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Q9NZS9 (BFAR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional apoptosis regulator
Alternative name(s):
RING finger protein 47
Gene names
Name:BFAR
Synonyms:BAR, RNF47
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length450 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Apoptosis regulator. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors. Ref.5

Subunit structure

Interacts with CASP8, BCL2 and BCL2L1 through SAM domain and also with HIP1, IFT57, ESRRBL1 and BCAP31. Ref.1 Ref.5

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein Ref.1 Ref.5.

Tissue specificity

Expressed highly in brain, moderately in small intestine, weakly in testes and only faintly in liver and skeletal muscle. Not expressed in heart, kidney, lung and spleen. Ref.1 Ref.5

Sequence similarities

Contains 1 RING-type zinc finger.

Contains 1 SAM (sterile alpha motif) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 450450Bifunctional apoptosis regulator
PRO_0000055822

Regions

Topological domain1 – 140140Cytoplasmic Potential
Transmembrane141 – 16121Helical; Potential
Topological domain162 – 331170Lumenal Potential
Transmembrane332 – 35221Helical; Potential
Topological domain353 – 3608Cytoplasmic Potential
Transmembrane361 – 38121Helical; Potential
Topological domain382 – 40423Lumenal Potential
Transmembrane405 – 42521Helical; Potential
Topological domain426 – 45025Cytoplasmic Potential
Domain182 – 24968SAM
Zinc finger34 – 7441RING-type

Amino acid modifications

Glycosylation2321N-linked (GlcNAc...) Potential

Natural variations

Natural variant1401M → R.
Corresponds to variant rs11546303 [ dbSNP | Ensembl ].
VAR_052075
Natural variant2451R → H.
Corresponds to variant rs35377618 [ dbSNP | Ensembl ].
VAR_052076

Sequences

Sequence LengthMass (Da)Tools
Q9NZS9 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: A662454FC2806CE6

FASTA45052,738
        10         20         30         40         50         60 
MEEPQKSYVN TMDLERDEPL KSTGPQISVS EFSCHCCYDI LVNPTTLNCG HSFCRHCLAL 

        70         80         90        100        110        120 
WWASSKKTEC PECREKWEGF PKVSILLRDA IEKLFPDAIR LRFEDIQQNN DIVQSLAAFQ 

       130        140        150        160        170        180 
KYGNDQIPLA PNTGRANQQM GGGFFSGVLT ALTGVAVVLL VYHWSSRESE HDLLVHKAVA 

       190        200        210        220        230        240 
KWTAEEVVLW LEQLGPWASL YRERFLSERV NGRLLLTLTE EEFSKTPYTI ENSSHRRAIL 

       250        260        270        280        290        300 
MELERVKALG VKPPQNLWEY KAVNPGRSLF LLYALKSSPR LSLLYLYLFD YTDTFLPFIH 

       310        320        330        340        350        360 
TICPLQEDSS GEDIVTKLLD LKEPTWKQWR EFLVKYSFLP YQLIAEFAWD WLEVHYWTSR 

       370        380        390        400        410        420 
FLIINAMLLS VLELFSFWRI WSRSELKTVP QRMWSHFWKV STQGLFVAMF WPLIPQFVCN 

       430        440        450 
CLFYWALYFN PIINIDLVVK ELRRLETQVL 

« Hide

References

« Hide 'large scale' references
[1]"BAR: an apoptosis regulator at the intersection of caspases and Bcl-2 family proteins."
Zhang H., Xu Q., Krajewski S., Krajewska M., Xie Z., Fuess S., Kitada S., Pawlowski K., Godzik A., Reed J.C.
Proc. Natl. Acad. Sci. U.S.A. 97:2597-2602(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH CASP8; BCL2 AND BCL2L1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Tissue: Hepatoma.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[5]"Bifunctional apoptosis inhibitor (BAR) protects neurons from diverse cell death pathways."
Roth W., Kermer P., Krajewska M., Welsh K., Davis S., Krajewski S., Reed J.C.
Cell Death Differ. 10:1178-1187(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH IFT57; HIP1; ESRRBL1 AND BCAP31, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF173003 mRNA. Translation: AAF59975.1.
AK291114 mRNA. Translation: BAF83803.1.
CH471112 Genomic DNA. Translation: EAW85105.1.
CH471112 Genomic DNA. Translation: EAW85108.1.
BC003054 mRNA. Translation: AAH03054.1.
RefSeqNP_057645.1. NM_016561.2.
UniGeneHs.435556.

3D structure databases

ProteinModelPortalQ9NZS9.
SMRQ9NZS9. Positions 3-110, 170-248.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119435. 18 interactions.
IntActQ9NZS9. 9 interactions.
STRING9606.ENSP00000261658.

PTM databases

PhosphoSiteQ9NZS9.

Polymorphism databases

DMDM74753089.

Proteomic databases

PaxDbQ9NZS9.
PRIDEQ9NZS9.

Protocols and materials databases

DNASU51283.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000261658; ENSP00000261658; ENSG00000103429.
GeneID51283.
KEGGhsa:51283.
UCSCuc002dco.3. human.

Organism-specific databases

CTD51283.
GeneCardsGC16P014634.
HGNCHGNC:17613. BFAR.
HPAHPA045905.
neXtProtNX_Q9NZS9.
PharmGKBPA38460.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG251630.
HOGENOMHOG000285958.
HOVERGENHBG056789.
InParanoidQ9NZS9.
KOK15684.
OMAFVCNCLF.
OrthoDBEOG7PP56P.
PhylomeDBQ9NZS9.
TreeFamTF332303.

Gene expression databases

ArrayExpressQ9NZS9.
BgeeQ9NZS9.
CleanExHS_BFAR.
GenevestigatorQ9NZS9.

Family and domain databases

Gene3D1.10.150.50. 1 hit.
3.30.40.10. 1 hit.
InterProIPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamPF00536. SAM_1. 1 hit.
[Graphical view]
SMARTSM00184. RING. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMSSF47769. SSF47769. 1 hit.
PROSITEPS50105. SAM_DOMAIN. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi51283.
NextBio54523.
PROQ9NZS9.

Entry information

Entry nameBFAR_HUMAN
AccessionPrimary (citable) accession number: Q9NZS9
Secondary accession number(s): A8K4Z9, D3DUG8
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM