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Protein

Zinc finger imprinted 2

Gene

ZIM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri328 – 35023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri356 – 37823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri412 – 43423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri466 – 48823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri494 – 51623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: GO_Central
  • zinc ion binding Source: UniProtKB

GO - Biological processi

  • regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger imprinted 2
Alternative name(s):
Zinc finger protein 656
Gene namesi
Name:ZIM2
Synonyms:ZNF656
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:12875. ZIM2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37464.

Polymorphism and mutation databases

BioMutaiZIM2.
DMDMi20141058.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 527527Zinc finger imprinted 2PRO_0000047774Add
BLAST

Proteomic databases

EPDiQ9NZV7.
PaxDbiQ9NZV7.
PeptideAtlasiQ9NZV7.
PRIDEiQ9NZV7.

PTM databases

iPTMnetiQ9NZV7.
PhosphoSiteiQ9NZV7.

Expressioni

Tissue specificityi

Highest levels of expression in adult testis; modest levels in fetal kidney and brain.

Gene expression databases

BgeeiQ9NZV7.
ExpressionAtlasiQ9NZV7. baseline and differential.
GenevisibleiQ9NZV7. HS.

Interactioni

Protein-protein interaction databases

BioGridi117152. 8 interactions.
STRINGi9606.ENSP00000221722.

Structurei

3D structure databases

ProteinModelPortaliQ9NZV7.
SMRiQ9NZV7. Positions 288-517.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini176 – 24671KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri328 – 35023C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri356 – 37823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri412 – 43423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri466 – 48823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri494 – 51623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00680000099963.
HOGENOMiHOG000015354.
HOVERGENiHBG100067.
InParanoidiQ9NZV7.
KOiK09229.
OMAiPGKDPQE.
OrthoDBiEOG78SQHF.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NZV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYQPEDDNNS DVTSDDDMTR NRRESSPPHS VHSFSGDRDW DRRGRSRDME
60 70 80 90 100
PRDRWSHTRN PRSRMPPRDL SLPVVAKTSF EMDREDDRDS RAYESRSQDA
110 120 130 140 150
ESYQNVVDLA EDRKPHNTIQ DNMENYRKLL SLGFLAQDSV PAEKRNTEML
160 170 180 190 200
DNLPSAGSQF PDFKHLGTFL VFEELVTFED VLVDFSPEEL SSLSAAQRNL
210 220 230 240 250
YREVMLENYR NLVSLGHQFS KPDIISRLEE EESYAMETDS RHTVICQGES
260 270 280 290 300
HDDPLEPHQG NQEKLLTPIT MNDPKTLTPE RSYGSDEFER SSNLSKQSKD
310 320 330 340 350
PLGKDPQEGT APGICTSPQS ASQENKHNRC EFCKRTFSTQ VALRRHERIH
360 370 380 390 400
TGKKPYECKQ CAEAFYLMPH LNRHQKTHSG RKTSGCNEGR KPSVQCANLC
410 420 430 440 450
ERVRIHSQED YFECFQCGKA FLQNVHLLQH LKAHEAARVL PPGLSHSKTY
460 470 480 490 500
LIRYQRKHDY VGERACQCCD CGRVFSRNSY LIQHYRTHTQ ERPYQCQLCG
510 520
KCFGRPSYLT QHYQLHSQEK TVECDHC
Length:527
Mass (Da):61,164
Last modified:October 1, 2000 - v1
Checksum:i6FC2ED68C50B0DCF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti110 – 1101A → T.
Corresponds to variant rs2191432 [ dbSNP | Ensembl ].
VAR_021896
Natural varianti408 – 4081Q → R.
Corresponds to variant rs8112407 [ dbSNP | Ensembl ].
VAR_052931
Natural varianti473 – 4731R → K.
Corresponds to variant rs10422475 [ dbSNP | Ensembl ].
VAR_052932

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF166122 mRNA. Translation: AAF61478.1.
BC104876 mRNA. Translation: AAI04877.1.
BC104878 mRNA. Translation: AAI04879.1.
CCDSiCCDS33123.1.
RefSeqiNP_001139798.1. NM_001146326.1.
NP_001139799.1. NM_001146327.1.
NP_056178.3. NM_015363.4.
UniGeneiHs.731875.

Genome annotation databases

EnsembliENST00000593711; ENSP00000472306; ENSG00000269699.
ENST00000599935; ENSP00000468984; ENSG00000269699.
ENST00000601070; ENSP00000470326; ENSG00000269699.
ENST00000629319; ENSP00000486502; ENSG00000269699.
GeneIDi23619.
KEGGihsa:23619.
UCSCiuc002qnr.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF166122 mRNA. Translation: AAF61478.1.
BC104876 mRNA. Translation: AAI04877.1.
BC104878 mRNA. Translation: AAI04879.1.
CCDSiCCDS33123.1.
RefSeqiNP_001139798.1. NM_001146326.1.
NP_001139799.1. NM_001146327.1.
NP_056178.3. NM_015363.4.
UniGeneiHs.731875.

3D structure databases

ProteinModelPortaliQ9NZV7.
SMRiQ9NZV7. Positions 288-517.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117152. 8 interactions.
STRINGi9606.ENSP00000221722.

PTM databases

iPTMnetiQ9NZV7.
PhosphoSiteiQ9NZV7.

Polymorphism and mutation databases

BioMutaiZIM2.
DMDMi20141058.

Proteomic databases

EPDiQ9NZV7.
PaxDbiQ9NZV7.
PeptideAtlasiQ9NZV7.
PRIDEiQ9NZV7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000593711; ENSP00000472306; ENSG00000269699.
ENST00000599935; ENSP00000468984; ENSG00000269699.
ENST00000601070; ENSP00000470326; ENSG00000269699.
ENST00000629319; ENSP00000486502; ENSG00000269699.
GeneIDi23619.
KEGGihsa:23619.
UCSCiuc002qnr.4. human.

Organism-specific databases

CTDi23619.
GeneCardsiZIM2.
HGNCiHGNC:12875. ZIM2.
neXtProtiNX_Q9NZV7.
PharmGKBiPA37464.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00680000099963.
HOGENOMiHOG000015354.
HOVERGENiHBG100067.
InParanoidiQ9NZV7.
KOiK09229.
OMAiPGKDPQE.
OrthoDBiEOG78SQHF.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZIM2. human.
GenomeRNAii23619.
PROiQ9NZV7.

Gene expression databases

BgeeiQ9NZV7.
ExpressionAtlasiQ9NZV7. baseline and differential.
GenevisibleiQ9NZV7. HS.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Exon sharing of a novel human zinc-finger gene, ZIM2, and paternally expressed gene 3 (PEG3)."
    Kim J., Bergmann A., Stubbs L.
    Genomics 64:114-118(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiZIM2_HUMAN
AccessioniPrimary (citable) accession number: Q9NZV7
Secondary accession number(s): Q2M3K1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: October 1, 2000
Last modified: July 6, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.