Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9P000 (COMD9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
COMM domain-containing protein 9
Gene names
Name:COMMD9
ORF Names:HSPC166
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length198 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Tissue specificity

Ubiquitous. Ref.1

Sequence similarities

Contains 1 COMM domain.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9P000-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9P000-2)

The sequence of this isoform differs from the canonical sequence as follows:
     18-59: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 198198COMM domain-containing protein 9
PRO_0000077403

Regions

Domain122 – 19675COMM

Natural variations

Alternative sequence18 – 5942Missing in isoform 2.
VSP_041499

Experimental info

Sequence conflict451V → F in CAB66623. Ref.3
Sequence conflict1611G → R in AAS22246. Ref.1
Sequence conflict1611G → R in AAF29130. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 54DA2FE525C3A24F

FASTA19821,819
        10         20         30         40         50         60 
MAALTAEHFA ALQSLLKASS KDVVRQLCQE SFSSSALGLK KLLDVTCSSL SVTQEEAEEL 

        70         80         90        100        110        120 
LQALHRLTRL VAFRDLSSAE AILALFPENF HQNLKNLLTK IILEHVSTWR TEAQANQISL 

       130        140        150        160        170        180 
PRLVDLDWRV DIKTSSDSIS RMAVPTCLLQ MKIQEDPSLC GDKPSISAVT VELSKETLDT 

       190 
MLDGLGRIRD QLSAVASK 

« Hide

Isoform 2 [UniParc].

Checksum: 9AF5728847F609AC
Show »

FASTA15617,333

References

« Hide 'large scale' references
[1]"COMMD proteins, a novel family of structural and functional homologs of MURR1."
Burstein E., Hoberg J.E., Wilkinson A.S., Rumble J.M., Csomos R.A., Komarck C.M., Maine G.N., Wilkinson J.C., Mayo M.W., Duckett C.S.
J. Biol. Chem. 280:22222-22232(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. expand/collapse author list , Gu J., Chen S.-J., Chen Z.
Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Umbilical cord blood.
[3]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[4]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Skin.
[6]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY542164 mRNA. Translation: AAS22246.1.
AF161515 mRNA. Translation: AAF29130.1.
AL136688 mRNA. Translation: CAB66623.1.
AC087277 Genomic DNA. No translation available.
BC010892 mRNA. Translation: AAH10892.1.
RefSeqNP_054905.2. NM_014186.3.
UniGeneHs.279836.

3D structure databases

ProteinModelPortalQ9P000.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid118867. 5 interactions.
IntActQ9P000. 2 interactions.
STRING9606.ENSP00000263401.

PTM databases

PhosphoSiteQ9P000.

Polymorphism databases

DMDM124056492.

Proteomic databases

PaxDbQ9P000.
PeptideAtlasQ9P000.
PRIDEQ9P000.

Protocols and materials databases

DNASU29099.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000263401; ENSP00000263401; ENSG00000110442. [Q9P000-1]
ENST00000452374; ENSP00000392510; ENSG00000110442. [Q9P000-2]
GeneID29099.
KEGGhsa:29099.
UCSCuc001mwn.4. human. [Q9P000-1]
uc009ykj.3. human. [Q9P000-2]

Organism-specific databases

CTD29099.
GeneCardsGC11M036251.
HGNCHGNC:25014. COMMD9.
HPAHPA009142.
MIM612299. gene.
neXtProtNX_Q9P000.
PharmGKBPA134930445.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG41673.
HOGENOMHOG000232004.
HOVERGENHBG080522.
InParanoidQ9P000.
OMAQMKIQED.
OrthoDBEOG718KDD.
PhylomeDBQ9P000.
TreeFamTF323880.

Gene expression databases

ArrayExpressQ9P000.
BgeeQ9P000.
CleanExHS_COMMD9.
GenevestigatorQ9P000.

Family and domain databases

InterProIPR017920. COMM.
IPR009886. HCaRG.
[Graphical view]
PfamPF07258. HCaRG. 1 hit.
[Graphical view]
PROSITEPS51269. COMM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCOMMD9.
GenomeRNAi29099.
NextBio52128.
PROQ9P000.
SOURCESearch...

Entry information

Entry nameCOMD9_HUMAN
AccessionPrimary (citable) accession number: Q9P000
Secondary accession number(s): E9PAN2, Q96FI2, Q9H0R0
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: January 23, 2007
Last modified: March 19, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM