Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Calmodulin-like protein 5

Gene

CALML5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds calcium. May be involved in terminal differentiation of keratinocytes.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi21 – 321Add BLAST12
Calcium bindingi57 – 682PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi91 – 1023PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi127 – 1384PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: ProtInc

GO - Biological processi

  • epidermis development Source: ProtInc
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000178372-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin-like protein 5
Alternative name(s):
Calmodulin-like skin protein
Gene namesi
Name:CALML5
Synonyms:CLSP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:18180. CALML5.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi51806.
OpenTargetsiENSG00000178372.
PharmGKBiPA134862009.

Polymorphism and mutation databases

BioMutaiCALML5.
DMDMi215273944.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000738542 – 146Calmodulin-like protein 5Add BLAST145

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9NZT1.
MaxQBiQ9NZT1.
PaxDbiQ9NZT1.
PeptideAtlasiQ9NZT1.
PRIDEiQ9NZT1.
TopDownProteomicsiQ9NZT1.

PTM databases

iPTMnetiQ9NZT1.
PhosphoSitePlusiQ9NZT1.

Expressioni

Tissue specificityi

Particularly abundant in the epidermis where its expression is directly related to keratinocyte differentiation. Very low expression in lung.

Gene expression databases

BgeeiENSG00000178372.
CleanExiHS_CALML5.
GenevisibleiQ9NZT1. HS.

Organism-specific databases

HPAiHPA040725.

Interactioni

Subunit structurei

Associates with transglutaminase 3.

Protein-protein interaction databases

BioGridi119732. 42 interactors.
IntActiQ9NZT1. 9 interactors.
MINTiMINT-5003638.
STRINGi9606.ENSP00000369689.

Structurei

Secondary structure

1146
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi80 – 87Combined sources8
Beta strandi93 – 99Combined sources7
Helixi100 – 106Combined sources7
Helixi107 – 109Combined sources3
Helixi116 – 125Combined sources10
Beta strandi128 – 135Combined sources8
Helixi138 – 143Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B1UNMR-A76-146[»]
ProteinModelPortaliQ9NZT1.
SMRiQ9NZT1.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NZT1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 43EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini44 – 77EF-hand 2PROSITE-ProRule annotationAdd BLAST34
Domaini78 – 113EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini114 – 146EF-hand 4PROSITE-ProRule annotationAdd BLAST33

Sequence similaritiesi

Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118901.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiQ9NZT1.
KOiK02183.
OMAiFTRFDKD.
OrthoDBiEOG091G0RVC.
PhylomeDBiQ9NZT1.
TreeFamiTF300912.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NZT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGELTPEEE AQYKKAFSAV DTDGNGTINA QELGAALKAT GKNLSEAQLR
60 70 80 90 100
KLISEVDSDG DGEISFQEFL TAAKKARAGL EDLQVAFRAF DQDGDGHITV
110 120 130 140
DELRRAMAGL GQPLPQEELD AMIREADVDQ DGRVNYEEFA RMLAQE
Length:146
Mass (Da):15,893
Last modified:November 25, 2008 - v2
Checksum:i70746291268494CC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04754558S → G Polymorphism; confirmed at protein level. 2 PublicationsCorresponds to variant rs11546426dbSNPEnsembl.1
Natural variantiVAR_04754674K → R Polymorphism; confirmed at protein level. 3 PublicationsCorresponds to variant rs10904516dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF172852 mRNA. Translation: AAF66821.1.
AL732437 Genomic DNA. Translation: CAI11030.1.
BC039172 mRNA. Translation: AAH39172.1.
CCDSiCCDS7068.1.
RefSeqiNP_059118.2. NM_017422.4.
UniGeneiHs.180142.

Genome annotation databases

EnsembliENST00000380332; ENSP00000369689; ENSG00000178372.
GeneIDi51806.
KEGGihsa:51806.
UCSCiuc001iic.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF172852 mRNA. Translation: AAF66821.1.
AL732437 Genomic DNA. Translation: CAI11030.1.
BC039172 mRNA. Translation: AAH39172.1.
CCDSiCCDS7068.1.
RefSeqiNP_059118.2. NM_017422.4.
UniGeneiHs.180142.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B1UNMR-A76-146[»]
ProteinModelPortaliQ9NZT1.
SMRiQ9NZT1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119732. 42 interactors.
IntActiQ9NZT1. 9 interactors.
MINTiMINT-5003638.
STRINGi9606.ENSP00000369689.

PTM databases

iPTMnetiQ9NZT1.
PhosphoSitePlusiQ9NZT1.

Polymorphism and mutation databases

BioMutaiCALML5.
DMDMi215273944.

Proteomic databases

EPDiQ9NZT1.
MaxQBiQ9NZT1.
PaxDbiQ9NZT1.
PeptideAtlasiQ9NZT1.
PRIDEiQ9NZT1.
TopDownProteomicsiQ9NZT1.

Protocols and materials databases

DNASUi51806.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380332; ENSP00000369689; ENSG00000178372.
GeneIDi51806.
KEGGihsa:51806.
UCSCiuc001iic.3. human.

Organism-specific databases

CTDi51806.
DisGeNETi51806.
GeneCardsiCALML5.
H-InvDBHIX0025916.
HGNCiHGNC:18180. CALML5.
HPAiHPA040725.
MIMi605183. gene.
neXtProtiNX_Q9NZT1.
OpenTargetsiENSG00000178372.
PharmGKBiPA134862009.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118901.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiQ9NZT1.
KOiK02183.
OMAiFTRFDKD.
OrthoDBiEOG091G0RVC.
PhylomeDBiQ9NZT1.
TreeFamiTF300912.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000178372-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

EvolutionaryTraceiQ9NZT1.
GeneWikiiCALML5.
GenomeRNAii51806.
PROiQ9NZT1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000178372.
CleanExiHS_CALML5.
GenevisibleiQ9NZT1. HS.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCALL5_HUMAN
AccessioniPrimary (citable) accession number: Q9NZT1
Secondary accession number(s): Q5SQI3, Q8IXU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: November 25, 2008
Last modified: November 30, 2016
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.