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Protein

Cysteine-rich motor neuron 1 protein

Gene

CRIM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface.2 Publications

GO - Molecular functioni

  • insulin-like growth factor-activated receptor activity Source: ProtInc
  • PDZ domain binding Source: MGI
  • serine-type endopeptidase inhibitor activity Source: InterPro

GO - Biological processi

  • nervous system development Source: ProtInc
  • regulation of cell growth Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000150938-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich motor neuron 1 protein
Short name:
CRIM-1
Alternative name(s):
Cysteine-rich repeat-containing protein S52
Cleaved into the following chain:
Gene namesi
Name:CRIM1
Synonyms:S52
ORF Names:UNQ1886/PRO4330
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:2359. CRIM1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini35 – 939ExtracellularSequence analysisAdd BLAST905
Transmembranei940 – 960HelicalSequence analysisAdd BLAST21
Topological domaini961 – 1036CytoplasmicSequence analysisAdd BLAST76

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: ProtInc
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi51232.
OpenTargetsiENSG00000150938.
PharmGKBiPA26877.

Polymorphism and mutation databases

BioMutaiCRIM1.
DMDMi67460590.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000296243? – 1036Processed cysteine-rich motor neuron 1 protein
Signal peptidei1 – 342 PublicationsAdd BLAST34
ChainiPRO_000002100135 – 1036Cysteine-rich motor neuron 1 proteinAdd BLAST1002

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi71N-linked (GlcNAc...)Sequence analysis1
Glycosylationi113N-linked (GlcNAc...)Sequence analysis1
Glycosylationi330N-linked (GlcNAc...)Sequence analysis1
Glycosylationi474N-linked (GlcNAc...)Sequence analysis1
Glycosylationi746N-linked (GlcNAc...)Sequence analysis1
Modified residuei1035PhosphothreonineCombined sources1

Post-translational modificationi

N-glycosylated.2 Publications

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9NZV1.
PaxDbiQ9NZV1.
PeptideAtlasiQ9NZV1.
PRIDEiQ9NZV1.

PTM databases

iPTMnetiQ9NZV1.
PhosphoSitePlusiQ9NZV1.
SwissPalmiQ9NZV1.

Miscellaneous databases

PMAP-CutDBQ9NZV1.

Expressioni

Tissue specificityi

Expressed in pancreas, kidney, skeletal muscle, lung, placenta, brain, heart, spleen, liver and small intestine. Expressed in blood vessels (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000150938.
CleanExiHS_CRIM1.
ExpressionAtlasiQ9NZV1. baseline and differential.
GenevisibleiQ9NZV1. HS.

Organism-specific databases

HPAiHPA000556.

Interactioni

Subunit structurei

Interacts with BMP4 and BMP7.1 Publication

GO - Molecular functioni

  • PDZ domain binding Source: MGI

Protein-protein interaction databases

BioGridi119395. 2 interactors.
DIPiDIP-58932N.
IntActiQ9NZV1. 9 interactors.
STRINGi9606.ENSP00000280527.

Structurei

3D structure databases

ProteinModelPortaliQ9NZV1.
SMRiQ9NZV1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 112IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST78
Domaini334 – 391VWFC 1PROSITE-ProRule annotationAdd BLAST58
Domaini401 – 457VWFC 2PROSITE-ProRule annotationAdd BLAST57
Domaini469 – 498Antistasin-like 1PROSITE-ProRule annotationAdd BLAST30
Domaini505 – 532Antistasin-like 2PROSITE-ProRule annotationAdd BLAST28
Domaini539 – 564Antistasin-like 3PROSITE-ProRule annotationAdd BLAST26
Domaini567 – 592Antistasin-like 4PROSITE-ProRule annotationAdd BLAST26
Domaini606 – 663VWFC 3PROSITE-ProRule annotationAdd BLAST58
Domaini677 – 735VWFC 4PROSITE-ProRule annotationAdd BLAST59
Domaini751 – 809VWFC 5PROSITE-ProRule annotationAdd BLAST59
Domaini817 – 874VWFC 6PROSITE-ProRule annotationAdd BLAST58

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi314 – 316Cell attachment siteSequence analysis3

Sequence similaritiesi

Contains 4 antistasin-like domains.PROSITE-ProRule annotation
Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
Contains 6 VWFC domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IR8F. Eukaryota.
ENOG410Z6K0. LUCA.
GeneTreeiENSGT00840000129763.
HOGENOMiHOG000063671.
HOVERGENiHBG081345.
InParanoidiQ9NZV1.
OMAiDYRENNR.
OrthoDBiEOG091G01IV.
PhylomeDBiQ9NZV1.
TreeFamiTF106451.

Family and domain databases

Gene3Di2.10.22.10. 3 hits.
InterProiIPR004094. Antistasin-like.
IPR009030. Growth_fac_rcpt_.
IPR011061. Hirudin/antistatin.
IPR000867. IGFBP-like.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF02822. Antistasin. 4 hits.
PF00219. IGFBP. 1 hit.
PF00093. VWC. 6 hits.
[Graphical view]
SMARTiSM00121. IB. 1 hit.
SM00214. VWC. 6 hits.
SM00215. VWC_out. 4 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57262. SSF57262. 3 hits.
PROSITEiPS51252. ANTISTASIN. 4 hits.
PS51323. IGFBP_N_2. 1 hit.
PS01208. VWFC_1. 6 hits.
PS50184. VWFC_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NZV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYLVAGDRGL AGCGHLLVSL LGLLLLLARS GTRALVCLPC DESKCEEPRN
60 70 80 90 100
CPGSIVQGVC GCCYTCASQR NESCGGTFGI YGTCDRGLRC VIRPPLNGDS
110 120 130 140 150
LTEYEAGVCE DENWTDDQLL GFKPCNENLI AGCNIINGKC ECNTIRTCSN
160 170 180 190 200
PFEFPSQDMC LSALKRIEEE KPDCSKARCE VQFSPRCPED SVLIEGYAPP
210 220 230 240 250
GECCPLPSRC VCNPAGCLRK VCQPGNLNIL VSKASGKPGE CCDLYECKPV
260 270 280 290 300
FGVDCRTVEC PPVQQTACPP DSYETQVRLT ADGCCTLPTR CECLSGLCGF
310 320 330 340 350
PVCEVGSTPR IVSRGDGTPG KCCDVFECVN DTKPACVFNN VEYYDGDMFR
360 370 380 390 400
MDNCRFCRCQ GGVAICFTAQ CGEINCERYY VPEGECCPVC EDPVYPFNNP
410 420 430 440 450
AGCYANGLIL AHGDRWREDD CTFCQCVNGE RHCVATVCGQ TCTNPVKVPG
460 470 480 490 500
ECCPVCEEPT IITVDPPACG ELSNCTLTGK DCINGFKRDH NGCRTCQCIN
510 520 530 540 550
TEELCSERKQ GCTLNCPFGF LTDAQNCEIC ECRPRPKKCR PIICDKYCPL
560 570 580 590 600
GLLKNKHGCD ICRCKKCPEL SCSKICPLGF QQDSHGCLIC KCREASASAG
610 620 630 640 650
PPILSGTCLT VDGHHHKNEE SWHDGCRECY CLNGREMCAL ITCPVPACGN
660 670 680 690 700
PTIHPGQCCP SCADDFVVQK PELSTPSICH APGGEYFVEG ETWNIDSCTQ
710 720 730 740 750
CTCHSGRVLC ETEVCPPLLC QNPSRTQDSC CPQCTDQPFR PSLSRNNSVP
760 770 780 790 800
NYCKNDEGDI FLAAESWKPD VCTSCICIDS VISCFSESCP SVSCERPVLR
810 820 830 840 850
KGQCCPYCIE DTIPKKVVCH FSGKAYADEE RWDLDSCTHC YCLQGQTLCS
860 870 880 890 900
TVSCPPLPCV EPINVEGSCC PMCPEMYVPE PTNIPIEKTN HRGEVDLEVP
910 920 930 940 950
LWPTPSENDI VHLPRDMGHL QVDYRDNRLH PSEDSSLDSI ASVVVPIIIC
960 970 980 990 1000
LSIIIAFLFI NQKKQWIPLL CWYRTPTKPS SLNNQLVSVD CKKGTRVQVD
1010 1020 1030
SSQRMLRIAE PDARFSGFYS MQKQNHLQAD NFYQTV
Length:1,036
Mass (Da):113,738
Last modified:October 1, 2000 - v1
Checksum:i10CBF02A5C579C27
GO

