Reviewed,
UniProtKB/Swiss-Prot Q9NZV1 (CRIM1_HUMAN)
Last modified
January 19, 2010.
Version 71.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Cysteine-rich motor neuron 1 protein Short name=CRIM-1 Alternative name(s): Cysteine-rich repeat-containing protein S52 Cleaved into the following chain: 1- Recommended name: Processed cysteine-rich motor neuron 1 protein | ||||||
| Gene names |
| ||||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||||
| Taxonomic identifier | 9606 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 1036 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface. Ref.5 Ref.7 |
| Subunit structure | Interacts with BMP4 and BMP7. Ref.5 |
| Subcellular location | Processed cysteine-rich motor neuron 1 protein: Secreted Ref.5. |
| Tissue specificity | Expressed in pancreas, kidney, skeletal muscle, lung, placenta, brain, heart, spleen, liver and small intestine. Expressed in blood vessels (at protein level). Ref.7 Ref.1 |
| Post-translational modification | |
| Sequence similarities | Contains 4 antistasin-like domains. Contains 1 IGFBP N-terminal domain. Contains 6 VWFC domains. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cell membrane Membrane Secreted |
| Coding sequence diversity | Polymorphism |
| Domain | Repeat Signal Transmembrane |
| PTM | Glycoprotein Phosphoprotein |
| Technical term | Complete proteome Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | nervous system development Ref.1 Traceable author statement. Source: ProtInc regulation of cell growthInferred from electronic annotation. Source: InterPro |
| Cellular component | extracellular region Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Ref.1Traceable author statement. Source: ProtInc plasma membraneInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | insulin-like growth factor binding Inferred from electronic annotation. Source: InterPro insulin-like growth factor receptor activity Ref.1Traceable author statement. Source: ProtInc serine-type endopeptidase inhibitor activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 34 | 34 | Ref.5 Ref.6 | ||||||
| Chain | 35 – 1036 | 1002 | Cysteine-rich motor neuron 1 protein | PRO_0000021001 | |||||
| Chain | ? – 1036 | Processed cysteine-rich motor neuron 1 protein | PRO_0000296243 | ||||||
Regions | |||||||||
| Topological domain | 35 – 939 | 905 | Extracellular Potential | ||||||
| Transmembrane | 940 – 960 | 21 | Potential | ||||||
| Topological domain | 961 – 1036 | 76 | Cytoplasmic Potential | ||||||
| Domain | 35 – 112 | 78 | IGFBP N-terminal | ||||||
| Domain | 334 – 391 | 58 | VWFC 1 | ||||||
| Domain | 401 – 457 | 57 | VWFC 2 | ||||||
| Domain | 469 – 498 | 30 | Antistasin-like 1 | ||||||
| Domain | 505 – 532 | 28 | Antistasin-like 2 | ||||||
| Domain | 539 – 564 | 26 | Antistasin-like 3 | ||||||
| Domain | 567 – 592 | 26 | Antistasin-like 4 | ||||||
| Domain | 606 – 663 | 58 | VWFC 3 | ||||||
| Domain | 677 – 735 | 59 | VWFC 4 | ||||||
| Domain | 751 – 809 | 59 | VWFC 5 | ||||||
| Domain | 817 – 874 | 58 | VWFC 6 | ||||||
| Motif | 314 – 316 | 3 | Cell attachment site Potential | ||||||
Amino acid modifications | |||||||||
| Modified residue | 1019 | 1 | Phosphotyrosine Ref.9 | ||||||
| Modified residue | 1035 | 1 | Phosphothreonine Ref.8 | ||||||
| Glycosylation | 71 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 113 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 330 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 474 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 746 | 1 | N-linked (GlcNAc...) Potential | ||||||
Natural variations | |||||||||
| Natural variant | 502 | 1 | E → K: dbSNP rs12997487. | VAR_050907 | |||||
| Natural variant | 781 | 1 | V → I: dbSNP rs59929305. | VAR_061625 | |||||
Experimental info | |||||||||
