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Q9NZV1

- CRIM1_HUMAN

UniProt

Q9NZV1 - CRIM1_HUMAN

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Protein

Cysteine-rich motor neuron 1 protein

Gene

CRIM1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface.2 Publications

GO - Molecular functioni

  1. insulin-like growth factor-activated receptor activity Source: ProtInc
  2. PDZ domain binding Source: MGI
  3. serine-type endopeptidase inhibitor activity Source: InterPro

GO - Biological processi

  1. insulin-like growth factor receptor signaling pathway Source: GOC
  2. nervous system development Source: ProtInc
  3. regulation of cell growth Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich motor neuron 1 protein
Short name:
CRIM-1
Alternative name(s):
Cysteine-rich repeat-containing protein S52
Cleaved into the following chain:
Gene namesi
Name:CRIM1
Synonyms:S52
ORF Names:UNQ1886/PRO4330
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:2359. CRIM1.

Subcellular locationi

Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. integral component of membrane Source: ProtInc
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26877.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 1036Processed cysteine-rich motor neuron 1 proteinPRO_0000296243
Signal peptidei1 – 34342 PublicationsAdd
BLAST
Chaini35 – 10361002Cysteine-rich motor neuron 1 proteinPRO_0000021001Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi71 – 711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi474 – 4741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi746 – 7461N-linked (GlcNAc...)Sequence Analysis
Modified residuei1035 – 10351Phosphothreonine1 Publication

Post-translational modificationi

N-glycosylated.2 Publications

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9NZV1.
PaxDbiQ9NZV1.
PeptideAtlasiQ9NZV1.
PRIDEiQ9NZV1.

PTM databases

PhosphoSiteiQ9NZV1.

Miscellaneous databases

PMAP-CutDBQ9NZV1.

Expressioni

Tissue specificityi

Expressed in pancreas, kidney, skeletal muscle, lung, placenta, brain, heart, spleen, liver and small intestine. Expressed in blood vessels (at protein level).2 Publications

Gene expression databases

BgeeiQ9NZV1.
CleanExiHS_CRIM1.
ExpressionAtlasiQ9NZV1. baseline and differential.
GenevestigatoriQ9NZV1.

Organism-specific databases

HPAiHPA000556.

Interactioni

Subunit structurei

Interacts with BMP4 and BMP7.1 Publication

Protein-protein interaction databases

BioGridi119395. 3 interactions.
DIPiDIP-58932N.
IntActiQ9NZV1. 5 interactions.
STRINGi9606.ENSP00000280527.

Structurei

3D structure databases

ProteinModelPortaliQ9NZV1.
SMRiQ9NZV1. Positions 683-715, 817-854.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini35 – 939905ExtracellularSequence AnalysisAdd
BLAST
Topological domaini961 – 103676CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei940 – 96021HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 11278IGFBP N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini334 – 39158VWFC 1PROSITE-ProRule annotationAdd
BLAST
Domaini401 – 45757VWFC 2PROSITE-ProRule annotationAdd
BLAST
Domaini469 – 49830Antistasin-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini505 – 53228Antistasin-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini539 – 56426Antistasin-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini567 – 59226Antistasin-like 4PROSITE-ProRule annotationAdd
BLAST
Domaini606 – 66358VWFC 3PROSITE-ProRule annotationAdd
BLAST
Domaini677 – 73559VWFC 4PROSITE-ProRule annotationAdd
BLAST
Domaini751 – 80959VWFC 5PROSITE-ProRule annotationAdd
BLAST
Domaini817 – 87458VWFC 6PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi314 – 3163Cell attachment siteSequence Analysis

Sequence similaritiesi

Contains 4 antistasin-like domains.PROSITE-ProRule annotation
Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
Contains 6 VWFC domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG283828.
GeneTreeiENSGT00760000119335.
HOGENOMiHOG000063671.
HOVERGENiHBG081345.
InParanoidiQ9NZV1.
OMAiWREDDCT.
PhylomeDBiQ9NZV1.
TreeFamiTF106451.

Family and domain databases

Gene3Di2.10.22.10. 3 hits.
InterProiIPR004094. Antistasin-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR011061. Hirudin/antistatin.
IPR000867. IGFBP-like.
IPR001007. VWF_C.
[Graphical view]
PfamiPF02822. Antistasin. 4 hits.
PF00093. VWC. 6 hits.
[Graphical view]
SMARTiSM00121. IB. 1 hit.
SM00214. VWC. 6 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57262. SSF57262. 3 hits.
PROSITEiPS51252. ANTISTASIN. 4 hits.
PS51323. IGFBP_N_2. 1 hit.
PS01208. VWFC_1. 6 hits.
PS50184. VWFC_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NZV1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYLVAGDRGL AGCGHLLVSL LGLLLLLARS GTRALVCLPC DESKCEEPRN
60 70 80 90 100
CPGSIVQGVC GCCYTCASQR NESCGGTFGI YGTCDRGLRC VIRPPLNGDS
110 120 130 140 150
LTEYEAGVCE DENWTDDQLL GFKPCNENLI AGCNIINGKC ECNTIRTCSN
160 170 180 190 200
PFEFPSQDMC LSALKRIEEE KPDCSKARCE VQFSPRCPED SVLIEGYAPP
210 220 230 240 250
GECCPLPSRC VCNPAGCLRK VCQPGNLNIL VSKASGKPGE CCDLYECKPV
260 270 280 290 300
FGVDCRTVEC PPVQQTACPP DSYETQVRLT ADGCCTLPTR CECLSGLCGF
310 320 330 340 350
PVCEVGSTPR IVSRGDGTPG KCCDVFECVN DTKPACVFNN VEYYDGDMFR
360 370 380 390 400
MDNCRFCRCQ GGVAICFTAQ CGEINCERYY VPEGECCPVC EDPVYPFNNP
410 420 430 440 450
AGCYANGLIL AHGDRWREDD CTFCQCVNGE RHCVATVCGQ TCTNPVKVPG
460 470 480 490 500
ECCPVCEEPT IITVDPPACG ELSNCTLTGK DCINGFKRDH NGCRTCQCIN
510 520 530 540 550
TEELCSERKQ GCTLNCPFGF LTDAQNCEIC ECRPRPKKCR PIICDKYCPL
560 570 580 590 600
GLLKNKHGCD ICRCKKCPEL SCSKICPLGF QQDSHGCLIC KCREASASAG
610 620 630 640 650
PPILSGTCLT VDGHHHKNEE SWHDGCRECY CLNGREMCAL ITCPVPACGN
660 670 680 690 700
PTIHPGQCCP SCADDFVVQK PELSTPSICH APGGEYFVEG ETWNIDSCTQ
710 720 730 740 750
CTCHSGRVLC ETEVCPPLLC QNPSRTQDSC CPQCTDQPFR PSLSRNNSVP
760 770 780 790 800
NYCKNDEGDI FLAAESWKPD VCTSCICIDS VISCFSESCP SVSCERPVLR
810 820 830 840 850
KGQCCPYCIE DTIPKKVVCH FSGKAYADEE RWDLDSCTHC YCLQGQTLCS
860 870 880 890 900
TVSCPPLPCV EPINVEGSCC PMCPEMYVPE PTNIPIEKTN HRGEVDLEVP
910 920 930 940 950
LWPTPSENDI VHLPRDMGHL QVDYRDNRLH PSEDSSLDSI ASVVVPIIIC
960 970 980 990 1000
LSIIIAFLFI NQKKQWIPLL CWYRTPTKPS SLNNQLVSVD CKKGTRVQVD
1010 1020 1030
SSQRMLRIAE PDARFSGFYS MQKQNHLQAD NFYQTV
Length:1,036
Mass (Da):113,738
Last modified:October 1, 2000 - v1
Checksum:i10CBF02A5C579C27
GO

Sequence cautioni

The sequence BAD92376.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti433 – 4331C → F in BAD92376. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti502 – 5021E → K.
Corresponds to variant rs12997487 [ dbSNP | Ensembl ].
VAR_050907
Natural varianti781 – 7811V → I.
Corresponds to variant rs59929305 [ dbSNP | Ensembl ].
VAR_061625

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF167706 mRNA. Translation: AAF34409.1.
AF168681 Genomic DNA. Translation: AAG37011.1.
AB209139 mRNA. Translation: BAD92376.1. Different initiation.
AY358371 mRNA. Translation: AAQ88737.1.
BC111989 mRNA. Translation: AAI11990.1.
BC113371 mRNA. Translation: AAI13372.1.
CCDSiCCDS1783.1.
RefSeqiNP_057525.1. NM_016441.2.
UniGeneiHs.699247.

