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Q9NZU5 (LMCD1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
LIM and cysteine-rich domains protein 1
Alternative name(s):
Dyxin
Gene names
Name:LMCD1
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length365 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter By similarity. Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T cells signaling pathway. Ref.6

Subunit structure

Interacts with GATA1 and GATA4 By similarity. Interacts with beta-dystroglycan. Interacts with GATA6. Ref.5

Subcellular location

Cytoplasm By similarity. Nucleus By similarity. Note: May shuttle between the cytoplasm and the nucleus By similarity.

Tissue specificity

Expressed in the heart (at protein level). Expressed in many tissues with highest abundance in skeletal muscle. Ref.6

Domain

The LIM zinc-binding domains and the Cys-rich region mediate interaction with GATA6 By similarity.

Sequence similarities

Contains 2 LIM zinc-binding domains.

Contains 1 PET domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 365365LIM and cysteine-rich domains protein 1
PRO_0000075815

Regions

Domain99 – 206108PET
Domain241 – 30666LIM zinc-binding 1
Domain307 – 36559LIM zinc-binding 2
Compositional bias28 – 5831Cys-rich

Sequences

Sequence LengthMass (Da)Tools
Q9NZU5 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: D84BFD53C43D2DD7

FASTA36540,833
        10         20         30         40         50         60 
MAKVAKDLNP GVKKMSLGQL QSARGVACLG CKGTCSGFEP HSWRKICKSC KCSQEDHCLT 

        70         80         90        100        110        120 
SDLEDDRKIG RLLMDSKYST LTARVKGGDG IRIYKRNRMI MTNPIATGKD PTFDTITYEW 

       130        140        150        160        170        180 
APPGVTQKLG LQYMELIPKE KQPVTGTEGA FYRRRQLMHQ LPIYDQDPSR CRGLLENELK 

       190        200        210        220        230        240 
LMEEFVKQYK SEALGVGEVA LPGQGGLPKE EGKQQEKPEG AETTAATTNG SLSDPSKEVE 

       250        260        270        280        290        300 
YVCELCKGAA PPDSPVVYSD RAGYNKQWHP TCFVCAKCSE PLVDLIYFWK DGAPWCGRHY 

       310        320        330        340        350        360 
CESLRPRCSG CDEIIFAEDY QRVEDLAWHR KHFVCEGCEQ LLSGRAYIVT KGQLLCPTCS 


KSKRS 

« Hide

References

« Hide 'large scale' references
[1]"Identification of a novel LIM domain gene, LMCD1, and chromosomal localization in human and mouse."
Bespalova I.N., Burmeister M.
Genomics 63:69-74(2000) [PubMed: 10662546] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Identification of Dyxin: a novel intracellular binding partner of beta-dystroglycan."
Holt H.H., Crosbie R.H., Saito F., Campbell K.P.
Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary gland.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
[5]"LMCD1/Dyxin is a novel transcriptional cofactor that restricts GATA6 function by inhibiting DNA binding."
Rath N., Wang Z., Lu M.M., Morrisey E.E.
Mol. Cell. Biol. 25:8864-8873(2005) [PubMed: 16199866] [Abstract]
Cited for: INTERACTION WITH GATA6.
[6]"LIM and cysteine-rich domains 1 regulates cardiac hypertrophy by targeting calcineurin/nuclear factor of activated T cells signaling."
Bian Z.Y., Huang H., Jiang H., Shen D.F., Yan L., Zhu L.H., Wang L., Cao F., Liu C., Tang Q.Z., Li H.
Hypertension 55:257-263(2010) [PubMed: 20026769] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF169284 mRNA. Translation: AAF34411.1.
AF216709 mRNA. Translation: AAG36778.1.
AK022176 mRNA. Translation: BAB13976.1.
BC000646 mRNA. Translation: AAH00646.1.
IPIIPI00303258.
RefSeqNP_055398.1. NM_014583.2.
UniGeneHs.475353.

3D structure databases

ProteinModelPortalQ9NZU5.
SMRQ9NZU5. Positions 240-365.
ModBaseSearch...

Protein-protein interaction databases

MINTMINT-6492974.
STRINGQ9NZU5.

Polymorphism databases

DMDM20978521.

Proteomic databases

PeptideAtlasQ9NZU5.
PRIDEQ9NZU5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000157600; ENSP00000157600; ENSG00000071282.
GeneID29995.
KEGGhsa:29995.
UCSCuc003bqq.1. human.

Organism-specific databases

CTD29995.
GeneCardsGC03P008518.
H-InvDBHIX0003018.
HGNCHGNC:6633. LMCD1.
HPAHPA024059.
MIM604859. gene.
neXtProtNX_Q9NZU5.
PharmGKBPA30401.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG06308.
GeneTreeENSGT00550000074438.
HOGENOMHBG716344.
HOVERGENHBG001038.
InParanoidQ9NZU5.
OMALSGRAYI.
OrthoDBEOG45B1G6.
PhylomeDBQ9NZU5.

Gene expression databases

ArrayExpressQ9NZU5.
BgeeQ9NZU5.
CleanExHS_LMCD1.
GenevestigatorQ9NZU5.
GermOnlineENSG00000071282. Homo sapiens.

Family and domain databases

InterProIPR010442. PET_domain.
IPR001781. Znf_LIM.
[Graphical view]
Gene3DG3DSA:2.10.110.10. Znf_LIM. 2 hits.
PfamPF00412. LIM. 2 hits.
PF06297. PET. 1 hit.
[Graphical view]
SMARTSM00132. LIM. 2 hits.
[Graphical view]
PROSITEPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
PS51303. PET. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio52796.
SOURCESearch...

Entry information

Entry nameLMCD1_HUMAN
AccessionPrimary (citable) accession number: Q9NZU5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: October 1, 2000
Last modified: December 14, 2011
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families