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Reviewed, UniProtKB/Swiss-Prot Q9NZV6 (MSRB1_HUMAN)

Last modified June 16, 2009. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Methionine-R-sulfoxide reductase B1
    EC=1.8.4.-
Alternative name(s):
    Selenoprotein X
      Short name=SelX
Gene names
Name: SEPX1
Synonyms: MSRB1
ORF Names: HSPC270
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length116 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Catalytic activity

L-methionine + oxidized thioredoxin = L-methionine R-oxide + reduced thioredoxin.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the msrB Met sulfoxide reductase family.

Sequence caution

The sequence AAF28948.1 differs from that shown. Reason: Erroneous termination at position 95. Translated as Sec.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversitySelenocysteine
   LigandMetal-binding
Selenium
Zinc
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

protein repair

Inferred from sequence or structural similarity. Source: HGNC

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionpeptide-methionine-(S)-S-oxide reductase activity

Inferred from electronic annotation. Source: InterPro

selenium binding

Inferred from electronic annotation. Source: UniProtKB-KW

zinc ion binding

Inferred from sequence or structural similarity. Source: HGNC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 116116Methionine-R-sulfoxide reductase B1
PRO_0000140321

Sites

Active site951Nucleophile By similarity
Metal binding231Zinc By similarity
Metal binding261Zinc By similarity
Metal binding711Zinc By similarity
Metal binding741Zinc By similarity

Amino acid modifications

Non-standard residue951Selenocysteine

Sequences

Sequence LengthMass (Da)Tools
Q9NZV6-1 [UniParc].

Last modified February 26, 2008. Version 3.
Checksum: 812B033BE02B7C0E

FASTA11612,760
        10         20         30         40         50         60 
MSFCSFFGGE VFQNHFEPGV YVCAKCGYEL FSSRSKYAHS SPWPAFTETI HADSVAKRPE 

        70         80         90        100        110 
HNRSEALKVS CGKCGNGLGH EFLNDGPKPG QSRFUIFSSS LKFVPKGKET SASQGH 

« Hide

References

« Hide 'large scale' references
[1]"Novel selenoproteins identified in silico and in vivo by using a conserved RNA structural motif."
Lescure A., Gautheret D., Carbon P., Krol A.
J. Biol. Chem. 274:38147-38154(1999) [PubMed: 10608886] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The human methionine sulfoxide reductase mRNA codes for a selenoprotein."
Chabot M., de Medicis E.
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. expand/collapse author list , Gu J., Chen S.-J., Chen Z.
Genome Res. 10:1546-1560(2000) [PubMed: 11042152] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Umbilical cord blood.
[4]"Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.
Hum. Mol. Genet. 10:339-352(2001) [PubMed: 11157797] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skin.
+Additional computationally mapped references.

Cross-references

Sequence databases

AF166124 mRNA. Translation: AAF21429.1.
AF187272 mRNA. Translation: AAG17033.1.
AF161388 mRNA. Translation: AAF28948.1. Sequence problems.
AE006640 Genomic DNA. Translation: AAK61300.1.
BC003127 mRNA. Translation: AAH03127.2.
IPIIPI00021576.
RefSeqNP_057416.1.
UniGeneHs.655346

3D structure databases

HSSPHSSP built from PDB template 1L1D based on UniProtKB P14930.
ModBaseSearch...

Genome annotation databases

EnsemblENSG00000198736. Homo sapiens. [Contig view]
GeneID51734.
KEGGhsa:51734.

Organism-specific databases

GeneCardsGC16M001928.
H-InvDBHIX0012700.
HGNCHGNC:14133. SEPX1.
HPACAB008650.
MIM606216. gene.
PharmGKBPA37848.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ9NZV6.
HOVERGENQ9NZV6.

Gene expression databases

ArrayExpressQ9NZV6.
BgeeQ9NZV6.
CleanExHS_SEPX1.
GermOnlineENSG00000198736. Homo sapiens.

Family and domain databases

InterProIPR002579. Methionine_sulphoxide_MsrB.
[Graphical view]
Gene3DG3DSA:2.170.150.20. MsrB. 1 hit.
PfamPF01641. SelR. 1 hit.
[Graphical view]
ProDomPD004057. DUF25. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Other Resources

DrugBankDB00134. L-Methionine.
NextBio55800.
SOURCESearch...

Entry information

Entry nameMSRB1_HUMAN
AccessionPrimary (citable) accession number: Q9NZV6
Secondary accession number(s): Q96RX6, Q9BTV2, Q9P0B1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: February 26, 2008
Last modified: June 16, 2009
This is version 73 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents