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Q9NZS6

- Q9NZS6_HUMAN

UniProt

Q9NZS6 - Q9NZS6_HUMAN

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Protein
Elongation factor 1-alpha
Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis By similarity.UniRule annotation

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTPase activity Source: InterPro
  3. translation elongation factor activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Elongation factorUniRule annotationImported, ReceptorImported

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-bindingUniRule annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Elongation factor 1-alphaUniRule annotation
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro
    Complete GO annotation...

    PTM / Processingi

    Proteomic databases

    PRIDEiQ9NZS6.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NZS6.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOVERGENiHBG000179.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR000795. EF_GTP-bd_dom.
    IPR027417. P-loop_NTPase.
    IPR009000. Transl_B-barrel.
    IPR009001. Transl_elong_EF1A/Init_IF2_C.
    IPR004539. Transl_elong_EF1A_euk/arc.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    IPR004160. Transl_elong_EFTu/EF1A_C.
    [Graphical view]
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF03143. GTP_EFTU_D3. 1 hit.
    [Graphical view]
    PRINTSiPR00315. ELONGATNFCT.
    SUPFAMiSSF50447. SSF50447. 1 hit.
    SSF50465. SSF50465. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00483. EF-1_alpha. 1 hit.
    PROSITEiPS00301. EFACTOR_GTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q9NZS6-1 [UniParc]FASTAAdd to Basket

    « Hide

    GNSGKFEKEA AEMGKGSFKY AWVWDKLKAE RERGITIDIS LWKFETSKYY    50
    VTIIDAPGHR DFIKNMITGT SQADCAVLIV AAGVGEFEAG ISKNGQTREH 100
    ALLAYTLGVK QLIVGVNKSH STEPPYSQKR YEEIVKEVRT YIKKIGYNPD 150
    TVAFVPISGW NGDNMLEPSA NMPWFKGWKV TRKDGNASGT TLLEALDCIL 200
    PPHSPTDKPL RLPLQDVYKI GGIGTVPVGR VETGVLKPGM VVTFAPVNVT 250
    TEVKSVEMHH EALSEALPGD NVGFNVKNVS VKDVRRGNVA GDSKNDPPME 300
    AAGFTAQVII LNHPGQISAG YAPVLDCHTA HIACKFAELK EKIDRRSCKK 350
    LEDGPKFLKS GDAAIVDMVP GKPMCVESFS DYPPLGRFAV RDMRQTVAVG 400
    VIKAVDKKAA GAGKVTKSAQ KAQKAK 426
    Length:426
    Mass (Da):46,269
    Last modified:October 1, 2000 - v1
    Checksum:i092EB842BF4BF260
    GO

    Non-terminal residue

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF174496 mRNA. Translation: AAF36537.1.
    UniGeneiHs.535192.
    Hs.586423.
    Hs.745122.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF174496 mRNA. Translation: AAF36537.1 .
    UniGenei Hs.535192.
    Hs.586423.
    Hs.745122.

    3D structure databases

    ProteinModelPortali Q9NZS6.
    ModBasei Search...

    Proteomic databases

    PRIDEi Q9NZS6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG000179.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR000795. EF_GTP-bd_dom.
    IPR027417. P-loop_NTPase.
    IPR009000. Transl_B-barrel.
    IPR009001. Transl_elong_EF1A/Init_IF2_C.
    IPR004539. Transl_elong_EF1A_euk/arc.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    IPR004160. Transl_elong_EFTu/EF1A_C.
    [Graphical view ]
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF03143. GTP_EFTU_D3. 1 hit.
    [Graphical view ]
    PRINTSi PR00315. ELONGATNFCT.
    SUPFAMi SSF50447. SSF50447. 1 hit.
    SSF50465. SSF50465. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00483. EF-1_alpha. 1 hit.
    PROSITEi PS00301. EFACTOR_GTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Glucocorticoid receptor AF-1 specific elongation factor."
      Govindan M.V., Warriar N.
      Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: PlacentaImported.

    Entry informationi

    Entry nameiQ9NZS6_HUMAN
    AccessioniPrimary (citable) accession number: Q9NZS6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 1, 2000
    Last sequence update: October 1, 2000
    Last modified: April 16, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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