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Q9NZS6

- Q9NZS6_HUMAN

UniProt

Q9NZS6 - Q9NZS6_HUMAN

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Protein

Elongation factor 1-alpha

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.UniRule annotation

GO - Molecular functioni

  1. GTPase activity Source: InterPro
  2. GTP binding Source: UniProtKB-KW
  3. translation elongation factor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Elongation factorUniRule annotationImported, ReceptorImported

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor 1-alphaUniRule annotation
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ9NZS6.

Structurei

3D structure databases

ProteinModelPortaliQ9NZS6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.UniRule annotation

Phylogenomic databases

HOVERGENiHBG000179.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004539. Transl_elong_EF1A_euk/arc.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00483. EF-1_alpha. 1 hit.
PROSITEiPS00301. EFACTOR_GTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9NZS6 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
GNSGKFEKEA AEMGKGSFKY AWVWDKLKAE RERGITIDIS LWKFETSKYY
60 70 80 90 100
VTIIDAPGHR DFIKNMITGT SQADCAVLIV AAGVGEFEAG ISKNGQTREH
110 120 130 140 150
ALLAYTLGVK QLIVGVNKSH STEPPYSQKR YEEIVKEVRT YIKKIGYNPD
160 170 180 190 200
TVAFVPISGW NGDNMLEPSA NMPWFKGWKV TRKDGNASGT TLLEALDCIL
210 220 230 240 250
PPHSPTDKPL RLPLQDVYKI GGIGTVPVGR VETGVLKPGM VVTFAPVNVT
260 270 280 290 300
TEVKSVEMHH EALSEALPGD NVGFNVKNVS VKDVRRGNVA GDSKNDPPME
310 320 330 340 350
AAGFTAQVII LNHPGQISAG YAPVLDCHTA HIACKFAELK EKIDRRSCKK
360 370 380 390 400
LEDGPKFLKS GDAAIVDMVP GKPMCVESFS DYPPLGRFAV RDMRQTVAVG
410 420
VIKAVDKKAA GAGKVTKSAQ KAQKAK
Length:426
Mass (Da):46,269
Last modified:October 1, 2000 - v1
Checksum:i092EB842BF4BF260
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF174496 mRNA. Translation: AAF36537.1.
UniGeneiHs.535192.
Hs.586423.
Hs.745122.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF174496 mRNA. Translation: AAF36537.1 .
UniGenei Hs.535192.
Hs.586423.
Hs.745122.

3D structure databases

ProteinModelPortali Q9NZS6.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q9NZS6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG000179.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004539. Transl_elong_EF1A_euk/arc.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view ]
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view ]
PRINTSi PR00315. ELONGATNFCT.
SUPFAMi SSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00483. EF-1_alpha. 1 hit.
PROSITEi PS00301. EFACTOR_GTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Glucocorticoid receptor AF-1 specific elongation factor."
    Govindan M.V., Warriar N.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: PlacentaImported.

Entry informationi

Entry nameiQ9NZS6_HUMAN
AccessioniPrimary (citable) accession number: Q9NZS6
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.