belongs to the ribosomal protein L15P family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0846. Eukaryota.
COG0200. LUCA.
GeneTreeiENSGT00390000009040.
HOGENOMiHOG000231264.
HOVERGENiHBG088294.
InParanoidiQ9P015.
KOiK02876.
OMAiINIEVQH.
OrthoDBiEOG091G0VT9.
PhylomeDBiQ9P015.
TreeFamiTF105918.

Family and domain databases

HAMAPiMF_01341. Ribosomal_L15. 1 hit.
InterProiIPR030878. Ribosomal_L15.
IPR005749. Ribosomal_L15_bac-type.
IPR021131. Ribosomal_L18e/L15P.
[Graphical view]
PANTHERiPTHR12934. PTHR12934. 1 hit.
PfamiPF00828. Ribosomal_L27A. 1 hit.
[Graphical view]
SUPFAMiSSF52080. SSF52080. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9P015-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPLQGGGA RALDLLRGLP RVSLANLKPN PGSKKPERRP RGRRRGRKCG
60 70 80 90 100
RGHKGERQRG TRPRLGFEGG QTPFYIRIPK YGFNEGHSFR RQYKPLSLNR
110 120 130 140 150
LQYLIDLGRV DPSQPIDLTQ LVNGRGVTIQ PLKRDYGVQL VEEGADTFTA
160 170 180 190 200
KVNIEVQLAS ELAIAAIEKN GGVVTTAFYD PRSLDIVCKP VPFFLRGQPI
210 220 230 240 250
PKRMLPPEEL VPYYTDAKNR GYLADPAKFP EARLELARKY GYILPDITKD
260 270 280 290
ELFKMLCTRK DPRQIFFGLA PGWVVNMADK KILKPTDENL LKYYTS
Length:296
Mass (Da):33,420
Last modified:October 1, 2000 - v1
Checksum:iD7396086F808A72C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96L → M in CAB66600 (PubMed:11230166).Curated1
Sequence conflicti96L → M in CAG38562 (Ref. 3) Curated1
Sequence conflicti137G → D in CAB66600 (PubMed:11230166).Curated1
Sequence conflicti137G → D in CAG38562 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161494 mRNA. Translation: AAF29109.1.
AL136665 mRNA. Translation: CAB66600.1.
CR533531 mRNA. Translation: CAG38562.1.
BC000891 mRNA. Translation: AAH00891.1.
AB051619 Genomic DNA. Translation: BAB54947.1.
CCDSiCCDS6158.1.
RefSeqiNP_054894.1. NM_014175.3.
UniGeneiHs.18349.

Genome annotation databases

EnsembliENST00000260102; ENSP00000260102; ENSG00000137547.
GeneIDi29088.
KEGGihsa:29088.
UCSCiuc003xsa.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161494 mRNA. Translation: AAF29109.1.
AL136665 mRNA. Translation: CAB66600.1.
CR533531 mRNA. Translation: CAG38562.1.
BC000891 mRNA. Translation: AAH00891.1.
AB051619 Genomic DNA. Translation: BAB54947.1.
CCDSiCCDS6158.1.
RefSeqiNP_054894.1. NM_014175.3.
UniGeneiHs.18349.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40M1-296[»]
3J9Melectron microscopy3.50M1-296[»]
ProteinModelPortaliQ9P015.
SMRiQ9P015.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118857. 58 interactors.
IntActiQ9P015. 12 interactors.
MINTiMINT-3066248.
STRINGi9606.ENSP00000260102.

PTM databases

iPTMnetiQ9P015.
PhosphoSitePlusiQ9P015.
SwissPalmiQ9P015.

Polymorphism and mutation databases

BioMutaiMRPL15.
DMDMi74734761.

Proteomic databases

EPDiQ9P015.
MaxQBiQ9P015.
PaxDbiQ9P015.
PeptideAtlasiQ9P015.
PRIDEiQ9P015.

Protocols and materials databases

DNASUi29088.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260102; ENSP00000260102; ENSG00000137547.
GeneIDi29088.
KEGGihsa:29088.
UCSCiuc003xsa.3. human.

Organism-specific databases

CTDi29088.
GeneCardsiMRPL15.
HGNCiHGNC:14054. MRPL15.
HPAiHPA044425.
MIMi611828. gene.
neXtProtiNX_Q9P015.
OpenTargetsiENSG00000137547.
PharmGKBiPA30944.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0846. Eukaryota.
COG0200. LUCA.
GeneTreeiENSGT00390000009040.
HOGENOMiHOG000231264.
HOVERGENiHBG088294.
InParanoidiQ9P015.
KOiK02876.
OMAiINIEVQH.
OrthoDBiEOG091G0VT9.
PhylomeDBiQ9P015.
TreeFamiTF105918.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000137547-MONOMER.
ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Miscellaneous databases

ChiTaRSiMRPL15. human.
GeneWikiiMRPL15.
GenomeRNAii29088.
PROiQ9P015.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000137547.
CleanExiHS_MRPL15.
ExpressionAtlasiQ9P015. baseline and differential.
GenevisibleiQ9P015. HS.

Family and domain databases

HAMAPiMF_01341. Ribosomal_L15. 1 hit.
InterProiIPR030878. Ribosomal_L15.
IPR005749. Ribosomal_L15_bac-type.
IPR021131. Ribosomal_L18e/L15P.
[Graphical view]
PANTHERiPTHR12934. PTHR12934. 1 hit.
PfamiPF00828. Ribosomal_L27A. 1 hit.
[Graphical view]
SUPFAMiSSF52080. SSF52080. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRM15_HUMAN
AccessioniPrimary (citable) accession number: Q9P015
Secondary accession number(s): Q96Q54, Q9H0Y1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.