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Q9NZT2 (OGFR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Opioid growth factor receptor

Short name=OGFr
Alternative name(s):
Protein 7-60
Zeta-type opioid receptor
Gene names
Name:OGFR
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length677 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity. Note: The OGF/OGFR complex is probably translocated to the nucleus.

Tissue specificity

Highly expressed in the heart and liver, moderately in skeletal muscle and kidney and to a lesser extent in brain and pancreas. Expressed in fetal tissues including liver and kidney.

Sequence similarities

Belongs to the opioid growth factor receptor family.

Sequence caution

The sequence AAD03737.1 differs from that shown. Reason: Frameshift at positions 1 and 181.

The sequence AAD03745.1 differs from that shown. Reason: Frameshift at positions 1 and 181.

The sequence CAC28882.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Biological processGrowth regulation
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
   Molecular functionReceptor
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processopioid receptor signaling pathway

Non-traceable author statement Ref.1. Source: GOC

regulation of cell growth

Non-traceable author statement Ref.1. Source: UniProtKB

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

membrane

Inferred from electronic annotation. Source: InterPro

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionopioid receptor activity

Non-traceable author statement Ref.1. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NZT2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NZT2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     558-577: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 677677Opioid growth factor receptor
PRO_0000058030

Regions

Repeat517 – 536201
Repeat537 – 556202
Repeat557 – 576203
Repeat577 – 596204
Repeat597 – 616205
Repeat617 – 636206
Repeat637 – 656207
Region517 – 6561407 X 20 AA approximate tandem repeats of [ST]-P-S-E-T-P-G-P-[SR]-P-A-G-P-[AT]-[GR]-D-E-P-A-[EK]
Motif267 – 28317Bipartite nuclear localization signal Potential

Amino acid modifications

Modified residue11N-acetylmethionine Ref.12
Modified residue3151Phosphoserine Ref.7 Ref.15 Ref.17
Modified residue3611Phosphoserine Ref.15
Modified residue3781Phosphoserine Ref.11 Ref.13 Ref.14 Ref.15 Ref.17
Modified residue4201Phosphoserine Ref.9
Modified residue4841Phosphoserine Ref.10 Ref.15
Modified residue5371Phosphoserine Ref.15
Modified residue5571Phosphoserine Ref.15
Modified residue6171Phosphoserine Ref.15

Natural variations

Alternative sequence558 – 57720Missing in isoform 2.
VSP_004060
Natural variant5451R → S.
Corresponds to variant rs6122313 [ dbSNP | Ensembl ].
VAR_059706
Natural variant5771S → T. Ref.1 Ref.2 Ref.5
Corresponds to variant rs6122315 [ dbSNP | Ensembl ].
VAR_030011

Experimental info

Sequence conflict27 – 282DG → EA Ref.2
Sequence conflict37 – 8044DAGDE…RHNYP → GARRALGVLGQPGGLQMRLP ERHGGPQGSLCLMDPCCPLS LALQ Ref.5
Sequence conflict50 – 523AAR → GPE Ref.2
Sequence conflict1721E → A Ref.2
Sequence conflict220 – 2212LG → PC in AAF64404. Ref.1
Sequence conflict220 – 2212LG → PC in AAF64405. Ref.1
Sequence conflict2241G → S in AAF64404. Ref.1
Sequence conflict2241G → S in AAF64405. Ref.1
Sequence conflict2241G → S in AAF64406. Ref.1
Sequence conflict2401T → S in AAD03745. Ref.2
Sequence conflict2401T → S in AAD03737. Ref.2
Sequence conflict2621R → G in AAD03745. Ref.2
Sequence conflict2621R → G in AAD03737. Ref.2
Sequence conflict3311G → E in AAF64406. Ref.1
Sequence conflict3981E → G in AAF64406. Ref.1
Sequence conflict4651A → T in AAF64406. Ref.1
Sequence conflict5351A → AKTPSETPGPSPAGPTRDEP A in AAF64405. Ref.1
Sequence conflict5641P → L in AAF64404. Ref.1
Sequence conflict5761E → K in AAF64406. Ref.1
Sequence conflict5761E → K Ref.2
Sequence conflict5761E → K in BAB15775. Ref.5
Sequence conflict5771S → I in AAF64406. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 6, 2007. Version 3.
Checksum: D4DD6AF86291B663

FASTA67773,325
        10         20         30         40         50         60 
MDDPDCDSTW EEDEEDAEDA EDEDCEDGEA AGARDADAGD EDEESEEPRA ARPSSFQSRM 

        70         80         90        100        110        120 
TGSRNWRATR DMCRYRHNYP DLVERDCNGD TPNLSFYRNE IRFLPNGCFI EDILQNWTDN 

       130        140        150        160        170        180 
YDLLEDNHSY IQWLFPLREP GVNWHAKPLT LREVEVFKSS QEIQERLVRA YELMLGFYGI 

       190        200        210        220        230        240 
RLEDRGTGTV GRAQNYQKRF QNLNWRSHNN LRITRILKSL GELGLEHFQA PLVRFFLEET 

       250        260        270        280        290        300 
LVRRELPGVR QSALDYFMFA VRCRHQRRQL VHFAWEHFRP RCKFVWGPQD KLRRFKPSSL 

       310        320        330        340        350        360 
PHPLEGSRKV EEEGSPGDPD HEASTQGRTC GPEHSKGGGR VDEGPQPRSV EPQDAGPLER 

       370        380        390        400        410        420 
SQGDEAGGHG EDRPEPLSPK ESKKRKLELS RREQPPTEPG PQSASEVEKI ALNLEGCALS 

       430        440        450        460        470        480 
QGSLRTGTQE VGGQDPGEAV QPCRQPLGAR VADKVRKRRK VDEGAGDSAA VASGGAQTLA 

       490        500        510        520        530        540 
LAGSPAPSGH PKAGHSENGV EEDTEGRTGP KEGTPGSPSE TPGPSPAGPA GDEPAESPSE 

       550        560        570        580        590        600 
TPGPRPAGPA GDEPAESPSE TPGPRPAGPA GDEPAESPSE TPGPSPAGPT RDEPAESPSE 

       610        620        630        640        650        660 
TPGPRPAGPA GDEPAESPSE TPGPRPAGPA GDEPAESPSE TPGPSPAGPT RDEPAKAGEA 

       670 
AELQDAEVES SAKSGKP 

« Hide

Isoform 2 [UniParc].

Checksum: B7A3F384ECCE5FB7
Show »

FASTA65771,424

References

« Hide 'large scale' references
[1]"Cloning, sequencing, chromosomal location, and function of cDNAs encoding an opioid growth factor receptor (OGFr) in humans."
Zagon I.S., Verderame M.F., Allen S.S., McLaughlin P.J.
Brain Res. 856:75-83(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT THR-577.
Tissue: Placenta.
[2]"Genomic structure of human gene 7-60."
Takanosu M., Liu J., Mayne R., Wood B.M., Brewton R.G.
Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), VARIANT THR-577.
[3]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Skin.
[5]"Characterization of long cDNA clones from human adult spleen."
Hattori A., Okumura K., Nagase T., Kikuno R., Hirosawa M., Ohara O.
DNA Res. 7:357-366(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 37-677 (ISOFORM 1), VARIANT THR-577.
Tissue: Spleen.
[6]"The biology of the opioid growth factor receptor (OGFr)."
Zagon I.S., Verderame M.F., McLaughlin P.J.
Brain Res. Brain Res. Rev. 38:351-376(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[7]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-315, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[8]"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-420, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic kidney.
[10]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-484, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[11]"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J.
Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-378, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[12]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]"Large-scale proteomics analysis of the human kinome."
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H.
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-378, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[14]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-378, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[15]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-315; SER-361; SER-378; SER-484; SER-537; SER-557 AND SER-617, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[16]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[17]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-315 AND SER-378, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Web resources

Wikipedia

OGFr entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF172451 mRNA. Translation: AAF64404.1.
AF172452 mRNA. Translation: AAF64405.1.
AF172453 mRNA. Translation: AAF64406.1.
AF112980 Genomic DNA. Translation: AAD03745.1. Frameshift.
AF109134 mRNA. Translation: AAD03737.1. Frameshift.
AL035669 Genomic DNA. Translation: CAC28882.1. Sequence problems.
AL035669 Genomic DNA. Translation: CAI95763.1.
BC014137 mRNA. Translation: AAH14137.1.
AK024485 mRNA. Translation: BAB15775.1.
RefSeqNP_031372.2. NM_007346.2.
UniGeneHs.67896.

3D structure databases

ProteinModelPortalQ9NZT2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116239. 13 interactions.
MINTMINT-5005689.

PTM databases

PhosphoSiteQ9NZT2.

Polymorphism databases

DMDM146331047.

Proteomic databases

PaxDbQ9NZT2.
PRIDEQ9NZT2.

Protocols and materials databases

DNASU11054.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000290291; ENSP00000290291; ENSG00000060491. [Q9NZT2-1]
GeneID11054.
KEGGhsa:11054.
UCSCuc002ydj.3. human. [Q9NZT2-1]

Organism-specific databases

CTD11054.
GeneCardsGC20P061436.
H-InvDBHIX0015988.
HGNCHGNC:15768. OGFR.
HPAHPA017899.
MIM606459. gene.
neXtProtNX_Q9NZT2.
PharmGKBPA31911.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG28316.
HOVERGENHBG024736.
InParanoidQ9NZT2.
OMANWRSHNN.
OrthoDBEOG7RV9G9.
PhylomeDBQ9NZT2.
TreeFamTF331377.

Gene expression databases

ArrayExpressQ9NZT2.
BgeeQ9NZT2.
GenevestigatorQ9NZT2.

Family and domain databases

InterProIPR006757. OGF_rcpt.
IPR006770. OGF_rcpt_rpt.
[Graphical view]
PfamPF04680. OGFr_III. 7 hits.
PF04664. OGFr_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSOGFR. human.
GeneWikiOGFr.
GenomeRNAi11054.
NextBio41999.
PROQ9NZT2.
SOURCESearch...

Entry information

Entry nameOGFR_HUMAN
AccessionPrimary (citable) accession number: Q9NZT2
Secondary accession number(s): O96029 expand/collapse secondary AC list , Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: March 6, 2007
Last modified: April 16, 2014
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM