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Q9NZT1

- CALL5_HUMAN

UniProt

Q9NZT1 - CALL5_HUMAN

Protein

Calmodulin-like protein 5

Gene

CALML5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Binds calcium. May be involved in terminal differentiation of keratinocytes.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi21 – 32121Add
    BLAST
    Calcium bindingi57 – 68122PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi91 – 102123PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi127 – 138124PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: ProtInc

    GO - Biological processi

    1. epidermis development Source: ProtInc
    2. signal transduction Source: ProtInc

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calmodulin-like protein 5
    Alternative name(s):
    Calmodulin-like skin protein
    Gene namesi
    Name:CALML5
    Synonyms:CLSP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:18180. CALML5.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134862009.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 146145Calmodulin-like protein 5PRO_0000073854Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9NZT1.
    PaxDbiQ9NZT1.
    PRIDEiQ9NZT1.

    PTM databases

    PhosphoSiteiQ9NZT1.

    Expressioni

    Tissue specificityi

    Particularly abundant in the epidermis where its expression is directly related to keratinocyte differentiation. Very low expression in lung.

    Gene expression databases

    BgeeiQ9NZT1.
    CleanExiHS_CALML5.
    GenevestigatoriQ9NZT1.

    Organism-specific databases

    HPAiHPA040725.

    Interactioni

    Subunit structurei

    Associates with transglutaminase 3.

    Protein-protein interaction databases

    BioGridi119732. 11 interactions.
    IntActiQ9NZT1. 5 interactions.
    MINTiMINT-5003638.
    STRINGi9606.ENSP00000369689.

    Structurei

    Secondary structure

    1
    146
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi80 – 878
    Beta strandi93 – 997
    Helixi100 – 1067
    Helixi107 – 1093
    Helixi116 – 12510
    Beta strandi128 – 1358
    Helixi138 – 1436

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2B1UNMR-A76-146[»]
    ProteinModelPortaliQ9NZT1.
    SMRiQ9NZT1. Positions 2-146.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9NZT1.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 4336EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini44 – 7734EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini78 – 11336EF-hand 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini114 – 14633EF-hand 4PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 4 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5126.
    HOGENOMiHOG000233018.
    HOVERGENiHBG012180.
    InParanoidiQ9NZT1.
    KOiK02183.
    OMAiNYEEFAR.
    OrthoDBiEOG7GBFZP.
    PhylomeDBiQ9NZT1.
    TreeFamiTF300912.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view]
    PfamiPF13499. EF-hand_7. 2 hits.
    [Graphical view]
    SMARTiSM00054. EFh. 4 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 4 hits.
    PS50222. EF_HAND_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9NZT1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGELTPEEE AQYKKAFSAV DTDGNGTINA QELGAALKAT GKNLSEAQLR    50
    KLISEVDSDG DGEISFQEFL TAAKKARAGL EDLQVAFRAF DQDGDGHITV 100
    DELRRAMAGL GQPLPQEELD AMIREADVDQ DGRVNYEEFA RMLAQE 146
    Length:146
    Mass (Da):15,893
    Last modified:November 25, 2008 - v2
    Checksum:i70746291268494CC
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti58 – 581S → G Polymorphism confirmed at protein level. 2 Publications
    Corresponds to variant rs11546426 [ dbSNP | Ensembl ].
    VAR_047545
    Natural varianti74 – 741K → R Polymorphism confirmed at protein level. 3 Publications
    Corresponds to variant rs10904516 [ dbSNP | Ensembl ].
    VAR_047546

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF172852 mRNA. Translation: AAF66821.1.
    AL732437 Genomic DNA. Translation: CAI11030.1.
    BC039172 mRNA. Translation: AAH39172.1.
    CCDSiCCDS7068.1.
    RefSeqiNP_059118.2. NM_017422.4.
    UniGeneiHs.180142.

    Genome annotation databases

    EnsembliENST00000380332; ENSP00000369689; ENSG00000178372.
    GeneIDi51806.
    KEGGihsa:51806.
    UCSCiuc001iic.2. human.

    Polymorphism databases

    DMDMi215273944.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF172852 mRNA. Translation: AAF66821.1 .
    AL732437 Genomic DNA. Translation: CAI11030.1 .
    BC039172 mRNA. Translation: AAH39172.1 .
    CCDSi CCDS7068.1.
    RefSeqi NP_059118.2. NM_017422.4.
    UniGenei Hs.180142.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2B1U NMR - A 76-146 [» ]
    ProteinModelPortali Q9NZT1.
    SMRi Q9NZT1. Positions 2-146.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119732. 11 interactions.
    IntActi Q9NZT1. 5 interactions.
    MINTi MINT-5003638.
    STRINGi 9606.ENSP00000369689.

    PTM databases

    PhosphoSitei Q9NZT1.

    Polymorphism databases

    DMDMi 215273944.

    Proteomic databases

    MaxQBi Q9NZT1.
    PaxDbi Q9NZT1.
    PRIDEi Q9NZT1.

    Protocols and materials databases

    DNASUi 51806.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000380332 ; ENSP00000369689 ; ENSG00000178372 .
    GeneIDi 51806.
    KEGGi hsa:51806.
    UCSCi uc001iic.2. human.

    Organism-specific databases

    CTDi 51806.
    GeneCardsi GC10M005530.
    H-InvDB HIX0025916.
    HGNCi HGNC:18180. CALML5.
    HPAi HPA040725.
    MIMi 605183. gene.
    neXtProti NX_Q9NZT1.
    PharmGKBi PA134862009.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5126.
    HOGENOMi HOG000233018.
    HOVERGENi HBG012180.
    InParanoidi Q9NZT1.
    KOi K02183.
    OMAi NYEEFAR.
    OrthoDBi EOG7GBFZP.
    PhylomeDBi Q9NZT1.
    TreeFami TF300912.

    Miscellaneous databases

    EvolutionaryTracei Q9NZT1.
    GeneWikii CALML5.
    GenomeRNAii 51806.
    NextBioi 55928.
    PROi Q9NZT1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9NZT1.
    CleanExi HS_CALML5.
    Genevestigatori Q9NZT1.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view ]
    Pfami PF13499. EF-hand_7. 2 hits.
    [Graphical view ]
    SMARTi SM00054. EFh. 4 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 4 hits.
    PS50222. EF_HAND_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and cloning of a new calmodulin-like protein from human epidermis."
      Mehul B., Bernard D., Simonetti L., Bernard M.A., Schmidt R.
      J. Biol. Chem. 275:12841-12847(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, VARIANT ARG-74.
      Tissue: Skin.
    2. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLY-58 AND ARG-74.
      Tissue: Skin.
    4. Bienvenut W.V., Dhillon A.S., Kolch W.
      Submitted (FEB-2008) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-50, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Hepatoma.
    5. "A structural and dynamic characterization of the EF-hand protein CLSP."
      Babini E., Bertini I., Capozzi F., Chirivino E., Luchinat C.
      Structure 14:1029-1038(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 76-146, CALCIUM-BINDING.
    6. "Detection and validation of non-synonymous coding SNPs from orthogonal analysis of shotgun proteomics data."
      Bunger M.K., Cargile B.J., Sevinsky J.R., Deyanova E., Yates N.A., Hendrickson R.C., Stephenson J.L. Jr.
      J. Proteome Res. 6:2331-2340(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS GLY-58 AND ARG-74, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiCALL5_HUMAN
    AccessioniPrimary (citable) accession number: Q9NZT1
    Secondary accession number(s): Q5SQI3, Q8IXU8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 122 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3