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Protein

MAGUK p55 subfamily member 6

Gene

MPP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • protein complex assembly Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
MAGUK p55 subfamily member 6
Alternative name(s):
Veli-associated MAGUK 1
Short name:
VAM-1
Gene namesi
Name:MPP6
Synonyms:VAM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:18167. MPP6.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • membrane Source: UniProtKB
  • plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38511.

Polymorphism and mutation databases

BioMutaiMPP6.
DMDMi42560556.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 540540MAGUK p55 subfamily member 6PRO_0000094584Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei500 – 5001PhosphotyrosineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NZW5.
MaxQBiQ9NZW5.
PaxDbiQ9NZW5.
PeptideAtlasiQ9NZW5.
PRIDEiQ9NZW5.

PTM databases

iPTMnetiQ9NZW5.
PhosphoSiteiQ9NZW5.
SwissPalmiQ9NZW5.

Expressioni

Tissue specificityi

Abundant in testis, brain, and kidney with lower levels detectable in other tissues.

Gene expression databases

BgeeiQ9NZW5.
CleanExiHS_MPP6.
ExpressionAtlasiQ9NZW5. baseline and differential.
GenevisibleiQ9NZW5. HS.

Organism-specific databases

HPAiHPA019085.
HPA020456.

Interactioni

Subunit structurei

Interacts with CADM1 (By similarity). Interacts with the LIN7 proteins.By similarity

Protein-protein interaction databases

BioGridi119675. 37 interactions.
IntActiQ9NZW5. 5 interactions.
STRINGi9606.ENSP00000222644.

Structurei

3D structure databases

ProteinModelPortaliQ9NZW5.
SMRiQ9NZW5. Positions 126-539.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 4848L27 1PROSITE-ProRule annotationAdd
BLAST
Domaini49 – 10759L27 2PROSITE-ProRule annotationAdd
BLAST
Domaini130 – 20980PDZPROSITE-ProRule annotationAdd
BLAST
Domaini215 – 28470SH3PROSITE-ProRule annotationAdd
BLAST
Domaini338 – 525188Guanylate kinase-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MAGUK family.Curated
Contains 1 guanylate kinase-like domain.PROSITE-ProRule annotation
Contains 2 L27 domains.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG0609. Eukaryota.
COG0194. LUCA.
GeneTreeiENSGT00760000118866.
HOGENOMiHOG000233034.
HOVERGENiHBG001858.
InParanoidiQ9NZW5.
OMAiDTIIPQQ.
PhylomeDBiQ9NZW5.
TreeFamiTF314263.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR020590. Guanylate_kinase_CS.
IPR014775. L27_C.
IPR004172. L27_dom.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
PF02828. L27. 2 hits.
PF00595. PDZ. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
SM00569. L27. 2 hits.
SM00228. PDZ. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF101288. SSF101288. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS51022. L27. 2 hits.
PS50106. PDZ. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NZW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQQVLENLTE LPSSTGAEEI DLIFLKGIME NPIVKSLAKA HERLEDSKLE
60 70 80 90 100
AVSDNNLELV NEILEDITPL INVDENVAEL VGILKEPHFQ SLLEAHDIVA
110 120 130 140 150
SKCYDSPPSS PEMNNSSINN QLLPVDAIRI LGIHKRAGEP LGVTFRVENN
160 170 180 190 200
DLVIARILHG GMIDRQGLLH VGDIIKEVNG HEVGNNPKEL QELLKNISGS
210 220 230 240 250
VTLKILPSYR DTITPQQVFV KCHFDYNPYN DNLIPCKEAG LKFSKGEILQ
260 270 280 290 300
IVNREDPNWW QASHVKEGGS AGLIPSQFLE EKRKAFVRRD WDNSGPFCGT
310 320 330 340 350
ISSKKKKKMM YLTTRNAEFD RHEIQIYEEV AKMPPFQRKT LVLIGAQGVG
360 370 380 390 400
RRSLKNRFIV LNPTRFGTTV PFTSRKPRED EKDGQAYKFV SRSEMEADIK
410 420 430 440 450
AGKYLEHGEY EGNLYGTKID SILEVVQTGR TCILDVNPQA LKVLRTSEFM
460 470 480 490 500
PYVVFIAAPE LETLRAMHKA VVDAGITTKL LTDSDLKKTV DESARIQRAY
510 520 530 540
NHYFDLIIIN DNLDKAFEKL QTAIEKLRME PQWVPISWVY
Length:540
Mass (Da):61,117
Last modified:February 16, 2004 - v2
Checksum:i86310E4F6AF632BD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti41 – 411H → R in AAD45919 (PubMed:11311936).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF162130 mRNA. Translation: AAD45919.2.
AL136836 mRNA. Translation: CAB66770.1.
AC005084 Genomic DNA. Translation: AAQ96847.1.
CH236948 Genomic DNA. Translation: EAL24247.1.
CH471073 Genomic DNA. Translation: EAW93810.1.
BC023638 mRNA. Translation: AAH23638.1.
CCDSiCCDS5388.1.
RefSeqiNP_001289966.1. NM_001303037.1.
NP_057531.2. NM_016447.3.
XP_006715801.1. XM_006715738.2.
XP_006715802.1. XM_006715739.2.
XP_006715803.1. XM_006715740.2.
XP_011513727.1. XM_011515425.1.
UniGeneiHs.533355.
Hs.563501.
Hs.594275.

