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Q9NZV6 (MSRB1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Methionine-R-sulfoxide reductase B1

Short name=MsrB1
EC=1.8.4.-
Alternative name(s):
Selenoprotein X
Short name=SelX
Gene names
Name:SEPX1
Synonyms:MSRB1
ORF Names:HSPC270
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length116 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

L-methionine + oxidized thioredoxin = L-methionine R-oxide + reduced thioredoxin.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the MsrB Met sulfoxide reductase family.

Sequence caution

The sequence AAF28948.1 differs from that shown. Reason: Erroneous termination at position 95. Translated as Sec.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversitySelenocysteine
   LigandMetal-binding
Zinc
   Molecular functionOxidoreductase
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological processprotein repair

Inferred from sequence or structural similarity. Source: HGNC

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionpeptide-methionine-(S)-S-oxide reductase activity

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from sequence or structural similarity. Source: HGNC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 116116Methionine-R-sulfoxide reductase B1
PRO_0000140321

Sites

Active site951Nucleophile By similarity
Metal binding231Zinc By similarity
Metal binding261Zinc By similarity
Metal binding711Zinc By similarity
Metal binding741Zinc By similarity

Amino acid modifications

Non-standard residue951Selenocysteine

Secondary structure

.................... 116
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9NZV6 [UniParc].

Last modified February 26, 2008. Version 3.
Checksum: 812B033BE02B7C0E

FASTA11612,760
        10         20         30         40         50         60 
MSFCSFFGGE VFQNHFEPGV YVCAKCGYEL FSSRSKYAHS SPWPAFTETI HADSVAKRPE 

        70         80         90        100        110 
HNRSEALKVS CGKCGNGLGH EFLNDGPKPG QSRFUIFSSS LKFVPKGKET SASQGH 

« Hide

References

« Hide 'large scale' references
[1]"Novel selenoproteins identified in silico and in vivo by using a conserved RNA structural motif."
Lescure A., Gautheret D., Carbon P., Krol A.
J. Biol. Chem. 274:38147-38154(1999) [PubMed: 10608886] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The human methionine sulfoxide reductase mRNA codes for a selenoprotein."
Chabot M., de Medicis E.
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. expand/collapse author list , Gu J., Chen S.-J., Chen Z.
Genome Res. 10:1546-1560(2000) [PubMed: 11042152] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Umbilical cord blood.
[4]"Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
Hum. Mol. Genet. 10:339-352(2001) [PubMed: 11157797] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skin.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF166124 mRNA. Translation: AAF21429.1.
AF187272 mRNA. Translation: AAG17033.1.
AF161388 mRNA. Translation: AAF28948.1. Sequence problems.
AE006640 Genomic DNA. Translation: AAK61300.1.
BC003127 mRNA. Translation: AAH03127.2.
IPIIPI00021576.
RefSeqNP_057416.1. NM_016332.2.
UniGeneHs.655346.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3MAOX-ray1.42A10-112[»]
ProteinModelPortalQ9NZV6.
SMRQ9NZV6. Positions 10-112.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9NZV6.

Polymorphism databases

DMDM182676387.

Proteomic databases

PRIDEQ9NZV6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000361871; ENSP00000355084; ENSG00000198736.
GeneID51734.
KEGGhsa:51734.

Organism-specific databases

CTD51734.
GeneCardsGC16M001992.
H-InvDBHIX0012700.
HGNCHGNC:14133. SEPX1.
HPACAB008650.
MIM606216. gene.
neXtProtNX_Q9NZV6.
PharmGKBPA37848.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG20822.
GeneTreeENSGT00510000047678.
HOVERGENHBG002192.
OrthoDBEOG4GTKF9.
PhylomeDBQ9NZV6.

Gene expression databases

ArrayExpressQ9NZV6.
BgeeQ9NZV6.
CleanExHS_SEPX1.
GenevestigatorQ9NZV6.
GermOnlineENSG00000198736. Homo sapiens.

Family and domain databases

InterProIPR002579. Methionine_sulphoxide_MsrB.
IPR011057. Mss4-like.
[Graphical view]
Gene3DG3DSA:2.170.150.20. MsrB. 1 hit.
PfamPF01641. SelR. 1 hit.
[Graphical view]
SUPFAMSSF51316. Mss4_like. 1 hit.
ProtoNetSearch...

Other

DrugBankDB00134. L-Methionine.
NextBio55800.
SOURCESearch...

Entry information

Entry nameMSRB1_HUMAN
AccessionPrimary (citable) accession number: Q9NZV6
Secondary accession number(s): Q96RX6, Q9BTV2, Q9P0B1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: February 26, 2008
Last modified: January 25, 2012
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families