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Protein

Protein cornichon homolog 4

Gene

CNIH4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery (PubMed:24405750).1 Publication

GO - Molecular functioni

  • CCR5 chemokine receptor binding Source: UniProtKB

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: UniProtKB
  • protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein cornichon homolog 4
Short name:
CNIH-4
Alternative name(s):
Cornichon family AMPA receptor auxiliary protein 4
Gene namesi
Name:CNIH4
ORF Names:HSPC163
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:25013. CNIH4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521HelicalSequence analysisAdd
BLAST
Transmembranei57 – 7721HelicalSequence analysisAdd
BLAST
Transmembranei118 – 13821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum Source: UniProtKB
  • endoplasmic reticulum-Golgi intermediate compartment Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672091.

Polymorphism and mutation databases

DMDMi12229837.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 139139Protein cornichon homolog 4PRO_0000122230Add
BLAST

Proteomic databases

EPDiQ9P003.
MaxQBiQ9P003.
PaxDbiQ9P003.
PeptideAtlasiQ9P003.
PRIDEiQ9P003.

PTM databases

SwissPalmiQ9P003.

Expressioni

Gene expression databases

BgeeiQ9P003.
CleanExiHS_CNIH4.
ExpressionAtlasiQ9P003. baseline and differential.
GenevisibleiQ9P003. HS.

Organism-specific databases

HPAiHPA044268.

Interactioni

Subunit structurei

Interacts with Sec23/24 complex components SEC24B and SEC24D (PubMed:24405750). Interacts with CCR5 (PubMed:24405750). Interacts with ADRB2 in the early secretory pathway (PubMed:24405750).1 Publication

GO - Molecular functioni

  • CCR5 chemokine receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi118865. 5 interactions.
IntActiQ9P003. 2 interactions.
MINTiMINT-3077512.
STRINGi9606.ENSP00000420443.

Structurei

3D structure databases

ProteinModelPortaliQ9P003.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cornichon family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2729. Eukaryota.
ENOG4111MWH. LUCA.
GeneTreeiENSGT00390000015751.
HOGENOMiHOG000214661.
HOVERGENiHBG003814.
InParanoidiQ9P003.
OMAiHWFIFIL.
OrthoDBiEOG7GTT65.
PhylomeDBiQ9P003.
TreeFamiTF300083.

Family and domain databases

InterProiIPR003377. Cornichon.
[Graphical view]
PfamiPF03311. Cornichon. 1 hit.
[Graphical view]
SMARTiSM01398. Cornichon. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9P003-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAVVFVFSL LDCCALIFLS VYFIITLSDL ECDYINARSC CSKLNKWVIP
60 70 80 90 100
ELIGHTIVTV LLLMSLHWFI FLLNLPVATW NIYRYIMVPS GNMGVFDPTE
110 120 130
IHNRGQLKSH MKEAMIKLGF HLLCFFMYLY SMILALIND
Length:139
Mass (Da):16,093
Last modified:October 1, 2000 - v1
Checksum:i9452E9BDEC2A8DEF
GO
Isoform 2 (identifier: Q9P003-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     85-131: Missing.

Show »
Length:92
Mass (Da):10,615
Checksum:iA99857E36401B352
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti3 – 31A → G.
Corresponds to variant rs12123896 [ dbSNP | Ensembl ].
VAR_048830

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei85 – 13147Missing in isoform 2. 2 PublicationsVSP_013466Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161512 mRNA. Translation: AAF29127.1.
AL136930 mRNA. Translation: CAB66864.1.
AK289973 mRNA. Translation: BAF82662.1.
AK312064 mRNA. Translation: BAG35000.1.
CH471098 Genomic DNA. Translation: EAW69717.1.
CH471098 Genomic DNA. Translation: EAW69719.1.
BC000573 mRNA. Translation: AAH00573.1.
CCDSiCCDS1543.1. [Q9P003-1]
CCDS60430.1. [Q9P003-2]
RefSeqiNP_001264126.1. NM_001277197.1. [Q9P003-2]
NP_054903.1. NM_014184.3. [Q9P003-1]
UniGeneiHs.445890.

