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Protein

Leucine-rich repeat transmembrane protein FLRT3

Gene

FLRT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. Plays a role in the spatial organization of brain neurons. Plays a role in vascular development in the retina (By similarity). Plays a role in cell-cell adhesion via its interaction with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells (PubMed:26235030). Interaction with the intracellular domain of ROBO1 mediates axon attraction towards cells expressing NTN1. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5B, and possibly also other UNC-5 family members (By similarity). Promotes neurite outgrowth (in vitro) (PubMed:14706654). Mediates cell-cell contacts that promote an increase both in neurite number and in neurite length. Plays a role in the regulation of the density of glutamaergic synapses. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal morphogenesis during embryonic development, but not for normal embryonic patterning. Required for normal ventral closure, headfold fusion and definitive endoderm migration during embryonic development. Required for the formation of a normal basement membrane and the maintenance of a normal anterior visceral endoderm during embryonic development (By similarity).By similarity2 Publications

GO - Molecular functioni

  • chemorepellent activity Source: Ensembl
  • protein binding, bridging Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • protein kinase inhibitor activity Source: GO_Central
  • signal transducer activity, downstream of receptor Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125848-MONOMER.
ReactomeiR-HSA-5654687. Downstream signaling of activated FGFR1.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat transmembrane protein FLRT3
Alternative name(s):
Fibronectin-like domain-containing leucine-rich transmembrane protein 3
Gene namesi
Name:FLRT3
Synonyms:KIAA1469
ORF Names:UNQ856/PRO1865
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:3762. FLRT3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 528ExtracellularSequence analysisAdd BLAST500
Transmembranei529 – 549HelicalSequence analysisAdd BLAST21
Topological domaini550 – 649CytoplasmicSequence analysisAdd BLAST100

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Endoplasmic reticulum, Membrane, Secreted

Pathology & Biotechi

Involvement in diseasei

Hypogonadotropic hypogonadism 21 with or without anosmia (HH21)1 Publication
The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry. Some patients carrying mutations in FLRT3 also have a mutation in another HH-associated gene including FGFR1, HS6ST1 and FGF17 (PubMed:23643382).1 Publication
Disease descriptionA disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).
See also OMIM:615271
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06995069Q → K in HH21; rare variant associated with susceptibility to disease; the patient has a second mutation in the HH-associated gene FGFR1. 1 PublicationCorresponds to variant rs398124653dbSNPEnsembl.1
Natural variantiVAR_06995197E → G in HH21; rare variant associated with susceptibility to disease; patients have a second mutation in another HH-associated gene including FGFR1, HS6ST1 and FGF17. 1 PublicationCorresponds to variant rs398124651dbSNPEnsembl.1
Natural variantiVAR_069952144S → I in HH21; rare variant associated with susceptibility to disease; patients have a second mutation in another HH-associated gene including FGFR1, HS6ST1 and FGF17. 1 PublicationCorresponds to variant rs398124652dbSNPEnsembl.1
Natural variantiVAR_069953339K → R in HH21. 1 PublicationCorresponds to variant rs398124654dbSNPEnsembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi38D → A: Abolishes ADGRL3 binding; when associated with A-43; A-45 and A-47. 1 Publication1
Mutagenesisi43Y → A: Abolishes ADGRL3 binding; when associated with A-64. Abolishes ADGRL3 binding; when associated with A-38; A-43 and A-47. 1 Publication1
Mutagenesisi45N → A: Abolishes ADGRL3 binding; when associated with A-38; A-43 and A-47. 1 Publication1
Mutagenesisi47R → A: Abolishes ADGRL3 binding; when associated with A-38; A-43 and A-45. 1 Publication1
Mutagenesisi64Y → A: Abolishes ADGRL3 binding; when associated with A-43. 1 Publication1
Mutagenesisi89Y → A: Abolishes ADGRL3 binding; when associated with A-91. 1 Publication1
Mutagenesisi91Y → A: Abolishes ADGRL3 binding; when associated with A-89. 1 Publication1
Mutagenesisi181R → A: No effect on homodimerization; when associated with A-183. 1 Publication1
Mutagenesisi181R → N: Adds a glycosylation site that strongly reduces homodimerization; when associated with T-183. 1 Publication1
Mutagenesisi183D → A: No effect on homodimerization; when associated with A-181. 1 Publication1
Mutagenesisi183D → T: Adds a glycosylation site that strongly reduces homodimerization; when associated with T-183. 1 Publication1

Keywords - Diseasei

Disease mutation, Hypogonadotropic hypogonadism, Kallmann syndrome

Organism-specific databases

DisGeNETi23767.
MalaCardsiFLRT3.
MIMi615271. phenotype.
OpenTargetsiENSG00000125848.
Orphaneti478. Kallmann syndrome.
PharmGKBiPA28179.

