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Protein

Bifunctional apoptosis regulator

Gene

BFAR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Apoptosis regulator. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri34 – 7441RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. structural molecule activity Source: ProtInc
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. negative regulation of apoptotic process Source: MGI
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional apoptosis regulator
Alternative name(s):
RING finger protein 47
Gene namesi
Name:BFAR
Synonyms:BAR, RNF47
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16, UP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:17613. BFAR.

Subcellular locationi

Endoplasmic reticulum membrane 2 Publications; Multi-pass membrane protein 2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 140140CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei141 – 16121HelicalSequence AnalysisAdd
BLAST
Topological domaini162 – 331170LumenalSequence AnalysisAdd
BLAST
Transmembranei332 – 35221HelicalSequence AnalysisAdd
BLAST
Topological domaini353 – 3608CytoplasmicSequence Analysis
Transmembranei361 – 38121HelicalSequence AnalysisAdd
BLAST
Topological domaini382 – 40423LumenalSequence AnalysisAdd
BLAST
Transmembranei405 – 42521HelicalSequence AnalysisAdd
BLAST
Topological domaini426 – 45025CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of plasma membrane Source: ProtInc
  3. membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38460.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 450450Bifunctional apoptosis regulatorPRO_0000055822Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi232 – 2321N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9NZS9.
PaxDbiQ9NZS9.
PRIDEiQ9NZS9.

PTM databases

PhosphoSiteiQ9NZS9.

Expressioni

Tissue specificityi

Expressed highly in brain, moderately in small intestine, weakly in testes and only faintly in liver and skeletal muscle. Not expressed in heart, kidney, lung and spleen.2 Publications

Gene expression databases

BgeeiQ9NZS9.
CleanExiHS_BFAR.
ExpressionAtlasiQ9NZS9. baseline and differential.
GenevestigatoriQ9NZS9.

Organism-specific databases

HPAiHPA045905.

Interactioni

Subunit structurei

Interacts with CASP8, BCL2 and BCL2L1 through SAM domain and also with HIP1, IFT57, ESRRBL1 and BCAP31.2 Publications

Protein-protein interaction databases

BioGridi119435. 19 interactions.
IntActiQ9NZS9. 9 interactions.
STRINGi9606.ENSP00000261658.

Structurei

3D structure databases

ProteinModelPortaliQ9NZS9.
SMRiQ9NZS9. Positions 3-94, 170-248.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini182 – 24968SAMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation
Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri34 – 7441RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiNOG251630.
GeneTreeiENSGT00390000005386.
HOGENOMiHOG000285958.
HOVERGENiHBG056789.
InParanoidiQ9NZS9.
KOiK15684.
OMAiFVCNCLF.
OrthoDBiEOG7PP56P.
PhylomeDBiQ9NZS9.
TreeFamiTF332303.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS50105. SAM_DOMAIN. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NZS9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEPQKSYVN TMDLERDEPL KSTGPQISVS EFSCHCCYDI LVNPTTLNCG
60 70 80 90 100
HSFCRHCLAL WWASSKKTEC PECREKWEGF PKVSILLRDA IEKLFPDAIR
110 120 130 140 150
LRFEDIQQNN DIVQSLAAFQ KYGNDQIPLA PNTGRANQQM GGGFFSGVLT
160 170 180 190 200
ALTGVAVVLL VYHWSSRESE HDLLVHKAVA KWTAEEVVLW LEQLGPWASL
210 220 230 240 250
YRERFLSERV NGRLLLTLTE EEFSKTPYTI ENSSHRRAIL MELERVKALG
260 270 280 290 300
VKPPQNLWEY KAVNPGRSLF LLYALKSSPR LSLLYLYLFD YTDTFLPFIH
310 320 330 340 350
TICPLQEDSS GEDIVTKLLD LKEPTWKQWR EFLVKYSFLP YQLIAEFAWD
360 370 380 390 400
WLEVHYWTSR FLIINAMLLS VLELFSFWRI WSRSELKTVP QRMWSHFWKV
410 420 430 440 450
STQGLFVAMF WPLIPQFVCN CLFYWALYFN PIINIDLVVK ELRRLETQVL
Length:450
Mass (Da):52,738
Last modified:October 1, 2000 - v1
Checksum:iA662454FC2806CE6
GO
Isoform 2 (identifier: Q9NZS9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: MEEPQKSYVNTMDLERDEPLKSTGPQIS → MVGIFKENRMSRMQRKMGRFPQSQYSPQ
     29-156: Missing.

Note: No experimental confirmation available.