| Sequence conflict | 433 | 1 | C → F in BAD92376. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis." Kolle G.V., Georgas K., Holmes G.P., Little M.H., Yamada T. Mech. Dev. 90:181-193(2000) [PubMed: 10642437] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY. |
| [2] | Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [3] | "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. Gray A.M.Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [5] | "CRIM1 regulates the rate of processing and delivery of bone morphogenetic proteins to the cell surface." Wilkinson L., Kolle G.V., Wen D., Piper M., Scott J., Little M.H. J. Biol. Chem. 278:34181-34188(2003) [PubMed: 12805376] [Abstract] Cited for: PROTEIN SEQUENCE OF 35-44, FUNCTION, GLYCOSYLATION, SUBCELLULAR LOCATION, INTERACTION WITH BMP4 AND BMP7, IDENTIFICATION OF A SOLUBLE FORM. |
| [6] | "Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 35-49. |
| [7] | "CRIM1 is involved in endothelial cell capillary formation in vitro and is expressed in blood vessels in vivo." Glienke J., Sturz A., Menrad A., Thierauch K.-H. Mech. Dev. 119:165-175(2002) [PubMed: 12464430] [Abstract] Cited for: FUNCTION, GLYCOSYLATION, TISSUE SPECIFICITY. |
| [8] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1035, MASS SPECTROMETRY. |
| [9] | "An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells." Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A., Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D., Wiley H.S., Qian W.-J. J. Proteome Res. 8:3852-3861(2009) [PubMed: 19534553] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1019, MASS SPECTROMETRY. Tissue: Mammary epithelium. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF167706 mRNA. Translation: AAF34409.1. AF168681 Genomic DNA. Translation: AAG37011.1. AB209139 mRNA. Translation: BAD92376.1. Different initiation. AY358371 mRNA. Translation: AAQ88737.1. BC111989 mRNA. Translation: AAI11990.1. BC113371 mRNA. Translation: AAI13372.1. |
| IPI | IPI00009294. |
| RefSeq | NP_057525.1. |
| UniGene | Hs.699247 |
3D structure databases | |
| SMR | Q9NZV1. Positions 34-94, 397-460, 814-878. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9NZV1. |
PTM databases | |
| PhosphoSite | Q9NZV1. |
Proteomic databases | |
| PeptideAtlas | Q9NZV1. |
| PRIDE | Q9NZV1. |
Genome annotation databases | |
| Ensembl | ENST00000280527; ENSP00000280527; ENSG00000150938; Homo sapiens. [Genome view] |
| GeneID | 51232. |
| KEGG | hsa:51232. |
| UCSC | uc002rpd.1. human. |
Organism-specific databases | |
| CTD | 51232. |
| GeneCards | GC02P036495. |
| H-InvDB | HIX0001964. HIX0030218. |
| HGNC | HGNC:2359. CRIM1. |
| HPA | HPA000556. |
| MIM | 606189. gene. |
| PharmGKB | PA26877. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG12116. |
| HOGENOM | HBG357186. |
| HOVERGEN | Q9NZV1. |
| InParanoid | Q9NZV1. |
| OMA | WREDDCT. |
| OrthoDB | EOG9JQ6GT. |
| PhylomeDB | Q9NZV1. |
Gene expression databases | |
| ArrayExpress | Q9NZV1. |
| Bgee | Q9NZV1. |
| CleanEx | HS_CRIM1. |
| Genevestigator | Q9NZV1. |
| GermOnline | ENSG00000150938. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR000867. IGFBP-like. IPR011061. Prot_inh_I14/15_hirudin/antisn. IPR004094. Prot_inh_I15_antistasin-like. IPR001007. VWF_C. [Graphical view] |
| Pfam | PF02822. Antistasin. 4 hits. PF00093. VWC. 6 hits. [Graphical view] |
| SMART | SM00121. IB. 1 hit. SM00214. VWC. 6 hits. [Graphical view] |
| PROSITE | PS51252. ANTISTASIN. 4 hits. PS51323. IGFBP_N_2. 1 hit. PS01208. VWFC_1. 6 hits. PS50184. VWFC_2. 6 hits. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 54338. |
| PMAP-CutDB | Q9NZV1. |
| SOURCE | Search... |
Entry information
| Entry name | CRIM1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9NZV1 Secondary accession number(s): Q2M2G4 Q9H318 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 2 Human chromosome 2: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