Polymorphism and mutation databases

BioMutaiFLRT3.
DMDMi20138400.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000002128029 – 649Leucine-rich repeat transmembrane protein FLRT3Add BLAST621

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 371 Publication
Disulfide bondi35 ↔ 441 Publication
Glycosylationi226N-linked (GlcNAc...)Sequence analysis1 Publication1
Glycosylationi282N-linked (GlcNAc...)Sequence analysis1
Glycosylationi296N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi309 ↔ 3341 Publication

Post-translational modificationi

N-glycosylated.By similarity
Proteolytic cleavage in the juxtamembrane region gives rise to a soluble ectodomain. Cleavage is probably effected by a metalloprotease.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9NZU0.
MaxQBiQ9NZU0.
PaxDbiQ9NZU0.
PeptideAtlasiQ9NZU0.
PRIDEiQ9NZU0.

PTM databases

iPTMnetiQ9NZU0.
PhosphoSitePlusiQ9NZU0.

Expressioni

Tissue specificityi

Expressed in kidney, brain, pancreas, skeletal muscle, lung, liver, placenta, and heart.1 Publication

Gene expression databases

BgeeiENSG00000125848.
CleanExiHS_FLRT3.
GenevisibleiQ9NZU0. HS.

Organism-specific databases

HPAiCAB026166.
HPA056033.

Interactioni

Subunit structurei

Monomer and homodimer. Self-associates (via leucine-rich repeats), giving rise to homooligomers (PubMed:26235030). Interacts with FGFR1. Interacts (via extracellular domain) with ADGRL1/LPHN1 and LPHN2 (via olfactomedin-like domain) (By similarity). Interacts (via extracellular domain) with ADGRL3 (via olfactomedin-like domain); the interaction is direct (PubMed:26235030). Interacts (via extracellular domain) with UNC5B and UNC5D (via extracellular domain); the interaction is direct (PubMed:26235030). Identified in complexes composed of FLRT3, ADGRL3 and UNC5B, respectively FLRT3, ADGRL3 and UNC5D (PubMed:26235030). May also interact (via extracellular domain) with UNC5A and UNC5C. Interacts (via cytoplasmic domain) with ROBO1 (By similarity).By similarity1 Publication

GO - Molecular functioni

  • protein binding, bridging Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi117267. 2 interactors.
DIPiDIP-50407N.
STRINGi9606.ENSP00000339912.

Structurei

Secondary structure

1649
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi33 – 38Combined sources6
Beta strandi41 – 43Combined sources3
Beta strandi62 – 64Combined sources3
Helixi72 – 74Combined sources3
Helixi77 – 81Combined sources5
Beta strandi87 – 89Combined sources3
Beta strandi108 – 110Combined sources3
Helixi121 – 125Combined sources5
Beta strandi132 – 134Combined sources3
Turni147 – 152Combined sources6
Beta strandi158 – 160Combined sources3
Beta strandi179 – 181Combined sources3
Helixi192 – 195Combined sources4
Beta strandi203 – 205Combined sources3
Helixi213 – 215Combined sources3
Turni218 – 223Combined sources6
Beta strandi229 – 231Combined sources3
Beta strandi251 – 253Combined sources3
Turni264 – 269Combined sources6
Beta strandi275 – 277Combined sources3
Turni288 – 293Combined sources6
Beta strandi299 – 301Combined sources3
Helixi314 – 322Combined sources9
Beta strandi328 – 331Combined sources4
Helixi338 – 340Combined sources3
Helixi345 – 347Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5CMNX-ray3.61A/B/C/D29-357[»]
5CMPX-ray2.60A/B/C/D29-357[»]
ProteinModelPortaliQ9NZU0.
SMRiQ9NZU0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 58LRRNTSequence analysisAdd BLAST30
Repeati59 – 80LRR 1Sequence analysisAdd BLAST22
Repeati84 – 104LRR 2Sequence analysisAdd BLAST21
Repeati105 – 126LRR 3Sequence analysisAdd BLAST22
Repeati129 – 150LRR 4Sequence analysisAdd BLAST22
Repeati155 – 175LRR 5Sequence analysisAdd BLAST21
Repeati176 – 197LRR 6Sequence analysisAdd BLAST22
Repeati200 – 220LRR 7Sequence analysisAdd BLAST21
Repeati226 – 247LRR 8Sequence analysisAdd BLAST22
Repeati248 – 269LRR 9Sequence analysisAdd BLAST22
Repeati272 – 293LRR 10Sequence analysisAdd BLAST22
Domaini305 – 357LRRCTSequence analysisAdd BLAST53
Domaini409 – 504Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST96