Show »
Length:322
Mass (Da):38,652
Checksum:iDFB542F608342396
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti140 – 1401M → R.
Corresponds to variant rs11546303 [ dbSNP | Ensembl ].
VAR_052075
Natural varianti245 – 2451R → H.
Corresponds to variant rs35377618 [ dbSNP | Ensembl ].
VAR_052076

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2828MEEPQ…GPQIS → MVGIFKENRMSRMQRKMGRF PQSQYSPQ in isoform 2. CuratedVSP_055879Add
BLAST
Alternative sequencei29 – 156128Missing in isoform 2. CuratedVSP_055880Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF173003 mRNA. Translation: AAF59975.1.
AK291114 mRNA. Translation: BAF83803.1.
AK300778 mRNA. Translation: BAG62442.1.
AC009167 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85105.1.
CH471112 Genomic DNA. Translation: EAW85108.1.
BC003054 mRNA. Translation: AAH03054.1.
CCDSiCCDS10554.1. [Q9NZS9-1]
RefSeqiNP_057645.1. NM_016561.2. [Q9NZS9-1]
XP_005255407.1. XM_005255350.1. [Q9NZS9-2]
XP_006725259.1. XM_006725196.1. [Q9NZS9-2]
UniGeneiHs.435556.

Genome annotation databases

EnsembliENST00000261658; ENSP00000261658; ENSG00000103429. [Q9NZS9-1]
ENST00000619034; ENSP00000478190; ENSG00000275618. [Q9NZS9-1]
GeneIDi51283.
KEGGihsa:51283.
UCSCiuc002dco.3. human. [Q9NZS9-1]

Polymorphism databases

DMDMi74753089.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF173003 mRNA. Translation: AAF59975.1.
AK291114 mRNA. Translation: BAF83803.1.
AK300778 mRNA. Translation: BAG62442.1.
AC009167 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85105.1.
CH471112 Genomic DNA. Translation: EAW85108.1.
BC003054 mRNA. Translation: AAH03054.1.
CCDSiCCDS10554.1. [Q9NZS9-1]
RefSeqiNP_057645.1. NM_016561.2. [Q9NZS9-1]
XP_005255407.1. XM_005255350.1. [Q9NZS9-2]
XP_006725259.1. XM_006725196.1. [Q9NZS9-2]
UniGeneiHs.435556.

3D structure databases

ProteinModelPortaliQ9NZS9.
SMRiQ9NZS9. Positions 3-94, 170-248.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119435. 19 interactions.
IntActiQ9NZS9. 9 interactions.
STRINGi9606.ENSP00000261658.

PTM databases

PhosphoSiteiQ9NZS9.

Polymorphism databases

DMDMi74753089.

Proteomic databases

MaxQBiQ9NZS9.
PaxDbiQ9NZS9.
PRIDEiQ9NZS9.

Protocols and materials databases

DNASUi51283.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261658; ENSP00000261658; ENSG00000103429. [Q9NZS9-1]
ENST00000619034; ENSP00000478190; ENSG00000275618. [Q9NZS9-1]
GeneIDi51283.
KEGGihsa:51283.
UCSCiuc002dco.3. human. [Q9NZS9-1]

Organism-specific databases

CTDi51283.
GeneCardsiGC16P014634.
HGNCiHGNC:17613. BFAR.
HPAiHPA045905.
neXtProtiNX_Q9NZS9.
PharmGKBiPA38460.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG251630.
GeneTreeiENSGT00390000005386.
HOGENOMiHOG000285958.
HOVERGENiHBG056789.
InParanoidiQ9NZS9.
KOiK15684.
OMAiFVCNCLF.
OrthoDBiEOG7PP56P.
PhylomeDBiQ9NZS9.
TreeFamiTF332303.

Miscellaneous databases

ChiTaRSiBFAR. human.
GenomeRNAii51283.
NextBioi35475267.
PROiQ9NZS9.

Gene expression databases

BgeeiQ9NZS9.
CleanExiHS_BFAR.
ExpressionAtlasiQ9NZS9. baseline and differential.
GenevestigatoriQ9NZS9.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS50105. SAM_DOMAIN. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "BAR: an apoptosis regulator at the intersection of caspases and Bcl-2 family proteins."
    Zhang H., Xu Q., Krajewski S., Krajewska M., Xie Z., Fuess S., Kitada S., Pawlowski K., Godzik A., Reed J.C.
    Proc. Natl. Acad. Sci. U.S.A. 97:2597-2602(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH CASP8; BCL2 AND BCL2L1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Hepatoma.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  6. "Bifunctional apoptosis inhibitor (BAR) protects neurons from diverse cell death pathways."
    Roth W., Kermer P., Krajewska M., Welsh K., Davis S., Krajewski S., Reed J.C.
    Cell Death Differ. 10:1178-1187(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH IFT57; HIP1; ESRRBL1 AND BCAP31, TISSUE SPECIFICITY.

Entry informationi

Entry nameiBFAR_HUMAN
AccessioniPrimary (citable) accession number: Q9NZS9
Secondary accession number(s): A8K4Z9, B4DUT0, D3DUG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: October 1, 2000
Last modified: February 4, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.