Genome annotation databases

EnsembliENST00000366857; ENSP00000355822; ENSG00000143771. [Q9P003-2]
ENST00000465271; ENSP00000420443; ENSG00000143771. [Q9P003-1]
GeneIDi29097.
KEGGihsa:29097.
UCSCiuc001hom.3. human. [Q9P003-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161512 mRNA. Translation: AAF29127.1.
AL136930 mRNA. Translation: CAB66864.1.
AK289973 mRNA. Translation: BAF82662.1.
AK312064 mRNA. Translation: BAG35000.1.
CH471098 Genomic DNA. Translation: EAW69717.1.
CH471098 Genomic DNA. Translation: EAW69719.1.
BC000573 mRNA. Translation: AAH00573.1.
CCDSiCCDS1543.1. [Q9P003-1]
CCDS60430.1. [Q9P003-2]
RefSeqiNP_001264126.1. NM_001277197.1. [Q9P003-2]
NP_054903.1. NM_014184.3. [Q9P003-1]
UniGeneiHs.445890.

3D structure databases

ProteinModelPortaliQ9P003.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118865. 5 interactions.
IntActiQ9P003. 2 interactions.
MINTiMINT-3077512.
STRINGi9606.ENSP00000420443.

PTM databases

SwissPalmiQ9P003.

Polymorphism and mutation databases

DMDMi12229837.

Proteomic databases

EPDiQ9P003.
MaxQBiQ9P003.
PaxDbiQ9P003.
PeptideAtlasiQ9P003.
PRIDEiQ9P003.

Protocols and materials databases

DNASUi29097.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366857; ENSP00000355822; ENSG00000143771. [Q9P003-2]
ENST00000465271; ENSP00000420443; ENSG00000143771. [Q9P003-1]
GeneIDi29097.
KEGGihsa:29097.
UCSCiuc001hom.3. human. [Q9P003-1]

Organism-specific databases

CTDi29097.
GeneCardsiCNIH4.
HGNCiHGNC:25013. CNIH4.
HPAiHPA044268.
neXtProtiNX_Q9P003.
PharmGKBiPA142672091.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2729. Eukaryota.
ENOG4111MWH. LUCA.
GeneTreeiENSGT00390000015751.
HOGENOMiHOG000214661.
HOVERGENiHBG003814.
InParanoidiQ9P003.
OMAiHWFIFIL.
OrthoDBiEOG7GTT65.
PhylomeDBiQ9P003.
TreeFamiTF300083.

Miscellaneous databases

ChiTaRSiCNIH4. human.
GeneWikiiCNIH4.
GenomeRNAii29097.
PROiQ9P003.

Gene expression databases

BgeeiQ9P003.
CleanExiHS_CNIH4.
ExpressionAtlasiQ9P003. baseline and differential.
GenevisibleiQ9P003. HS.

Family and domain databases

InterProiIPR003377. Cornichon.
[Graphical view]
PfamiPF03311. Cornichon. 1 hit.
[Graphical view]
SMARTiSM01398. Cornichon. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Umbilical cord blood.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Uterus.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Cerebellum and Hippocampus.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "CNIH4 interacts with newly synthesized GPCR and controls their export from the endoplasmic reticulum."
    Sauvageau E., Rochdi M.D., Oueslati M., Hamdan F.F., Percherancier Y., Simpson J.C., Pepperkok R., Bouvier M.
    Traffic 15:383-400(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CCR5; ADRB2; SEC24B AND SEC24D.

Entry informationi

Entry nameiCNIH4_HUMAN
AccessioniPrimary (citable) accession number: Q9P003
Secondary accession number(s): A8K1Q8, B2R553, Q9H0X8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: October 1, 2000
Last modified: July 6, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.