Reviewed, UniProtKB/Swiss-Prot Q9NZV6 (MSRB1_HUMAN)

Names and origin

Protein names

Recommended name:
    Methionine-R-sulfoxide reductase B1
    EC=1.8.4.-
Alternative name(s):
    Selenoprotein X
      Short name=SelX

Gene names

Name:	SEPX1
Synonyms:	MSRB1
ORF Names:	HSPC270

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	116 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	L-methionine + oxidized thioredoxin = L-methionine R-oxide + reduced thioredoxin.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the msrB Met sulfoxide reductase family.
Sequence caution	The sequence AAF28948.1 differs from that shown. Reason: Erroneous termination at position 95. Translated as Sec.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Selenocysteine
Ligand	Metal-binding Selenium Zinc
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW protein repair Inferred from sequence or structural similarity. Source: HGNC
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: InterPro selenium binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from sequence or structural similarity. Source: HGNC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 116	116	Methionine-R-sulfoxide reductase B1		PRO_0000140321
Sites
	Active site	95	1	Nucleophile By similarity
	Metal binding	23	1	Zinc By similarity
	Metal binding	26	1	Zinc By similarity
	Metal binding	71	1	Zinc By similarity
	Metal binding	74	1	Zinc By similarity
Amino acid modifications
	Non-standard residue	95	1	Selenocysteine

Sequences

	Sequence		Length	Mass (Da)
	Q9NZV6-1 [UniParc]. Last modified February 26, 2008. Version 3. Checksum: 812B033BE02B7C0E	FASTA	116	12,760
	10 20 30 40 50 60 MSFCSFFGGE VFQNHFEPGV YVCAKCGYEL FSSRSKYAHS SPWPAFTETI HADSVAKRPE 70 80 90 100 110 HNRSEALKVS CGKCGNGLGH EFLNDGPKPG QSRFUIFSSS LKFVPKGKET SASQGH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Novel selenoproteins identified in silico and in vivo by using a conserved RNA structural motif." Lescure A., Gautheret D., Carbon P., Krol A. J. Biol. Chem. 274:38147-38154(1999) [PubMed: 10608886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The human methionine sulfoxide reductase mRNA codes for a selenoprotein." Chabot M., de Medicis E. Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. , Gu J., Chen S.-J., Chen Z. Genome Res. 10:1546-1560(2000) [PubMed: 11042152] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Umbilical cord blood.
[4]	"Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16." Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R. Hum. Mol. Genet. 10:339-352(2001) [PubMed: 11157797] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF166124 mRNA. Translation: AAF21429.1. AF187272 mRNA. Translation: AAG17033.1. AF161388 mRNA. Translation: AAF28948.1. Sequence problems. AE006640 Genomic DNA. Translation: AAK61300.1. BC003127 mRNA. Translation: AAH03127.2.
IPI	IPI00021576.
RefSeq	NP_057416.1.
UniGene	Hs.655346
3D structure databases
HSSP	HSSP built from PDB template 1L1D based on UniProtKB P14930.
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000198736. Homo sapiens. [Contig view]
GeneID	51734.
KEGG	hsa:51734.
Organism-specific databases
GeneCards	GC16M001928.
H-InvDB	HIX0012700.
HGNC	HGNC:14133. SEPX1.
HPA	CAB008650.
MIM	606216. gene.
PharmGKB	PA37848.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9NZV6.
HOVERGEN	Q9NZV6.
Gene expression databases
ArrayExpress	Q9NZV6.
Bgee	Q9NZV6.
CleanEx	HS_SEPX1.
GermOnline	ENSG00000198736. Homo sapiens.
Family and domain databases
InterPro	IPR002579. Methionine_sulphoxide_MsrB. [Graphical view]
Gene3D	G3DSA:2.170.150.20. MsrB. 1 hit.
Pfam	PF01641. SelR. 1 hit. [Graphical view]
ProDom	PD004057. DUF25. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...
Other Resources
DrugBank	DB00134. L-Methionine.
NextBio	55800.
SOURCE	Search...

Entry information

Entry name

MSRB1_HUMAN

Accession

Primary (citable) accession number: Q9NZV6
Secondary accession number(s): Q96RX6, Q9BTV2, Q9P0B1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	February 26, 2008
Last modified:	June 16, 2009
This is version 73 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)