Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leucine-rich repeat transmembrane protein FLRT3

Gene

FLRT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development in the retina (By similarity). Plays a role in cell-cell adhesion via its interaction with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells (PubMed:26235030). Interaction with the intracellular domain of ROBO1 mediates axon attraction towards cells expressing NTN1. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5B, and possibly also other UNC-5 family members (By similarity). Promotes neurite outgrowth (in vitro) (PubMed:14706654). Mediates cell-cell contacts that promote an increase both in neurite number and in neurite length. Plays a role in the regulation of the density of glutamaergic synapses. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal morphogenesis during embryonic development, but not for normal embryonic patterning. Required for normal ventral closure, headfold fusion and definitive endoderm migration during embryonic development. Required for the formation of a normal basement membrane and the maintenance of a normal anterior visceral endoderm during embryonic development (By similarity).By similarity2 Publications

GO - Molecular functioni

  • chemorepellent activity Source: Ensembl
  • protein binding, bridging Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • protein kinase inhibitor activity Source: GO_Central
  • receptor signaling protein activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-5654687. Downstream signaling of activated FGFR1.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat transmembrane protein FLRT3
Alternative name(s):
Fibronectin-like domain-containing leucine-rich transmembrane protein 3
Gene namesi
Name:FLRT3
Synonyms:KIAA1469
ORF Names:UNQ856/PRO1865
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:3762. FLRT3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 528500ExtracellularSequence analysisAdd
BLAST
Transmembranei529 – 54921HelicalSequence analysisAdd
BLAST
Topological domaini550 – 649100CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Endoplasmic reticulum, Membrane, Secreted

Pathology & Biotechi

Involvement in diseasei

Hypogonadotropic hypogonadism 21 with or without anosmia (HH21)1 Publication
The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. Some patients carrying mutations in FLRT3 also have a mutation in another HH-associated gene including FGFR1, HS6ST1 and FGF17 (PubMed:23643382).1 Publication
Disease descriptionA disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).
See also OMIM:615271
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti69 – 691Q → K in HH21; rare variant associated with susceptibility to disease; the patient has a second mutation in the HH-associated gene FGFR1. 1 Publication
Corresponds to variant rs398124653 [ dbSNP | Ensembl ].
VAR_069950
Natural varianti97 – 971E → G in HH21; rare variant associated with susceptibility to disease; patients have a second mutation in another HH-associated gene including FGFR1, HS6ST1 and FGF17. 1 Publication
Corresponds to variant rs398124651 [ dbSNP | Ensembl ].
VAR_069951
Natural varianti144 – 1441S → I in HH21; rare variant associated with susceptibility to disease; patients have a second mutation in another HH-associated gene including FGFR1, HS6ST1 and FGF17. 1 Publication
Corresponds to variant rs398124652 [ dbSNP | Ensembl ].
VAR_069952
Natural varianti339 – 3391K → R in HH21. 1 Publication
Corresponds to variant rs398124654 [ dbSNP | Ensembl ].
VAR_069953

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi38 – 381D → A: Abolishes ADGRL3 binding; when associated with A-43; A-45 and A-47. 1 Publication
Mutagenesisi43 – 431Y → A: Abolishes ADGRL3 binding; when associated with A-64. Abolishes ADGRL3 binding; when associated with A-38; A-43 and A-47. 1 Publication
Mutagenesisi45 – 451N → A: Abolishes ADGRL3 binding; when associated with A-38; A-43 and A-47. 1 Publication
Mutagenesisi47 – 471R → A: Abolishes ADGRL3 binding; when associated with A-38; A-43 and A-45. 1 Publication
Mutagenesisi64 – 641Y → A: Abolishes ADGRL3 binding; when associated with A-43. 1 Publication
Mutagenesisi89 – 891Y → A: Abolishes ADGRL3 binding; when associated with A-91. 1 Publication
Mutagenesisi91 – 911Y → A: Abolishes ADGRL3 binding; when associated with A-89. 1 Publication
Mutagenesisi181 – 1811R → A: No effect on homodimerization; when associated with A-183. 1 Publication
Mutagenesisi181 – 1811R → N: Adds a glycosylation site that strongly reduces homodimerization; when associated with T-183. 1 Publication
Mutagenesisi183 – 1831D → A: No effect on homodimerization; when associated with A-181. 1 Publication
Mutagenesisi183 – 1831D → T: Adds a glycosylation site that strongly reduces homodimerization; when associated with T-183. 1 Publication

Keywords - Diseasei

Disease mutation, Hypogonadotropic hypogonadism, Kallmann syndrome

Organism-specific databases

MalaCardsiFLRT3.
MIMi615271. phenotype.
Orphaneti478. Kallmann syndrome.
PharmGKBiPA28179.

Polymorphism and mutation databases

BioMutaiFLRT3.
DMDMi20138400.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 649621Leucine-rich repeat transmembrane protein FLRT3PRO_0000021280Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 371 Publication
Disulfide bondi35 ↔ 441 Publication
Glycosylationi226 – 2261N-linked (GlcNAc...)Sequence analysis1 Publication
Glycosylationi282 – 2821N-linked (GlcNAc...)Sequence analysis
Glycosylationi296 – 2961N-linked (GlcNAc...)Sequence analysis
Disulfide bondi309 ↔ 3341 Publication

Post-translational modificationi

N-glycosylated.By similarity
Proteolytic cleavage in the juxtamembrane region gives rise to a soluble ectodomain. Cleavage is probably effected by a metalloprotease.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9NZU0.
MaxQBiQ9NZU0.
PaxDbiQ9NZU0.
PeptideAtlasiQ9NZU0.
PRIDEiQ9NZU0.

PTM databases

iPTMnetiQ9NZU0.
PhosphoSiteiQ9NZU0.

Expressioni

Tissue specificityi

Expressed in kidney, brain, pancreas, skeletal muscle, lung, liver, placenta, and heart.1 Publication

Gene expression databases

BgeeiENSG00000125848.
CleanExiHS_FLRT3.
GenevisibleiQ9NZU0. HS.

Organism-specific databases

HPAiCAB026166.
HPA056033.

Interactioni

Subunit structurei

Monomer and homodimer. Self-associates (via leucine-rich repeats), giving rise to homooligomers (PubMed:26235030). Interacts with FGFR1. Interacts (via extracellular domain) with ADGRL1/LPHN1 and LPHN2 (via olfactomedin-like domain) (By similarity). Interacts (via extracellular domain) with ADGRL3 (via olfactomedin-like domain); the interaction is direct (PubMed:26235030). Interacts (via extracellular domain) with UNC5B and UNC5D (via extracellular domain); the interaction is direct (PubMed:26235030). Identified in complexes composed of FLRT3, ADGRL3 and UNC5B, respectively FLRT3, ADGRL3 and UNC5D (PubMed:26235030). May also interact (via extracellular domain) with UNC5A and UNC5C. Interacts (via cytoplasmic domain) with ROBO1 (By similarity).By similarity1 Publication

GO - Molecular functioni

  • protein binding, bridging Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi117267. 2 interactions.
DIPiDIP-50407N.
STRINGi9606.ENSP00000339912.

Structurei

Secondary structure

1
649
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi33 – 386Combined sources
Beta strandi41 – 433Combined sources
Beta strandi62 – 643Combined sources
Helixi72 – 743Combined sources
Helixi77 – 815Combined sources
Beta strandi87 – 893Combined sources
Beta strandi108 – 1103Combined sources
Helixi121 – 1255Combined sources
Beta strandi132 – 1343Combined sources
Turni147 – 1526Combined sources
Beta strandi158 – 1603Combined sources
Beta strandi179 – 1813Combined sources
Helixi192 – 1954Combined sources
Beta strandi203 – 2053Combined sources
Helixi213 – 2153Combined sources
Turni218 – 2236Combined sources
Beta strandi229 – 2313Combined sources
Beta strandi251 – 2533Combined sources
Turni264 – 2696Combined sources
Beta strandi275 – 2773Combined sources
Turni288 – 2936Combined sources
Beta strandi299 – 3013Combined sources
Helixi314 – 3229Combined sources
Beta strandi328 – 3314Combined sources
Helixi338 – 3403Combined sources
Helixi345 – 3473Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5CMNX-ray3.61A/B/C/D29-357[»]
5CMPX-ray2.60A/B/C/D29-357[»]
ProteinModelPortaliQ9NZU0.
SMRiQ9NZU0. Positions 29-352.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 5830LRRNTSequence analysisAdd
BLAST
Repeati59 – 8022LRR 1Sequence analysisAdd
BLAST
Repeati84 – 10421LRR 2Sequence analysisAdd
BLAST
Repeati105 – 12622LRR 3Sequence analysisAdd
BLAST
Repeati129 – 15022LRR 4Sequence analysisAdd
BLAST
Repeati155 – 17521LRR 5Sequence analysisAdd
BLAST
Repeati176 – 19722LRR 6Sequence analysisAdd
BLAST
Repeati200 – 22021LRR 7Sequence analysisAdd
BLAST
Repeati226 – 24722LRR 8Sequence analysisAdd
BLAST
Repeati248 – 26922LRR 9Sequence analysisAdd
BLAST
Repeati272 – 29322LRR 10Sequence analysisAdd
BLAST
Domaini305 – 35753LRRCTSequence analysisAdd
BLAST
Domaini409 – 50496Fibronectin type-IIIPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni38 – 6730Interaction with ADGRL31 PublicationAdd
BLAST

Sequence similaritiesi

Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation
Contains 10 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIEA. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118969.
HOVERGENiHBG051629.
InParanoidiQ9NZU0.
KOiK16362.
OMAiSPYRVCM.
OrthoDBiEOG091G05YU.
PhylomeDBiQ9NZU0.
TreeFamiTF331598.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR003961. FN3_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 7 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF52058. SSF52058. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
PS51450. LRR. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NZU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISAAWSIFL IGTKIGLFLQ VAPLSVMAKS CPSVCRCDAG FIYCNDRFLT
60 70 80 90 100
SIPTGIPEDA TTLYLQNNQI NNAGIPSDLK NLLKVERIYL YHNSLDEFPT
110 120 130 140 150
NLPKYVKELH LQENNIRTIT YDSLSKIPYL EELHLDDNSV SAVSIEEGAF
160 170 180 190 200
RDSNYLRLLF LSRNHLSTIP WGLPRTIEEL RLDDNRISTI SSPSLQGLTS
210 220 230 240 250
LKRLVLDGNL LNNHGLGDKV FFNLVNLTEL SLVRNSLTAA PVNLPGTNLR
260 270 280 290 300
KLYLQDNHIN RVPPNAFSYL RQLYRLDMSN NNLSNLPQGI FDDLDNITQL
310 320 330 340 350
ILRNNPWYCG CKMKWVRDWL QSLPVKVNVR GLMCQAPEKV RGMAIKDLNA
360 370 380 390 400
ELFDCKDSGI VSTIQITTAI PNTVYPAQGQ WPAPVTKQPD IKNPKLTKDH
410 420 430 440 450
QTTGSPSRKT ITITVKSVTS DTIHISWKLA LPMTALRLSW LKLGHSPAFG
460 470 480 490 500
SITETIVTGE RSEYLVTALE PDSPYKVCMV PMETSNLYLF DETPVCIETE
510 520 530 540 550
TAPLRMYNPT TTLNREQEKE PYKNPNLPLA AIIGGAVALV TIALLALVCW
560 570 580 590 600
YVHRNGSLFS RNCAYSKGRR RKDDYAEAGT KKDNSILEIR ETSFQMLPIS
610 620 630 640
NEPISKEEFV IHTIFPPNGM NLYKNNHSES SSNRSYRDSG IPDSDHSHS
Length:649
Mass (Da):73,004
Last modified:October 1, 2000 - v1
Checksum:i9EFF666C46181F08
GO

Sequence cautioni

The sequence BAA95993 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB55282 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB55303 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti198 – 1981L → P in BAB55282 (PubMed:14702039).Curated
Sequence conflicti307 – 3071W → R in BAB55282 (PubMed:14702039).Curated
Sequence conflicti519 – 5191K → Q in BAB55023 (PubMed:14702039).Curated
Sequence conflicti638 – 6381D → G in BAB55282 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti69 – 691Q → K in HH21; rare variant associated with susceptibility to disease; the patient has a second mutation in the HH-associated gene FGFR1. 1 Publication
Corresponds to variant rs398124653 [ dbSNP | Ensembl ].
VAR_069950
Natural varianti97 – 971E → G in HH21; rare variant associated with susceptibility to disease; patients have a second mutation in another HH-associated gene including FGFR1, HS6ST1 and FGF17. 1 Publication
Corresponds to variant rs398124651 [ dbSNP | Ensembl ].
VAR_069951
Natural varianti144 – 1441S → I in HH21; rare variant associated with susceptibility to disease; patients have a second mutation in another HH-associated gene including FGFR1, HS6ST1 and FGF17. 1 Publication
Corresponds to variant rs398124652 [ dbSNP | Ensembl ].
VAR_069952
Natural varianti339 – 3391K → R in HH21. 1 Publication
Corresponds to variant rs398124654 [ dbSNP | Ensembl ].
VAR_069953
Natural varianti377 – 3771A → T.
Corresponds to variant rs8120693 [ dbSNP | Ensembl ].
VAR_050997
Natural varianti400 – 4001H → Q.3 Publications
Corresponds to variant rs6079391 [ dbSNP | Ensembl ].
VAR_017152
Natural varianti452 – 4521I → V Found in a renal cell carcinoma case; somatic mutation. 1 Publication
VAR_064714
Natural varianti460 – 4601E → D.
Corresponds to variant rs35253731 [ dbSNP | Ensembl ].
VAR_050998

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169677 mRNA. Translation: AAF28461.1.
AB040902 mRNA. Translation: BAA95993.1. Different initiation.
AK027297 mRNA. Translation: BAB55023.1.
AK027670 mRNA. Translation: BAB55282.1. Different initiation.
AK027694 mRNA. Translation: BAB55303.1. Different initiation.
AY358319 mRNA. Translation: AAQ88685.1.
AK074909 mRNA. Translation: BAC11284.1.
AL132826 Genomic DNA. Translation: CAB86687.1.
CH471133 Genomic DNA. Translation: EAX10300.1.
CH471133 Genomic DNA. Translation: EAX10301.1.
BC020870 mRNA. Translation: AAH20870.1.
CCDSiCCDS13121.1.
RefSeqiNP_037413.1. NM_013281.3.
NP_938205.1. NM_198391.2.
XP_005260739.1. XM_005260682.4.
XP_011527506.1. XM_011529204.2.
XP_011527507.1. XM_011529205.2.
UniGeneiHs.41296.

Genome annotation databases

EnsembliENST00000341420; ENSP00000339912; ENSG00000125848.
ENST00000378053; ENSP00000367292; ENSG00000125848.
GeneIDi23767.
KEGGihsa:23767.
UCSCiuc002wov.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169677 mRNA. Translation: AAF28461.1.
AB040902 mRNA. Translation: BAA95993.1. Different initiation.
AK027297 mRNA. Translation: BAB55023.1.
AK027670 mRNA. Translation: BAB55282.1. Different initiation.
AK027694 mRNA. Translation: BAB55303.1. Different initiation.
AY358319 mRNA. Translation: AAQ88685.1.
AK074909 mRNA. Translation: BAC11284.1.
AL132826 Genomic DNA. Translation: CAB86687.1.
CH471133 Genomic DNA. Translation: EAX10300.1.
CH471133 Genomic DNA. Translation: EAX10301.1.
BC020870 mRNA. Translation: AAH20870.1.
CCDSiCCDS13121.1.
RefSeqiNP_037413.1. NM_013281.3.
NP_938205.1. NM_198391.2.
XP_005260739.1. XM_005260682.4.
XP_011527506.1. XM_011529204.2.
XP_011527507.1. XM_011529205.2.
UniGeneiHs.41296.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
5CMNX-ray3.61A/B/C/D29-357[»]
5CMPX-ray2.60A/B/C/D29-357[»]
ProteinModelPortaliQ9NZU0.
SMRiQ9NZU0. Positions 29-352.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117267. 2 interactions.
DIPiDIP-50407N.
STRINGi9606.ENSP00000339912.

PTM databases

iPTMnetiQ9NZU0.
PhosphoSiteiQ9NZU0.

Polymorphism and mutation databases

BioMutaiFLRT3.
DMDMi20138400.

Proteomic databases

EPDiQ9NZU0.
MaxQBiQ9NZU0.
PaxDbiQ9NZU0.
PeptideAtlasiQ9NZU0.
PRIDEiQ9NZU0.

Protocols and materials databases

DNASUi23767.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341420; ENSP00000339912; ENSG00000125848.
ENST00000378053; ENSP00000367292; ENSG00000125848.
GeneIDi23767.
KEGGihsa:23767.
UCSCiuc002wov.3. human.

Organism-specific databases

CTDi23767.
GeneCardsiFLRT3.
HGNCiHGNC:3762. FLRT3.
HPAiCAB026166.
HPA056033.
MalaCardsiFLRT3.
MIMi604808. gene.
615271. phenotype.
neXtProtiNX_Q9NZU0.
Orphaneti478. Kallmann syndrome.
PharmGKBiPA28179.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIEA. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118969.
HOVERGENiHBG051629.
InParanoidiQ9NZU0.
KOiK16362.
OMAiSPYRVCM.
OrthoDBiEOG091G05YU.
PhylomeDBiQ9NZU0.
TreeFamiTF331598.

Enzyme and pathway databases

ReactomeiR-HSA-5654687. Downstream signaling of activated FGFR1.

Miscellaneous databases

GeneWikiiFLRT3.
GenomeRNAii23767.
PROiQ9NZU0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125848.
CleanExiHS_FLRT3.
GenevisibleiQ9NZU0. HS.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR003961. FN3_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 7 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF52058. SSF52058. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
PS51450. LRR. 8 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFLRT3_HUMAN
AccessioniPrimary (citable) accession number: Q9NZU0
Secondary accession number(s): D3DW20
, Q542Z9, Q96K39, Q96K42, Q96KB1, Q9P259
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 154 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.