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Protein

Opioid growth factor receptor

Gene

OGFR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation.

GO - Molecular functioni

  • opioid receptor activity Source: UniProtKB

GO - Biological processi

  • regulation of cell growth Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Growth regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Opioid growth factor receptor
Short name:
OGFr
Alternative name(s):
Protein 7-60
Zeta-type opioid receptor
Gene namesi
Name:OGFR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15768. OGFR.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: The OGF/OGFR complex is probably translocated to the nucleus.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi11054.
OpenTargetsiENSG00000060491.
PharmGKBiPA31911.

Polymorphism and mutation databases

BioMutaiOGFR.
DMDMi146331047.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000580301 – 677Opioid growth factor receptorAdd BLAST677

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei299PhosphoserineCombined sources1
Modified residuei315PhosphoserineCombined sources1
Modified residuei349PhosphoserineCombined sources1
Modified residuei361PhosphoserineCombined sources1
Modified residuei378PhosphoserineCombined sources1
Modified residuei382PhosphoserineCombined sources1
Modified residuei403PhosphoserineCombined sources1
Modified residuei420PhosphoserineCombined sources1
Modified residuei484PhosphoserineCombined sources1
Modified residuei537PhosphoserineCombined sources1
Modified residuei557PhosphoserineCombined sources1
Modified residuei617PhosphoserineCombined sources1
Modified residuei637PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9NZT2.
MaxQBiQ9NZT2.
PaxDbiQ9NZT2.
PeptideAtlasiQ9NZT2.
PRIDEiQ9NZT2.

PTM databases

iPTMnetiQ9NZT2.
PhosphoSitePlusiQ9NZT2.
SwissPalmiQ9NZT2.

Expressioni

Tissue specificityi

Highly expressed in the heart and liver, moderately in skeletal muscle and kidney and to a lesser extent in brain and pancreas. Expressed in fetal tissues including liver and kidney.

Gene expression databases

BgeeiENSG00000060491.
ExpressionAtlasiQ9NZT2. baseline and differential.
GenevisibleiQ9NZT2. HS.

Organism-specific databases

HPAiHPA017899.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TERF2IPQ9NYB02EBI-1044212,EBI-750109

Protein-protein interaction databases

BioGridi116239. 15 interactors.
IntActiQ9NZT2. 2 interactors.
MINTiMINT-5005689.
STRINGi9606.ENSP00000290291.

Structurei

3D structure databases

ProteinModelPortaliQ9NZT2.
SMRiQ9NZT2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati517 – 5361Add BLAST20
Repeati537 – 5562Add BLAST20
Repeati557 – 5763Add BLAST20
Repeati577 – 5964Add BLAST20
Repeati597 – 6165Add BLAST20
Repeati617 – 6366Add BLAST20
Repeati637 – 6567Add BLAST20

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni517 – 6567 X 20 AA approximate tandem repeats of [ST]-P-S-E-T-P-G-P-[SR]-P-A-G-P-[AT]-[GR]-D-E-P-A-[EK]Add BLAST140

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi267 – 283Bipartite nuclear localization signalSequence analysisAdd BLAST17

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IH5X. Eukaryota.
ENOG4111XCW. LUCA.
GeneTreeiENSGT00390000018730.
HOVERGENiHBG024736.
InParanoidiQ9NZT2.
OMAiGRVDEGP.
OrthoDBiEOG091G04CN.
PhylomeDBiQ9NZT2.
TreeFamiTF331377.

