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Protein

Leucine-rich repeat transmembrane protein FLRT1

Gene

FLRT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in fibroblast growth factor-mediated signaling cascades that lead to the activation of MAP kinases. Promotes neurite outgrowth via FGFR1-mediated activation of downstream MAP kinases. Promotes an increase both in neurite number and in neurite length. May play a role in cell-cell adhesion and cell guidance via its interaction with ADGRL1/LPHN1 and ADGRL3.By similarity

GO - Molecular functioni

  • protein binding, bridging Source: UniProtKB
  • protein kinase inhibitor activity Source: GO_Central
  • signal transducer activity, downstream of receptor Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126500-MONOMER.
ReactomeiR-HSA-5654687. Downstream signaling of activated FGFR1.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat transmembrane protein FLRT1
Alternative name(s):
Fibronectin-like domain-containing leucine-rich transmembrane protein 1
Gene namesi
Name:FLRT1
ORF Names:UNQ752/PRO1483
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:3760. FLRT1.

Subcellular locationi

  • Cell membrane By similarity; Single-pass membrane protein By similarity
  • Endoplasmic reticulum membrane By similarity
  • Cytoplasmic vesicle membrane By similarity
  • Cytoplasmperinuclear region By similarity
  • Cell junctionfocal adhesion By similarity
  • Secreted By similarity
  • Cell projection By similarity
  • Cell junction By similarity

  • Note: In addition to its location at the cell membrane, colocalizes with FGFR1 in punctate perinuclear cytoplasmic vesicles. Detected along neurites and at contacts between neurite termini and other cells. Proteolytic cleavage gives rise to a shedded ectodomain.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 524ExtracellularSequence analysisAdd BLAST504
Transmembranei525 – 545HelicalSequence analysisAdd BLAST21
Topological domaini546 – 646CytoplasmicSequence analysisAdd BLAST101

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

MalaCardsiFLRT1.
Orphaneti401825. Autosomal recessive spastic paraplegia type 68.
PharmGKBiPA28177.

Polymorphism and mutation databases

BioMutaiFLRT1.
DMDMi215274159.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000002127821 – 646Leucine-rich repeat transmembrane protein FLRT1Add BLAST626

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 32By similarity
Disulfide bondi30 ↔ 39By similarity
Glycosylationi221N-linked (GlcNAc...)Sequence analysis1
Glycosylationi277N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi304 ↔ 329By similarity

Post-translational modificationi

N-glycosylated.1 Publication
Phosphorylated in response to FGFR1 signaling, but is not a direct substrate of FGFR1 or SRC. A mutant where the Tyr phosphorylation sites have been replaced by Phe displays constitutive FGFR1-dependent activation of downstream MAP kinases.By similarity
Proteolytic cleavage in the juxtamembrane region gives rise to a soluble ectodomain.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9NZU1.
PaxDbiQ9NZU1.
PeptideAtlasiQ9NZU1.
PRIDEiQ9NZU1.

PTM databases

iPTMnetiQ9NZU1.
PhosphoSitePlusiQ9NZU1.

Expressioni

Tissue specificityi

Expressed in kidney and brain.1 Publication

Gene expression databases

BgeeiENSG00000126500.
CleanExiHS_FLRT1.
GenevisibleiQ9NZU1. HS.

Organism-specific databases

HPAiHPA054589.

Interactioni

Subunit structurei

Interacts with FGFR1. Interacts (via extracellular domain) with ADGRL1/LPHN1 and ADGRL3 (via olfactomedin-like domain).By similarity

GO - Molecular functioni

  • protein binding, bridging Source: UniProtKB

Protein-protein interaction databases

BioGridi117269. 15 interactors.
IntActiQ9NZU1. 2 interactors.
MINTiMINT-1778423.
STRINGi9606.ENSP00000246841.

Structurei

3D structure databases

ProteinModelPortaliQ9NZU1.
SMRiQ9NZU1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 53LRRNTAdd BLAST33
Repeati54 – 75LRR 1Add BLAST22
Repeati79 – 99LRR 2Add BLAST21
Repeati100 – 121LRR 3Add BLAST22
Repeati124 – 145LRR 4Add BLAST22
Repeati150 – 171LRR 5Add BLAST22
Repeati172 – 192LRR 6Add BLAST21
Repeati195 – 218LRR 7Add BLAST24
Repeati221 – 241LRR 8Add BLAST21
Repeati243 – 264LRR 9Add BLAST22
Repeati267 – 288LRR 10Add BLAST22
Domaini300 – 352LRRCTAdd BLAST53
Domaini409 – 504Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST96

