Q9NZT2 (OGFR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Opioid growth factor receptor
Short name=OGFr

Alternative name(s):
Protein 7-60
Zeta-type opioid receptor

Gene names

Name:

OGFR

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	677 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity. Note: The OGF/OGFR complex is probably translocated to the nucleus.
Tissue specificity	Highly expressed in the heart and liver, moderately in skeletal muscle and kidney and to a lesser extent in brain and pancreas. Expressed in fetal tissues including liver and kidney.
Post-translational modification	Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.7 Ref.8 Ref.9 Ref.10 Ref.11 Ref.12 Ref.13 Ref.14 Ref.15
Sequence similarities	Belongs to the opioid growth factor receptor family.
Sequence caution	The sequence AAD03737.1 differs from that shown. Reason: Frameshift at positions 1 and 181. The sequence AAD03745.1 differs from that shown. Reason: Frameshift at positions 1 and 181. The sequence CAC28882.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Growth regulation
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
Molecular function	Receptor
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of cell growth Non-traceable author statement Ref.1. Source: UniProtKB
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: InterPro nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	opioid receptor activity Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NZT2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NZT2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     558-577: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 677	677	Opioid growth factor receptor		PRO_0000058030
Regions
	Repeat	517 – 536	20	1
	Repeat	537 – 556	20	2
	Repeat	557 – 576	20	3
	Repeat	577 – 596	20	4
	Repeat	597 – 616	20	5
	Repeat	617 – 636	20	6
	Repeat	637 – 656	20	7
	Region	517 – 656	140	7 X 20 AA approximate tandem repeats of [ST]-P-S-E-T-P-G-P-[SR]-P-A-G-P-[AT]-[GR]-D-E-P-A-[EK]
	Motif	267 – 283	17	Bipartite nuclear localization signal Potential
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine Ref.13
	Modified residue	315	1	Phosphoserine Ref.7 Ref.8 Ref.13 Ref.15
	Modified residue	349	1	Phosphoserine Ref.11 Ref.15
	Modified residue	361	1	Phosphoserine Ref.11
	Modified residue	378	1	Phosphoserine Ref.7 Ref.10 Ref.11 Ref.12 Ref.14 Ref.15
	Modified residue	420	1	Phosphoserine Ref.9
	Modified residue	484	1	Phosphoserine Ref.11
Natural variations
	Alternative sequence	558 – 577	20	Missing in isoform 2.		VSP_004060
	Natural variant	545	1	R → S. Corresponds to variant rs6122313 [ dbSNP | Ensembl ].		VAR_059706
	Natural variant	577	1	S → T. Ref.1 Ref.2 Ref.5 Corresponds to variant rs6122315 [ dbSNP | Ensembl ].		VAR_030011
Experimental info
	Sequence conflict	27 – 28	2	DG → EA Ref.2
	Sequence conflict	37 – 80	44	DAGDE…RHNYP → GARRALGVLGQPGGLQMRLP ERHGGPQGSLCLMDPCCPLS LALQ Ref.5
	Sequence conflict	50 – 52	3	AAR → GPE Ref.2
	Sequence conflict	172	1	E → A Ref.2
	Sequence conflict	220 – 221	2	LG → PC in AAF64404. Ref.1
	Sequence conflict	220 – 221	2	LG → PC in AAF64405. Ref.1
	Sequence conflict	224	1	G → S in AAF64404. Ref.1
	Sequence conflict	224	1	G → S in AAF64405. Ref.1
	Sequence conflict	224	1	G → S in AAF64406. Ref.1
	Sequence conflict	240	1	T → S in AAD03745. Ref.2
	Sequence conflict	240	1	T → S in AAD03737. Ref.2
	Sequence conflict	262	1	R → G in AAD03745. Ref.2
	Sequence conflict	262	1	R → G in AAD03737. Ref.2
	Sequence conflict	331	1	G → E in AAF64406. Ref.1
	Sequence conflict	398	1	E → G in AAF64406. Ref.1
	Sequence conflict	465	1	A → T in AAF64406. Ref.1
	Sequence conflict	535	1	A → AKTPSETPGPSPAGPTRDEP A in AAF64405. Ref.1
	Sequence conflict	564	1	P → L in AAF64404. Ref.1
	Sequence conflict	576	1	E → K in AAF64406. Ref.1
	Sequence conflict	576	1	E → K Ref.2
	Sequence conflict	576	1	E → K in BAB15775. Ref.5
	Sequence conflict	577	1	S → I in AAF64406. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 6, 2007. Version 3. Checksum: D4DD6AF86291B663	FASTA	677	73,325