Sequence cautioni

The sequence BAD92376 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti433C → F in BAD92376 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050907502E → K.Corresponds to variant rs12997487dbSNPEnsembl.1
Natural variantiVAR_061625781V → I.Corresponds to variant rs59929305dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF167706 mRNA. Translation: AAF34409.1.
AF168681 Genomic DNA. Translation: AAG37011.1.
AB209139 mRNA. Translation: BAD92376.1. Different initiation.
AY358371 mRNA. Translation: AAQ88737.1.
BC111989 mRNA. Translation: AAI11990.1.
BC113371 mRNA. Translation: AAI13372.1.
CCDSiCCDS1783.1.
RefSeqiNP_057525.1. NM_016441.2.
UniGeneiHs.699247.

Genome annotation databases

EnsembliENST00000280527; ENSP00000280527; ENSG00000150938.
GeneIDi51232.
KEGGihsa:51232.
UCSCiuc002rpd.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF167706 mRNA. Translation: AAF34409.1.
AF168681 Genomic DNA. Translation: AAG37011.1.
AB209139 mRNA. Translation: BAD92376.1. Different initiation.
AY358371 mRNA. Translation: AAQ88737.1.
BC111989 mRNA. Translation: AAI11990.1.
BC113371 mRNA. Translation: AAI13372.1.
CCDSiCCDS1783.1.
RefSeqiNP_057525.1. NM_016441.2.
UniGeneiHs.699247.

3D structure databases

ProteinModelPortaliQ9NZV1.
SMRiQ9NZV1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119395. 2 interactors.
DIPiDIP-58932N.
IntActiQ9NZV1. 9 interactors.
STRINGi9606.ENSP00000280527.

PTM databases

iPTMnetiQ9NZV1.
PhosphoSitePlusiQ9NZV1.
SwissPalmiQ9NZV1.

Polymorphism and mutation databases

BioMutaiCRIM1.
DMDMi67460590.

Proteomic databases

MaxQBiQ9NZV1.
PaxDbiQ9NZV1.
PeptideAtlasiQ9NZV1.
PRIDEiQ9NZV1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000280527; ENSP00000280527; ENSG00000150938.
GeneIDi51232.
KEGGihsa:51232.
UCSCiuc002rpd.4. human.

Organism-specific databases

CTDi51232.
DisGeNETi51232.
GeneCardsiCRIM1.
H-InvDBHIX0030218.
HGNCiHGNC:2359. CRIM1.
HPAiHPA000556.
MIMi606189. gene.
neXtProtiNX_Q9NZV1.
OpenTargetsiENSG00000150938.
PharmGKBiPA26877.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IR8F. Eukaryota.
ENOG410Z6K0. LUCA.
GeneTreeiENSGT00840000129763.
HOGENOMiHOG000063671.
HOVERGENiHBG081345.
InParanoidiQ9NZV1.
OMAiDYRENNR.
OrthoDBiEOG091G01IV.
PhylomeDBiQ9NZV1.
TreeFamiTF106451.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000150938-MONOMER.

Miscellaneous databases

ChiTaRSiCRIM1. human.
GeneWikiiCRIM1.
GenomeRNAii51232.
PMAP-CutDBQ9NZV1.
PROiQ9NZV1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000150938.
CleanExiHS_CRIM1.
ExpressionAtlasiQ9NZV1. baseline and differential.
GenevisibleiQ9NZV1. HS.

Family and domain databases

Gene3Di2.10.22.10. 3 hits.
InterProiIPR004094. Antistasin-like.
IPR009030. Growth_fac_rcpt_.
IPR011061. Hirudin/antistatin.
IPR000867. IGFBP-like.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF02822. Antistasin. 4 hits.
PF00219. IGFBP. 1 hit.
PF00093. VWC. 6 hits.
[Graphical view]
SMARTiSM00121. IB. 1 hit.
SM00214. VWC. 6 hits.
SM00215. VWC_out. 4 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57262. SSF57262. 3 hits.
PROSITEiPS51252. ANTISTASIN. 4 hits.
PS51323. IGFBP_N_2. 1 hit.
PS01208. VWFC_1. 6 hits.
PS50184. VWFC_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRIM1_HUMAN
AccessioniPrimary (citable) accession number: Q9NZV1
Secondary accession number(s): Q2M2G4
, Q59GH0, Q7LCQ5, Q9H318
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.