Family and domain databases

InterProiIPR006757. OGF_rcpt.
IPR006770. OGF_rcpt_rpt.
[Graphical view]
PfamiPF04680. OGFr_III. 7 hits.
PF04664. OGFr_N. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NZT2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDDPDCDSTW EEDEEDAEDA EDEDCEDGEA AGARDADAGD EDEESEEPRA
60 70 80 90 100
ARPSSFQSRM TGSRNWRATR DMCRYRHNYP DLVERDCNGD TPNLSFYRNE
110 120 130 140 150
IRFLPNGCFI EDILQNWTDN YDLLEDNHSY IQWLFPLREP GVNWHAKPLT
160 170 180 190 200
LREVEVFKSS QEIQERLVRA YELMLGFYGI RLEDRGTGTV GRAQNYQKRF
210 220 230 240 250
QNLNWRSHNN LRITRILKSL GELGLEHFQA PLVRFFLEET LVRRELPGVR
260 270 280 290 300
QSALDYFMFA VRCRHQRRQL VHFAWEHFRP RCKFVWGPQD KLRRFKPSSL
310 320 330 340 350
PHPLEGSRKV EEEGSPGDPD HEASTQGRTC GPEHSKGGGR VDEGPQPRSV
360 370 380 390 400
EPQDAGPLER SQGDEAGGHG EDRPEPLSPK ESKKRKLELS RREQPPTEPG
410 420 430 440 450
PQSASEVEKI ALNLEGCALS QGSLRTGTQE VGGQDPGEAV QPCRQPLGAR
460 470 480 490 500
VADKVRKRRK VDEGAGDSAA VASGGAQTLA LAGSPAPSGH PKAGHSENGV
510 520 530 540 550
EEDTEGRTGP KEGTPGSPSE TPGPSPAGPA GDEPAESPSE TPGPRPAGPA
560 570 580 590 600
GDEPAESPSE TPGPRPAGPA GDEPAESPSE TPGPSPAGPT RDEPAESPSE
610 620 630 640 650
TPGPRPAGPA GDEPAESPSE TPGPRPAGPA GDEPAESPSE TPGPSPAGPT
660 670
RDEPAKAGEA AELQDAEVES SAKSGKP
Length:677
Mass (Da):73,325
Last modified:March 6, 2007 - v3
Checksum:iD4DD6AF86291B663
GO
Isoform 2 (identifier: Q9NZT2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     558-577: Missing.

Show »
Length:657
Mass (Da):71,424
Checksum:iB7A3F384ECCE5FB7
GO

Sequence cautioni

The sequence AAD03737 differs from that shown. Reason: Frameshift at positions 1 and 181.Curated
The sequence AAD03745 differs from that shown. Reason: Frameshift at positions 1 and 181.Curated
The sequence CAC28882 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27 – 28DG → EA (Ref. 2) Curated2
Sequence conflicti37 – 80DAGDE…RHNYP → GARRALGVLGQPGGLQMRLP ERHGGPQGSLCLMDPCCPLS LALQ (PubMed:11214971).CuratedAdd BLAST44
Sequence conflicti50 – 52AAR → GPE (Ref. 2) Curated3
Sequence conflicti172E → A (Ref. 2) Curated1
Sequence conflicti220 – 221LG → PC in AAF64404 (PubMed:10677613).Curated2
Sequence conflicti220 – 221LG → PC in AAF64405 (PubMed:10677613).Curated2
Sequence conflicti224G → S in AAF64404 (PubMed:10677613).Curated1
Sequence conflicti224G → S in AAF64405 (PubMed:10677613).Curated1
Sequence conflicti224G → S in AAF64406 (PubMed:10677613).Curated1
Sequence conflicti240T → S in AAD03745 (Ref. 2) Curated1
Sequence conflicti240T → S in AAD03737 (Ref. 2) Curated1
Sequence conflicti262R → G in AAD03745 (Ref. 2) Curated1
Sequence conflicti262R → G in AAD03737 (Ref. 2) Curated1
Sequence conflicti331G → E in AAF64406 (PubMed:10677613).Curated1
Sequence conflicti398E → G in AAF64406 (PubMed:10677613).Curated1
Sequence conflicti465A → T in AAF64406 (PubMed:10677613).Curated1
Sequence conflicti535A → AKTPSETPGPSPAGPTRDEP A in AAF64405 (PubMed:10677613).Curated1
Sequence conflicti564P → L in AAF64404 (PubMed:10677613).Curated1
Sequence conflicti576E → K in AAF64406 (PubMed:10677613).Curated1
Sequence conflicti576E → K (Ref. 2) Curated1
Sequence conflicti576E → K in BAB15775 (PubMed:11214971).Curated1
Sequence conflicti577S → I in AAF64406 (PubMed:10677613).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059706545R → S.Corresponds to variant rs6122313dbSNPEnsembl.1
Natural variantiVAR_030011577S → T.3 PublicationsCorresponds to variant rs6122315dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_004060558 – 577Missing in isoform 2. 2 PublicationsAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF172451 mRNA. Translation: AAF64404.1.
AF172452 mRNA. Translation: AAF64405.1.
AF172453 mRNA. Translation: AAF64406.1.
AF112980 Genomic DNA. Translation: AAD03745.1. Frameshift.
AF109134 mRNA. Translation: AAD03737.1. Frameshift.
AL035669 Genomic DNA. Translation: CAC28882.1. Sequence problems.
AL035669 Genomic DNA. Translation: CAI95763.1.
BC014137 mRNA. Translation: AAH14137.1.
AK024485 mRNA. Translation: BAB15775.1.
CCDSiCCDS13504.1. [Q9NZT2-1]
RefSeqiNP_031372.2. NM_007346.2. [Q9NZT2-1]
UniGeneiHs.67896.

Genome annotation databases

EnsembliENST00000290291; ENSP00000290291; ENSG00000060491. [Q9NZT2-1]
GeneIDi11054.
KEGGihsa:11054.
UCSCiuc002ydj.4. human. [Q9NZT2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

OGFr entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF172451 mRNA. Translation: AAF64404.1.
AF172452 mRNA. Translation: AAF64405.1.
AF172453 mRNA. Translation: AAF64406.1.
AF112980 Genomic DNA. Translation: AAD03745.1. Frameshift.
AF109134 mRNA. Translation: AAD03737.1. Frameshift.
AL035669 Genomic DNA. Translation: CAC28882.1. Sequence problems.
AL035669 Genomic DNA. Translation: CAI95763.1.
BC014137 mRNA. Translation: AAH14137.1.
AK024485 mRNA. Translation: BAB15775.1.
CCDSiCCDS13504.1. [Q9NZT2-1]
RefSeqiNP_031372.2. NM_007346.2. [Q9NZT2-1]
UniGeneiHs.67896.

3D structure databases

ProteinModelPortaliQ9NZT2.
SMRiQ9NZT2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116239. 15 interactors.
IntActiQ9NZT2. 2 interactors.
MINTiMINT-5005689.
STRINGi9606.ENSP00000290291.

PTM databases

iPTMnetiQ9NZT2.
PhosphoSitePlusiQ9NZT2.
SwissPalmiQ9NZT2.

Polymorphism and mutation databases

BioMutaiOGFR.
DMDMi146331047.

Proteomic databases

EPDiQ9NZT2.
MaxQBiQ9NZT2.
PaxDbiQ9NZT2.
PeptideAtlasiQ9NZT2.
PRIDEiQ9NZT2.

Protocols and materials databases

DNASUi11054.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000290291; ENSP00000290291; ENSG00000060491. [Q9NZT2-1]
GeneIDi11054.
KEGGihsa:11054.
UCSCiuc002ydj.4. human. [Q9NZT2-1]

Organism-specific databases

CTDi11054.
DisGeNETi11054.
GeneCardsiOGFR.
H-InvDBHIX0015988.
HGNCiHGNC:15768. OGFR.
HPAiHPA017899.
MIMi606459. gene.
neXtProtiNX_Q9NZT2.
OpenTargetsiENSG00000060491.
PharmGKBiPA31911.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IH5X. Eukaryota.
ENOG4111XCW. LUCA.
GeneTreeiENSGT00390000018730.
HOVERGENiHBG024736.
InParanoidiQ9NZT2.
OMAiGRVDEGP.
OrthoDBiEOG091G04CN.
PhylomeDBiQ9NZT2.
TreeFamiTF331377.

Miscellaneous databases

ChiTaRSiOGFR. human.
GeneWikiiOGFr.
GenomeRNAii11054.
PROiQ9NZT2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000060491.
ExpressionAtlasiQ9NZT2. baseline and differential.
GenevisibleiQ9NZT2. HS.

Family and domain databases

InterProiIPR006757. OGF_rcpt.
IPR006770. OGF_rcpt_rpt.
[Graphical view]
PfamiPF04680. OGFr_III. 7 hits.
PF04664. OGFr_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOGFR_HUMAN
AccessioniPrimary (citable) accession number: Q9NZT2
Secondary accession number(s): O96029
, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: March 6, 2007
Last modified: November 2, 2016
This is version 140 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.