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Protein

Spliceosome-associated protein CWC15 homolog

Gene

CWC15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Spliceosome-associated protein CWC15 homolog
Gene namesi
Name:CWC15
Synonyms:C11orf5
ORF Names:AD-002, HSPC148
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000150316.11.
HGNCiHGNC:26939. CWC15.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi51503.
OpenTargetsiENSG00000150316.
PharmGKBiPA162383026.

Polymorphism and mutation databases

BioMutaiCWC15.
DMDMi150438891.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002915432 – 229Spliceosome-associated protein CWC15 homologAdd BLAST228

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonine1 Publication1
Modified residuei18N6-acetyllysineBy similarity1
Modified residuei47PhosphothreonineCombined sources1
Modified residuei110PhosphothreonineCombined sources1
Modified residuei121PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9P013.
MaxQBiQ9P013.
PeptideAtlasiQ9P013.
PRIDEiQ9P013.
TopDownProteomicsiQ9P013.

PTM databases

iPTMnetiQ9P013.
PhosphoSitePlusiQ9P013.

Expressioni

Gene expression databases

BgeeiENSG00000150316.
CleanExiHS_CWC15.
GenevisibleiQ9P013. HS.

Organism-specific databases

HPAiHPA039878.

Interactioni

Subunit structurei

Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts directly with CTNNBL1 in the complex.1 Publication

Protein-protein interaction databases

BioGridi119575. 26 interactors.
CORUMiQ9P013.
IntActiQ9P013. 24 interactors.
MINTiMINT-3077614.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5MQFelectron microscopy5.90R1-229[»]
ProteinModelPortaliQ9P013.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili123 – 165Sequence analysisAdd BLAST43

Sequence similaritiesi

Belongs to the CWC15 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00390000012084.
HOGENOMiHOG000214250.
HOVERGENiHBG107412.
InParanoidiQ9P013.
KOiK12863.
OMAiFKNCARS.
OrthoDBiEOG091G0TA6.
PhylomeDBiQ9P013.

Family and domain databases

InterProiView protein in InterPro
IPR006973. Cwf_Cwc_15.
PANTHERiPTHR12718. PTHR12718. 1 hit.
PfamiView protein in Pfam
PF04889. Cwf_Cwc_15. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9P013-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTAARPTFE PARGGRGKGE GDLSQLSKQY SSRDLPSHTK IKYRQTTQDA
60 70 80 90 100
PEEVRNRDFR RELEERERAA AREKNRDRPT REHTTSSSVS KKPRLDQIPA
110 120 130 140 150
ANLDADDPLT DEEDEDFEEE SDDDDTAALL AELEKIKKER AEEQARKEQE
160 170 180 190 200
QKAEEERIRM ENILSGNPLL NLTGPSQPQA NFKVKRRWDD DVVFKNCAKG
210 220
VDDQKKDKRF VNDTLRSEFH KKFMEKYIK
Length:229
Mass (Da):26,624
Last modified:June 26, 2007 - v2
Checksum:iB21E6EEF46C4427C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti148E → D in AAF29112 (PubMed:11042152).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ250393 mRNA. Translation: CAB96541.1.
AF161497 mRNA. Translation: AAF29112.1.
AF110775 mRNA. Translation: AAF14858.1.
AK314900 mRNA. Translation: BAG37414.1.
BC006975 mRNA. Translation: AAH06975.1. Different termination.
BC032629 mRNA. Translation: AAH32629.1. Different termination.
BC040946 mRNA. Translation: AAH40946.1.
CCDSiCCDS73369.1.
RefSeqiNP_057487.2. NM_016403.3.
XP_011541170.1. XM_011542868.2.
XP_016873405.1. XM_017017916.1.
UniGeneiHs.503597.

Genome annotation databases

EnsembliENST00000279839; ENSP00000475615; ENSG00000150316.
GeneIDi51503.
KEGGihsa:51503.
UCSCiuc031ybh.1. human.

Similar proteinsi

Entry informationi

Entry nameiCWC15_HUMAN
AccessioniPrimary (citable) accession number: Q9P013
Secondary accession number(s): B2RC17
, Q05BV9, Q05DM1, Q9UI29
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 26, 2007
Last modified: September 27, 2017
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Has been termed C11orf5, but is not the official C11orf5 as defined by HGNC.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families