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Q9NZT1 (CALL5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Calmodulin-like protein 5
Alternative name(s):
Calmodulin-like skin protein
Gene names
Name:CALML5
Synonyms:CLSP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length146 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds calcium. May be involved in terminal differentiation of keratinocytes.

Subunit structure

Associates with transglutaminase 3.

Tissue specificity

Particularly abundant in the epidermis where its expression is directly related to keratinocyte differentiation. Very low expression in lung.

Sequence similarities

Contains 4 EF-hand domains.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DomainRepeat
   LigandCalcium
Metal-binding
   PTMAcetylation
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processepidermis development

Traceable author statement Ref.1. Source: ProtInc

signal transduction

Traceable author statement Ref.1. Source: ProtInc

   Molecular_functioncalcium ion binding

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.4
Chain2 – 146145Calmodulin-like protein 5
PRO_0000073854

Regions

Domain8 – 4336EF-hand 1
Domain44 – 7734EF-hand 2
Domain78 – 11336EF-hand 3
Domain114 – 14633EF-hand 4
Calcium binding21 – 32121 Ref.5
Calcium binding57 – 68122 Potential
Calcium binding91 – 102123 Potential
Calcium binding127 – 138124 Potential

Amino acid modifications

Modified residue21N-acetylalanine Ref.4

Natural variations

Natural variant581S → G Polymorphism confirmed at protein level. Ref.3 Ref.6
Corresponds to variant rs11546426 [ dbSNP | Ensembl ].
VAR_047545
Natural variant741K → R Polymorphism confirmed at protein level. Ref.1 Ref.3 Ref.6
Corresponds to variant rs10904516 [ dbSNP | Ensembl ].
VAR_047546

Secondary structure

............. 146
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9NZT1 [UniParc].

Last modified November 25, 2008. Version 2.
Checksum: 70746291268494CC

FASTA14615,893
        10         20         30         40         50         60 
MAGELTPEEE AQYKKAFSAV DTDGNGTINA QELGAALKAT GKNLSEAQLR KLISEVDSDG 

        70         80         90        100        110        120 
DGEISFQEFL TAAKKARAGL EDLQVAFRAF DQDGDGHITV DELRRAMAGL GQPLPQEELD 

       130        140 
AMIREADVDQ DGRVNYEEFA RMLAQE 

« Hide

References

« Hide 'large scale' references
[1]"Identification and cloning of a new calmodulin-like protein from human epidermis."
Mehul B., Bernard D., Simonetti L., Bernard M.A., Schmidt R.
J. Biol. Chem. 275:12841-12847(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, VARIANT ARG-74.
Tissue: Skin.
[2]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLY-58 AND ARG-74.
Tissue: Skin.
[4]Bienvenut W.V., Dhillon A.S., Kolch W.
Submitted (FEB-2008) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 2-50, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Hepatoma.
[5]"A structural and dynamic characterization of the EF-hand protein CLSP."
Babini E., Bertini I., Capozzi F., Chirivino E., Luchinat C.
Structure 14:1029-1038(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 76-146, CALCIUM-BINDING.
[6]"Detection and validation of non-synonymous coding SNPs from orthogonal analysis of shotgun proteomics data."
Bunger M.K., Cargile B.J., Sevinsky J.R., Deyanova E., Yates N.A., Hendrickson R.C., Stephenson J.L. Jr.
J. Proteome Res. 6:2331-2340(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS GLY-58 AND ARG-74, IDENTIFICATION BY MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF172852 mRNA. Translation: AAF66821.1.
AL732437 Genomic DNA. Translation: CAI11030.1.
BC039172 mRNA. Translation: AAH39172.1.
CCDSCCDS7068.1.
RefSeqNP_059118.2. NM_017422.4.
UniGeneHs.180142.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2B1UNMR-A76-146[»]
ProteinModelPortalQ9NZT1.
SMRQ9NZT1. Positions 2-146.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119732. 12 interactions.
IntActQ9NZT1. 4 interactions.
MINTMINT-5003638.
STRING9606.ENSP00000369689.

PTM databases

PhosphoSiteQ9NZT1.

Polymorphism databases

DMDM215273944.

Proteomic databases

MaxQBQ9NZT1.
PaxDbQ9NZT1.
PRIDEQ9NZT1.

Protocols and materials databases

DNASU51806.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000380332; ENSP00000369689; ENSG00000178372.
GeneID51806.
KEGGhsa:51806.
UCSCuc001iic.2. human.

Organism-specific databases

CTD51806.
GeneCardsGC10M005530.
H-InvDBHIX0025916.
HGNCHGNC:18180. CALML5.
HPAHPA040725.
MIM605183. gene.
neXtProtNX_Q9NZT1.
PharmGKBPA134862009.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5126.
HOGENOMHOG000233018.
HOVERGENHBG012180.
InParanoidQ9NZT1.
KOK02183.
OMANYEEFAR.
OrthoDBEOG7GBFZP.
PhylomeDBQ9NZT1.
TreeFamTF300912.

Gene expression databases

BgeeQ9NZT1.
CleanExHS_CALML5.
GenevestigatorQ9NZT1.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTSM00054. EFh. 4 hits.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ9NZT1.
GeneWikiCALML5.
GenomeRNAi51806.
NextBio55928.
PROQ9NZT1.
SOURCESearch...

Entry information

Entry nameCALL5_HUMAN
AccessionPrimary (citable) accession number: Q9NZT1
Secondary accession number(s): Q5SQI3, Q8IXU8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: November 25, 2008
Last modified: July 9, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM