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Protein

Zinc finger imprinted 2

Gene

ZIM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri328 – 350C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri356 – 378C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri412 – 434C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger imprinted 2
Alternative name(s):
Zinc finger protein 656
Gene namesi
Name:ZIM2
Synonyms:ZNF656
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000269699.5
HGNCiHGNC:12875 ZIM2
neXtProtiNX_Q9NZV7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23619
OpenTargetsiENSG00000269699
PharmGKBiPA37464

Polymorphism and mutation databases

BioMutaiZIM2
DMDMi20141058

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477741 – 527Zinc finger imprinted 2Add BLAST527

Proteomic databases

MaxQBiQ9NZV7
PaxDbiQ9NZV7
PeptideAtlasiQ9NZV7
PRIDEiQ9NZV7

PTM databases

iPTMnetiQ9NZV7
PhosphoSitePlusiQ9NZV7

Expressioni

Tissue specificityi

Highest levels of expression in adult testis; modest levels in fetal kidney and brain.

Gene expression databases

BgeeiENSG00000269699
ExpressionAtlasiQ9NZV7 baseline and differential
GenevisibleiQ9NZV7 HS

Organism-specific databases

HPAiHPA071856

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
EPM2AIP1Q7L7754EBI-11962760,EBI-6255981

Protein-protein interaction databases

BioGridi117152, 8 interactors
IntActiQ9NZV7, 29 interactors
STRINGi9606.ENSP00000221722

Structurei

3D structure databases

ProteinModelPortaliQ9NZV7
SMRiQ9NZV7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini176 – 246KRABPROSITE-ProRule annotationAdd BLAST71

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri328 – 350C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri356 – 378C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri412 – 434C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144582
HOGENOMiHOG000015354
HOVERGENiHBG100067
InParanoidiQ9NZV7
KOiK09229
OMAiQCGEAFY
OrthoDBiEOG091G0P6J

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequencei

Sequence statusi: Complete.

Q9NZV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYQPEDDNNS DVTSDDDMTR NRRESSPPHS VHSFSGDRDW DRRGRSRDME
60 70 80 90 100
PRDRWSHTRN PRSRMPPRDL SLPVVAKTSF EMDREDDRDS RAYESRSQDA
110 120 130 140 150
ESYQNVVDLA EDRKPHNTIQ DNMENYRKLL SLGFLAQDSV PAEKRNTEML
160 170 180 190 200
DNLPSAGSQF PDFKHLGTFL VFEELVTFED VLVDFSPEEL SSLSAAQRNL
210 220 230 240 250
YREVMLENYR NLVSLGHQFS KPDIISRLEE EESYAMETDS RHTVICQGES
260 270 280 290 300
HDDPLEPHQG NQEKLLTPIT MNDPKTLTPE RSYGSDEFER SSNLSKQSKD
310 320 330 340 350
PLGKDPQEGT APGICTSPQS ASQENKHNRC EFCKRTFSTQ VALRRHERIH
360 370 380 390 400
TGKKPYECKQ CAEAFYLMPH LNRHQKTHSG RKTSGCNEGR KPSVQCANLC
410 420 430 440 450
ERVRIHSQED YFECFQCGKA FLQNVHLLQH LKAHEAARVL PPGLSHSKTY
460 470 480 490 500
LIRYQRKHDY VGERACQCCD CGRVFSRNSY LIQHYRTHTQ ERPYQCQLCG
510 520
KCFGRPSYLT QHYQLHSQEK TVECDHC
Length:527
Mass (Da):61,164
Last modified:October 1, 2000 - v1
Checksum:i6FC2ED68C50B0DCF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_021896110A → T. Corresponds to variant dbSNP:rs2191432Ensembl.1
Natural variantiVAR_052931408Q → R. Corresponds to variant dbSNP:rs8112407Ensembl.1
Natural variantiVAR_052932473R → K. Corresponds to variant dbSNP:rs10422475Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF166122 mRNA Translation: AAF61478.1
BC104876 mRNA Translation: AAI04877.1
BC104878 mRNA Translation: AAI04879.1
CCDSiCCDS33123.1
RefSeqiNP_001139798.1, NM_001146326.1
NP_001139799.1, NM_001146327.1
NP_056178.3, NM_015363.4
UniGeneiHs.731875

Genome annotation databases

EnsembliENST00000593711; ENSP00000472306; ENSG00000269699
ENST00000599935; ENSP00000468984; ENSG00000269699
ENST00000601070; ENSP00000470326; ENSG00000269699
ENST00000629319; ENSP00000486502; ENSG00000269699
GeneIDi23619
KEGGihsa:23619
UCSCiuc002qnr.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZIM2_HUMAN
AccessioniPrimary (citable) accession number: Q9NZV7
Secondary accession number(s): Q2M3K1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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