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Q9P000

- COMD9_HUMAN

UniProt

Q9P000 - COMD9_HUMAN

Protein

COMM domain-containing protein 9

Gene

COMMD9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    COMM domain-containing protein 9
    Gene namesi
    Name:COMMD9
    ORF Names:HSPC166
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:25014. COMMD9.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134930445.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 198198COMM domain-containing protein 9PRO_0000077403Add
    BLAST

    Proteomic databases

    MaxQBiQ9P000.
    PaxDbiQ9P000.
    PeptideAtlasiQ9P000.
    PRIDEiQ9P000.

    PTM databases

    PhosphoSiteiQ9P000.

    Expressioni

    Tissue specificityi

    Ubiquitous.1 Publication

    Gene expression databases

    ArrayExpressiQ9P000.
    BgeeiQ9P000.
    CleanExiHS_COMMD9.
    GenevestigatoriQ9P000.

    Organism-specific databases

    HPAiHPA009142.

    Interactioni

    Protein-protein interaction databases

    BioGridi118867. 5 interactions.
    IntActiQ9P000. 2 interactions.
    STRINGi9606.ENSP00000263401.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9P000.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini122 – 19675COMMPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 COMM domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG41673.
    HOGENOMiHOG000232004.
    HOVERGENiHBG080522.
    InParanoidiQ9P000.
    OMAiSTWRTEA.
    OrthoDBiEOG718KDD.
    PhylomeDBiQ9P000.
    TreeFamiTF323880.

    Family and domain databases

    InterProiIPR017920. COMM.
    IPR009886. HCaRG.
    [Graphical view]
    PfamiPF07258. HCaRG. 1 hit.
    [Graphical view]
    PROSITEiPS51269. COMM. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9P000-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAALTAEHFA ALQSLLKASS KDVVRQLCQE SFSSSALGLK KLLDVTCSSL    50
    SVTQEEAEEL LQALHRLTRL VAFRDLSSAE AILALFPENF HQNLKNLLTK 100
    IILEHVSTWR TEAQANQISL PRLVDLDWRV DIKTSSDSIS RMAVPTCLLQ 150
    MKIQEDPSLC GDKPSISAVT VELSKETLDT MLDGLGRIRD QLSAVASK 198
    Length:198
    Mass (Da):21,819
    Last modified:January 23, 2007 - v2
    Checksum:i54DA2FE525C3A24F
    GO
    Isoform 2 (identifier: Q9P000-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         18-59: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:156
    Mass (Da):17,333
    Checksum:i9AF5728847F609AC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti45 – 451V → F in CAB66623. (PubMed:11230166)Curated
    Sequence conflicti161 – 1611G → R in AAS22246. (PubMed:15799966)Curated
    Sequence conflicti161 – 1611G → R in AAF29130. (PubMed:11042152)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei18 – 5942Missing in isoform 2. CuratedVSP_041499Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY542164 mRNA. Translation: AAS22246.1.
    AF161515 mRNA. Translation: AAF29130.1.
    AL136688 mRNA. Translation: CAB66623.1.
    AC087277 Genomic DNA. No translation available.
    BC010892 mRNA. Translation: AAH10892.1.
    CCDSiCCDS44571.1. [Q9P000-2]
    CCDS7900.1. [Q9P000-1]
    RefSeqiNP_054905.2. NM_014186.3. [Q9P000-1]
    UniGeneiHs.279836.

    Genome annotation databases

    EnsembliENST00000263401; ENSP00000263401; ENSG00000110442. [Q9P000-1]
    ENST00000452374; ENSP00000392510; ENSG00000110442. [Q9P000-2]
    GeneIDi29099.
    KEGGihsa:29099.
    UCSCiuc001mwn.4. human. [Q9P000-1]
    uc009ykj.3. human. [Q9P000-2]

    Polymorphism databases

    DMDMi124056492.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY542164 mRNA. Translation: AAS22246.1 .
    AF161515 mRNA. Translation: AAF29130.1 .
    AL136688 mRNA. Translation: CAB66623.1 .
    AC087277 Genomic DNA. No translation available.
    BC010892 mRNA. Translation: AAH10892.1 .
    CCDSi CCDS44571.1. [Q9P000-2 ]
    CCDS7900.1. [Q9P000-1 ]
    RefSeqi NP_054905.2. NM_014186.3. [Q9P000-1 ]
    UniGenei Hs.279836.

    3D structure databases

    ProteinModelPortali Q9P000.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118867. 5 interactions.
    IntActi Q9P000. 2 interactions.
    STRINGi 9606.ENSP00000263401.

    PTM databases

    PhosphoSitei Q9P000.

    Polymorphism databases

    DMDMi 124056492.

    Proteomic databases

    MaxQBi Q9P000.
    PaxDbi Q9P000.
    PeptideAtlasi Q9P000.
    PRIDEi Q9P000.

    Protocols and materials databases

    DNASUi 29099.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000263401 ; ENSP00000263401 ; ENSG00000110442 . [Q9P000-1 ]
    ENST00000452374 ; ENSP00000392510 ; ENSG00000110442 . [Q9P000-2 ]
    GeneIDi 29099.
    KEGGi hsa:29099.
    UCSCi uc001mwn.4. human. [Q9P000-1 ]
    uc009ykj.3. human. [Q9P000-2 ]

    Organism-specific databases

    CTDi 29099.
    GeneCardsi GC11M036251.
    HGNCi HGNC:25014. COMMD9.
    HPAi HPA009142.
    MIMi 612299. gene.
    neXtProti NX_Q9P000.
    PharmGKBi PA134930445.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG41673.
    HOGENOMi HOG000232004.
    HOVERGENi HBG080522.
    InParanoidi Q9P000.
    OMAi STWRTEA.
    OrthoDBi EOG718KDD.
    PhylomeDBi Q9P000.
    TreeFami TF323880.

    Miscellaneous databases

    GeneWikii COMMD9.
    GenomeRNAii 29099.
    NextBioi 52128.
    PROi Q9P000.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9P000.
    Bgeei Q9P000.
    CleanExi HS_COMMD9.
    Genevestigatori Q9P000.

    Family and domain databases

    InterProi IPR017920. COMM.
    IPR009886. HCaRG.
    [Graphical view ]
    Pfami PF07258. HCaRG. 1 hit.
    [Graphical view ]
    PROSITEi PS51269. COMM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
      Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
      , Gu J., Chen S.-J., Chen Z.
      Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Umbilical cord blood.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Skin.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCOMD9_HUMAN
    AccessioniPrimary (citable) accession number: Q9P000
    Secondary accession number(s): E9PAN2, Q96FI2, Q9H0R0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 91 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3