Q9NZV6 (MSRB1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Methionine-R-sulfoxide reductase B1
Short name=MsrB1
EC=1.8.4.-

Alternative name(s):
Selenoprotein X
Short name=SelX

Gene names

Name:	SEPX1
Synonyms:	MSRB1
ORF Names:	HSPC270

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	116 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	L-methionine + oxidized thioredoxin = L-methionine R-oxide + reduced thioredoxin.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the MsrB Met sulfoxide reductase family.
Sequence caution	The sequence AAF28948.1 differs from that shown. Reason: Erroneous termination at position 95. Translated as Sec.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Selenocysteine
Ligand	Metal-binding Zinc
Molecular function	Oxidoreductase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein repair Inferred from sequence or structural similarity. Source: HGNC
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from sequence or structural similarity. Source: HGNC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 116

116

Methionine-R-sulfoxide reductase B1

PRO_0000140321

Sites

Active site

95

1

Nucleophile By similarity

Metal binding

23

1

Zinc By similarity

Metal binding

26

1

Zinc By similarity

Metal binding

71

1

Zinc By similarity

Metal binding

74

1

Zinc By similarity

Amino acid modifications

Non-standard residue

95

1

Selenocysteine

Secondary structure

1

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116

Helix Strand Turn

Details...

Beta strand

21 – 24

4

Beta strand

29 – 31

3

Helix

33 – 35

3

Beta strand

40 – 43

4

Beta strand

45 – 47

3

Beta strand

56 – 59

4

Beta strand

66 – 70

5

Beta strand

93 – 95

3

Helix

98 – 100

3

Beta strand

101 – 103

3

Sequences

	Sequence		Length	Mass (Da)
	Q9NZV6 [UniParc]. Last modified February 26, 2008. Version 3. Checksum: 812B033BE02B7C0E	FASTA	116	12,760
	10 20 30 40 50 60 MSFCSFFGGE VFQNHFEPGV YVCAKCGYEL FSSRSKYAHS SPWPAFTETI HADSVAKRPE 70 80 90 100 110 HNRSEALKVS CGKCGNGLGH EFLNDGPKPG QSRFUIFSSS LKFVPKGKET SASQGH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Novel selenoproteins identified in silico and in vivo by using a conserved RNA structural motif." Lescure A., Gautheret D., Carbon P., Krol A. J. Biol. Chem. 274:38147-38154(1999) [PubMed: 10608886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The human methionine sulfoxide reductase mRNA codes for a selenoprotein." Chabot M., de Medicis E. Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. , Gu J., Chen S.-J., Chen Z. Genome Res. 10:1546-1560(2000) [PubMed: 11042152] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Umbilical cord blood.
[4]	"Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16." Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R. Hum. Mol. Genet. 10:339-352(2001) [PubMed: 11157797] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF166124 mRNA. Translation: AAF21429.1.
AF187272 mRNA. Translation: AAG17033.1.
AF161388 mRNA. Translation: AAF28948.1. Sequence problems.
AE006640 Genomic DNA. Translation: AAK61300.1.
BC003127 mRNA. Translation: AAH03127.2.

IPI

IPI00021576.

RefSeq

NP_057416.1. NM_016332.2.

UniGene

Hs.655346.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3MAO	X-ray	1.42	A	10-112	[»]

ProteinModelPortal

Q9NZV6.

SMR

Q9NZV6. Positions 10-112.

ModBase

Search...

Protein-protein interaction databases

STRING

Q9NZV6.

Polymorphism databases

DMDM

182676387.

Proteomic databases

PRIDE

Q9NZV6.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000361871; ENSP00000355084; ENSG00000198736.

GeneID

51734.

KEGG

hsa:51734.

Organism-specific databases

CTD

51734.

GeneCards

GC16M001992.

H-InvDB

HIX0012700.

HGNC

HGNC:14133. SEPX1.

HPA

CAB008650.

MIM

606216. gene.

neXtProt

NX_Q9NZV6.

PharmGKB

PA37848.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG20822.

GeneTree

ENSGT00510000047678.

HOVERGEN

HBG002192.

OrthoDB

EOG4GTKF9.

PhylomeDB

Q9NZV6.

Gene expression databases

ArrayExpress

Q9NZV6.

Bgee

Q9NZV6.

CleanEx

HS_SEPX1.

Genevestigator

Q9NZV6.

GermOnline

ENSG00000198736. Homo sapiens.

Family and domain databases

InterPro

IPR002579. Methionine_sulphoxide_MsrB.
IPR011057. Mss4-like.
[Graphical view]

Gene3D

G3DSA:2.170.150.20. MsrB. 1 hit.

Pfam

PF01641. SelR. 1 hit.
[Graphical view]

SUPFAM

SSF51316. Mss4_like. 1 hit.

ProtoNet

Search...

Other

DrugBank

DB00134. L-Methionine.

NextBio

55800.

SOURCE

Search...

Entry information

Entry name

MSRB1_HUMAN

Accession

Primary (citable) accession number: Q9NZV6
Secondary accession number(s): Q96RX6, Q9BTV2, Q9P0B1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	February 26, 2008
Last modified:	January 25, 2012
This is version 96 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.