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Protein

Methionine-R-sulfoxide reductase B1

Gene

MSRB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages (By similarity).By similarity

Catalytic activityi

L-methionine + oxidized thioredoxin = L-methionine R-oxide + reduced thioredoxin.By similarity

Cofactori

Zn2+1 PublicationNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi23ZincPROSITE-ProRule annotation1 Publication1
Metal bindingi26ZincPROSITE-ProRule annotation1 Publication1
Metal bindingi71ZincPROSITE-ProRule annotation1 Publication1
Metal bindingi74ZincPROSITE-ProRule annotation1 Publication1
Active sitei95NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • actin filament polymerization Source: UniProtKB
  • innate immune response Source: UniProtKB
  • protein repair Source: HGNC
  • response to oxidative stress Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Immunity, Innate immunity

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BRENDAi1.8.4.12. 2681.
ReactomeiR-HSA-5676934. Protein repair.

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine-R-sulfoxide reductase B1 (EC:1.8.4.-)
Short name:
MsrB1
Alternative name(s):
Selenoprotein X
Short name:
SelX
Gene namesi
Name:MSRB1
Synonyms:SEPX1
ORF Names:HSPC270
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:14133. MSRB1.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity
  • Cytoplasmcytoskeleton By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi51734.
OpenTargetsiENSG00000198736.
PharmGKBiPA37848.

Chemistry databases

DrugBankiDB00134. L-Methionine.

Polymorphism and mutation databases

BioMutaiMSRB1.
DMDMi182676387.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001403211 – 116Methionine-R-sulfoxide reductase B1Add BLAST116

Proteomic databases

EPDiQ9NZV6.
PaxDbiQ9NZV6.
PeptideAtlasiQ9NZV6.
PRIDEiQ9NZV6.

PTM databases

PhosphoSitePlusiQ9NZV6.

Expressioni

Gene expression databases

BgeeiENSG00000198736.
CleanExiHS_SEPX1.
ExpressionAtlasiQ9NZV6. baseline and differential.
GenevisibleiQ9NZV6. HS.

Organism-specific databases

HPAiCAB008650.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119704. 3 interactors.
IntActiQ9NZV6. 3 interactors.
STRINGi9606.ENSP00000355084.

Structurei

Secondary structure

1116
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi18 – 23Combined sources6
Turni24 – 26Combined sources3
Beta strandi29 – 32Combined sources4
Helixi33 – 35Combined sources3
Beta strandi40 – 43Combined sources4
Beta strandi45 – 47Combined sources3
Beta strandi54 – 59Combined sources6
Beta strandi66 – 71Combined sources6
Turni72 – 74Combined sources3
Beta strandi77 – 82Combined sources6
Beta strandi86 – 88Combined sources3
Beta strandi93 – 96Combined sources4
Helixi98 – 100Combined sources3
Beta strandi101 – 105Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MAOX-ray1.42A10-112[»]
ProteinModelPortaliQ9NZV6.
SMRiQ9NZV6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 106MsrBPROSITE-ProRule annotationAdd BLAST106

Sequence similaritiesi

Contains 1 MsrB (methionine-R-sulfoxide reductase) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0856. Eukaryota.
COG0229. LUCA.
GeneTreeiENSGT00510000047678.
HOGENOMiHOG000243424.
HOVERGENiHBG002192.
InParanoidiQ9NZV6.
KOiK07305.
PhylomeDBiQ9NZV6.
TreeFamiTF329147.

