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Q9P000

- COMD9_HUMAN

UniProt

Q9P000 - COMD9_HUMAN

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Protein

COMM domain-containing protein 9

Gene

COMMD9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
COMM domain-containing protein 9
Gene namesi
Name:COMMD9
ORF Names:HSPC166
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:25014. COMMD9.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134930445.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 198198COMM domain-containing protein 9PRO_0000077403Add
BLAST

Proteomic databases

MaxQBiQ9P000.
PaxDbiQ9P000.
PeptideAtlasiQ9P000.
PRIDEiQ9P000.

PTM databases

PhosphoSiteiQ9P000.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiQ9P000.
CleanExiHS_COMMD9.
ExpressionAtlasiQ9P000. baseline and differential.
GenevestigatoriQ9P000.

Organism-specific databases

HPAiHPA009142.

Interactioni

Protein-protein interaction databases

BioGridi118867. 9 interactions.
IntActiQ9P000. 2 interactions.
STRINGi9606.ENSP00000263401.

Structurei

3D structure databases

ProteinModelPortaliQ9P000.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini122 – 19675COMMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 COMM domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG41673.
GeneTreeiENSGT00390000006218.
HOGENOMiHOG000232004.
HOVERGENiHBG080522.
InParanoidiQ9P000.
OMAiSTWRTEA.
OrthoDBiEOG718KDD.
PhylomeDBiQ9P000.
TreeFamiTF323880.

Family and domain databases

InterProiIPR017920. COMM.
IPR009886. HCaRG.
[Graphical view]
PfamiPF07258. HCaRG. 1 hit.
[Graphical view]
PROSITEiPS51269. COMM. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9P000-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAALTAEHFA ALQSLLKASS KDVVRQLCQE SFSSSALGLK KLLDVTCSSL
60 70 80 90 100
SVTQEEAEEL LQALHRLTRL VAFRDLSSAE AILALFPENF HQNLKNLLTK
110 120 130 140 150
IILEHVSTWR TEAQANQISL PRLVDLDWRV DIKTSSDSIS RMAVPTCLLQ
160 170 180 190
MKIQEDPSLC GDKPSISAVT VELSKETLDT MLDGLGRIRD QLSAVASK
Length:198
Mass (Da):21,819
Last modified:January 23, 2007 - v2
Checksum:i54DA2FE525C3A24F
GO
Isoform 2 (identifier: Q9P000-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     18-59: Missing.

Note: No experimental confirmation available.

Show »
Length:156
Mass (Da):17,333
Checksum:i9AF5728847F609AC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti45 – 451V → F in CAB66623. (PubMed:11230166)Curated
Sequence conflicti161 – 1611G → R in AAS22246. (PubMed:15799966)Curated
Sequence conflicti161 – 1611G → R in AAF29130. (PubMed:11042152)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei18 – 5942Missing in isoform 2. CuratedVSP_041499Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY542164 mRNA. Translation: AAS22246.1.
AF161515 mRNA. Translation: AAF29130.1.
AL136688 mRNA. Translation: CAB66623.1.
AC087277 Genomic DNA. No translation available.
BC010892 mRNA. Translation: AAH10892.1.
CCDSiCCDS44571.1. [Q9P000-2]
CCDS7900.1. [Q9P000-1]
RefSeqiNP_054905.2. NM_014186.3. [Q9P000-1]
UniGeneiHs.279836.

Genome annotation databases

EnsembliENST00000263401; ENSP00000263401; ENSG00000110442. [Q9P000-1]
ENST00000452374; ENSP00000392510; ENSG00000110442. [Q9P000-2]
GeneIDi29099.
KEGGihsa:29099.
UCSCiuc001mwn.4. human. [Q9P000-1]
uc009ykj.3. human. [Q9P000-2]

Polymorphism databases

DMDMi124056492.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY542164 mRNA. Translation: AAS22246.1 .
AF161515 mRNA. Translation: AAF29130.1 .
AL136688 mRNA. Translation: CAB66623.1 .
AC087277 Genomic DNA. No translation available.
BC010892 mRNA. Translation: AAH10892.1 .
CCDSi CCDS44571.1. [Q9P000-2 ]
CCDS7900.1. [Q9P000-1 ]
RefSeqi NP_054905.2. NM_014186.3. [Q9P000-1 ]
UniGenei Hs.279836.

3D structure databases

ProteinModelPortali Q9P000.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118867. 9 interactions.
IntActi Q9P000. 2 interactions.
STRINGi 9606.ENSP00000263401.

PTM databases

PhosphoSitei Q9P000.

Polymorphism databases

DMDMi 124056492.

Proteomic databases

MaxQBi Q9P000.
PaxDbi Q9P000.
PeptideAtlasi Q9P000.
PRIDEi Q9P000.

Protocols and materials databases

DNASUi 29099.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000263401 ; ENSP00000263401 ; ENSG00000110442 . [Q9P000-1 ]
ENST00000452374 ; ENSP00000392510 ; ENSG00000110442 . [Q9P000-2 ]
GeneIDi 29099.
KEGGi hsa:29099.
UCSCi uc001mwn.4. human. [Q9P000-1 ]
uc009ykj.3. human. [Q9P000-2 ]

Organism-specific databases

CTDi 29099.
GeneCardsi GC11M036293.
HGNCi HGNC:25014. COMMD9.
HPAi HPA009142.
MIMi 612299. gene.
neXtProti NX_Q9P000.
PharmGKBi PA134930445.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG41673.
GeneTreei ENSGT00390000006218.
HOGENOMi HOG000232004.
HOVERGENi HBG080522.
InParanoidi Q9P000.
OMAi STWRTEA.
OrthoDBi EOG718KDD.
PhylomeDBi Q9P000.
TreeFami TF323880.

Miscellaneous databases

GeneWikii COMMD9.
GenomeRNAii 29099.
NextBioi 52128.
PROi Q9P000.
SOURCEi Search...

Gene expression databases

Bgeei Q9P000.
CleanExi HS_COMMD9.
ExpressionAtlasi Q9P000. baseline and differential.
Genevestigatori Q9P000.

Family and domain databases

InterProi IPR017920. COMM.
IPR009886. HCaRG.
[Graphical view ]
Pfami PF07258. HCaRG. 1 hit.
[Graphical view ]
PROSITEi PS51269. COMM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Umbilical cord blood.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skin.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCOMD9_HUMAN
AccessioniPrimary (citable) accession number: Q9P000
Secondary accession number(s): E9PAN2, Q96FI2, Q9H0R0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3