Genome annotation databases

EnsembliENST00000222644; ENSP00000222644; ENSG00000105926.
ENST00000396475; ENSP00000379737; ENSG00000105926.
GeneIDi51678.
KEGGihsa:51678.
UCSCiuc003swx.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF162130 mRNA. Translation: AAD45919.2.
AL136836 mRNA. Translation: CAB66770.1.
AC005084 Genomic DNA. Translation: AAQ96847.1.
CH236948 Genomic DNA. Translation: EAL24247.1.
CH471073 Genomic DNA. Translation: EAW93810.1.
BC023638 mRNA. Translation: AAH23638.1.
CCDSiCCDS5388.1.
RefSeqiNP_001289966.1. NM_001303037.1.
NP_057531.2. NM_016447.3.
XP_006715801.1. XM_006715738.2.
XP_006715802.1. XM_006715739.2.
XP_006715803.1. XM_006715740.2.
XP_011513727.1. XM_011515425.1.
UniGeneiHs.533355.
Hs.563501.
Hs.594275.

3D structure databases

ProteinModelPortaliQ9NZW5.
SMRiQ9NZW5. Positions 126-539.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119675. 37 interactions.
IntActiQ9NZW5. 5 interactions.
STRINGi9606.ENSP00000222644.

PTM databases

iPTMnetiQ9NZW5.
PhosphoSiteiQ9NZW5.
SwissPalmiQ9NZW5.

Polymorphism and mutation databases

BioMutaiMPP6.
DMDMi42560556.

Proteomic databases

EPDiQ9NZW5.
MaxQBiQ9NZW5.
PaxDbiQ9NZW5.
PeptideAtlasiQ9NZW5.
PRIDEiQ9NZW5.

Protocols and materials databases

DNASUi51678.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222644; ENSP00000222644; ENSG00000105926.
ENST00000396475; ENSP00000379737; ENSG00000105926.
GeneIDi51678.
KEGGihsa:51678.
UCSCiuc003swx.4. human.

Organism-specific databases

CTDi51678.
GeneCardsiMPP6.
HGNCiHGNC:18167. MPP6.
HPAiHPA019085.
HPA020456.
MIMi606959. gene.
neXtProtiNX_Q9NZW5.
PharmGKBiPA38511.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0609. Eukaryota.
COG0194. LUCA.
GeneTreeiENSGT00760000118866.
HOGENOMiHOG000233034.
HOVERGENiHBG001858.
InParanoidiQ9NZW5.
OMAiDTIIPQQ.
PhylomeDBiQ9NZW5.
TreeFamiTF314263.

Miscellaneous databases

ChiTaRSiMPP6. human.
GeneWikiiMPP6.
GenomeRNAii51678.
PROiQ9NZW5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NZW5.
CleanExiHS_MPP6.
ExpressionAtlasiQ9NZW5. baseline and differential.
GenevisibleiQ9NZW5. HS.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR020590. Guanylate_kinase_CS.
IPR014775. L27_C.
IPR004172. L27_dom.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
PF02828. L27. 2 hits.
PF00595. PDZ. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
SM00569. L27. 2 hits.
SM00228. PDZ. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF101288. SSF101288. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS51022. L27. 2 hits.
PS50106. PDZ. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "VAM-1: a new member of the MAGUK family binds to human Veli-1 through a conserved domain."
    Tseng T.-C., Marfatia S.M., Bryant P.J., Pack S., Zhuang Z., O'Brien J.E., Lin L., Hanada T., Chishti A.H.
    Biochim. Biophys. Acta 1518:249-259(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  7. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
    Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
    Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-500, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMPP6_HUMAN
AccessioniPrimary (citable) accession number: Q9NZW5
Secondary accession number(s): A4D157, Q9H0E1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: February 16, 2004
Last modified: July 6, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.