Family and domain databases

Gene3Di2.170.150.20. 1 hit.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002579. Met_Sox_Rdtase_MsrB.
IPR011057. Mss4-like.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01641. SelR. 1 hit.
[Graphical view]
SUPFAMiSSF51316. SSF51316. 1 hit.
PROSITEiPS51790. MSRB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NZV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFCSFFGGE VFQNHFEPGV YVCAKCGYEL FSSRSKYAHS SPWPAFTETI
60 70 80 90 100
HADSVAKRPE HNRSEALKVS CGKCGNGLGH EFLNDGPKPG QSRFUIFSSS
110
LKFVPKGKET SASQGH
Length:116
Mass (Da):12,760
Last modified:February 26, 2008 - v3
Checksum:i812B033BE02B7C0E
GO

Sequence cautioni

The sequence AAF28948 differs from that shown. Reason: Erroneous termination at position 95. Translated as Sec.Curated

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-standard residuei95Selenocysteine1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF166124 mRNA. Translation: AAF21429.1.
AF187272 mRNA. Translation: AAG17033.1.
AF161388 mRNA. Translation: AAF28948.1. Sequence problems.
AE006640 Genomic DNA. Translation: AAK61300.1.
AC005363 Genomic DNA. No translation available.
BC003127 mRNA. Translation: AAH03127.2.
CCDSiCCDS42100.1.
RefSeqiNP_057416.1. NM_016332.2.
UniGeneiHs.655346.

Genome annotation databases

EnsembliENST00000361871; ENSP00000355084; ENSG00000198736.
GeneIDi51734.
KEGGihsa:51734.
UCSCiuc021tam.2. human.

Keywords - Coding sequence diversityi

Selenocysteine

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF166124 mRNA. Translation: AAF21429.1.
AF187272 mRNA. Translation: AAG17033.1.
AF161388 mRNA. Translation: AAF28948.1. Sequence problems.
AE006640 Genomic DNA. Translation: AAK61300.1.
AC005363 Genomic DNA. No translation available.
BC003127 mRNA. Translation: AAH03127.2.
CCDSiCCDS42100.1.
RefSeqiNP_057416.1. NM_016332.2.
UniGeneiHs.655346.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MAOX-ray1.42A10-112[»]
ProteinModelPortaliQ9NZV6.
SMRiQ9NZV6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119704. 3 interactors.
IntActiQ9NZV6. 3 interactors.
STRINGi9606.ENSP00000355084.

Chemistry databases

DrugBankiDB00134. L-Methionine.

PTM databases

PhosphoSitePlusiQ9NZV6.

Polymorphism and mutation databases

BioMutaiMSRB1.
DMDMi182676387.

Proteomic databases

EPDiQ9NZV6.
PaxDbiQ9NZV6.
PeptideAtlasiQ9NZV6.
PRIDEiQ9NZV6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361871; ENSP00000355084; ENSG00000198736.
GeneIDi51734.
KEGGihsa:51734.
UCSCiuc021tam.2. human.

Organism-specific databases

CTDi51734.
DisGeNETi51734.
GeneCardsiMSRB1.
H-InvDBHIX0012700.
HGNCiHGNC:14133. MSRB1.
HPAiCAB008650.
MIMi606216. gene.
neXtProtiNX_Q9NZV6.
OpenTargetsiENSG00000198736.
PharmGKBiPA37848.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0856. Eukaryota.
COG0229. LUCA.
GeneTreeiENSGT00510000047678.
HOGENOMiHOG000243424.
HOVERGENiHBG002192.
InParanoidiQ9NZV6.
KOiK07305.
PhylomeDBiQ9NZV6.
TreeFamiTF329147.

Enzyme and pathway databases

BRENDAi1.8.4.12. 2681.
ReactomeiR-HSA-5676934. Protein repair.

Miscellaneous databases

GeneWikiiSEPX1.
GenomeRNAii51734.
PROiQ9NZV6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198736.
CleanExiHS_SEPX1.
ExpressionAtlasiQ9NZV6. baseline and differential.
GenevisibleiQ9NZV6. HS.

Family and domain databases

Gene3Di2.170.150.20. 1 hit.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002579. Met_Sox_Rdtase_MsrB.
IPR011057. Mss4-like.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01641. SelR. 1 hit.
[Graphical view]
SUPFAMiSSF51316. SSF51316. 1 hit.
PROSITEiPS51790. MSRB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMSRB1_HUMAN
AccessioniPrimary (citable) accession number: Q9NZV6
Secondary accession number(s): Q96RX6, Q9BTV2, Q9P0B1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: February 26, 2008
Last modified: November 30, 2016
This is version 137 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.