	10 20 30 40 50 60 MDDPDCDSTW EEDEEDAEDA EDEDCEDGEA AGARDADAGD EDEESEEPRA ARPSSFQSRM 70 80 90 100 110 120 TGSRNWRATR DMCRYRHNYP DLVERDCNGD TPNLSFYRNE IRFLPNGCFI EDILQNWTDN 130 140 150 160 170 180 YDLLEDNHSY IQWLFPLREP GVNWHAKPLT LREVEVFKSS QEIQERLVRA YELMLGFYGI 190 200 210 220 230 240 RLEDRGTGTV GRAQNYQKRF QNLNWRSHNN LRITRILKSL GELGLEHFQA PLVRFFLEET 250 260 270 280 290 300 LVRRELPGVR QSALDYFMFA VRCRHQRRQL VHFAWEHFRP RCKFVWGPQD KLRRFKPSSL 310 320 330 340 350 360 PHPLEGSRKV EEEGSPGDPD HEASTQGRTC GPEHSKGGGR VDEGPQPRSV EPQDAGPLER 370 380 390 400 410 420 SQGDEAGGHG EDRPEPLSPK ESKKRKLELS RREQPPTEPG PQSASEVEKI ALNLEGCALS 430 440 450 460 470 480 QGSLRTGTQE VGGQDPGEAV QPCRQPLGAR VADKVRKRRK VDEGAGDSAA VASGGAQTLA 490 500 510 520 530 540 LAGSPAPSGH PKAGHSENGV EEDTEGRTGP KEGTPGSPSE TPGPSPAGPA GDEPAESPSE 550 560 570 580 590 600 TPGPRPAGPA GDEPAESPSE TPGPRPAGPA GDEPAESPSE TPGPSPAGPT RDEPAESPSE 610 620 630 640 650 660 TPGPRPAGPA GDEPAESPSE TPGPRPAGPA GDEPAESPSE TPGPSPAGPT RDEPAKAGEA 670 AELQDAEVES SAKSGKP
	Isoform 2 [UniParc]. Checksum: B7A3F384ECCE5FB7	FASTA	657	71,424
	10 20 30 40 50 60 MDDPDCDSTW EEDEEDAEDA EDEDCEDGEA AGARDADAGD EDEESEEPRA ARPSSFQSRM 70 80 90 100 110 120 TGSRNWRATR DMCRYRHNYP DLVERDCNGD TPNLSFYRNE IRFLPNGCFI EDILQNWTDN 130 140 150 160 170 180 YDLLEDNHSY IQWLFPLREP GVNWHAKPLT LREVEVFKSS QEIQERLVRA YELMLGFYGI 190 200 210 220 230 240 RLEDRGTGTV GRAQNYQKRF QNLNWRSHNN LRITRILKSL GELGLEHFQA PLVRFFLEET 250 260 270 280 290 300 LVRRELPGVR QSALDYFMFA VRCRHQRRQL VHFAWEHFRP RCKFVWGPQD KLRRFKPSSL 310 320 330 340 350 360 PHPLEGSRKV EEEGSPGDPD HEASTQGRTC GPEHSKGGGR VDEGPQPRSV EPQDAGPLER 370 380 390 400 410 420 SQGDEAGGHG EDRPEPLSPK ESKKRKLELS RREQPPTEPG PQSASEVEKI ALNLEGCALS 430 440 450 460 470 480 QGSLRTGTQE VGGQDPGEAV QPCRQPLGAR VADKVRKRRK VDEGAGDSAA VASGGAQTLA 490 500 510 520 530 540 LAGSPAPSGH PKAGHSENGV EEDTEGRTGP KEGTPGSPSE TPGPSPAGPA GDEPAESPSE 550 560 570 580 590 600 TPGPRPAGPA GDEPAESPSE TPGPSPAGPT RDEPAESPSE TPGPRPAGPA GDEPAESPSE 610 620 630 640 650 TPGPRPAGPA GDEPAESPSE TPGPSPAGPT RDEPAKAGEA AELQDAEVES SAKSGKP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, sequencing, chromosomal location, and function of cDNAs encoding an opioid growth factor receptor (OGFr) in humans." Zagon I.S., Verderame M.F., Allen S.S., McLaughlin P.J. Brain Res. 856:75-83(2000) [PubMed: 10677613] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT THR-577. Tissue: Placenta.
[2]	"Genomic structure of human gene 7-60." Takanosu M., Liu J., Mayne R., Wood B.M., Brewton R.G. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), VARIANT THR-577.
[3]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed: 11780052] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Skin.
[5]	"Characterization of long cDNA clones from human adult spleen." Hattori A., Okumura K., Nagase T., Kikuno R., Hirosawa M., Ohara O. DNA Res. 7:357-366(2000) [PubMed: 11214971] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 37-677 (ISOFORM 1), VARIANT THR-577. Tissue: Spleen.
[6]	"The biology of the opioid growth factor receptor (OGFr)." Zagon I.S., Verderame M.F., McLaughlin P.J. Brain Res. Brain Res. Rev. 38:351-376(2002) [PubMed: 11890982] [Abstract] Cited for: REVIEW.
[7]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-315 AND SER-378, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry." Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A. Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007) [PubMed: 17287340] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-315, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[9]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-420, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[10]	"Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment." Carrascal M., Ovelleiro D., Casas V., Gay M., Abian J. J. Proteome Res. 7:5167-5176(2008) [PubMed: 19367720] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-378, MASS SPECTROMETRY. Tissue: T-cell.
[11]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-349; SER-361; SER-378 AND SER-484, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[12]	"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography." Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D., Zou H., Gu J. Proteomics 8:1346-1361(2008) [PubMed: 18318008] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-378, MASS SPECTROMETRY. Tissue: Liver.
[13]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-315, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[14]	"Large-scale proteomics analysis of the human kinome." Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H. Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed: 19369195] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-378, MASS SPECTROMETRY.
[15]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-315; SER-349 AND SER-378, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[16]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Web resources

Wikipedia

OGFr entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF172451 mRNA. Translation: AAF64404.1. AF172452 mRNA. Translation: AAF64405.1. AF172453 mRNA. Translation: AAF64406.1. AF112980 Genomic DNA. Translation: AAD03745.1. Frameshift. AF109134 mRNA. Translation: AAD03737.1. Frameshift. AL035669 Genomic DNA. Translation: CAC28882.1. Sequence problems. AL035669 Genomic DNA. Translation: CAI95763.1. BC014137 mRNA. Translation: AAH14137.1. AK024485 mRNA. Translation: BAB15775.1.
IPI	IPI00021537. IPI00216130.
RefSeq	NP_031372.2. NM_007346.2.
UniGene	Hs.67896.
3D structure databases
ProteinModelPortal	Q9NZT2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9NZT2.
PTM databases
PhosphoSite	Q9NZT2.
Polymorphism databases
DMDM	146331047.
Proteomic databases
PRIDE	Q9NZT2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000290291; ENSP00000290291; ENSG00000060491.
GeneID	11054.
KEGG	hsa:11054.
UCSC	uc002ydj.1. human.
Organism-specific databases
CTD	11054.
GeneCards	GC20P061436.
H-InvDB	HIX0015988.
HGNC	HGNC:15768. OGFR.
HPA	HPA017899.
MIM	606459. gene.
neXtProt	NX_Q9NZT2.
PharmGKB	PA31911.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG07195.
GeneTree	ENSGT00390000018730.
HOVERGEN	HBG024736.
InParanoid	Q9NZT2.
OMA	RCKFVWG.
OrthoDB	EOG4FBHTH.
PhylomeDB	Q9NZT2.
Gene expression databases
ArrayExpress	Q9NZT2.
Bgee	Q9NZT2.
Genevestigator	Q9NZT2.
GermOnline	ENSG00000060491. Homo sapiens.
Family and domain databases
InterPro	IPR006757. OGF_rcpt. IPR006770. OGF_rcpt_rpt. [Graphical view]
Pfam	PF04680. OGFr_III. 7 hits. PF04664. OGFr_N. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	41999.
SOURCE	Search...

Entry information

Entry name

OGFR_HUMAN

Accession

Primary (citable) accession number: Q9NZT2
Secondary accession number(s): O96029 , Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2003
Last sequence update:	March 6, 2007
Last modified:	January 25, 2012
This is version 97 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.