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Protein

COMM domain-containing protein 9

Gene

COMMD9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). Modulates Na+ transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits (PubMed:23637203).2 Publications1 Publication

Keywords - Biological processi

Ion transport, Sodium transport, Transcription, Transcription regulation, Transport, Ubl conjugation pathway

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
COMM domain-containing protein 9
Gene namesi
Name:COMMD9
ORF Names:HSPC166
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:25014. COMMD9.

Subcellular locationi

Nucleus 1 Publication. Cytoplasmic vesicle 1 Publication

Keywords - Cellular componenti

Cytoplasmic vesicle, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134930445.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 198198COMM domain-containing protein 9PRO_0000077403Add
BLAST

Proteomic databases

MaxQBiQ9P000.
PaxDbiQ9P000.
PeptideAtlasiQ9P000.
PRIDEiQ9P000.

PTM databases

PhosphoSiteiQ9P000.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiQ9P000.
CleanExiHS_COMMD9.
ExpressionAtlasiQ9P000. baseline and differential.
GenevestigatoriQ9P000.

Organism-specific databases

HPAiHPA009142.

Interactioni

Subunit structurei

Interacts with RELB and NFKB1/p105. Interacts with CCDC22, CCDC93, SCNN1B, CUL1.5 Publications

Protein-protein interaction databases

BioGridi118867. 9 interactions.
IntActiQ9P000. 2 interactions.
STRINGi9606.ENSP00000263401.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4NKNX-ray2.79A/B/C/D/E/F1-116[»]
ProteinModelPortaliQ9P000.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini122 – 19675COMMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 COMM domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG41673.
GeneTreeiENSGT00390000006218.
HOGENOMiHOG000232004.
HOVERGENiHBG080522.
InParanoidiQ9P000.
OMAiQMKIQED.
OrthoDBiEOG718KDD.
PhylomeDBiQ9P000.
TreeFamiTF323880.

Family and domain databases

InterProiIPR017920. COMM.
IPR009886. HCaRG.
[Graphical view]
PfamiPF07258. HCaRG. 1 hit.
[Graphical view]
PROSITEiPS51269. COMM. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9P000-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAALTAEHFA ALQSLLKASS KDVVRQLCQE SFSSSALGLK KLLDVTCSSL
60 70 80 90 100
SVTQEEAEEL LQALHRLTRL VAFRDLSSAE AILALFPENF HQNLKNLLTK
110 120 130 140 150
IILEHVSTWR TEAQANQISL PRLVDLDWRV DIKTSSDSIS RMAVPTCLLQ
160 170 180 190
MKIQEDPSLC GDKPSISAVT VELSKETLDT MLDGLGRIRD QLSAVASK
Length:198
Mass (Da):21,819
Last modified:January 23, 2007 - v2
Checksum:i54DA2FE525C3A24F
GO
Isoform 2 (identifier: Q9P000-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     18-59: Missing.

Note: No experimental confirmation available.

Show »
Length:156
Mass (Da):17,333
Checksum:i9AF5728847F609AC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti45 – 451V → F in CAB66623. (PubMed:11230166)Curated
Sequence conflicti161 – 1611G → R in AAS22246. (PubMed:15799966)Curated
Sequence conflicti161 – 1611G → R in AAF29130. (PubMed:11042152)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei18 – 5942Missing in isoform 2. CuratedVSP_041499Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY542164 mRNA. Translation: AAS22246.1.
AF161515 mRNA. Translation: AAF29130.1.
AL136688 mRNA. Translation: CAB66623.1.
AC087277 Genomic DNA. No translation available.
BC010892 mRNA. Translation: AAH10892.1.
CCDSiCCDS44571.1. [Q9P000-2]
CCDS7900.1. [Q9P000-1]
RefSeqiNP_054905.2. NM_014186.3. [Q9P000-1]
UniGeneiHs.279836.

Genome annotation databases

EnsembliENST00000263401; ENSP00000263401; ENSG00000110442. [Q9P000-1]
ENST00000452374; ENSP00000392510; ENSG00000110442. [Q9P000-2]
GeneIDi29099.
KEGGihsa:29099.
UCSCiuc001mwn.4. human. [Q9P000-1]
uc009ykj.3. human. [Q9P000-2]

Polymorphism databases

DMDMi124056492.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY542164 mRNA. Translation: AAS22246.1.
AF161515 mRNA. Translation: AAF29130.1.
AL136688 mRNA. Translation: CAB66623.1.
AC087277 Genomic DNA. No translation available.
BC010892 mRNA. Translation: AAH10892.1.
CCDSiCCDS44571.1. [Q9P000-2]
CCDS7900.1. [Q9P000-1]
RefSeqiNP_054905.2. NM_014186.3. [Q9P000-1]
UniGeneiHs.279836.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4NKNX-ray2.79A/B/C/D/E/F1-116[»]
ProteinModelPortaliQ9P000.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118867. 9 interactions.
IntActiQ9P000. 2 interactions.
STRINGi9606.ENSP00000263401.

PTM databases

PhosphoSiteiQ9P000.

Polymorphism databases

DMDMi124056492.

Proteomic databases

MaxQBiQ9P000.
PaxDbiQ9P000.
PeptideAtlasiQ9P000.
PRIDEiQ9P000.

Protocols and materials databases

DNASUi29099.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263401; ENSP00000263401; ENSG00000110442. [Q9P000-1]
ENST00000452374; ENSP00000392510; ENSG00000110442. [Q9P000-2]
GeneIDi29099.
KEGGihsa:29099.
UCSCiuc001mwn.4. human. [Q9P000-1]
uc009ykj.3. human. [Q9P000-2]

Organism-specific databases

CTDi29099.
GeneCardsiGC11M036293.
HGNCiHGNC:25014. COMMD9.
HPAiHPA009142.
MIMi612299. gene.
neXtProtiNX_Q9P000.
PharmGKBiPA134930445.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG41673.
GeneTreeiENSGT00390000006218.
HOGENOMiHOG000232004.
HOVERGENiHBG080522.
InParanoidiQ9P000.
OMAiQMKIQED.
OrthoDBiEOG718KDD.
PhylomeDBiQ9P000.
TreeFamiTF323880.

Miscellaneous databases

ChiTaRSiCOMMD9. human.
GeneWikiiCOMMD9.
GenomeRNAii29099.
NextBioi52128.
PROiQ9P000.
SOURCEiSearch...

Gene expression databases

BgeeiQ9P000.
CleanExiHS_COMMD9.
ExpressionAtlasiQ9P000. baseline and differential.
GenevestigatoriQ9P000.

Family and domain databases

InterProiIPR017920. COMM.
IPR009886. HCaRG.
[Graphical view]
PfamiPF07258. HCaRG. 1 hit.
[Graphical view]
PROSITEiPS51269. COMM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH RELB AND NFKB1, TISSUE SPECIFICITY.
  2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Umbilical cord blood.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skin.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding."
    Mao X., Gluck N., Chen B., Starokadomskyy P., Li H., Maine G.N., Burstein E.
    J. Biol. Chem. 286:32355-32365(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CUL1, SUBCELLULAR LOCATION.
  8. "Functional interaction of COMMD3 and COMMD9 with the epithelial sodium channel."
    Liu Y.F., Swart M., Ke Y., Ly K., McDonald F.J.
    Am. J. Physiol. 305:F80-F89(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SCNN1B.
  9. Cited for: INTERACTION WITH CCDC22.
  10. Cited for: INTERACTION WITH CCDC93.

Entry informationi

Entry nameiCOMD9_HUMAN
AccessioniPrimary (citable) accession number: Q9P000
Secondary accession number(s): E9PAN2, Q96FI2, Q9H0R0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: February 4, 2015
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.