Q9NZW5 (MPP6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
MAGUK p55 subfamily member 6

Alternative name(s):
Veli-associated MAGUK 1
Short name=VAM-1

Gene names

Name:	MPP6
Synonyms:	VAM1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	540 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Interacts with CADM1 By similarity. Interacts with the LIN7 proteins.
Subcellular location	Membrane; Peripheral membrane protein By similarity.
Tissue specificity	Abundant in testis, brain, and kidney with lower levels detectable in other tissues.
Sequence similarities	Belongs to the MAGUK family. Contains 1 guanylate kinase-like domain. Contains 2 L27 domains. Contains 1 PDZ (DHR) domain. Contains 1 SH3 domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Repeat SH3 domain
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein complex assembly Non-traceable author statement Ref.1. Source: UniProtKB
Molecular function	protein binding Inferred from physical interaction Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 540	540	MAGUK p55 subfamily member 6		PRO_0000094584
Regions
	Domain	1 – 48	48	L27 1
	Domain	49 – 107	59	L27 2
	Domain	130 – 209	80	PDZ
	Domain	215 – 284	70	SH3
	Domain	338 – 525	188	Guanylate kinase-like
Amino acid modifications
	Modified residue	500	1	Phosphotyrosine Ref.7
Experimental info
	Sequence conflict	41	1	H → R in AAD45919. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9NZW5 [UniParc]. Last modified February 16, 2004. Version 2. Checksum: 86310E4F6AF632BD	FASTA	540	61,117
	10 20 30 40 50 60 MQQVLENLTE LPSSTGAEEI DLIFLKGIME NPIVKSLAKA HERLEDSKLE AVSDNNLELV 70 80 90 100 110 120 NEILEDITPL INVDENVAEL VGILKEPHFQ SLLEAHDIVA SKCYDSPPSS PEMNNSSINN 130 140 150 160 170 180 QLLPVDAIRI LGIHKRAGEP LGVTFRVENN DLVIARILHG GMIDRQGLLH VGDIIKEVNG 190 200 210 220 230 240 HEVGNNPKEL QELLKNISGS VTLKILPSYR DTITPQQVFV KCHFDYNPYN DNLIPCKEAG 250 260 270 280 290 300 LKFSKGEILQ IVNREDPNWW QASHVKEGGS AGLIPSQFLE EKRKAFVRRD WDNSGPFCGT 310 320 330 340 350 360 ISSKKKKKMM YLTTRNAEFD RHEIQIYEEV AKMPPFQRKT LVLIGAQGVG RRSLKNRFIV 370 380 390 400 410 420 LNPTRFGTTV PFTSRKPRED EKDGQAYKFV SRSEMEADIK AGKYLEHGEY EGNLYGTKID 430 440 450 460 470 480 SILEVVQTGR TCILDVNPQA LKVLRTSEFM PYVVFIAAPE LETLRAMHKA VVDAGITTKL 490 500 510 520 530 540 LTDSDLKKTV DESARIQRAY NHYFDLIIIN DNLDKAFEKL QTAIEKLRME PQWVPISWVY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"VAM-1: a new member of the MAGUK family binds to human Veli-1 through a conserved domain." Tseng T.-C., Marfatia S.M., Bryant P.J., Pack S., Zhuang Z., O'Brien J.E., Lin L., Hanada T., Chishti A.H. Biochim. Biophys. Acta 1518:249-259(2001) [PubMed: 11311936] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed: 11230166] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[3]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed: 12690205] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed: 12853948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
[7]	"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells." Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J. Nat. Biotechnol. 23:94-101(2005) [PubMed: 15592455] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-500, MASS SPECTROMETRY.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF162130 mRNA. Translation: AAD45919.2. AL136836 mRNA. Translation: CAB66770.1. AC005084 Genomic DNA. Translation: AAQ96847.1. CH236948 Genomic DNA. Translation: EAL24247.1. CH471073 Genomic DNA. Translation: EAW93810.1. BC023638 mRNA. Translation: AAH23638.1.
IPI	IPI00303280.
RefSeq	NP_057531.2. NM_016447.2.
UniGene	Hs.533355.
3D structure databases
ProteinModelPortal	Q9NZW5.
SMR	Q9NZW5. Positions 1-537.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NZW5. 2 interactions.
STRING	Q9NZW5.
PTM databases
PhosphoSite	Q9NZW5.
Polymorphism databases
DMDM	42560556.
Proteomic databases
PeptideAtlas	Q9NZW5.
PRIDE	Q9NZW5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000222644; ENSP00000222644; ENSG00000105926. ENST00000396475; ENSP00000379737; ENSG00000105926.
GeneID	51678.
KEGG	hsa:51678.
UCSC	uc003swx.1. human.
Organism-specific databases
CTD	51678.
GeneCards	GC07P024612.
H-InvDB	HIX0006526.
HGNC	HGNC:18167. MPP6.
HPA	HPA019085. HPA020456.
MIM	606959. gene.
neXtProt	NX_Q9NZW5.
PharmGKB	PA38511.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00560000077048.
HOVERGEN	HBG001858.
OrthoDB	EOG4T1HM6.
PhylomeDB	Q9NZW5.
Gene expression databases
ArrayExpress	Q9NZW5.
Bgee	Q9NZW5.
CleanEx	HS_MPP6.
Genevestigator	Q9NZW5.
GermOnline	ENSG00000105926. Homo sapiens.
Family and domain databases
InterPro	IPR008144. Guanylate_kin. IPR008145. Guanylate_kin/L-typ_Ca_channel. IPR020590. Guanylate_kinase_CS. IPR004172. L27. IPR014775. L27_C. IPR001478. PDZ/DHR/GLGF. IPR011511. SH3_2. IPR001452. SH3_domain. [Graphical view]
Pfam	PF00625. Guanylate_kin. 1 hit. PF02828. L27. 2 hits. PF00595. PDZ. 1 hit. PF07653. SH3_2. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. SM00569. L27. 2 hits. SM00228. PDZ. 1 hit. SM00326. SH3. 1 hit. [Graphical view]
SUPFAM	SSF50156. PDZ. 1 hit. SSF50044. SH3. 1 hit.
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. PS51022. L27. 2 hits. PS50106. PDZ. 1 hit. PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	55682.
SOURCE	Search...

Entry information

Entry name

MPP6_HUMAN

Accession

Primary (citable) accession number: Q9NZW5
Secondary accession number(s): A4D157, Q9H0E1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2003
Last sequence update:	February 16, 2004
Last modified:	January 25, 2012
This is version 92 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.