Sequence similaritiesi

Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation
Contains 10 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIEA. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000290188.
HOVERGENiHBG051629.
InParanoidiQ9NZU1.
KOiK16362.
OrthoDBiEOG091G05YU.
PhylomeDBiQ9NZU1.
TreeFamiTF331598.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF13855. LRR_8. 3 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 8 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF52058. SSF52058. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
PS51450. LRR. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NZU1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLRDWLFLC YGLIAFLTEV IDSTTCPSVC RCDNGFIYCN DRGLTSIPAD
60 70 80 90 100
IPDDATTLYL QNNQINNAGI PQDLKTKVNV QVIYLYENDL DEFPINLPRS
110 120 130 140 150
LRELHLQDNN VRTIARDSLA RIPLLEKLHL DDNSVSTVSI EEDAFADSKQ
160 170 180 190 200
LKLLFLSRNH LSSIPSGLPH TLEELRLDDN RISTIPLHAF KGLNSLRRLV
210 220 230 240 250
LDGNLLANQR IADDTFSRLQ NLTELSLVRN SLAAPPLNLP SAHLQKLYLQ
260 270 280 290 300
DNAISHIPYN TLAKMRELER LDLSNNNLTT LPRGLFDDLG NLAQLLLRNN
310 320 330 340 350
PWFCGCNLMW LRDWVKARAA VVNVRGLMCQ GPEKVRGMAI KDITSEMDEC
360 370 380 390 400
FETGPQGGVA NAAAKTTASN HASATTPQGS LFTLKAKRPG LRLPDSNIDY
410 420 430 440 450
PMATGDGAKT LAIHVKALTA DSIRITWKAT LPASSFRLSW LRLGHSPAVG
460 470 480 490 500
SITETLVQGD KTEYLLTALE PKSTYIICMV TMETSNAYVA DETPVCAKAE
510 520 530 540 550
TADSYGPTTT LNQEQNAGPM ASLPLAGIIG GAVALVFLFL VLGAICWYVH
560 570 580 590 600
QAGELLTRER AYNRGSRKKD DYMESGTKKD NSILEIRGPG LQMLPINPYR
610 620 630 640
AKEEYVVHTI FPSNGSSLCK ATHTIGYGTT RGYRDGGIPD IDYSYT
Length:646
Mass (Da):71,358
Last modified:November 25, 2008 - v3
Checksum:i0F81FF7C9CA13129
GO

Sequence cautioni

The sequence AAF28459 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH18370 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAQ88675 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAF82620 differs from that shown. Reason: Erroneous initiation.Curated
The sequence EAW74194 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti568K → E in AAF28459 (PubMed:10644439).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169675 mRNA. Translation: AAF28459.1. Different initiation.
AY358308 mRNA. Translation: AAQ88675.1. Different initiation.
AK289931 mRNA. Translation: BAF82620.1. Different initiation.
AP006333 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74194.1. Different initiation.
BC018370 mRNA. Translation: AAH18370.1. Different initiation.
RefSeqiNP_037412.2. NM_013280.4.
XP_005273918.1. XM_005273861.1.
XP_011543185.1. XM_011544883.1.
UniGeneiHs.584876.

Genome annotation databases

EnsembliENST00000246841; ENSP00000246841; ENSG00000126500.
GeneIDi23769.
KEGGihsa:23769.
UCSCiuc001nyi.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169675 mRNA. Translation: AAF28459.1. Different initiation.
AY358308 mRNA. Translation: AAQ88675.1. Different initiation.
AK289931 mRNA. Translation: BAF82620.1. Different initiation.
AP006333 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74194.1. Different initiation.
BC018370 mRNA. Translation: AAH18370.1. Different initiation.
RefSeqiNP_037412.2. NM_013280.4.
XP_005273918.1. XM_005273861.1.
XP_011543185.1. XM_011544883.1.
UniGeneiHs.584876.

3D structure databases

ProteinModelPortaliQ9NZU1.
SMRiQ9NZU1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117269. 15 interactors.
IntActiQ9NZU1. 2 interactors.
MINTiMINT-1778423.
STRINGi9606.ENSP00000246841.

PTM databases

iPTMnetiQ9NZU1.
PhosphoSitePlusiQ9NZU1.

Polymorphism and mutation databases

BioMutaiFLRT1.
DMDMi215274159.

Proteomic databases

MaxQBiQ9NZU1.
PaxDbiQ9NZU1.
PeptideAtlasiQ9NZU1.
PRIDEiQ9NZU1.

Protocols and materials databases

DNASUi23769.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246841; ENSP00000246841; ENSG00000126500.
GeneIDi23769.
KEGGihsa:23769.
UCSCiuc001nyi.2. human.

Organism-specific databases

CTDi23769.
GeneCardsiFLRT1.
HGNCiHGNC:3760. FLRT1.
HPAiHPA054589.
MalaCardsiFLRT1.
MIMi604806. gene.
neXtProtiNX_Q9NZU1.
Orphaneti401825. Autosomal recessive spastic paraplegia type 68.
PharmGKBiPA28177.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIEA. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000290188.
HOVERGENiHBG051629.
InParanoidiQ9NZU1.
KOiK16362.
OrthoDBiEOG091G05YU.
PhylomeDBiQ9NZU1.
TreeFamiTF331598.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126500-MONOMER.
ReactomeiR-HSA-5654687. Downstream signaling of activated FGFR1.

Miscellaneous databases

GenomeRNAii23769.
PROiQ9NZU1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000126500.
CleanExiHS_FLRT1.
GenevisibleiQ9NZU1. HS.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF13855. LRR_8. 3 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 8 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF52058. SSF52058. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
PS51450. LRR. 8 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFLRT1_HUMAN
AccessioniPrimary (citable) accession number: Q9NZU1
Secondary accession number(s): Q8WVA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: November 25, 2008
Last modified: November 30, 2016
This is version 150 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.