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Protein

Calmodulin-like protein 5

Gene

CALML5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds calcium. May be involved in terminal differentiation of keratinocytes.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi21 – 32121Add
BLAST
Calcium bindingi57 – 68122PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi91 – 102123PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi127 – 138124PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • calcium ion binding Source: ProtInc

GO - Biological processi

  • epidermis development Source: ProtInc
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin-like protein 5
Alternative name(s):
Calmodulin-like skin protein
Gene namesi
Name:CALML5
Synonyms:CLSP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:18180. CALML5.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134862009.

Polymorphism and mutation databases

BioMutaiCALML5.
DMDMi215273944.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 146145Calmodulin-like protein 5PRO_0000073854Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9NZT1.
PaxDbiQ9NZT1.
PRIDEiQ9NZT1.

PTM databases

PhosphoSiteiQ9NZT1.

Expressioni

Tissue specificityi

Particularly abundant in the epidermis where its expression is directly related to keratinocyte differentiation. Very low expression in lung.

Gene expression databases

BgeeiQ9NZT1.
CleanExiHS_CALML5.
GenevisibleiQ9NZT1. HS.

Organism-specific databases

HPAiHPA040725.

Interactioni

Subunit structurei

Associates with transglutaminase 3.

Protein-protein interaction databases

BioGridi119732. 30 interactions.
IntActiQ9NZT1. 6 interactions.
MINTiMINT-5003638.
STRINGi9606.ENSP00000369689.

Structurei

Secondary structure

1
146
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi80 – 878Combined sources
Beta strandi93 – 997Combined sources
Helixi100 – 1067Combined sources
Helixi107 – 1093Combined sources
Helixi116 – 12510Combined sources
Beta strandi128 – 1358Combined sources
Helixi138 – 1436Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2B1UNMR-A76-146[»]
ProteinModelPortaliQ9NZT1.
SMRiQ9NZT1. Positions 5-146.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NZT1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 4336EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini44 – 7734EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini78 – 11336EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini114 – 14633EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5126.
GeneTreeiENSGT00760000118901.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiQ9NZT1.
KOiK02183.
OMAiNYEEFAR.
OrthoDBiEOG7GBFZP.
PhylomeDBiQ9NZT1.
TreeFamiTF300912.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NZT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGELTPEEE AQYKKAFSAV DTDGNGTINA QELGAALKAT GKNLSEAQLR
60 70 80 90 100
KLISEVDSDG DGEISFQEFL TAAKKARAGL EDLQVAFRAF DQDGDGHITV
110 120 130 140
DELRRAMAGL GQPLPQEELD AMIREADVDQ DGRVNYEEFA RMLAQE
Length:146
Mass (Da):15,893
Last modified:November 25, 2008 - v2
Checksum:i70746291268494CC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti58 – 581S → G Polymorphism; confirmed at protein level. 2 Publications
Corresponds to variant rs11546426 [ dbSNP | Ensembl ].
VAR_047545
Natural varianti74 – 741K → R Polymorphism; confirmed at protein level. 3 Publications
Corresponds to variant rs10904516 [ dbSNP | Ensembl ].
VAR_047546

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF172852 mRNA. Translation: AAF66821.1.
AL732437 Genomic DNA. Translation: CAI11030.1.
BC039172 mRNA. Translation: AAH39172.1.
CCDSiCCDS7068.1.
RefSeqiNP_059118.2. NM_017422.4.
UniGeneiHs.180142.

Genome annotation databases

EnsembliENST00000380332; ENSP00000369689; ENSG00000178372.
GeneIDi51806.
KEGGihsa:51806.
UCSCiuc001iic.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF172852 mRNA. Translation: AAF66821.1.
AL732437 Genomic DNA. Translation: CAI11030.1.
BC039172 mRNA. Translation: AAH39172.1.
CCDSiCCDS7068.1.
RefSeqiNP_059118.2. NM_017422.4.
UniGeneiHs.180142.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2B1UNMR-A76-146[»]
ProteinModelPortaliQ9NZT1.
SMRiQ9NZT1. Positions 5-146.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119732. 30 interactions.
IntActiQ9NZT1. 6 interactions.
MINTiMINT-5003638.
STRINGi9606.ENSP00000369689.

PTM databases

PhosphoSiteiQ9NZT1.

Polymorphism and mutation databases

BioMutaiCALML5.
DMDMi215273944.

Proteomic databases

MaxQBiQ9NZT1.
PaxDbiQ9NZT1.
PRIDEiQ9NZT1.

Protocols and materials databases

DNASUi51806.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380332; ENSP00000369689; ENSG00000178372.
GeneIDi51806.
KEGGihsa:51806.
UCSCiuc001iic.2. human.

Organism-specific databases

CTDi51806.
GeneCardsiGC10M005530.
H-InvDBHIX0025916.
HGNCiHGNC:18180. CALML5.
HPAiHPA040725.
MIMi605183. gene.
neXtProtiNX_Q9NZT1.
PharmGKBiPA134862009.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5126.
GeneTreeiENSGT00760000118901.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiQ9NZT1.
KOiK02183.
OMAiNYEEFAR.
OrthoDBiEOG7GBFZP.
PhylomeDBiQ9NZT1.
TreeFamiTF300912.

Miscellaneous databases

EvolutionaryTraceiQ9NZT1.
GeneWikiiCALML5.
GenomeRNAii51806.
NextBioi55928.
PROiQ9NZT1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NZT1.
CleanExiHS_CALML5.
GenevisibleiQ9NZT1. HS.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and cloning of a new calmodulin-like protein from human epidermis."
    Mehul B., Bernard D., Simonetti L., Bernard M.A., Schmidt R.
    J. Biol. Chem. 275:12841-12847(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, VARIANT ARG-74.
    Tissue: Skin.
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLY-58 AND ARG-74.
    Tissue: Skin.
  4. Bienvenut W.V., Dhillon A.S., Kolch W.
    Submitted (FEB-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-50, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Hepatoma.
  5. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. "A structural and dynamic characterization of the EF-hand protein CLSP."
    Babini E., Bertini I., Capozzi F., Chirivino E., Luchinat C.
    Structure 14:1029-1038(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 76-146, CALCIUM-BINDING.
  7. "Detection and validation of non-synonymous coding SNPs from orthogonal analysis of shotgun proteomics data."
    Bunger M.K., Cargile B.J., Sevinsky J.R., Deyanova E., Yates N.A., Hendrickson R.C., Stephenson J.L. Jr.
    J. Proteome Res. 6:2331-2340(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS GLY-58 AND ARG-74, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiCALL5_HUMAN
AccessioniPrimary (citable) accession number: Q9NZT1
Secondary accession number(s): Q5SQI3, Q8IXU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: November 25, 2008
Last modified: June 24, 2015
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.