Genome annotation databases

EnsembliENST00000280527; ENSP00000280527; ENSG00000150938.
GeneIDi51232.
KEGGihsa:51232.
UCSCiuc002rpd.3. human.

Polymorphism databases

DMDMi67460590.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF167706 mRNA. Translation: AAF34409.1 .
AF168681 Genomic DNA. Translation: AAG37011.1 .
AB209139 mRNA. Translation: BAD92376.1 . Different initiation.
AY358371 mRNA. Translation: AAQ88737.1 .
BC111989 mRNA. Translation: AAI11990.1 .
BC113371 mRNA. Translation: AAI13372.1 .
CCDSi CCDS1783.1.
RefSeqi NP_057525.1. NM_016441.2.
UniGenei Hs.699247.

3D structure databases

ProteinModelPortali Q9NZV1.
SMRi Q9NZV1. Positions 683-715, 817-854.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119395. 3 interactions.
DIPi DIP-58932N.
IntActi Q9NZV1. 5 interactions.
STRINGi 9606.ENSP00000280527.

PTM databases

PhosphoSitei Q9NZV1.

Polymorphism databases

DMDMi 67460590.

Proteomic databases

MaxQBi Q9NZV1.
PaxDbi Q9NZV1.
PeptideAtlasi Q9NZV1.
PRIDEi Q9NZV1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000280527 ; ENSP00000280527 ; ENSG00000150938 .
GeneIDi 51232.
KEGGi hsa:51232.
UCSCi uc002rpd.3. human.

Organism-specific databases

CTDi 51232.
GeneCardsi GC02P036583.
H-InvDB HIX0030218.
HGNCi HGNC:2359. CRIM1.
HPAi HPA000556.
MIMi 606189. gene.
neXtProti NX_Q9NZV1.
PharmGKBi PA26877.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG283828.
GeneTreei ENSGT00760000119335.
HOGENOMi HOG000063671.
HOVERGENi HBG081345.
InParanoidi Q9NZV1.
OMAi WREDDCT.
PhylomeDBi Q9NZV1.
TreeFami TF106451.

Miscellaneous databases

ChiTaRSi CRIM1. human.
GeneWikii CRIM1.
GenomeRNAii 51232.
NextBioi 54338.
PMAP-CutDB Q9NZV1.
PROi Q9NZV1.
SOURCEi Search...

Gene expression databases

Bgeei Q9NZV1.
CleanExi HS_CRIM1.
ExpressionAtlasi Q9NZV1. baseline and differential.
Genevestigatori Q9NZV1.

Family and domain databases

Gene3Di 2.10.22.10. 3 hits.
InterProi IPR004094. Antistasin-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR011061. Hirudin/antistatin.
IPR000867. IGFBP-like.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF02822. Antistasin. 4 hits.
PF00093. VWC. 6 hits.
[Graphical view ]
SMARTi SM00121. IB. 1 hit.
SM00214. VWC. 6 hits.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 1 hit.
SSF57262. SSF57262. 3 hits.
PROSITEi PS51252. ANTISTASIN. 4 hits.
PS51323. IGFBP_N_2. 1 hit.
PS01208. VWFC_1. 6 hits.
PS50184. VWFC_2. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis."
    Kolle G.V., Georgas K., Holmes G.P., Little M.H., Yamada T.
    Mech. Dev. 90:181-193(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
  2. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "CRIM1 regulates the rate of processing and delivery of bone morphogenetic proteins to the cell surface."
    Wilkinson L., Kolle G.V., Wen D., Piper M., Scott J., Little M.H.
    J. Biol. Chem. 278:34181-34188(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 35-44, FUNCTION, GLYCOSYLATION, SUBCELLULAR LOCATION, INTERACTION WITH BMP4 AND BMP7, IDENTIFICATION OF A SOLUBLE FORM.
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 35-49.
  7. "CRIM1 is involved in endothelial cell capillary formation in vitro and is expressed in blood vessels in vivo."
    Glienke J., Sturz A., Menrad A., Thierauch K.-H.
    Mech. Dev. 119:165-175(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, GLYCOSYLATION, TISSUE SPECIFICITY.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1035, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiCRIM1_HUMAN
AccessioniPrimary (citable) accession number: Q9NZV1
Secondary accession number(s): Q2M2G4
, Q59GH0, Q7LCQ5, Q9H318
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3