Q9P000 (COMD9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
COMM domain-containing protein 9

Gene names

Name:	COMMD9
ORF Names:	HSPC166

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	198 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Tissue specificity	Ubiquitous. Ref.1
Sequence similarities	Contains 1 COMM domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9P000-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9P000-2)

The sequence of this isoform differs from the canonical sequence as follows:
     18-59: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 198	198	COMM domain-containing protein 9		PRO_0000077403
Regions
	Domain	122 – 196	75	COMM
Natural variations
	Alternative sequence	18 – 59	42	Missing in isoform 2.		VSP_041499
Experimental info
	Sequence conflict	45	1	V → F in CAB66623. Ref.3
	Sequence conflict	161	1	G → R in AAS22246. Ref.1
	Sequence conflict	161	1	G → R in AAF29130. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 54DA2FE525C3A24F	FASTA	198	21,819
	10 20 30 40 50 60 MAALTAEHFA ALQSLLKASS KDVVRQLCQE SFSSSALGLK KLLDVTCSSL SVTQEEAEEL 70 80 90 100 110 120 LQALHRLTRL VAFRDLSSAE AILALFPENF HQNLKNLLTK IILEHVSTWR TEAQANQISL 130 140 150 160 170 180 PRLVDLDWRV DIKTSSDSIS RMAVPTCLLQ MKIQEDPSLC GDKPSISAVT VELSKETLDT 190 MLDGLGRIRD QLSAVASK
	Isoform 2 [UniParc]. Checksum: 9AF5728847F609AC	FASTA	156	17,333
	10 20 30 40 50 60 MAALTAEHFA ALQSLLKLLQ ALHRLTRLVA FRDLSSAEAI LALFPENFHQ NLKNLLTKII 70 80 90 100 110 120 LEHVSTWRTE AQANQISLPR LVDLDWRVDI KTSSDSISRM AVPTCLLQMK IQEDPSLCGD 130 140 150 KPSISAVTVE LSKETLDTML DGLGRIRDQL SAVASK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"COMMD proteins, a novel family of structural and functional homologs of MURR1." Burstein E., Hoberg J.E., Wilkinson A.S., Rumble J.M., Csomos R.A., Komarck C.M., Maine G.N., Wilkinson J.C., Mayo M.W., Duckett C.S. J. Biol. Chem. 280:22222-22232(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]	"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. , Gu J., Chen S.-J., Chen Z. Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Umbilical cord blood.
[3]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[4]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Skin.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY542164 mRNA. Translation: AAS22246.1. AF161515 mRNA. Translation: AAF29130.1. AL136688 mRNA. Translation: CAB66623.1. AC087277 Genomic DNA. No translation available. BC010892 mRNA. Translation: AAH10892.1.
IPI	IPI00305212. IPI00856091.
RefSeq	NP_054905.2. NM_014186.3.
UniGene	Hs.279836.
3D structure databases
ProteinModelPortal	Q9P000.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9P000. 2 interactions.
STRING	9606.ENSP00000263401.
PTM databases
PhosphoSite	Q9P000.
Polymorphism databases
DMDM	124056492.
Proteomic databases
PaxDb	Q9P000.
PeptideAtlas	Q9P000.
PRIDE	Q9P000.
Protocols and materials databases
DNASU	29099.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000263401; ENSP00000263401; ENSG00000110442. ENST00000452374; ENSP00000392510; ENSG00000110442.
GeneID	29099.
KEGG	hsa:29099.
UCSC	uc001mwn.4. human. uc009ykj.3. human.
Organism-specific databases
CTD	29099.
GeneCards	GC11M036251.
HGNC	HGNC:25014. COMMD9.
HPA	HPA009142.
MIM	612299. gene.
neXtProt	NX_Q9P000.
PharmGKB	PA134930445.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG41673.
HOGENOM	HOG000232004.
HOVERGEN	HBG080522.
InParanoid	Q9P000.
OMA	QMKIQED.
PhylomeDB	Q9P000.
Gene expression databases
ArrayExpress	Q9P000.
Bgee	Q9P000.
CleanEx	HS_COMMD9.
Genevestigator	Q9P000.
GermOnline	ENSG00000110442. Homo sapiens.
Family and domain databases
InterPro	IPR017920. COMM. IPR009886. HCaRG. [Graphical view]
Pfam	PF07258. HCaRG. 1 hit. [Graphical view]
PROSITE	PS51269. COMM. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	29099.
NextBio	52128.
SOURCE	Search...

Entry information

Entry name

COMD9_HUMAN

Accession

Primary (citable) accession number: Q9P000
Secondary accession number(s): E9PAN2, Q96FI2, Q9H0R0

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 82 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.