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni38 – 67Interaction with ADGRL31 PublicationAdd BLAST30

Sequence similaritiesi

Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation
Contains 10 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIEA. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118969.
HOVERGENiHBG051629.
InParanoidiQ9NZU0.
KOiK16362.
OMAiSPYRVCM.
OrthoDBiEOG091G05YU.
PhylomeDBiQ9NZU0.
TreeFamiTF331598.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 7 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF52058. SSF52058. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
PS51450. LRR. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NZU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISAAWSIFL IGTKIGLFLQ VAPLSVMAKS CPSVCRCDAG FIYCNDRFLT
60 70 80 90 100
SIPTGIPEDA TTLYLQNNQI NNAGIPSDLK NLLKVERIYL YHNSLDEFPT
110 120 130 140 150
NLPKYVKELH LQENNIRTIT YDSLSKIPYL EELHLDDNSV SAVSIEEGAF
160 170 180 190 200
RDSNYLRLLF LSRNHLSTIP WGLPRTIEEL RLDDNRISTI SSPSLQGLTS
210 220 230 240 250
LKRLVLDGNL LNNHGLGDKV FFNLVNLTEL SLVRNSLTAA PVNLPGTNLR
260 270 280 290 300
KLYLQDNHIN RVPPNAFSYL RQLYRLDMSN NNLSNLPQGI FDDLDNITQL
310 320 330 340 350
ILRNNPWYCG CKMKWVRDWL QSLPVKVNVR GLMCQAPEKV RGMAIKDLNA
360 370 380 390 400
ELFDCKDSGI VSTIQITTAI PNTVYPAQGQ WPAPVTKQPD IKNPKLTKDH
410 420 430 440 450
QTTGSPSRKT ITITVKSVTS DTIHISWKLA LPMTALRLSW LKLGHSPAFG
460 470 480 490 500
SITETIVTGE RSEYLVTALE PDSPYKVCMV PMETSNLYLF DETPVCIETE
510 520 530 540 550
TAPLRMYNPT TTLNREQEKE PYKNPNLPLA AIIGGAVALV TIALLALVCW
560 570 580 590 600
YVHRNGSLFS RNCAYSKGRR RKDDYAEAGT KKDNSILEIR ETSFQMLPIS
610 620 630 640
NEPISKEEFV IHTIFPPNGM NLYKNNHSES SSNRSYRDSG IPDSDHSHS
Length:649
Mass (Da):73,004
Last modified:October 1, 2000 - v1
Checksum:i9EFF666C46181F08
GO

Sequence cautioni

The sequence BAA95993 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB55282 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB55303 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti198L → P in BAB55282 (PubMed:14702039).Curated1
Sequence conflicti307W → R in BAB55282 (PubMed:14702039).Curated1
Sequence conflicti519K → Q in BAB55023 (PubMed:14702039).Curated1
Sequence conflicti638D → G in BAB55282 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06995069Q → K in HH21; rare variant associated with susceptibility to disease; the patient has a second mutation in the HH-associated gene FGFR1. 1 PublicationCorresponds to variant rs398124653dbSNPEnsembl.1
Natural variantiVAR_06995197E → G in HH21; rare variant associated with susceptibility to disease; patients have a second mutation in another HH-associated gene including FGFR1, HS6ST1 and FGF17. 1 PublicationCorresponds to variant rs398124651dbSNPEnsembl.1
Natural variantiVAR_069952144S → I in HH21; rare variant associated with susceptibility to disease; patients have a second mutation in another HH-associated gene including FGFR1, HS6ST1 and FGF17. 1 PublicationCorresponds to variant rs398124652dbSNPEnsembl.1
Natural variantiVAR_069953339K → R in HH21. 1 PublicationCorresponds to variant rs398124654dbSNPEnsembl.1
Natural variantiVAR_050997377A → T.Corresponds to variant rs8120693dbSNPEnsembl.1
Natural variantiVAR_017152400H → Q.3 PublicationsCorresponds to variant rs6079391dbSNPEnsembl.1
Natural variantiVAR_064714452I → V Found in a renal cell carcinoma case; somatic mutation. 1 Publication1
Natural variantiVAR_050998460E → D.Corresponds to variant rs35253731dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169677 mRNA. Translation: AAF28461.1.
AB040902 mRNA. Translation: BAA95993.1. Different initiation.
AK027297 mRNA. Translation: BAB55023.1.
AK027670 mRNA. Translation: BAB55282.1. Different initiation.
AK027694 mRNA. Translation: BAB55303.1. Different initiation.
AY358319 mRNA. Translation: AAQ88685.1.
AK074909 mRNA. Translation: BAC11284.1.
AL132826 Genomic DNA. Translation: CAB86687.1.
CH471133 Genomic DNA. Translation: EAX10300.1.
CH471133 Genomic DNA. Translation: EAX10301.1.
BC020870 mRNA. Translation: AAH20870.1.
CCDSiCCDS13121.1.
RefSeqiNP_037413.1. NM_013281.3.
NP_938205.1. NM_198391.2.
XP_005260739.1. XM_005260682.4.
XP_011527506.1. XM_011529204.2.
XP_011527507.1. XM_011529205.2.
UniGeneiHs.41296.

Genome annotation databases

EnsembliENST00000341420; ENSP00000339912; ENSG00000125848.
ENST00000378053; ENSP00000367292; ENSG00000125848.
GeneIDi23767.
KEGGihsa:23767.
UCSCiuc002wov.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF169677 mRNA. Translation: AAF28461.1.
AB040902 mRNA. Translation: BAA95993.1. Different initiation.
AK027297 mRNA. Translation: BAB55023.1.
AK027670 mRNA. Translation: BAB55282.1. Different initiation.
AK027694 mRNA. Translation: BAB55303.1. Different initiation.
AY358319 mRNA. Translation: AAQ88685.1.
AK074909 mRNA. Translation: BAC11284.1.
AL132826 Genomic DNA. Translation: CAB86687.1.
CH471133 Genomic DNA. Translation: EAX10300.1.
CH471133 Genomic DNA. Translation: EAX10301.1.
BC020870 mRNA. Translation: AAH20870.1.
CCDSiCCDS13121.1.
RefSeqiNP_037413.1. NM_013281.3.
NP_938205.1. NM_198391.2.
XP_005260739.1. XM_005260682.4.
XP_011527506.1. XM_011529204.2.
XP_011527507.1. XM_011529205.2.
UniGeneiHs.41296.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5CMNX-ray3.61A/B/C/D29-357[»]
5CMPX-ray2.60A/B/C/D29-357[»]
ProteinModelPortaliQ9NZU0.
SMRiQ9NZU0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117267. 2 interactors.
DIPiDIP-50407N.
STRINGi9606.ENSP00000339912.

PTM databases

iPTMnetiQ9NZU0.
PhosphoSitePlusiQ9NZU0.

Polymorphism and mutation databases

BioMutaiFLRT3.
DMDMi20138400.

Proteomic databases

EPDiQ9NZU0.
MaxQBiQ9NZU0.
PaxDbiQ9NZU0.
PeptideAtlasiQ9NZU0.
PRIDEiQ9NZU0.

Protocols and materials databases

DNASUi23767.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341420; ENSP00000339912; ENSG00000125848.
ENST00000378053; ENSP00000367292; ENSG00000125848.
GeneIDi23767.
KEGGihsa:23767.
UCSCiuc002wov.3. human.

Organism-specific databases

CTDi23767.
DisGeNETi23767.
GeneCardsiFLRT3.
HGNCiHGNC:3762. FLRT3.
HPAiCAB026166.
HPA056033.
MalaCardsiFLRT3.
MIMi604808. gene.
615271. phenotype.
neXtProtiNX_Q9NZU0.
OpenTargetsiENSG00000125848.
Orphaneti478. Kallmann syndrome.
PharmGKBiPA28179.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIEA. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118969.
HOVERGENiHBG051629.
InParanoidiQ9NZU0.
KOiK16362.
OMAiSPYRVCM.
OrthoDBiEOG091G05YU.
PhylomeDBiQ9NZU0.
TreeFamiTF331598.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125848-MONOMER.
ReactomeiR-HSA-5654687. Downstream signaling of activated FGFR1.

Miscellaneous databases

GeneWikiiFLRT3.
GenomeRNAii23767.
PROiQ9NZU0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125848.
CleanExiHS_FLRT3.
GenevisibleiQ9NZU0. HS.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 7 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF52058. SSF52058. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
PS51450. LRR. 8 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFLRT3_HUMAN
AccessioniPrimary (citable) accession number: Q9NZU0
Secondary accession number(s): D3DW20
, Q542Z9, Q96K39, Q96K42, Q96KB1, Q9P259
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 157 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.