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Reviewed, UniProtKB/Swiss-Prot Q9NZU5 (LMCD1_HUMAN)

Last modified June 16, 2009. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    LIM and cysteine-rich domains protein 1
Alternative name(s):
    Dyxin
Gene names
Name: LMCD1
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length365 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Subunit structure

Interacts with beta-dystroglycan.

Tissue specificity

Expressed in many tissues with highest abundance in skeletal muscle.

Sequence similarities

Contains 2 LIM zinc-binding domains.

Contains 1 PET domain.

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Ontologies

Keywords
   DomainLIM domain
Repeat
   LigandMetal-binding
Zinc
Gene Ontology (GO)
   Molecular functionzinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 365365LIM and cysteine-rich domains protein 1
PRO_0000075815

Regions

Domain99 – 206108PET
Domain241 – 30666LIM zinc-binding 1
Domain307 – 36559LIM zinc-binding 2
Compositional bias28 – 5831Cys-rich

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Sequences

Sequence LengthMass (Da)Tools
Q9NZU5-1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: D84BFD53C43D2DD7

FASTA36540,833
        10         20         30         40         50         60 
MAKVAKDLNP GVKKMSLGQL QSARGVACLG CKGTCSGFEP HSWRKICKSC KCSQEDHCLT 

        70         80         90        100        110        120 
SDLEDDRKIG RLLMDSKYST LTARVKGGDG IRIYKRNRMI MTNPIATGKD PTFDTITYEW 

       130        140        150        160        170        180 
APPGVTQKLG LQYMELIPKE KQPVTGTEGA FYRRRQLMHQ LPIYDQDPSR CRGLLENELK 

       190        200        210        220        230        240 
LMEEFVKQYK SEALGVGEVA LPGQGGLPKE EGKQQEKPEG AETTAATTNG SLSDPSKEVE 

       250        260        270        280        290        300 
YVCELCKGAA PPDSPVVYSD RAGYNKQWHP TCFVCAKCSE PLVDLIYFWK DGAPWCGRHY 

       310        320        330        340        350        360 
CESLRPRCSG CDEIIFAEDY QRVEDLAWHR KHFVCEGCEQ LLSGRAYIVT KGQLLCPTCS 


KSKRS

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References

« Hide 'large scale' references
[1]"Identification of a novel LIM domain gene, LMCD1, and chromosomal localization in human and mouse."
Bespalova I.N., Burmeister M.
Genomics 63:69-74(2000) [PubMed: 10662546] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Identification of Dyxin: a novel intracellular binding partner of beta-dystroglycan."
Holt H.H., Crosbie R.H., Saito F., Campbell K.P.
Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary gland.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.

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Cross-references

Sequence databases

AF169284 mRNA. Translation: AAF34411.1.
AF216709 mRNA. Translation: AAG36778.1.
AK022176 mRNA. Translation: BAB13976.1.
BC000646 mRNA. Translation: AAH00646.1.
IPIIPI00303258.
RefSeqNP_055398.1.
UniGeneHs.475353

3D structure databases

HSSPHSSP built from PDB template 1CTL based on UniProtKB P32965.
ModBaseSearch...

Proteomic databases

PeptideAtlasQ9NZU5.
PRIDEQ9NZU5.

Genome annotation databases

EnsemblENSG00000071282. Homo sapiens. [Contig view]
GeneID29995.
KEGGhsa:29995.

Organism-specific databases

GeneCardsGC03P008518.
H-InvDBHIX0003018.
HGNCHGNC:6633. LMCD1.
MIM604859. gene.
PharmGKBPA30401.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ9NZU5.
HOVERGENQ9NZU5.

Gene expression databases

ArrayExpressQ9NZU5.
BgeeQ9NZU5.
CleanExHS_LMCD1.
GermOnlineENSG00000071282. Homo sapiens.

Family and domain databases

InterProIPR010442. PET_domain.
IPR001781. Znf_LIM.
[Graphical view]
Gene3DG3DSA:2.10.110.10. Znf_LIM. 1 hit.
PfamPF00412. LIM. 2 hits.
PF06297. PET. 1 hit.
[Graphical view]
ProDomPD000094. LIM. 2 hits.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00132. LIM. 2 hits.
[Graphical view]
PROSITEPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
PS51303. PET. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio52796.
SOURCESearch...

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Entry information

Entry nameLMCD1_HUMAN
AccessionPrimary (citable) accession number: Q9NZU5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: October 1, 2000
Last modified: June 16, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents