Q9P015 (RM15_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
39S ribosomal protein L15, mitochondrial
Short name=L15mt
Short name=MRP-L15

Gene names

Name:	MRPL15
ORF Names:	HSPC145

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	296 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the ribosomal protein L15P family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	translation Inferred from electronic annotation. Source: InterPro
Cellular_component	large ribosomal subunit Inferred from electronic annotation. Source: InterPro mitochondrion Inferred from direct assay. Source: LIFEdb
Molecular_function	structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 21	21	Mitochondrion By similarity
	Chain	22 – 296	275	39S ribosomal protein L15, mitochondrial		PRO_0000257838
Regions
	Compositional bias	38 – 64	27	Arg-rich
Experimental info
	Sequence conflict	96	1	L → M in CAB66600. Ref.2
	Sequence conflict	96	1	L → M in CAG38562. Ref.3
	Sequence conflict	137	1	G → D in CAB66600. Ref.2
	Sequence conflict	137	1	G → D in CAG38562. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q9P015 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: D7396086F808A72C	FASTA	296	33,420
	10 20 30 40 50 60 MAGPLQGGGA RALDLLRGLP RVSLANLKPN PGSKKPERRP RGRRRGRKCG RGHKGERQRG 70 80 90 100 110 120 TRPRLGFEGG QTPFYIRIPK YGFNEGHSFR RQYKPLSLNR LQYLIDLGRV DPSQPIDLTQ 130 140 150 160 170 180 LVNGRGVTIQ PLKRDYGVQL VEEGADTFTA KVNIEVQLAS ELAIAAIEKN GGVVTTAFYD 190 200 210 220 230 240 PRSLDIVCKP VPFFLRGQPI PKRMLPPEEL VPYYTDAKNR GYLADPAKFP EARLELARKY 250 260 270 280 290 GYILPDITKD ELFKMLCTRK DPRQIFFGLA PGWVVNMADK KILKPTDENL LKYYTS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. , Gu J., Chen S.-J., Chen Z. Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Blood.
[2]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Fetal brain.
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cervix.
[5]	"The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders." Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T. Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 259-296.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF161494 mRNA. Translation: AAF29109.1. AL136665 mRNA. Translation: CAB66600.1. CR533531 mRNA. Translation: CAG38562.1. BC000891 mRNA. Translation: AAH00891.1. AB051619 Genomic DNA. Translation: BAB54947.1.
IPI	IPI00023086.
RefSeq	NP_054894.1. NM_014175.3.
UniGene	Hs.18349.
3D structure databases
ProteinModelPortal	Q9P015.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9P015. 3 interactions.
STRING	9606.ENSP00000260102.
PTM databases
PhosphoSite	Q9P015.
Polymorphism databases
DMDM	74734761.
Proteomic databases
PaxDb	Q9P015.
PeptideAtlas	Q9P015.
PRIDE	Q9P015.
Protocols and materials databases
DNASU	29088.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000260102; ENSP00000260102; ENSG00000137547.
GeneID	29088.
KEGG	hsa:29088.
UCSC	uc003xsa.2. human.
Organism-specific databases
CTD	29088.
GeneCards	GC08P055097.
HGNC	HGNC:14054. MRPL15.
HPA	HPA044425.
MIM	611828. gene.
neXtProt	NX_Q9P015.
PharmGKB	PA30944.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0200.
HOGENOM	HOG000231264.
HOVERGEN	HBG088294.
InParanoid	Q9P015.
KO	K02876.
OMA	RRQYQPL.
OrthoDB	EOG441QC5.
PhylomeDB	Q9P015.
Gene expression databases
ArrayExpress	Q9P015.
Bgee	Q9P015.
CleanEx	HS_MRPL15.
Genevestigator	Q9P015.
GermOnline	ENSG00000137547. Homo sapiens.
Family and domain databases
InterPro	IPR005749. Ribosomal_L15_bac-type. IPR021131. Ribosomal_L18e/L15P. [Graphical view]
PANTHER	PTHR12934. PTHR12934. 1 hit.
Pfam	PF00828. Ribosomal_L18e. 1 hit. [Graphical view]
SUPFAM	SSF52080. Ribosomal_L18e/L15. 1 hit.
PROSITE	PS00475. RIBOSOMAL_L15. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	MRPL15. human.
GenomeRNAi	29088.
NextBio	52090.
SOURCE	Search...

Entry information

Entry name

RM15_HUMAN

Accession

Primary (citable) accession number: Q9P015
Secondary accession number(s): Q96Q54, Q9H0Y1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.